Maternal Diabetes: Effects on Embryonic Vascular Development—A Vascular Endothelial Growth Factor-A-mediated Process
Tóm tắt
Major congenital malformations, many of which result from abnormal cardiovascular patterning, remain the leading cause in infant mortality and morbidity. Targeted mutations of several genes (including VEGF and VEGF receptors) and certain teratogenic agents (including excess α-D-glucose) give rise to embryonic lethal phenotypes associated with failure in the formation of a functional vitelline circulation and aberrant organogenesis. Our work to date has demonstrated that yolk sac vasculopathy and failure of endocardial cushion epithelial-mesenchymal transformation occurs in hyperglycemic conditions in murine whole conceptus culture and in embryos from streptozotocin-induced diabetic mice. These cardiovascular abnormalities are associated with changes in expression and phosphorylation state of adhesion molecules such as platelet endothelial growth factor-1 and expression of growth factors such as vascular endothelial growth factor (VEGF-A). Further understanding of the effects of maternal diabetes on yolk sac and embryonic vasculogenesis/angiogenesis and organogenesis may lead to novel approaches in treating and preventing major birth defects.
Tài liệu tham khảo
P Carmeliet V Ferreira G Breier et al. (1996) ArticleTitleAbnormal blood vessel development and lethality in embryos lacking a single VEGF allele Nature 380 435–439 Occurrence Handle1:CAS:528:DyaK28XitVKqtLg%3D Occurrence Handle8602241
N Ferrara K Carver-Moore H Chen et al. (1996) ArticleTitleHeterozygous embryonic lethality induced by targeted inactivation of the VEGF gene Nature 380 439–442 Occurrence Handle1:CAS:528:DyaK28XitVKqtLk%3D Occurrence Handle8602242
L Miquerol BL Langille A Nagy (2000) ArticleTitleEmbryonic development is disrupted by modest increases in vascular endothelial growth factor gene expression Development 127 3941–3946 Occurrence Handle1:CAS:528:DC%2BD3cXnslGrt7s%3D Occurrence Handle10952892
Y Dor TD Camenisch A Itin et al. (2001) ArticleTitleA novel role for VEGF in endocardial cushion formation and its potential contribution to congenital heart defects Development 128 1531–1538 Occurrence Handle1:CAS:528:DC%2BD3MXktVWlsL0%3D Occurrence Handle11290292
C Suri PF Jones S Patan et al. (1996) ArticleTitleRequisite role of angiopoietin-1, a ligand for the TIE2 receptor, during embryonic angiogenesis Cell 87 1171–1180 Occurrence Handle1:CAS:528:DyaK2sXit1GhtQ%3D%3D Occurrence Handle8980224
PC Maisonpierre C Suri PF Jones et al. (1997) ArticleTitleAngiopoietin-2, a natural antagonist for Tie2 that disrupts in vivo angiogenesis Science 277 55–60 Occurrence Handle9204896
GH Fong J Rossant M Gertsenstein ML Breitman (1995) ArticleTitleRole of the Flt-1 receptor tyrosine kinase in regulating the assembly of vascular endothelium Nature 376 66–70 Occurrence Handle1:CAS:528:DyaK2MXmvVKjsrs%3D Occurrence Handle7596436
F Shalaby J Rossant TP Yamaguchi et al. (1995) ArticleTitleFailure of blood-island formation and vasculogenesis in Flk-1-deficient mice Nature 376 62–66 Occurrence Handle7596435
TN Sato Y Tozawa U Deutsch et al. (1995) ArticleTitleDistinct roles of the receptor tyrosine kinases Tie-1 and Tie-2 in blood vessel formation Nature 376 70–74 Occurrence Handle1:CAS:528:DyaK2MXmvVKjsrg%3D Occurrence Handle7596437
HU Wang ZF Chen DJ Anderson (1998) ArticleTitleMolecular distinction and angiogenic interaction between embryonic arteries and veins revealed by ephrin-B2 and its receptor Eph-B4 Cell 93 741–753 Occurrence Handle1:CAS:528:DyaK1cXjsl2ktrs%3D Occurrence Handle9630219
