Đo lường sự giảm mức độ sử dụng cần sa trong các thử nghiệm lâm sàng: một đánh giá về các thách thức phương pháp luận

Springer Science and Business Media LLC - Tập 6 - Trang 429-436 - 2019
Rachel L. Tomko1, Kevin M. Gray1, Marilyn A. Huestis2, Lindsay M. Squeglia1, Nathaniel L. Baker3, Erin A. McClure1
1Department of Psychiatry and Behavioral Sciences, Medical University of South Carolina, Charleston, USA
2Institute of Emerging Health Professions, Thomas Jefferson University, Philadelphia, USA
3Department of Public Health Sciences, Medical University of South Carolina, Charleston, USA

Tóm tắt

Việc kiêng cần sa, truyền thống, là kết quả chính trong các thử nghiệm điều trị rối loạn sử dụng cần sa (CUD). Do sự thay đổi tính hợp pháp của cần sa, mục tiêu của bệnh nhân và bằng chứng ban đầu cho thấy những người giảm sử dụng cần sa có thể cho thấy cải thiện chức năng, việc giảm sử dụng cần sa là một kết quả thay thế đáng mong đợi trong các thử nghiệm CUD. Chúng tôi xem xét các thách thức trong việc đo lường sự giảm mức độ sử dụng cần sa và bằng chứng để hỗ trợ cho các định nghĩa khác nhau về sự giảm. Sự giảm số ngày sử dụng cần sa được liên kết với những cải thiện về chức năng qua nhiều nghiên cứu. Sự giảm số lượng cần sa được sử dụng thì không nhất quán liên quan đến những cải thiện về chức năng, mặc dù các định nghĩa về số lượng thay đổi giữa các nghiên cứu. Các chỉ số sinh học khác nhau có thể được sử dụng tùy theo kết quả giảm. Sự giảm xác thực sinh học về tần suất những ngày sử dụng cần sa có thể đại diện cho một điểm kết thúc khả thi trong các thử nghiệm lâm sàng cho rối loạn sử dụng cần sa. Cần thêm nghiên cứu để định lượng tốt hơn sự giảm trong số lượng cần sa.

Từ khóa

#rối loạn sử dụng cần sa; giảm sử dụng cần sa; thử nghiệm lâm sàng; cải thiện chức năng; chỉ số sinh học

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