Matrix effect on baked egg tolerance in children with IgE‐mediated hen's egg allergy

Pediatric Allergy and Immunology - Tập 27 Số 5 - Trang 465-470 - 2016
Stefano Miceli Sopo1, Monica Greco1, Barbara Cuomo2, Annamaria Bianchi3, Lucia Liotti4, Serena Monaco1, Iride Dello Iacono5
1Department of Paediatrics, Allergy Unit, Agostino Gemelli Hospital, Sacred Heart Catholic University, Rome, Italy
2Department of Paediatrics, Belcolle, Viterbo, Italy
3Department of Paediatrics, Mazzoni Hospital, Ascoli Piceno, Italy
4Department of Paediatric, Senigallia Hospital, Senigallia, Italy
5Department of Paediatrics, Allergy Unit, Fatebenefratelli Hospital, Benevento, Italy

Tóm tắt

AbstractBackgroundChildren with IgE‐mediated hen's egg allergy (IgE‐HEA) often tolerate baked egg within a wheat matrix.ObjectiveTo evaluate the influence of wheat matrix and the effects of little standardized cooking procedures on baked egg tolerance.MethodsFifty‐four children with IgE‐HEA were enrolled. They underwent prick‐by‐prick (PbP) tests and open oral food challenges (OFC) performed with baked HE within a wheat matrix (a home‐made cake, locally called ciambellone), baked HE without a wheat matrix (in the form of an omelet, locally named frittata) and boiled HE. Three months after passing ciambellone OFC, parents were asked to answer a survey.ResultsAbout 88% of children tolerated ciambellone, 74% frittata, and 56% boiled HE. Negative predictive value of PbP performed with ciambellone, frittata, and boiled HE was 100%. No IgE‐mediated adverse reactions were detected at follow‐up carried out by the survey.ConclusionsWheat matrix seemed to be relevant only in few cases. If our results will be confirmed by larger studies, a negative PbP with ciambellone, frittata, or boiled HE will allow patients with IgE‐HEA to eat these foods without undergoing OFC. Moreover, our study showed that very strict standardized cooking procedures do not seem to be essential, to guarantee tolerance toward baked HE.

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Thông tin xuất bản

Pediatric Allergy and Immunology

Tập 27 Số 5

465-470

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