Mast Cells and Neutrophils Release IL-17 through Extracellular Trap Formation in Psoriasis
Tóm tắt
IL-17 and IL-23 are known to be absolutely central to psoriasis pathogenesis because drugs targeting either cytokine are highly effective treatments for this disease. The efficacy of these drugs has been attributed to blocking the function of IL-17–producing T cells and their IL-23–induced expansion. However, we demonstrate that mast cells and neutrophils, not T cells, are the predominant cell types that contain IL-17 in human skin. IL-17+ mast cells and neutrophils are found at higher densities than IL-17+ T cells in psoriasis lesions and frequently release IL-17 in the process of forming specialized structures called extracellular traps. Furthermore, we find that IL-23 and IL-1β can induce mast cell extracellular trap formation and degranulation of human mast cells. Release of IL-17 from innate immune cells may be central to the pathogenesis of psoriasis, representing a fundamental mechanism by which the IL-23–IL-17 axis mediates host defense and autoimmunity.
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Tài liệu tham khảo
Korn, 2009, IL-17 and Th17 Cells., Annu. Rev. Immunol., 27, 485, 10.1146/annurev.immunol.021908.132710
Wilson, 2007, Development, cytokine profile and function of human interleukin 17-producing helper T cells., Nat. Immunol., 8, 950, 10.1038/ni1497
Yang, 2008, IL-21 and TGF-beta are required for differentiation of human T(H)17 cells., Nature, 454, 350, 10.1038/nature07021
Manel, 2008, The differentiation of human T(H)-17 cells requires transforming growth factor-beta and induction of the nuclear receptor RORgammat., Nat. Immunol., 9, 641, 10.1038/ni.1610
Chang, 2007, Cytokine gene polymorphisms in Chinese patients with psoriasis., Br. J. Dermatol., 156, 899, 10.1111/j.1365-2133.2007.07820.x
Capon, 2007, Sequence variants in the genes for the interleukin-23 receptor (IL23R) and its ligand (IL12B) confer protection against psoriasis., Hum. Genet., 122, 201, 10.1007/s00439-007-0397-0
Cargill, 2007, A large-scale genetic association study confirms IL12B and leads to the identification of IL23R as psoriasis-risk genes., Am. J. Hum. Genet., 80, 273, 10.1086/511051
Smith, 2008, Polymorphisms in the IL-12beta and IL-23R genes are associated with psoriasis of early onset in a UK cohort., J. Invest. Dermatol., 128, 1325, 10.1038/sj.jid.5701140
Nair, 2008, Polymorphisms of the IL12B and IL23R genes are associated with psoriasis., J. Invest. Dermatol., 128, 1653, 10.1038/sj.jid.5701255
Lowes, 2008, Psoriasis vulgaris lesions contain discrete populations of Th1 and Th17 T cells., J. Invest. Dermatol., 128, 1207, 10.1038/sj.jid.5701213
Kryczek, 2008, Induction of IL-17+ T cell trafficking and development by IFN-gamma: mechanism and pathological relevance in psoriasis., J. Immunol., 181, 4733, 10.4049/jimmunol.181.7.4733
Tesmer, 2008, Th17 cells in human disease., Immunol. Rev., 223, 87, 10.1111/j.1600-065X.2008.00628.x
Hueber, 2010, Effects of AIN457, a fully human antibody to interleukin-17A, on psoriasis, rheumatoid arthritis, and uveitis., Sci. Transl. Med., 2, 52ra72, 10.1126/scitranslmed.3001107
Krueger, 2007, A human interleukin-12/23 monoclonal antibody for the treatment of psoriasis., N. Engl. J. Med., 356, 580, 10.1056/NEJMoa062382
Genovese, 2010, LY2439821, a humanized anti-interleukin-17 monoclonal antibody, in the treatment of patients with rheumatoid arthritis: A phase I randomized, double-blind, placebo-controlled, proof-of-concept study., Arthritis Rheum., 62, 929, 10.1002/art.27334
