Matrix effects: the Achilles heel of quantitative high-performance liquid chromatography–electrospray–tandem mass spectrometry

Clinical Biochemistry - Tập 38 Số 4 - Trang 328-334 - 2005
Paul J. Taylor1
1Department of Clinical Pharmacology and Australian Bioanalytical Services Pty Ltd, , 3rd Floor-R wing, Building One, Princess Alexandra Hospital, Ipswich Road, Brisbane, QLD 4102, Australia. [email protected]

Tóm tắt

Từ khóa


Tài liệu tham khảo

Covey, 1986, High-speed liquid chromatography/tandem mass spectrometry for the determination of drugs in biological samples, Anal. Chem., 58, 2453, 10.1021/ac00125a022

Fenn, 1989, Electrospray ionization for mass spectrometry of large biomolecules, Science, 246, 64, 10.1126/science.2675315

Bruins, 1991, Liquid chromatography–mass spectrometry with ionspray and electrospray interfaces in pharmaceutical and biomedical research, J. Chromatogr., 554, 39, 10.1016/S0021-9673(01)88435-1

Kebarle, 2000, A brief overview of the present status of the mechanisms involved in electrospray mass spectrometry, J. Mass Spectrom., 35, 804, 10.1002/1096-9888(200007)35:7<804::AID-JMS22>3.0.CO;2-Q

Brewer, 1998, Atmospheric pressure ionization LC/MS/MS techniques for drug disposition studies, J. Pharm. Sci., 87, 395, 10.1021/js9701059

Hopfgartner, 2003, Quantitative high-throughput analysis of drugs in biological matrices by mass spectrometry, Mass Spectrom. Rev., 22, 195, 10.1002/mas.10050

Bayliss, 2000, Parallel ultra-high flow rate liquid chromatography with mass spectrometric detection using a multiplex electrospray source for direct, sensitive determination of pharmaceuticals in plasma at extremely high throughput, Rapid Commun. Mass Spectrom., 14, 2039, 10.1002/1097-0231(20001115)14:21<2039::AID-RCM130>3.0.CO;2-2

Grant, 2002, Generic serial and parallel on-line direct injection using turbulent flow liquid chromatography/tandem mass spectrometry, Rapid Commun. Mass Spectrom., 16, 1785, 10.1002/rcm.784

Dooley, 2003, Tandem mass spectrometry in the clinical chemistry laboratory, Clin. Biochem., 36, 471, 10.1016/S0009-9120(03)00105-X

Chace, 2001, Mass spectrometry in the clinical laboratory, Chem. Rev., 101, 445, 10.1021/cr990077+

Fredline, 1997, A reference method for the analysis of aldosterone in blood by high performance liquid chromatography–atmospheric pressure chemical ionisation–tandem mass spectrometry, Anal. Biochem., 252, 308, 10.1006/abio.1997.2340

Johnson, 1999, Dimethylaminoethyl esters for trace, rapid analysis of fatty acids by electrospray tandem mass spectrometry, Rapid Commun. Mass Spectrom., 13, 2388, 10.1002/(SICI)1097-0231(19991215)13:23<2388::AID-RCM803>3.0.CO;2-X

Casetta, 2000, Development of a method for rapid quantitation of amino acids by liquid chromatography–tandem mass spectrometry, Clin. Chem. Lab. Med., 38, 391, 10.1515/CCLM.2000.057

Kushnir, 2002, Analysis of catecholamines in urine by positive ion electrospray tandem mass spectrometry, Clin. Chem., 48, 323, 10.1093/clinchem/48.2.323

Tai, 2002, Candidate reference method for total thyroxine in human serum: use of isotope-dilution liquid chromatography–mass spectrometry with electrospray ionization, Clin. Chem., 48, 637, 10.1093/clinchem/48.4.637

Taylor, 2004, Therapeutic drug monitoring of immunosuppressant drugs by high-performance liquid chromatography–mass spectrometry, Ther. Drug Monit., 26, 215, 10.1097/00007691-200404000-00023

Volosov, 2002, Simple rapid method for quantification of antiretrovirals by liquid chromatography–tandem mass-spectrometry, Clin. Biochem., 35, 99, 10.1016/S0009-9120(02)00286-2

Muller, 2000, Identification of selected pyschopharmaceuticals and their metabolites in hair by LC/ESI–CID/MS and LC/MS/MS, Forensic Sci. Int., 113, 415, 10.1016/S0379-0738(00)00202-4

Marquet, 2002, Progress of liquid chromatography–mass spectrometry in clinical and forensic toxicology, Ther. Drug Monit., 24, 255, 10.1097/00007691-200204000-00008

