Matrix metalloproteinases (MMPs) in oral diseases

Oral Diseases - Tập 10 Số 6 - Trang 311-318 - 2004
Timo Sorsa1,2,3, Leo Tjäderhane1,2, Tuula Salo4,5
1Department of Oral and Maxillofacial Diseases, Helsinki University Central Hospital (HUCH), Helsinki, Finland
2Institute of Dentistry, University of Helsinki, Helsinki, Finland
3ORTON Research Institute, Orthopaedic Hospital of Invalid Foundation, Helsinki, Finland
4Institute of Dentistry, University of Oulu, Oulu, Finland
5Oulu University Hospital (OUH), Oulu, Finland

Tóm tắt

Matrix metalloproteinases (MMPs) are a group of enzymes that in concert are responsible for the degradation of most extracellular matrix proteins during organogenesis, growth and normal tissue turnover. The expression and activity of MMPs in adult tissues is normally quite low, but increases significantly in various pathological conditions that may lead into unwanted tissue destruction, such as inflammatory diseases, tumour growth and metastasis. MMPs have a marked role also in tissue destructive oral diseases. The role of collagenases, especially MMP‐8, in periodontitis and peri‐implantitis is the best‐known example of the unwanted tissue destruction related to increased presence and activity of MMPs at the site of disease, but evidence has been brought forward to indicate that MMPs may be involved also in other oral diseases, such as dental caries and oral cancer. This brief review describes some of the history, the current status and the future aspects of the work mainly of our research groups looking at the presence and activity of various MMPs in different oral diseases, as well as some of the MMP‐related aspects that may facilitate the development of new means of diagnosis and treatment of oral diseases.

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Oral Diseases

Tập 10 Số 6

311-318

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