Mechanics, malignancy, and metastasis: The force journey of a tumor cell
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Lelievre, S. A., Weaver, V. M., Nickerson, J. A., Larabell, C. A., Bhaumik, A., Petersen, O. W., et al. (1998). Tissue phenotype depends on reciprocal interactions between the extracellular matrix and the structural organization of the nucleus. Proceedings of the National Academy of Sciences of the United States of America, 95(25), 14711–14716.
Nelson, C. A., & Bissell, M. J. (2005). Modeling dynamic reciprocity: Engineering three-dimensional culture models of breast architecture, function, and neoplastic transformation. Seminars in Cancer Biology, 15(5), 342–352.
Paszek, M. J., & Weaver, V. M. (2004). The tension mounts: Mechanics meets morphogenesis and malignancy. Journal of Mammary Gland Biology and Neoplasia, 9(4), 325–342.
Bershadsky, A. D., Balaban, N. Q., & Geiger, B. (2003). Adhesion-dependent cell mechanosensitivity. Annual Review of Cell and Developmental Biology, 19, 677–695.
Giancotti, F. G., & Ruoslahti, E. (1999). Transduction — Integrin signaling. Science, 285(5430), 1028–1032.
Ingber, D. E. (2008). Tensegrity-based mechanosensing from macro to micro. Progress in Biophysics & Molecular Biology, 97(2–3), 163–179.
Janmey, P. A. (1998). The cytoskeleton and cell signaling: Component localization and mechanical coupling. Physiological Reviews, 78(3), 763–781.
Lele, T. P., & Kumar, S. (2007). Brushes, cables, and anchors: Recent insights into multiscale assembly and mechanics of cellular structural networks. Cell Biochemistry and Biophysics, 47(3), 348–360.
Paszek, M. J., Zahir, N., Johnson, K. R., Lakins, J. N., Rozenberg, G. I., Gefen, A., et al. (2005). Tensional homeostasis and the malignant phenotype. Cancer Cell, 8, 241–254.
Wang, N., Butler, J. P., & Ingber, D. E. (1993). Mechanotransduction across the cell surface and through the cytoskeleton. Science, 260(5111), 1124–1127.
Ingber, D. E. (2003). Mechanobiology and diseases of mechanotransduction. Annals of Medicine, 35(8), 564–577.
Farge, E. (2003). Mechanical induction of Twist in the Drosophila foregut/stomodeal primordium. Current Biology, 13(16), 1365–1377.
Supatto, W., Debarre, D., Moulia, B., Brouzes, E., Martin, J. L., Farge, E., et al. (2005). In vivo modulation of morphogenetic movements in Drosophila embryos with femtosecond laser pulses. Proceedings of the National Academy of Sciences of the United States of America, 102(4), 1047–1052.
Wei, L., Roberts, W., Wang, L., Yamada, M., Zhang, S., Zhao, Z., et al. (2001). Rho kinases play an obligatory role in vertebrate embryonic organogenesis. Development, 128(15), 2953–2962.
Ewald, A. J., Brenot, A., Duong, M., Chan, B. S., & Werb, Z. (2008). Collective epithelial migration and cell rearrangements drive mammary branching morphogenesis. Developmental Cell, 14(4), 570–581.
Engler, A. J., Sen, S., Sweeney, H. L., & Discher, D. E. (2006). Matrix elasticity directs stem cell lineage specification. Cell, 126(4), 677–689.
Winer, J. P., Janmey, P. A., McCormick, M. E., & Funaki, M. (2009). Bone Marrow-Derived Human Mesenchymal Stem Cells Become Quiescent on Soft Substrates but Remain Responsive to Chemical or Mechanical Stimuli. Tissue Engineering Part A, 15(1), 147–154.
Saha, K., Keung, A. J., Irwin, E. F., Li, Y., Little, L., Schaffer, D. V., et al. (2008). Substrate modulus directs neural stem cell behavior. Biophysical Journal, 95(9), 4426–4438.
Kokkinos, M. I., Wafai, R., Wong, M. K., Newgreen, D. F., Thompson, E. W., & Waltham, M. (2007). Vimentin and epithelial-mesenchymal transition in human breast cancer—Observations in vitro and in vivo. Cells Tissues Organs, 185(1–3), 191–203.
