Mass spectrometry–based lipidomics of oral squamous cell carcinoma tissue reveals aberrant cholesterol and glycerophospholipid metabolism — A Pilot study

Annertz, 2012, The increase in incidence of cancer of the tongue in the Nordic countries continues into the twenty-first century, Acta Otolaryngol., 132, 552, 10.3109/00016489.2011.649146 Chinn, 2015, Oral cavity carcinoma: current management, controversies, and future directions, J Clin Oncol., 33, 3269, 10.1200/JCO.2015.61.2929 Medes, 1953, Metabolism of neoplastic tissue. IV. A study of lipid synthesis in neoplastic tissue slices in vitro, Cancer Res., 13, 27 Cheng, 2018, Lipid metabolism reprogramming and its potential targets in cancer, Cancer Commun (Lond)., 38, 27, 10.1186/s40880-018-0301-4 Perrotti, 2016, Advances in lipidomics for cancer biomarkers discovery, Int J Mol Sci, 17, 10.3390/ijms17121992 Sharma, 2019, Role of cholesterol homeostasis and its efflux pathways in cancer progression, J Steroid Biochem Mol Biol., 191, 105377, 10.1016/j.jsbmb.2019.105377 Fenn, 1989, Electrospray ionization for mass spectrometry of large biomolecules, Science., 246, 64, 10.1126/science.2675315 Gross, 2011, Lipidomics at the interface of structure and function in systems biology, Chem Biol., 18, 284, 10.1016/j.chembiol.2011.01.014 Stephenson, 2017, Lipidomics in translational research and the clinical significance of lipid-based biomarkers, Transl Res., 189, 13, 10.1016/j.trsl.2017.06.006 Beloribi-Djefaflia, 2016, Lipid metabolic reprogramming in cancer cells, Oncogenesis., 5, 10.1038/oncsis.2015.49 Ishikawa, 2012, Increased expression of phosphatidylcholine (16:0/18:1) and (16:0/18:2) in thyroid papillary cancer, PLoS One., 7, 10.1371/journal.pone.0048873 Wojakowska, 2018, Discrimination of papillary thyroid cancer from non-cancerous thyroid tissue based on lipid profiling by mass spectrometry imaging, Endokrynol Pol., 69, 2, 10.5603/EP.a2018.0003 Li, 2017, Aberrant lipid metabolism in hepatocellular carcinoma revealed by liver lipidomics, Int J Mol Sci, 18, 10.3390/ijms18122550 Xu, 2017, Tissue and serum lipidome shows altered lipid composition with diagnostic potential in mycosis fungoides, Oncotarget., 8, 48041, 10.18632/oncotarget.18228 Li, 2016, Integration of lipidomics and transcriptomics unravels aberrant lipid metabolism and defines cholesteryl oleate as potential biomarker of prostate cancer, Sci Rep., 6, 20984, 10.1038/srep20984 Marien, 2016, Phospholipid profiling identifies acyl chain elongation as a ubiquitous trait and potential target for the treatment of lung squamous cell carcinoma, Oncotarget., 7, 12582, 10.18632/oncotarget.7179 Cifkova, 2015, Lipidomic differentiation between human kidney tumors and surrounding normal tissues using HILIC-HPLC/ESI-MS and multivariate data analysis, J Chromatogr B Analyt Technol Biomed Life Sci., 1000, 14, 10.1016/j.jchromb.2015.07.011 Hilvo, 2011, Novel theranostic opportunities offered by characterization of altered membrane lipid metabolism in breast cancer progression, Cancer Res., 71, 3236, 10.1158/0008-5472.CAN-10-3894 Wang, 2017, Plasma lipid profiling and diagnostic biomarkers for oral squamous cell carcinoma, Oncotarget., 8, 92324, 10.18632/oncotarget.21289 Cals, 2018, Baatenburg de Jong RJ, Koljenovic S, Puppels GJ. Raman spectroscopic analysis of the molecular composition of oral cavity squamous cell carcinoma and healthy tongue tissue, Analyst., 143, 4090, 10.1039/C7AN02106B Sampaio, 2011, Membrane lipidome of an epithelial cell line, Proc Natl Acad Sci U S A., 108, 1903, 10.1073/pnas.1019267108 Ejsing, 2009, Global analysis of the yeast lipidome by quantitative shotgun mass spectrometry, Proc Natl Acad Sci U S A., 106, 2136, 10.1073/pnas.0811700106 Surma, 2015, An automated shotgun lipidomics platform for high throughput, comprehensive, and quantitative analysis of blood plasma intact lipids, Eur J Lipid Sci Technol., 117, 1540, 10.1002/ejlt.201500145 