Maternal separation of rat pups increases the risk of developing depressive-like behavior after subsequent chronic stress by altering corticosterone and neurotrophin levels in the hippocampus

Aisa, 2007, Cognitive impairment associated to HPA-axis hyperactivity after maternal separation in rats, Psychoneuroendocrinology, 32, 256, 10.1016/j.psyneuen.2006.12.013

Bannerman, 2004, Regional dissociations within the hippocampus—memory and anxiety, Neurosci. Biobehav. Rev., 28, 273, 10.1016/j.neubiorev.2004.03.004

Bareggi, 2007, The use of escitalopram beyond major depression: pharmacological aspects, efficacy and tolerability in anxiety disorders, Expert Opin. Drug Metab. Toxicol., 3, 741, 10.1517/17425255.3.5.741

Barnabé-Heider, 2003, Endogenously produced neurotrophins regulate survival and differentiation of cortical progenitors via distinct signaling pathways, J. Neurosci., 23, 5149, 10.1523/JNEUROSCI.23-12-05149.2003

Bremner, 2000, Hippocampal volume reduction in major depression, Am. J. Psychiatry, 157, 115, 10.1176/ajp.157.1.115

Calfa, 2007, Involvement of the lateral septum and the ventral hippocampus in the emotional sequelae induced by social defeat: role of glucocorticoid receptors, Behav. Brain Res., 181, 23, 10.1016/j.bbr.2007.03.020

Cirulli, 2000, NGF expression in the developing rat brain: effects of maternal separation, Dev. Brain Res., 123, 129, 10.1016/S0006-8993(00)02844-4

Cochrane, 1991, Mechanisms of oxidant injury of cells, Mol. Aspects Med., 12, 137, 10.1016/0098-2997(91)90009-B

Coffey, 1992, Quantitative cerebral anatomy of the aging human brain: a cross-sectional study using magnetic resonance imaging, Neurology, 42, 527, 10.1212/WNL.42.3.527

Daniels, 2004, Maternal separation in rats leads to anxiety-like behavior and a blunted ACTH response and altered neurotransmitter levels in response to a subsequent stressor, Metab. Brain Dis., 19, 3, 10.1023/B:MEBR.0000027412.19664.b3

Drevets, 1997, Subgenual prefrontal cortex abnormalities in mood disorders, Nature, 386, 824, 10.1038/386824a0

Dwivedi, 2006, Anti-depressants reverse corticosterone-mediated decrease in brain-derived neurotrophic factor expression: differential regulation of specific exons by anti-depressants and corticosterone, Neuroscience, 139, 1017, 10.1016/j.neuroscience.2005.12.058

El Khoury, 2006, Adult life behavioral consequences of early maternal separation are alleviated by escitalopram treatment in a rat model of depression, Prog. Neuropsychopharmacol. Biol. Psychiatry, 30, 533, 10.1016/j.pnpbp.2005.11.011

Faure, 2006, Early maternal separation followed by later stressors leads to dysregulation of the HPA-axis and increases in hippocampal NGF and NT-3 levels in a rat model, Metab. Brain Dis., 21, 10.1007/s11011-006-9013-6

Faure, 2007, Early maternal separation alters the response to traumatization: resulting in increased levels of hippocampal neurotrophic factors, Metab. Brain Dis., 22, 183, 10.1007/s11011-007-9048-3

Fontella, 2005, Repeated restraint stress induces oxidative damage in rat hippocampus, Neurochem. Res., 30, 105, 10.1007/s11064-004-9691-6

Greisen, 2005, Increased adult hippocampal brain-derived neurotrophic factor and normal levels of neurogenesis in maternal separation rats, J. Neurosci. Res., 79, 772, 10.1002/jnr.20418

Heim, 2001, The role of childhood trauma in the neurobiology of mood and anxiety disorder: preclinical and clinical studies, Soc. Biol. Psychiatry, 49, 1023, 10.1016/S0006-3223(01)01157-X

Heldin, 1995, Dimerization of cell surface receptors in signal transduction, Cell, 80, 213, 10.1016/0092-8674(95)90404-2

Holsboer, 1986, Human corticotropin-releasing hormone in depression, Biol. Psychiatry, 21, 601, 10.1016/0006-3223(86)90121-6

Husain, 1991, A magnetic resonance imaging study of putamen nuclei in major depression, Psychiatry Res., 40, 95, 10.1016/0925-4927(91)90001-7

Joëls, 1998, Corticosteroids in the brain. Cellular and molecular actions, Mol. Neurobiol., 17, 87, 10.1007/BF02802026

Kendler, 1999, Causal relationship between stressful life events and the onset of major depression, Am. J. Psychiatry, 156, 837, 10.1176/ajp.156.6.837

Kessler, 1993, Childhood adversities and adult depression: basic patterns of association in a US national survey, Psychol. Med., 23, 679, 10.1017/S0033291700025460

Kim do, 2007, Effects of fluoxetine on ischemic cells and expressions in BDNF and some anti-oxidants in the gerbil hippocampal CA1 region induced by transient ischemia, Exp. Neurol., 204, 748, 10.1016/j.expneurol.2007.01.008

Krishnan, 1992, Magnetic resonance imaging of the caudate nuclei in depression. Preliminary observations, Arch. Gen. Psychiatry, 49, 553, 10.1001/archpsyc.1992.01820070047007

Kuma, 2004, Early maternal deprivation induces alterations in brain-derived neurotrophic factor expression in the developing rat hippocampus, Neurosci. Lett., 372, 68, 10.1016/j.neulet.2004.09.012

Ladd, 2000, Long-term behavioral and neuroendocrine adaptations to adverse early experience, Prog. Brain Res., 122, 81, 10.1016/S0079-6123(08)62132-9