Pagan, R., Martin, I., Alonso, A., Llobera, M., & Vilaro, S. (1996). Vimentin filaments follow the preexisting cytokeratin network during epithelial-mesenchymal transition of cultured neonatal rat hepatocytes. Experimental Cell Research, 222(2), 333–344.
Willipinski-Stapelfeldt, B., Riethdorf, S., Assmann, V., Woelfle, U., Rau, T., Sauter, G., et al. (2005). Changes in cytoskeletal protein composition indicative of an epithelial-mesenchymal transition in human micrometastatic and primary breast carcinoma cells. Clinical Cancer Research, 11(22), 8006–8014.
Wang, H. B., Dembo, M., & Wang, Y. L. (2000). Substrate flexibility regulates growth and apoptosis of normal but not transformed cells. American Journal of Physiology — Cell Physiology, 279(5), C1345–1350.
Wozniak, M. A., Desai, R., Solski, P. A., Der, C. J., & Keely, P. J. (2003). ROCK-generated contractility regulates breast epithelial cell differentiation in response to the physical properties of a three-dimensional collagen matrix. Journal of Cell Biology, 163(3), 583–595.
Wolf, K., Friedl, P. (2008). Mapping proteolytic cancer cell-extracellular matrix interfaces. Clinical and Expermiental Metastasis, (in press).
Yamaguchi, H., Wyckoff, J., & Condeelis, J. (2005). Cell migration in tumors. Current Opinion in Cell Biology, 17(5), 559–564.
Yamaguchi, H., Lorenz, M., Kempiak, S., Sarmiento, C., Coniglio, S., Symons, M., et al. (2005). Molecular mechanisms of invadopodium formation: the role of the N-WASP-Arp2/3 complex pathway and cofilin. Journal of Cell Biology, 168(3), 441–452.
Wolf, K., Wu, Y. I., Liu, Y., Geiger, J., Tam, E., Overall, C., et al. (2007). Multi-step pericellular proteolysis controls the transition from individual to collective cancer cell invasion. Nature Cell Biology, 9(8), 893–904.
Khaled, W., Reichling, S., Bruhns, O. T., Boese, H., Baumann, M., Monkman, G., et al. (2004). Palpation imaging using a haptic system for virtual reality applications in medicine. Studies in Health Technology and Informatics, 98, 147–153.
Khaled, W., Reichling, S., Bruhns, O. T., & Ermert, H. (2006). Ultrasonic strain imaging and reconstructive elastography for biological tissue. Ultrasonics, 44(Suppl 1), e199–202.
Selbekk, T., Bang, J., & Unsgaard, G. (2005). Strain processing of intraoperative ultrasound images of brain tumours: initial results. Ultrasound in Medicine and Biology, 31(1), 45–51.
Unsgaard, G., Rygh, O. M., Selbekk, T., Muller, T. B., Kolstad, F., Lindseth, F., et al. (2006). Intra-operative 3D ultrasound in neurosurgery. Acta Neurochir (Wien), 148(3), 235–253 discussion 253.
Croft, D. R., Sahai, E., Mavria, G., Li, S., Tsai, J., Lee, W. M., et al. (2004). Conditional ROCK activation in vivo induces tumor cell dissemination and angiogenesis. Cancer Research, 64(24), 8994–9001.
O’Brien, L. E., Jou, T. S., Pollack, A. L., Zhang, Q., Hansen, S. H., Yurchenco, P., et al. (2001). Rac1 orientates epithelial apical polarity through effects on basolateral laminin assembly. Nature Cell Biology, 3(9), 831–838.
Wang, F., Weaver, V. M., Petersen, O. W., Larabell, C. A., Dedhar, S., Briand, P., et al. (1998). Reciprocal interactions between beta1-integrin and epidermal growth factor receptor in three-dimensional basement membrane breast cultures: a different perspective in epithelial biology. Proceedings of the National Academy of Sciences of the United States of America, 95(25), 14821–14826.
Ingman, W. V., Wyckoff, J., Gouon-Evans, V., Condeelis, J., & Pollard, J. W. (2006). Macrophages promote collagen fibrillogenesis around terminal end buds of the developing mammary gland. Developmental Dynamics, 235(12), 3222–3229.