S Gory-Faure MH Prandini H Pointu et al. (1999) ArticleTitleRole of vascular endothelial-cadherin in vascular morphogenesis Development 126 2093–2102 Occurrence Handle1:CAS:528:DyaK1MXjvVanu7Y%3D Occurrence Handle10207135
CA Combs JL Kitzmiller (1991) ArticleTitleSpontaneous abortion and congenital malformations in diabetes Baillieres Clin Obstet Gynaecol 5 315–331 Occurrence Handle1:STN:280:By2D28zmtlI%3D Occurrence Handle1954716
JL Kitzmiller TA Buchanan S Kjos CA Combs RE Ratner (1996) ArticleTitlePre-conception care of diabetes, congenital malformations, and spontaneous abortions Diabetes Care 19 514–541 Occurrence Handle1:STN:280:BymA3M7htVc%3D Occurrence Handle8732721
UJ Eriksson LA Borg H Forsberg J Styrud (1991) ArticleTitleDiabetic embryopathy. Studies with animal and in vitro models Diabetes 40 IssueIDSuppl 2 94–98 Occurrence Handle1:CAS:528:DyaK38XhsV2is7g%3D Occurrence Handle1748275
CA Loffredo PD Wilson C Ferencz (2001) ArticleTitleMaternal diabetes: an independent risk factor for major cardiovascular malformations with increased mortality of affected infants Teratology 64 98–106 Occurrence Handle10.1002/tera.1051 Occurrence Handle1:CAS:528:DC%2BD3MXls1GmtLs%3D Occurrence Handle11460261
CA Loffredo J Hirata PD Wilson C Ferencz IW Lurie (2001) ArticleTitleAtrioventricular septal defects: possible etiologic differences between complete and partial defects Teratology 63 87–93 Occurrence Handle10.1002/1096-9926(200102)63:2<87::AID-TERA1014>3.3.CO;2-X Occurrence Handle1:CAS:528:DC%2BD3MXhslSitrc%3D Occurrence Handle11241431
E Pinter M Barreuther T Lu BA Imhof JA Madri (1997) ArticleTitlePlatelet-endothelial cell adhesion molecule-1 (PECAM-1/CD31) tyrosine phosphorylation state changes during vasculogenesis in the murine conceptus Am J Pathol 150 1523–1530 Occurrence Handle1:CAS:528:DyaK2sXjtlertL8%3D Occurrence Handle9137078
E Pinter S Mahooti Y Wang BA Imhof JA Madri (1999) ArticleTitleHyperglycemia-induced vasculopathy in the murine vitelline vasculature: correlation with PECAM-1/CD31 tyrosine phosphorylation state Am J Pathol 154 1367–1379 Occurrence Handle1:CAS:528:DyaK1MXjtl2iu70%3D Occurrence Handle10329590
E Pinter J Haigh A Nagy JA Madri (2001) ArticleTitleHyperglycemia-induced vasculopathy in the murine conceptus is mediated via reductions of VEGF-A expression and VEGF receptor activation Am J Pathol 158 1199–1206 Occurrence Handle1:CAS:528:DC%2BD3MXjtVWhsL0%3D Occurrence Handle11290536
JM Enciso D Gratzinger TD Camenisch S Canosa E Pinter JA Madri (2003) ArticleTitleElevated glucose inhibits VEGF-A-mediated endocardial cushion formation: modulation by PECAM-1 and MMP-2 J Cell Biol 160 605–615 Occurrence Handle10.1083/jcb.200209014 Occurrence Handle1:CAS:528:DC%2BD3sXhsVOlsLo%3D Occurrence Handle12591918
UJ Eriksson (1984) ArticleTitleDiabetes in pregnancy: retarded fetal growth, congenital malformations and feto-maternal concentrations of zinc, copper and manganese in the rat J Nutr 114 477–484 Occurrence Handle1:CAS:528:DyaL2cXhtlKrurc%3D Occurrence Handle6699731
UJ Eriksson NJ Lewis N Freinkel (1984) ArticleTitleGrowth retardation during early organogenesis in embryos of experimentally diabetic rats Diabetes 33 281–284 Occurrence Handle1:STN:280:BiuC3szgtlc%3D Occurrence Handle6698318
N Ilan A Mohsenin L Cheung JA Madri (2001) ArticleTitlePECAM-1 shedding during apoptosis generates a membrane-anchored truncated molecule with unique signaling characteristics FASEB J 15 362–372 Occurrence Handle10.1096/fj.00-0372com Occurrence Handle1:CAS:528:DC%2BD3MXhsFenu7g%3D Occurrence Handle11156952