Ladd, 2004, Long-term adaptations in glucocorticoid receptor and mineralocorticoid receptor mRNA and negative feedback on the hypothalamo-pituitary-adrenal axis following neonatal maternal separation, Biol. Psychiatry, 55, 367, 10.1016/j.biopsych.2003.10.007

Lessmann, 2003, Neurotrophin secretion: current facts and future prospects, Prog. Neurobiol., 69, 341, 10.1016/S0301-0082(03)00019-4

Maggio, 2007, Striking variations in corticosteroids modulation of long-term potentiation along the septotemporal axis of the hippocampus, J. Neurosci., 27, 5757, 10.1523/JNEUROSCI.0155-07.2007

Manni, 1998, Neonatal handling in EAE-susceptible rats alters NGF levels and mast cell distribution in the brain, Int. J. Dev. Neurosci., 16, 1, 10.1016/S0736-5748(98)00003-3

Mattson, 1995, Neurotrophic factors attenuate glutamate-induced accumulation of peroxides, elevation of [Ca2+] and neurotoxicity, and increase anti-oxidant enzyme activities in hippocampal neurons, J. Neurochem., 65, 1740, 10.1046/j.1471-4159.1995.65041740.x

McIntosh, 1996, Glucocorticoids increase the accumulation of reactive oxygen species and enhance adriamycin-induced toxicity in neuronal culture, Exp. Neurol., 141, 201, 10.1006/exnr.1996.0154

Mirescu, 2004, Early life experience alters response of adult neurogenesis to stress, Nat. Neurosci., 7, 841, 10.1038/nn1290

Monteleone, 1995, Plasma melatonin and cortisol circadian patterns in patients with obsessive–compulsive disorder before and after fluoxetine treatment, Psychoneuroendocrinology, 20, 763, 10.1016/0306-4530(95)00013-5

Mullen, 1996, The long-term impact of the physical, emotional, and sexual abuse of children: a community study, Child Abuse Negl., 20, 7, 10.1016/0145-2134(95)00112-3

Nemeroff, 2004, Neurobiological consequences of childhood trauma, J. Clin. Psychiatry, 65, 18

Nemeroff, 1984, Elevated concentrations of CSF corticotropin-releasing factor-like immunoreactivity in depressed patients, Science, 226, 1342, 10.1126/science.6334362

Plotsky, 1993, Early, postnatal experience alters hypothalamic corticotropin-releasing factor (CRF) mRNA, median eminence CRF content and stress-induced release in adult rats. Molecular, Brain Res., 18, 195, 10.1016/0169-328X(93)90189-V

Plotsky, 2005, Long-term consequences of neonatal rearing on central corticotrophin-releasing factor systems in adult male rat offspring, Neuropsychopharmacology, 30, 2192, 10.1038/sj.npp.1300769

Roskoden, 2004, Early postnatal corticosterone administration regulates neurotrophins and their receptors in septum and hippocampus of the rat, Exp. Brain Res., 154, 183, 10.1007/s00221-003-1656-5

Sapolsky, 1985, A mechanism for glucocorticoid toxicity in the hippocampus: increased neuronal vulnerability to metabolic insults, J. Neurosci., 5, 1228, 10.1523/JNEUROSCI.05-05-01228.1985

Sapolsky, 1985, Glucocorticoid toxicity in the hippocampus: temporal aspects of neuronal vulnerability, Brain Res., 359, 300, 10.1016/0006-8993(85)91440-4

Sapolsky, 1992

Sapolsky, 1985, Prolonged glucocorticoid exposure reduces hippocampal neuron number: implications for aging, J. Neurosci., 5, 1222, 10.1523/JNEUROSCI.05-05-01222.1985

Servant, 1997, The role of corticotropin-releasing factor in anxiety, Biol. Psychiatry, 42, 156s, 10.1016/S0006-3223(97)87524-5

Sheline, 1999, Depression duration but not age predicts hippocampal volume loss in women with recurrent major depression, J. Neurosci., 19, 5034, 10.1523/JNEUROSCI.19-12-05034.1999

Slotten, 2006, Long-lasting changes is behavioral and neuroendocrine indices in the rat following neonatal maternal separation: gender-dependent effects, Brain Res., 1097, 123, 10.1016/j.brainres.2006.04.066

Smith, 1995, Stress and glucocorticoids affect the expression of brain-derived neurotrophic factor and neurotrophin-3 mRNAs in the hippocampus, J. Neurosci., 15, 1768, 10.1523/JNEUROSCI.15-03-01768.1995

Trivedi, 2004, Lesions of the ventral hippocampus, but not the dorsal hippocampus, impair conditioned fear expression and inhibitory avoidance on the elevated T-maze, Neurobiol. Learn Mem., 81, 172, 10.1016/j.nlm.2004.02.005

Uys, 2006, Developmental trauma is associated with behavioral hyperarousal, altered HPA-axis activity and decreased hippocampal neurotrophin expression in the adult rat, Ann. NY Ac. Sci., 1071, 543

Van Rensburg, 2006, The effect of stress on the anti-oxidative potential of serum: implications for Alzheimer's disease, Metab. Brain Dis., 21, 171, 10.1007/s11011-006-9020-7

Wals, 2005, Child and adolescent antecedents of adult mood disorders, Curr. Opin. Psychiatry, 18, 15

Yehuda, 1995, Low urinary cortisol excretion in Holocaust survivors with posttraumatic stress disorder, Am. J. Psychiatry, 152, 982, 10.1176/ajp.152.7.982

Zhang, 2002, Maternal deprivation increases cell death in the infant rat brain, Dev. Brain Res., 133, 1, 10.1016/S0926-6410(01)00118-5