Provenzano, P. P., Inman, D. R., Eliceiri, K. W., Knittel, J. G., Yan, L., Rueden, C. T., et al. (2008). Collagen density promotes mammary tumor initiation and progression. BMC Medicine, 6(1), 1–11.
Wyckoff, J. B., Pinner, S. E., Gschmeissner, S., Condeelis, J. S., & Sahai, E. (2006). ROCK- and myosin-dependent matrix deformation enables protease-independent tumor-cell invasion in vivo. Current Biology, 16(15), 1515–1523.
Ingber, D. E., Madri, J. A., & Jamieson, J. D. (1981). Role of basal lamina in neoplastic disorganization of tissue architecture. Proceedings of the National Academy of Sciences of the United States of America, 78(6), 3901–3905.
Black, P. (1998). Management of malignant glioma: role of surgery in relation to multimodality therapy. Journal of Neurovirology, 4(2), 227–236.
Schankin, C. J., Ferrari, U., Reinisch, V. M., Birnbaum, T., Goldbrunner, R., & Straube, A. (2007). Characteristics of brain tumour-associated headache. Cephalalgia, 27(8), 904–911.
Watanapa, P., & Williamson, R. C. N. (1992). Surgical Palliation for Pancreatic-Cancer—Developments during the Past 2 Decades. British Journal of Surgery, 79(1), 8–20.
Harris, A. L. (2002). Hypoxia—a key regulatory factor in tumour growth. Nature Reviews Cancer, 2(1), 38–47.
Roose, T., Netti, P. A., Munn, L. L., Boucher, Y., & Jain, R. K. (2003). Solid stress generated by spheroid growth estimated using a linear poroelasticity model small star, filled. Microvascular Research, 66(3), 204–212.
Tschumperlin, D. J., Dai, G., Maly, I. V., Kikuchi, T., Laiho, L. H., McVittie, A. K., et al. (2004). Mechanotransduction through growth-factor shedding into the extracellular space. Nature, 429(6987), 83–86.
Minchinton, A. I., & Tannock, I. F. (2006). Drug penetration in solid tumours. Nature Reviews Cancer, 6(8), 583–592.
Marshburn, P. B., & Hulka, J. F. (1990). A simple irrigator-aspirator cannula for laparoscopy: the Stewart system. Obstetrics and Gynecology, 75(3 Pt 1), 458–460.
Davies, P. F., Spaan, J. A., & Krams, R. (2005). Shear stress biology of the endothelium. Annals of Biomedical Engineering, 33(12), 1714–1718.
Thamilselvan, V., Craig, D. H., & Basson, M. D. (2007). FAK association with multiple signal proteins mediates pressure-induced colon cancer cell adhesion via a Src-dependent PI3K/Akt pathway. FASEB Journal, 21(8), 1730–1741.
von Sengbusch, A., Gassmann, P., Fisch, K. M., Enns, A., Nicolson, G. L., & Haier, J. (2005). Focal adhesion kinase regulates metastatic adhesion of carcinoma cells within liver sinusoids. American Journal of Pathology, 166(2), 585–596.
Miles, F. L., Pruitt, F. L., van Golen, K. L., & Cooper, C. R. (2008). Stepping out of the flow: capillary extravasation in cancer metastasis. Clinical and Expermiental Metastasis, 25(4), 305–324.
Stewart, D. A., Cooper, C. R., & Sikes, R. A. (2004). Changes in extracellular matrix (ECM) and ECM-associated proteins in the metastatic progression of prostate cancer. Reproductive Biology and Endocrinology, 2, 2.
Heino, J., & Massague, J. (1989). Transforming growth factor-beta switches the pattern of integrins expressed in MG-63 human osteosarcoma cells and causes a selective loss of cell adhesion to laminin. Journal of Biological Chemistry, 264(36), 21806–21811.
Mierke, C. T., Zitterbart, D. P., Kollmannsberger, P., Raupach, C., Schlotzer-Schrehardt, U., Goecke, T. W., et al. (2008). Breakdown of the endothelial barrier function in tumor cell transmigration. Biophysical Journal, 94(7), 2832–2846.
Levental, I., Georges, P. C., & Janmey, P. A. (2007). Soft biological materials and their impact on cell function. Soft Matter, 3(3), 299–306.
Janmey, P. A., Georges, P. C., & Hvidt, S. (2007). Basic rheology for biologists. Methods in Cell Biology, 83(1), 3–27.