Sandborn, 2008, A randomized trial of Ustekinumab, a human interleukin-12/23 monoclonal antibody, in patients with moderate-to-severe Crohn’s disease., Gastroenterology, 135, 1130, 10.1053/j.gastro.2008.07.014
Cua, 2010, Innate IL-17-producing cells: the sentinels of the immune system., Nat. Rev. Immunol., 10, 479, 10.1038/nri2800
de Boer, 2010, Differential expression of interleukin-17 family cytokines in intact and complicated human atherosclerotic plaques., J. Pathol., 220, 499, 10.1002/path.2667
Hueber, 2010, Mast cells express IL-17A in rheumatoid arthritis synovium., J. Immunol., 184, 3336, 10.4049/jimmunol.0903566
Cox, 1977, Mast cells in psoriasis, Psoriasis, Proceedings of the Second International Symposium, Stanford University, 1976., 36
Harvima, 1993, Mast cell tryptase and chymase in developing and mature psoriatic lesions., Arch. Dermatol. Res., 285, 184, 10.1007/BF00372007
Brody, 1978, Alterations of clinically normal skin in early eruptive guttate psoriasis. A light- and electron-microscopic study., J. Cutan. Pathol., 5, 219, 10.1111/j.1600-0560.1978.tb00216.x
Schubert, 1985, Mast cells and macrophages in early relapsing psoriasis., Arch. Dermatol. Res., 277, 352, 10.1007/BF00509232
Kneilling, 2009, Mast cells: novel clinical perspectives from recent insights., Exp. Dermatol., 18, 488, 10.1111/j.1600-0625.2009.00860.x
Yamamoto, 2000, Topical anthralin for psoriasis vulgaris: evaluation of 70 Japanese patients., J. Dermatol., 27, 482, 10.1111/j.1346-8138.2000.tb02212.x
Töyry, 1988, Mast cell density in psoriatic skin. The effect of PUVA and corticosteroid therapy., Arch. Dermatol. Res., 280, 282, 10.1007/BF00440601
Stellato, 1992, Anti-inflammatory effect of cyclosporin A on human skin mast cells., J. Invest. Dermatol., 98, 800, 10.1111/1523-1747.ep12499960
Chowaniec, 1981, Earliest clinical and histological changes in psoriasis., Dermatologica, 163, 42, 10.1159/000250139
Toichi, 2000, Rapid improvement of psoriasis vulgaris during drug-induced agranulocytosis., J. Am. Acad. Dermatol., 43, 391, 10.1067/mjd.2000.103264
Atherton, 1980, Razoxane (ICRF 159) in the treatment of psoriasis., Br. J. Dermatol., 102, 307, 10.1111/j.1365-2133.1980.tb08145.x
Res, 2010, Overrepresentation of IL-17A and IL-22 producing CD8 T cells in lesional skin suggests their involvement in the pathogenesis of psoriasis., PLoS One, 5, e14108, 10.1371/journal.pone.0014108
Yao, 1995, Human IL-17: a novel cytokine derived from T cells., J. Immunol., 155, 5483, 10.4049/jimmunol.155.12.5483
Nograles, 2008, Th17 cytokines interleukin (IL)-17 and IL-22 modulate distinct inflammatory and keratinocyte-response pathways., Br. J. Dermatol., 159, 1092
Liang, 2006, Interleukin (IL)-22 and IL-17 are coexpressed by Th17 cells and cooperatively enhance expression of antimicrobial peptides., J. Exp. Med., 203, 2271, 10.1084/jem.20061308
Peric, 2008, IL-17A enhances vitamin D3-induced expression of cathelicidin antimicrobial peptide in human keratinocytes., J. Immunol., 181, 8504, 10.4049/jimmunol.181.12.8504
Semprini, 2002, Evidence for differential S100 gene over-expression in psoriatic patients from genetically heterogeneous pedigrees., Hum. Genet., 111, 310, 10.1007/s00439-002-0812-5
Ong, 2002, Endogenous antimicrobial peptides and skin infections in atopic dermatitis., N. Engl. J. Med., 347, 1151, 10.1056/NEJMoa021481
Kojima, 1993, GRO-alpha mRNA is selectively overexpressed in psoriatic epidermis and is reduced by cyclosporin A in vivo, but not in cultured keratinocytes., J. Invest. Dermatol., 101, 767, 10.1111/1523-1747.ep12371692
Aujla, 2008, IL-22 mediates mucosal host defense against Gram-negative bacterial pneumonia., Nat. Med., 14, 275, 10.1038/nm1710
