Measurement of mRNA abundance using RNA-seq data: RPKM measure is inconsistent among samples

Theory in Biosciences - Tập 131 Số 4 - Trang 281-285 - 2012
Günter P. Wagner1, Koryu Kin1, Vincent J. Lynch1
1Yale University

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Tài liệu tham khảo

Houle D, Pelabon C, Wagner GP, Hansen TF (2011) Measurement and meaning in biology. Q Rev Biol 86:3–34

Jiang H, Wong WH (2009) Statistical inferences for isoform expression in RNA-seq. Bioinformatics 25:1026–1032

Mortazavi A, Williams BA, McCue K, Schaeffer L, Wold B (2008) Mapping and quantifying mammalian transcriptomes by RNA-seq. Nat Methods 5:621–628

Narens L (2002) Theories of meaningfulness. Lawrence Erlbaum Associates, Mahwah

Ozsolak F, Milos PM (2011) RNA sequencing: advances, challenges and opportunities. Nat Rev Genet 12:87–98

Stamm S, Ben-Ari S, Rafalska I, Tang Y, Zhang Z, Toiber D, Thanaraj TA, Soreq H (2005) Function of alternative splicing. Gene 344:1–20

Wang Z, Gerstein M, Snyder M (2009) RNA-seq: a revolutionary tool for transcriptomics. Nat Rev Genet 10:57–63

Wang Z, Young RL, Xue H, Wagner GP (2011) Transcriptomic analysis of avian digits reveals conserved and derived digit identities in birds. Nature 477:583–586