Chown, M. G., & Kumar, S. (2007). Imaging and manipulating the structural machinery of living cells on the micro- and nanoscale. International Journal of Nanomedicine, 2(3), 333–344.
Dao, M., Lim, C. T., & Suresh, S. (2003). Mechanics of the human red blood cell deformed by optical tweezers. Journal of the Mechanics and Physics of Solids, 51(11–12), 2259–2280.
Guck, J., Schinkinger, S., Lincoln, B., Wottawah, F., Ebert, S., Romeyke, M., et al. (2005). Optical deformability as an inherent cell marker for testing malignant transformation and metastatic competence. Biophysical Journal, 88(5), 3689–3698.
Lincoln, B., Wottawah, F., Schinkinger, S., Ebert, S., & Guck, J. (2007). High-throughput rheological measurements with an optical stretcher. Methods in Cell Biology, 83(1), 397–423.
Trepat, X., Grabulosa, M., Puig, F., Maksym, G. N., Navajas, D., & Farre, R. (2004). Viscoelasticity of human alveolar epithelial cells subjected to stretch. American Journal of Physiology-Lung Cellular and Molecular Physiology, 287(5), L1025–L1034.
Drury, J. L., & Dembo, M. (2001). Aspiration of human neutrophils: Effects of shear thinning and cortical dissipation. Biophysical Journal, 81(6), 3166–3177.
Hochmuth, R. M. (2000). Micropipette aspiration of living cells. Journal of Biomechanics, 33(1), 15–22.
Jones, W. R., Ting-Beall, H. P., Lee, G. M., Kelley, S. S., Hochmuth, R. M., & Guilak, F. (1999). Alterations in the Young’s modulus and volumetric properties of chondrocytes isolated from normal and osteoarthritic human cartilage. Journal of Biomechanics, 32(2), 119–127.
Koay, E. J., Shieh, A. C., & Athanasiou, K. A. (2003). Creep indentation of single cells. Journal of Biomechanical Engineering-Transactions of the ASME, 125(3), 334–341.
Trickey, W. R., Baaijens, F. P. T., Laursen, T. A., Alexopoulos, L. G., & Guilak, F. (2006). Determination of the Poisson’s ratio of the cell: recovery properties of chondrocytes after release from complete micropipette aspiration. Journal of Biomechanics, 39(1), 78–87.
Beningo, K. A., Dembo, M., Kaverina, I., Small, J. V., & Wang, Y. L. (2001). Nascent focal adhesions are responsible for the generation of strong propulsive forces in migrating fibroblasts. Journal of Cell Biology, 153(4), 881–887.
Butler, J. P., Tolic-Norrelykke, I. M., Fabry, B., & Fredberg, J. J. (2002). Traction fields, moments, and strain energy that cells exert on their surroundings. American Journal of Physiology-Cell Physiology, 282(3), C595–C605.
Munevar, S., Wang, Y. L., & Dembo, M. (2001). Traction force microscopy of migrating normal and H-ras transformed 3T3 fibroblasts. Biophysical Journal, 80(4), 1744–1757.
Pelham, R. J., & Wang, Y. L. (1999). High resolution detection of mechanical forces exerted by locomoting fibroblasts on the substrate. Molecular Biology of the Cell, 10(4), 935–945.
Hansma, H. G., & Hoh, J. H. (1994). Biomolecular Imaging with the Atomic-Force Microscope. Annual Review of Biophysics and Biomolecular Structure, 23(1), 115–139.
Kumar, S., & Hoh, J. H. (2001). Probing the machinery of intracellular trafficking with the atomic force microscope. Traffic, 2(11), 746–756.
Lal, R., & John, S. A. (1994). Biological Applications of Atomic-Force Microscopy. American Journal of Physiology, 266(1), C1–&.
Radmacher, M. (2002). Measuring the elastic properties of living cells by the atomic force microscope. Methods in Cell Biology, 68(1), 67–90.
An, S. S., Laudadio, R. E., Lai, J., Rogers, R. A., & Fredberg, J. J. (2002). Stiffness changes in cultured airway smooth muscle cells. American Journal of Physiology-Cell Physiology, 283(3), C792–C801.
Ingber, D. E., Prusty, D., Sun, Z. Q., Betensky, H., & Wang, N. (1995). Cell shape, cytoskeletal mechanics, and cell cycle control in angiogenesis. Journal of Biomechanics, 28(12), 1471–1484.
