Mass spectrometry identification of potential mediators of progestin-only contraceptive-induced abnormal uterine bleeding in human endometrial stromal cells

Abdel-Aleem, 2007, Treatment of vaginal bleeding irregularities induced by progestin only contraceptives, Cochrane Database Syst Rev, CD003449 Runic, 2000, Effects of norplant on endometrial tissue factor expression and blood vessel structure, J Clin Endocrinol Metab, 85, 3853 Hickey, 2006, Long-term progestin-only contraceptives result in reduced endometrial blood flow and oxidative stress, J Clin Endocrinol Metab, 91, 3633, 10.1210/jc.2006-0724 Krikun, 2010, Long-term progestin contraceptives (LTPOC) induce aberrant angiogenesis, oxidative stress and apoptosis in the guinea pig uterus: a model for abnormal uterine bleeding in humans, J Angiogenes Res, 2, 8, 10.1186/2040-2384-2-8 Versteeg, 2013, New fundamentals in hemostasis, Physiol Rev, 93, 327, 10.1152/physrev.00016.2011 Lockwood, 2004, Effects of thrombin, hypoxia, and steroids on interleukin-8 expression in decidualized human endometrial stromal cells: implications for long-term progestin-only contraceptive-induced bleeding, J Clin Endocrinol Metab, 89, 1467, 10.1210/jc.2003-030141 Kawabata, 2000, Protease-activated receptor (PAR), a novel family of G protein-coupled seven trans-membrane domain receptors: activation mechanisms and physiological roles, Jpn J Pharmacol, 82, 171, 10.1254/jjp.82.171 Lockwood, 2011, Mechanisms of normal and abnormal endometrial bleeding, Menopause, 18, 408, 10.1097/gme.0b013e31820bf288 Lockwood, 2009, Decidualized human endometrial stromal cells mediate hemostasis, angiogenesis, and abnormal uterine bleeding, Reprod Sci, 16, 162, 10.1177/1933719108325758 Schatz, 2006, Tibolone exerts progestational inhibition of matrix metalloproteinase expression in human endometrial stromal cells, Steroids, 71, 768, 10.1016/j.steroids.2006.05.006 Lockwood, 2012, Abruption-induced preterm delivery is associated with thrombin-mediated functional progesterone withdrawal in decidual cells, Am J Pathol, 181, 2138, 10.1016/j.ajpath.2012.08.036 Yi, 2003, A microcapillary trap cartridge-microcapillary high-performance liquid chromatography electrospray ionization emitter device capable of peptide tandem mass spectrometry at the attomole level on an ion trap mass spectrometer with automated routine operation, Rapid Commun Mass Spectrom, 17, 2093, 10.1002/rcm.1150 Shapiro, 2012, A quantitative proteomic workflow for characterization of frozen clinical biopsies: laser capture microdissection coupled with label-free mass spectrometry, J Proteomics, 77, 433, 10.1016/j.jprot.2012.09.019 Choi, 2008, Significance analysis of spectral count data in label-free shotgun proteomics, Mol Cell Proteomics, 7, 2373, 10.1074/mcp.M800203-MCP200 Ratkovic, 2008, Distribution of stanniocalcin binding sites in the lamina terminalis of the rat, Brain Res, 1218, 141, 10.1016/j.brainres.2008.04.070 dos Santos, 2011, Human stanniocalcin-1 interacts with nuclear and cytoplasmic proteins and acts as a SUMO E3 ligase, Mol Biosyst, 7, 180, 10.1039/C0MB00088D Harris, 2012, Increased vascularity and spontaneous metastasis of breast cancer by hedgehog signaling mediated upregulation of cyr61, Oncogene, 31, 3370, 10.1038/onc.2011.496 Zlot, 2003, Stanniocalcin 1 is an autocrine modulator of endothelial angiogenic responses to hepatocyte growth factor, J Biol Chem, 278, 47654, 10.1074/jbc.M301353200 Fukushi, 2004, NG2 proteoglycan promotes endothelial cell motility and angiogenesis via engagement of galectin-3 and alpha3beta1 integrin, Mol Biol Cell, 15, 3580, 10.1091/mbc.E04-03-0236 Heo, 2010, Expression profiling of ETS and MMP factors in VEGF-activated endothelial cells: role of MMP-10 in VEGF-induced angiogenesis, J Cell Physiol, 224, 734, 10.1002/jcp.22175 Dean, 2007, Mol Cell Biol, 27, 8454, 10.1128/MCB.00821-07 Harris, 2007, Vascular remodeling and extracellular matrix breakdown in the uterine spiral arteries during pregnancy, Reprod Sci, 14, 28, 10.1177/1933719107309588 Granata, 2007, Insulin-like growth factor binding protein-3 induces angiogenesis through IGF-I- and SphK1-dependent mechanisms, J Thromb Haemost, 5, 835, 10.1111/j.1538-7836.2007.02431.x Yoon, 2014, Proteomic analysis of hypoxia-induced U373MG glioma secretome reveals novel hypoxia-dependent migration factors, Proteomics, 14, 1494, 10.1002/pmic.201300554 Wagner, 1986, Purification, characterization, and bioassay of teleocalcin, a glycoprotein from salmon corpuscles of Stannius, Gen Comp Endocrinol, 63, 481, 10.1016/0016-6480(86)90149-8 Law, 2013, Stanniocalcin-1 and -2 promote angiogenic sprouting in HUVECs via VEGF/VEGFR2 and angiopoietin signaling pathways, Mol Cell Endocrinol, 374, 73, 10.1016/j.mce.2013.04.024 Basini, 2009, Stanniocalcin, a potential ovarian angiogenesis regulator, does not affect endothelial cell apoptosis, Ann N Y Acad Sci, 1171, 94, 10.1111/j.1749-6632.2009.04680.x Amoroso, 1997, Vascular endothelial growth factor: a key mediator of neoangiogenesis. A review, Eur Rev Med Pharmacol Sci, 1, 17 Gerritsen, 2002, In silico data filtering to identify new angiogenesis targets from a large in vitro gene profiling data set, Physiol Genomics, 10, 13, 10.1152/physiolgenomics.00035.2002 Ellard, 2007, The respiratory effects of stanniocalcin-1 (STC-1) on intact mitochondria and cells: STC-1 uncouples oxidative phosphorylation and its actions are modulated by nucleotide triphosphates, Mol Cell Endocrinol, 264, 90, 10.1016/j.mce.2006.10.008 Block, 2009, Multipotent stromal cells are activated to reduce apoptosis in part by upregulation and secretion of stanniocalcin-1, Stem Cells, 27, 670, 10.1002/stem.20080742 Liu, 2012, Human stanniocalcin-1 suppresses angiotensin II-induced superoxide generation in cardiomyocytes through UCP3-mediated anti-oxidant pathway, PLoS One, 7, e36994, 10.1371/journal.pone.0036994 Uusküla, 2012, Mid-gestational gene expression profile in placenta and link to pregnancy complications, PLoS One, 7, e49248, 10.1371/journal.pone.0049248 Nicolae, 2011, Endometrial metaplasias and reactive changes: a spectrum of altered differentiation, J Clin Pathol, 64, 97, 10.1136/jcp.2010.085555 Africander, 2011, Molecular mechanisms of steroid receptor-mediated actions by synthetic progestins used in HRT and contraception, Steroids, 76, 636, 10.1016/j.steroids.2011.03.001