Liebisch, 2006, High throughput quantification of cholesterol and cholesteryl ester by electrospray ionization tandem mass spectrometry (ESI-MS/MS), Biochim Biophys Acta., 1761, 121, 10.1016/j.bbalip.2005.12.007 Herzog, 2012, LipidXplorer: a software for consensual cross-platform lipidomics, PLoS One., 7, 10.1371/journal.pone.0029851 Herzog, 2011, A novel informatics concept for high-throughput shotgun lipidomics based on the molecular fragmentation query language, Genome Biol., 12, R8, 10.1186/gb-2011-12-1-r8 Pascual, 2017, Targeting metastasis-initiating cells through the fatty acid receptor CD36, Nature., 541, 41, 10.1038/nature20791 Luo, 2017, Acetyl-CoA carboxylase rewires cancer metabolism to allow cancer cells to survive inhibition of the Warburg effect by cetuximab, Cancer Lett., 384, 39, 10.1016/j.canlet.2016.09.020 Mohan, 2014, Oral field cancerization: an update on current concepts, Oncol Rev., 8, 244 Kuzu OF, 2016, The role of cholesterol in cancer, Cancer Res., 76, 2063, 10.1158/0008-5472.CAN-15-2613 Ding, 2019, The role of cholesterol metabolism in cancer, Am J Cancer Res., 9, 219 Kaneko, 2015, Liver X receptor reduces proliferation of human oral cancer cells by promoting cholesterol efflux via up-regulation of ABCA1 expression, Oncotarget., 6, 33345, 10.18632/oncotarget.5428 Murugan, 2012, Ras oncogenes in oral cancer: the past 20 years, Oral Oncol., 48, 383, 10.1016/j.oraloncology.2011.12.006 Kawasaki, 2018, mTORC1 and mTORC2 expression levels in oral squamous cell carcinoma: an immunohistochemical and clinicopathological study, Anticancer Res., 38, 1623 Acharya, 2016, Serum lipid profile in oral squamous cell carcinoma: alterations and association with some clinicopathological parameters and tobacco use, Int J Oral Maxillofac Surg., 45, 713, 10.1016/j.ijom.2016.01.015 Di Paolo, 2006, Phosphoinositides in cell regulation and membrane dynamics, Nature., 443, 651, 10.1038/nature05185 Simpson, 2015, Targeting the PI3K/AKT/mTOR pathway in squamous cell carcinoma of the head and neck, Oral Oncol., 51, 291, 10.1016/j.oraloncology.2014.11.012 Koizumi, 2019, Increased fatty acyl saturation of phosphatidylinositol phosphates in prostate cancer progression, Sci Rep., 9, 13257, 10.1038/s41598-019-49744-3 Naguib, 2015, p53 mutations change phosphatidylinositol acyl chain composition, Cell Rep., 10, 8, 10.1016/j.celrep.2014.12.010 Cheng, 2016, Targeting phospholipid metabolism in cancer, Front Oncol., 6, 266, 10.3389/fonc.2016.00266 Gibellini, 2010, The Kennedy pathway—de novo synthesis of phosphatidylethanolamine and phosphatidylcholine, IUBMB Life., 62, 414, 10.1002/iub.354 Santos, 2012, Lipid metabolism in cancer, FEBS J., 279, 2610, 10.1111/j.1742-4658.2012.08644.x Mariotto, 2018, Choline kinase alpha inhibition by EB-3D triggers cellular senescence, reduces tumor growth and metastatic dissemination in breast cancer, Cancers (Basel), 10, 10.3390/cancers10100391 Engelmann, 2010, Cellular phospholipid uptake: flexible paths to coregulate the functions of intracellular lipids, Biochim Biophys Acta., 1801, 609, 10.1016/j.bbalip.2010.02.013 Shindou, 2009, Acyl-CoA:lysophospholipid acyltransferases, J Biol Chem., 284, 1, 10.1074/jbc.R800046200 Silva, 2008, Fatty acid synthase expression in squamous cell carcinoma of the tongue: clinicopathological findings, Oral Dis., 14, 376, 10.1111/j.1601-0825.2007.01395.x McMahon, 2015, Membrane curvature at a glance, J Cell Sci., 128, 1065, 10.1242/jcs.114454 Rohrig, 2016, The multifaceted roles of fatty acid synthesis in cancer, Nat Rev Cancer., 16, 732, 10.1038/nrc.2016.89 Holder, 2013, High stearoyl-CoA desaturase 1 expression is associated with shorter survival in breast cancer patients, Breast Cancer Res Treat., 137, 319, 10.1007/s10549-012-2354-4 Minville-Walz, 2010, Inhibition of stearoyl-CoA desaturase 1 expression induces CHOP-dependent cell death in human cancer cells, PLoS One., 5, 10.1371/journal.pone.0014363