Annesley, 2003, Ion suppression in mass spectrometry, Clin. Chem., 49, 1041, 10.1373/49.7.1041

Matuszewski, 2003, Strategies for the assessment of matrix effect in quantitative bioanalytical methods based on HPLC–MS/MS, Anal. Chem., 75, 3019, 10.1021/ac020361s

Tang, 1993, Dependence of ion intensity in electrospray mass spectrometry on the concentration of the analytes in the electrosprayed solution, Anal. Chem., 65, 3654, 10.1021/ac00072a020

King, 2000, Mechanistic investigation of ionization suppression in electrospray ionization, J. Am. Soc. Mass Spectrom., 11, 942, 10.1016/S1044-0305(00)00163-X

Bonfiglio, 1999, The effects of sample preparation methods on variability of the electrospray ionization response for model drug compounds, Rapid Commun. Mass Spectrom., 13, 1175, 10.1002/(SICI)1097-0231(19990630)13:12<1175::AID-RCM639>3.0.CO;2-0

Lagerwerf, 2000, Exploring the boundaries of bioanalytical quantitative LC–MS–MS, TrAC, Trends Anal. Chem., 19, 418, 10.1016/S0165-9936(00)00009-1

Matuszewski, 1998, Matrix effect in quantitative LC/MS/MS analyses of biological fluids: a method for determination of finasteride in human plasma at picogram per millilitre concentrations, Anal. Chem., 70, 882, 10.1021/ac971078+

Buhrman, 1996, Quantitation of SR 27417 in human plasma using electrospray liquid chromatography–tandem mass spectrometry: a study of ion suppression, J. Am. Soc. Mass Spectrom., 7, 1099, 10.1016/S1044-0305(96)00072-4

Fu, 1998, Effect of the sample matrix on the determination of indinavir in human urine by HPLC with turbo ion spray tandem mass spectrometric detection, J. Pharm. Biomed. Anal., 18, 347, 10.1016/S0731-7085(98)00048-X

Fierens, 2000, Matrix effect in the quantitative analysis of urinary C-peptide by liquid chromatography tandem mass spectrometry, Rapid Commun. Mass Spectrom., 14, 936, 10.1002/(SICI)1097-0231(20000530)14:10<936::AID-RCM960>3.0.CO;2-A

Müller, 2002, Ion suppression effects in liquid chromatography–electrospray–ionisation transport-region collision induced dissociation mass spectrometry with different serum extraction methods for systematic toxicological analysis with mass spectral libraries, J. Chromatogr., A, 773, 47

Mallet, 2004, A study of ion suppression effects in electrospray ionization from mobile phase additives and solid-phase extracts, Rapid Commun. Mass Spectrom., 18, 49, 10.1002/rcm.1276

Dams, 2003, Matrix effect in bio-analysis of illicit drugs with LC–MS/MS: influence of ionization type, sample preparation, and biofluid, J. Am. Soc. Mass Spectrom., 14, 1290, 10.1016/S1044-0305(03)00574-9

Taylor, 1998, Quantitative analysis of sirolimus (Rapamycin) in blood by high performance liquid chromatography–electrospray tandem mass spectrometry, J. Chromatogr., B, 718, 251, 10.1016/S0378-4347(98)00371-5

Avery, 2003, Quantitative characterization of differential ion suppression on liquid chromatography/atmospheric pressure ionisation mass spectrometric bioanalytical methods, Rapid Commun. Mass Spectrom., 17, 197, 10.1002/rcm.895

Pascoe, 2001, Reduction in matrix-related signal suppression effects in electrospray ionization mass spectrometry using on-line two-dimensional liquid chromatography, Anal. Chem., 73, 6014, 10.1021/ac0106694

Schuhmacher, 2003, Matrix effects during analysis of plasma samples by electrospray and atmospheric pressure chemical ionization mass spectrometry: practical approaches to their elimination, Rapid Commun. Mass Spectrom., 17, 1950, 10.1002/rcm.1139

Mei, 2003, Investigation of matrix effects in bioanalytical high-performance liquid chromatography/tandem mass spectrometric assays: application to drug discovery, Rapid Commun. Mass Spectrom., 17, 97, 10.1002/rcm.876

Anon. Guidance for industry. Bioanalytical method validation.www.fda.gov/cder/guidance/guidance.htm Accessed May 28, 2001.

Shah, 2000, Bioanalytical method validation—A revisit with a decade of progress, Pharm. Res., 17, 1551, 10.1023/A:1007669411738

Taylor, 2003, A high-throughput HPLC–mass spectrometry method suitable for the TDM of cyclosporin [abstract], Ther. Drug Monit., 25, 506