Maksym, G. N., Fabry, B., Butler, J. P., Navajas, D., Tschumperlin, D. J., Laporte, J. D., et al. (2000). Mechanical properties of cultured human airway smooth muscle cells from 0.05 to 0.4 Hz. Journal of Applied Physiology, 89(4), 1619–1632.
Wang, N., Tolic-Norrelykke, I. M., Chen, J. X., Mijailovich, S. M., Butler, J. P., Fredberg, J. J., et al. (2002). Cell prestress. I. Stiffness and prestress are closely associated in adherent contractile cells. American Journal of Physiology-Cell Physiology, 282(3), C606–C616.
Berns, M. W., Aist, J., Edwards, J., Strahs, K., Girton, J., McNeill, P., et al. (1981). Laser microsurgery in cell and developmental biology. Science, 213(4507), 505–13.
Heisterkamp, A., Maxwell, I. Z., Mazur, E., Underwood, J. M., Nickerson, J. A., Kumar, S., et al. (2005). Pulse energy dependence of subcellular dissection by femtosecond laser pulses. Optics Express, 13(10), 3690–3696.
Kumar, S., Maxwell, I. Z., Heisterkamp, A., Polte, T. R., Lele, T. P., Salanga, M., et al. (2006). Viscoelastic retraction of single living stress fibers and its impact on cell shape, cytoskeletal organization, and extracellular matrix mechanics. Biophysical Journal, 90(10), 3762–3773.
Lele, T. P., Pendse, J., Kumar, S., Salanga, M., Karavitis, J., & Ingber, D. E. (2006). Mechanical forces alter zyxin unbinding kinetics within focal adhesions of living cells. Journal of Cellular Physiology, 207(1), 187–194.
Shen, N., Colvin, M., Genin, F., Huser, T., Cortopassi, G. A., Stearns, T., et al. (2004). Using femtosecond laser subcellular surgery to studycell biology. Biophysical Journal, 86(1), 520A–520A.
du Roure, O., Saez, A., Buguin, A., Austin, R. H., Chavrier, P., Siberzan, P., et al. (2005). Force mapping in epithelial cell migration. Proceedings of the National Academy of Sciences of the United States of America, 102(7), 2390–2395.
Nelson, C. M., Jean, R. P., Tan, J. L., Liu, W. F., Sniadecki, N. J., Spector, A. A., et al. (2005). Emergent patterns of growth controlled by multicellular form and mechanics. Proceedings of the National Academy of Sciences of the United States of America, 102(33), 11594–11599.
Poujade, M., Grasland-Mongrain, E., Hertzog, A., Jouanneau, J., Chavrier, P., Ladoux, B., et al. (2007). Collective migration of an epithelial monolayer in response to a model wound. Proceedings of the National Academy of Sciences of the United States of America, 104(41), 15988–15993.
Rabodzey, A., Alcaide, P., Luscinskas, F. W., & Ladoux, B. (2008). Mechanical forces induced by the transendothelial migration of human neutrophils. Biophysical Journal, 95(3), 1428–1438.
Sniadecki, N. J., Anguelouch, A., Yang, M. T., Lamb, C. M., Liu, Z., Kirschner, S. B., et al. (2007). Magnetic microposts as an approach to apply forces to living cells. Proceedings of the National Academy of Sciences of the United States of America, 104(37), 14553–14558.
Tan, J. L., Tien, J., Pirone, D. M., Gray, D. S., Bhadriraju, K., & Chen, C. S. (2003). Cells lying on a bed of microneedles: An approach to isolate mechanical force. Proceedings of the National Academy of Sciences of the United States of America, 100(4), 1484–1489.
Bausch, A. R., Ziemann, F., Boulbitch, A. A., Jacobson, K., & Sackmann, E. (1998). Local measurements of viscoelastic parameters of adherent cell surfaces by magnetic bead microrheometry. Biophysical Journal, 75(4), 2038–2049.
Tseng, Y., Kole, T. P., & Wirtz, D. (2002). Micromechanical mapping of live cells by multiple-particle-tracking microrheology. Biophysical Journal, 83(6), 3162–3176.