A Damert L Miquerol M Gertsenstein W Risau A Nagy (2002) ArticleTitleInsufficient VEGFA activity in yolk sac endoderm compromises haematopoietic and endothelial differentiation Development 129 1881–1892 Occurrence Handle1:CAS:528:DC%2BD38XjslSlsr0%3D Occurrence Handle11934854
CH Mjaatvedt RR Markwald (1989) ArticleTitleInduction of an epithelial-mesenchymal transition by an in vivo adheron-like complex Dev Biol 136 118–128
RB Runyan RR Markwald (1983) ArticleTitleInvasion of mesenchyme into three-dimensional collagen gels: a regional and temporal analysis of interaction in embryonic heart tissue Dev Biol 95 108–114 Occurrence Handle1:STN:280:BiyC3s3nvVA%3D Occurrence Handle6825921
AS Boyer II Ayerinskas EB Vincent LA McKinney DL Weeks RB Runyan (1999) ArticleTitleTGFbeta2 and TGFbeta3 have separate and sequential activities during epithelial-mesenchymal cell transformation in the embryonic heart Dev Biol 208 530–545 Occurrence Handle10.1006/dbio.1999.9211 Occurrence Handle1:CAS:528:DyaK1MXitFOntbs%3D Occurrence Handle10191064
AS Boyer RB Runyan (2001) ArticleTitleTGFbeta type III and TGFbeta type II receptors have distinct activities during epithelial-mesenchymal cell transformation in the embryonic heart Dev Dyn 221 454–459 Occurrence Handle10.1002/dvdy.1154 Occurrence Handle1:CAS:528:DC%2BD3MXmtVymsbw%3D Occurrence Handle11500982
Y Nakajima T Yamagishi S Hokari H Nakamura (2000) ArticleTitleMechanisms involved in valvuloseptal endocardial cushion formation in early cardiogenesis: roles of transforming growth factor (TGF)-beta and bone morphogenetic protein (BMP) Anat Rec 258 119–127 Occurrence Handle10.1002/(SICI)1097-0185(20000201)258:2<119::AID-AR1>3.0.CO;2-U Occurrence Handle1:CAS:528:DC%2BD3cXht1aqtr8%3D Occurrence Handle10645959
TD Camenisch AP Spicer T Brehm-Gibson et al. (2000) ArticleTitleDisruption of hyaluronan synthase-2 abrogates normal cardiac morphogenesis and hyaluronan-mediated transformation of epithelium to mesenchyme J Clin Invest 106 349–360 Occurrence Handle1:CAS:528:DC%2BD3cXlsFOrtLw%3D Occurrence Handle10930438
TD Camenisch JA Schroeder J Bradley SE Klewer JA McDonald (2002) ArticleTitleHeart-valve mesenchyme formation is dependent on hyaluronan-augmented activation of ErbB2-ErbB3 receptors Nat Med 8 850–855 Occurrence Handle1:CAS:528:DC%2BD38Xls12mt7w%3D Occurrence Handle12134143
TD Camenisch DG Molin A Person et al. (2002) ArticleTitleTemporal and distinct TGFbeta ligand requirements during mouse and avian endocardial cushion morphogenesis Dev Biol 248 170–181 Occurrence Handle10.1006/dbio.2002.0731 Occurrence Handle1:CAS:528:DC%2BD38XlsFKhsbw%3D Occurrence Handle12142029
HS Baldwin HM Shen HC Yan et al. (1994) ArticleTitlePlatelet endothelial cell adhesion molecule-1 (PECAM-1/CD31): alternatively spliced, functionally distinct isoforms expressed during mammalian cardiovascular development Development 120 2539–2553 Occurrence Handle1:CAS:528:DyaK2MXmvVGgug%3D%3D Occurrence Handle7956830
Y Nakajima V Mironov T Yamagishi H Nakamura RR Markwald (1997) ArticleTitleExpression of smooth muscle alpha-actin in mesenchymal cells during formation of avian endocardial cushion tissue: a role for transforming growth factor beta3 Dev Dyn 209 296–309 Occurrence Handle10.1002/(SICI)1097-0177(199707)209:3<296::AID-AJA5>3.3.CO;2-4 Occurrence Handle1:CAS:528:DyaK2sXkslCmtLo%3D Occurrence Handle9215644
SM Alexander KJ Jackson KM Bushnell PG Mcuire (1997) ArticleTitleSpatial and temporal expression of the 72-kDa type IV collagenase (MMP-2) correlates with development and differentiation of valves in the embryonic avian heart Dev Dyn 209 261–268 Occurrence Handle10.1002/(SICI)1097-0177(199707)209:3<261::AID-AJA2>3.0.CO;2-G Occurrence Handle1:CAS:528:DyaK2sXkslCmtLw%3D Occurrence Handle9215641