Wu, 2007, IL-23-dependent IL-17 production is essential in neutrophil recruitment and activity in mouse lung defense against respiratory Mycoplasma pneumoniae infection., Microbes Infect., 9, 78, 10.1016/j.micinf.2006.10.012
Huang, 2004, Requirement of interleukin-17A for systemic anti-Candida albicans host defense in mice., J. Infect. Dis., 190, 624, 10.1086/422329
Ma, 2008, Deficiency of Th17 cells in hyper IgE syndrome due to mutations in STAT3., J. Exp. Med., 205, 1551, 10.1084/jem.20080218
Brinkmann, 2004, Neutrophil extracellular traps kill bacteria., Science, 303, 1532, 10.1126/science.1092385
Buchanan, 2006, DNase expression allows the pathogen group A Streptococcus to escape killing in neutrophil extracellular traps., Curr. Biol., 16, 396, 10.1016/j.cub.2005.12.039
von Köckritz-Blickwede, 2008, Phagocytosis-independent antimicrobial activity of mast cells by means of extracellular trap formation., Blood, 111, 3070, 10.1182/blood-2007-07-104018
Brinkmann, 2007, Beneficial suicide: why neutrophils die to make NETs., Nat. Rev. Microbiol., 5, 577, 10.1038/nrmicro1710
Lauth, 2009, M1 protein allows Group A streptococcal survival in phagocyte extracellular traps through cathelicidin inhibition., J. Innate Immun., 1, 202, 10.1159/000203645
Oehmcke, 2009, Activation of the human contact system on neutrophil extracellular traps., J. Innate Immun., 1, 225, 10.1159/000203700
Beiter, 2006, An endonuclease allows Streptococcus pneumoniae to escape from neutrophil extracellular traps., Curr. Biol., 16, 401, 10.1016/j.cub.2006.01.056
Kessenbrock, 2009, Netting neutrophils in autoimmune small-vessel vasculitis., Nat. Med., 15, 623, 10.1038/nm.1959
Hakkim, 2010, Impairment of neutrophil extracellular trap degradation is associated with lupus nephritis., Proc. Natl. Acad. Sci. USA, 107, 9813, 10.1073/pnas.0909927107
Denny, 2010, A distinct subset of proinflammatory neutrophils isolated from patients with systemic lupus erythematosus induces vascular damage and synthesizes type I IFNs., J. Immunol., 184, 3284, 10.4049/jimmunol.0902199
Sedgwick, 1982, Abnormal granulocyte morphology in patients with psoriasis., Br. J. Dermatol., 107, 165, 10.1111/j.1365-2133.1982.tb00334.x
Biedermann, 2000, Mast cells control neutrophil recruitment during T cell-mediated delayed-type hypersensitivity reactions through tumor necrosis factor and macrophage inflammatory protein 2., J. Exp. Med., 192, 1441, 10.1084/jem.192.10.1441
Li, 2010, IL-17 produced by neutrophils regulates IFN-gamma-mediated neutrophil migration in mouse kidney ischemia-reperfusion injury., J. Clin. Invest., 120, 331, 10.1172/JCI38702
Marcos, 2010, CXCR2 mediates NADPH oxidase-independent neutrophil extracellular trap formation in cystic fibrosis airway inflammation., Nat. Med., 16, 1018, 10.1038/nm.2209
Lande, 2007, Plasmacytoid dendritic cells sense self-DNA coupled with antimicrobial peptide., Nature, 449, 564, 10.1038/nature06116
Gregorio, 2010, Plasmacytoid dendritic cells sense skin injury and promote wound healing through type I interferons., J. Exp. Med., 207, 2921, 10.1084/jem.20101102
Guiducci, 2010, Autoimmune skin inflammation is dependent on plasmacytoid dendritic cell activation by nucleic acids via TLR7 and TLR9., J. Exp. Med., 207, 2931, 10.1084/jem.20101048
Gelfand, 2007, The risk of mortality in patients with psoriasis: results from a population-based study., Arch. Dermatol., 143, 1493, 10.1001/archderm.143.12.1493
Erbel, 2009, Inhibition of IL-17A attenuates atherosclerotic lesion development in apoE-deficient mice., J. Immunol., 183, 8167, 10.4049/jimmunol.0901126
Clark, 2007, Platelet TLR4 activates neutrophil extracellular traps to ensnare bacteria in septic blood., Nat. Med., 13, 463, 10.1038/nm1565