Valentine, M. T., Perlman, Z. E., Gardel, M. L., Shin, J. H., Matsudaira, P., Mitchison, T. J., et al. (2004). Colloid surface chemistry critically affects multiple particle tracking measurements of biomaterials. Biophysical Journal, 86(6), 4004–4014.
Yamada, S., Wirtz, D., & Kuo, S. C. (2000). Mechanics of living cells measured by laser tracking microrheology. Biophysical Journal, 78(4), 1736–1747.
Yap, B., & Kamm, R. D. (2005). Mechanical deformation of neutrophils into narrow channels induces pseudopod projection and changes in biomechanical properties. Journal of Applied Physiology, 98(5), 1930–1939.
Pesen, D., & Hoh, J. H. (2005). Modes of remodeling in the cortical cytoskeleton of vascular endothelial cells. FEBS Letters, 579(2), 473–476.
Pesen, D., & Hoh, J. H. (2005). Micromechanical architecture of the endothelial cell cortex. Biophysical Journal, 88(1), 670–679.
Oberhauser, A. F., Badilla-Fernandez, C., Carrion-Vasquez, M., & Fernandez, J. M. (2002). The mechanical hierarchies of fibronectin observed with single-molecule AFM. Journal of Molecular Biology, 319, 433–447.
Carl, P., Kwok, C. H., Manderson, G., Speicher, D. W., & Discher, D. E. (2001). Forced unfolding modulated by disulfide bonds in the Ig domains of a cell adhesion molecule. Proceedings of the National Academy of Sciences of the United States of America, 98, 1565–1570.
Rotsch, C., Jacobson, K., & Radmacher, M. (1999). Dimensional and mechanical dynamics of active and stable edges in motile fibroblasts investigated by using atomic force microscopy. Proceedings of the National Academy of Sciences of the United States of America, 96(3), 921–926.
A-Hassan, E., Heinz, W. F., Antonik, M. D., D’Costa, N. P., Nageswaran, S., Schoenenberger, C. A., et al. (1998). Relative microelastic mapping of living cells by atomic force microscopy. Biophysical Journal, 74(3), 1564–1578.
Charras, G. T., & Horton, M. A. (2002). Single cell mechanotransduction and its modulation analyzed by atomic force microscope indentation. Biophysical Journal, 82(6), 2970–2981.
Parekh, S. H., Chaudhuri, O., Theriot, J. A., & Fletcher, D. A. (2005). Loading history determines the velocity of actin-network growth. Nature Cell Biology, 7(12), 1219–1223.
Chaudhuri, O., Parekh, S. H., & Fletcher, D. A. (2007). Reversible stress softening of actin networks. Nature, 445(7125), 295–298.
Prass, M., Jacobson, K., Mogilner, A., & Radmacher, M. (2006). Direct measurement of the lamellipodial protrusive force in a migrating cell. Journal of Cell Biology, 174(6), 767–772.
Lam, W. A., Rosenbluth, M. J., & Fletcher, D. A. (2008). Increased leukaemia cell stiffness is associated with symptoms of leucostasis in paediatric acute lymphoblastic leukaemia. British Journal of Haematology, 142(3), 497–501.
Lam, W. A., Rosenbluth, M. J., & Fletcher, D. A. (2007). Chemotherapy exposure increases leukemia cell stiffness. Blood, 109(8), 3505–3508.
Rosenbluth, M. J., Lam, W. A., & Fletcher, D. A. (2006). Force microscopy of nonadherent cells: A comparison of leukemia cell deformability. Biophysical Journal, 90(8), 2994–3003.
Strahs, K. R., Burt, J. M., & Berns, M. W. (1978). Contractility changes in cultured cardiac cells following laser microirradiation of myofibrils and the cell surface. Experimental Cell Research, 113(1), 75–83.
Strahs, K. R., & Berns, M. W. (1979). Laser microirradiation of stress fibers and intermediate filaments in non-muscle cells from cultured rat heart. Experimental Cell Research, 119(1), 31–45.
Koonce, M. P., Strahs, K. R., & Berns, M. W. (1982). Repair of laser-severed stress fibers in myocardial non-muscle cells. Experimental Cell Research, 141(2), 375–384.
Burt, J. M., Strahs, K. R., & Berns, M. W. (1979). Correlation of cell surface alterations with contractile response in laser microbeam irradiated myocardial cells. A scanning electron microscope study. Experimental Cell Research, 118(2), 341–351.
Botvinick, E. L., Venugopalan, V., Shah, J. V., Liaw, L. H., & Berns, M. W. (2004). Controlled ablation of microtubules using a picosecond laser. Biophysical Journal, 87(6), 4203–4212.
Ingber, D. E. (2002). Mechanical signalling and the cellular response to extracellular matrix in angiogenesis and cardiovascular physiology. Circulation Research, 91(10), 877–887.
Assoian, R. K., & Klein, E. A. (2008). Growth control by intracellular tension and extracellular stiffness. Trends in Cell Biology, 18(7), 347–352.
Burridge, K., & ChrzanowskaWodnicka, M. (1996). Focal adhesions, contractility, and signaling. Annual Review of Cell and Developmental Biology, 12, 463–518.
Hotulainen, P., & Lappalainen, P. (2006). Stress fibers are generated by two distinct actin assembly mechanisms in motile cells. Journal of Cell Biology, 173(3), 383–394.
Sipkema, P., van der Linden, P. J. W., Westerhof, N., & Yin, F. C. P. (2003). Effect of cyclic axial stretch of rat arteries on endothelial cytoskeletal morphology and vascular reactivity. Journal of Biomechanics, 36(5), 653–659.
Hayes, A. J., Benjamin, M., & Ralphs, J. R. (1999). Role of actin stress fibres in the development of the intervertebral disc: Cytoskeletal control of extracellular matrix assembly. Developmental Dynamics, 215(3), 179–189.
Elkin, B. S., Azeloglu, E. U., Costa, K. D., & Morrison, B. (2007). Mechanical heterogeneity of the rat hippocampus measured by atomic force microscope indentation. Journal of Neurotrauma, 24(5), 812–822.
Cavey, M., Rauzi, M., Lenne, P. F., & Lecuit, T. (2008). A two-tiered mechanism for stabilization and immobilization of E-cadherin. Nature, 453(7196), 751–U2.
Daniels, B. R., Masi, B. C., & Wirtz, D. (2006). Probing single-cell micromechanics in vivo: The microrheology of C-elegans developing embryos. Biophysical Journal, 90(12), 4712–4719.
Panorchan, P., Lee, J. S. H., Kole, T. P., Tseng, Y., & Wirtz, D. (2006). Microrheology and ROCK signaling of human endothelial cells embedded in a 3D matrix. Biophysical Journal, 91(9), 3499–3507.
Bloom, R. J., George, J. P., Celedon, A., Sun, S. X., & Wirtz, D. (2008). Mapping local matrix remodeling induced by a migrating tumor cell using 3-D multiple-particle tracking. Biophysical Journal, 95(8), 4077–4088.
Roy, P., Petroll, W. M., Cavanagh, H. D., & Jester, J. V. (1999). Exertion of tractional force requires the coordinated up-regulation of cell contractility and adhesion. Cell Motility and the Cytoskeleton, 43(1), 23–34.
Petroll, W. M., Ma, L., & Jester, J. V. (2003). Direct correlation of collagen matrix deformation with focal adhesion dynamics in living corneal fibroblasts. Journal of Cell Science, 116(8), 1481–1491.
Vanni, S., Lagerholm, B. C., Otey, C., Taylor, D. L., & Lanni, F. (2003). Internet-Based image analysis quantifies contractile behavior of individual fibroblasts inside model tissue. Biophysical Journal, 84(4), 2715–2727.
Vega, F. M., & Ridley, A. J. (2008). Rho GTPases in cancer cell biology. FEBS Letters, 582(14), 2093–2101.
Raftopoulou, M., & Hall, A. (2004). Cell migration: Rho GTPases lead the way. Developmental Biology, 265(1), 23–32.
Friedl, P., & Wolf, K. (2003). Tumour-cell invasion and migration: Diversity and escape mechanisms. Nature Reviews Cancer, 3(5), 362–374.
Lozano, E., Betson, M., & Braga, V. M. M. (2003). Tumor progression: small GTPases and loss of cell-cell adhesion. Bioessays, 25(5), 452–463.
Ying, H., Biroc, S. L., Li, W. W., Alicke, B., Xuan, J. A., Pagila, R., et al. (2006). The Rho kinase inhibitor fasudil inhibits tumor progression in human and rat tumor models. Molecular Cancer Therapeutics, 5(9), 2158–2164.
Bershadsky, A., Kozlov, M., & Geiger, B. (2006). Adhesion-mediated mechanosensitivity: a time to experiment, and a time to theorize. Current Opinion in Cell Biology, 18(5), 472–481.
Schlaepfer, D. D., Hanks, S. K., Hunter, T., & Vandergeer, P. (1994). Integrin-Mediated Signal-Transduction Linked to Ras Pathway by Grb2 Binding to Focal Adhesion Kinase. Nature, 372(6508), 786–791.
Ridley, A. J., & Hall, A. (1992). The Small Gtp-Binding Protein Rho Regulates the Assembly of Focal Adhesions and Actin Stress Fibers in Response to Growth-Factors. Cell, 70(3), 389–399.
Sechi, A. S., & Wehland, J. (2000). The actin cytoskeleton and plasma membrane connection: PtdIns(4,5)P-2 influences cytoskeletal protein activity at the plasma membrane. Journal of Cell Science, 113(21), 3685–3695.
Gilmore, A. P., & Burridge, K. (1996). Regulation of vinculin binding to talin and actin by phosphatidyl-inositol-4-5-bisphosphate. Nature, 381(6582), 531–535.
Schwartz, M. A., Schaller, M. D., & Ginsberg, M. H. (1995). Integrins: Emerging paradigms of signal transduction. Annual Review of Cell and Developmental Biology, 11, 549–599.
Tilghman, R. W., & Parsons, J. T. (2008). Focal adhesion kinase as a regulator of cell tension in the progression of cancer. Seminars in Cancer Biology, 18(1), 45–52.
Gabarra-Niecko, V., Schaller, M. D., & Dunty, J. M. (2003). FAK regulates biological processes important for the pathogenesis of cancer. Cancer and Metastasis Reviews, 22(4), 359–374.
Mitra, S. K., Hanson, D. A., & Schlaepfer, D. D. (2005). Focal adhesion kinase: In command and control of cell motility. Nature Reviews Molecular Cell Biology, 6(1), 56–68.
Parsons, J. T. (2003). Focal adhesion kinase: the first ten years. Journal of Cell Science, 116(8), 1409–1416.
Schlaepfer, D. D., Mitra, S. K., & Ilic, D. (2004). Control of motile and invasive cell phenotypes by focal adhesion kinase. Biochimica et Biophysica Acta-Molecular Cell Research, 1692(2–3), 77–102.
Liu, T. J., LaFortune, T., Honda, T., Ohmori, O., Hatakeyama, S., Meyer, T., et al. (2007). Inhibition of both focal adhesion kinase and insulin-like growth factor-I receptor kinase suppresses glioma proliferation in vitro and in vivo. Molecular Cancer Therapeutics, 6(4), 1357–1367.
Shen, T. L., & Guan, J. L. (2001). Differential regulation of cell migration and cell cycle progression by FAK complexes with Src, PI3K, Grb7 and Grb2 in focal contacts. FEBS Letters, 499(1–2), 176–181.
Izaguirre, G., Aguirre, L., Hu, Y. P., Lee, H. Y., Schlaepfer, D. D., Aneskievich, B. J., et al. (2001). The cytoskeletal/non-muscle isoform of alpha-actinin is phosphorylated on its actin-binding domain by the focal adhesion kinase. Journal of Biological Chemistry, 276(31), 28676–28685.
Wang, H. B., Dembo, M., Hanks, S. K., & Wang, Y. L. (2001). Focal adhesion kinase is involved in mechanosensing during fibroblast migration. Proceedings of the National Academy of Sciences of the United States of America, 98(20), 11295–11300.
Hamasaki, K., Mimura, T., Furuya, H., Morino, N., Yamazaki, T., Komuro, I., et al. (1995). Stretching Mesangial Cells Stimulates Tyrosine Phosphorylation of Focal Adhesion Kinase Pp125(Fak). Biochemical and Biophysical Research Communications, 212(2), 544–549.
Mofrad, M. R., Golji, J., Abdul Rahim, N. A., & Kamm, R. D. (2004). Force-induced unfolding of the focal adhesion targeting domain and the influence of paxillin binding. Mechanics and Chemistry of Biosystems, 1(4), 253–65.