Marked response to nivolumab combined with external radiation therapy for metastatic renal cell carcinoma: report of two cases

Atkins MB, Clark JI, Quinn DI (2017) Immune checkpoint inhibitors in advanced renal cell carcinoma: experience to date and future directions. Ann Oncol 28:1484–1494

Motzer RJ, Escudier B, McDermott DF et al (2015) Nivolumab versus everolimus in advanced renal-cell carcinoma. N Engl J Med 373:1803–1813

Tannir NM, Pal SK, Atkins MB (2018) Second-line treatment landscape for renal cell carcinoma: a comprehensive review. Oncologist 23:540–555

De Giorgi U, Cartenì G, Giannarelli D et al (2018) Safety and efficacy of nivolumab for metastatic renal cell carcinoma: real-world results from an expanded access programme. BJU Int in press

Chajon E, Castelli J, Marsiglia H et al (2017) The synergistic effect of radiotherapy and immunotherapy: A promising but not simple partnership. Crit Rev Oncol Hematol 111:124–132

Wang Y, Deng W, Li N et al (2018) Combining Immunotherapy and Radiotherapy for Cancer Treatment: Current Challenges and Future Directions. Front Pharmacol 9:185

Walle T, Martinez Monge R et al (2018) Radiation effects on antitumor immune responses: current perspectives and challenges. Ther Adv Med Oncol 10:1758834017742575

Ko EC, Formenti SC (2018) Radiotherapy and checkpoint inhibitors: a winning new combination? Ther Adv Med Oncol 10:1758835918768240

Koller KM, Mackley HB, Liu J et al (2017) Improved survival and complete response rates in patients with advanced melanoma treated with concurrent ipilimumab and radiotherapy versus ipilimumab alone. Cancer Biol Ther 18:36–42

Fiorica F, Belluomini L, Stefanelli A et al (2018) Immune Checkpoint Inhibitor Nivolumab and Radiotherapy in Pretreated Lung Cancer Patients: Efficacy and Safety of Combination. Am J Clin Oncol in press

Hlavata Z, Solinas C, De Silva P et al (2018) The Abscopal Effect in the Era of Cancer Immunotherapy: a Spontaneous Synergism Boosting Anti-tumor Immunity? Target Oncol 13:113–123

Brix N, Tiefenthaller A, Anders H et al (2017) Abscopal, immunological effects of radiotherapy: Narrowing the gap between clinical and preclinical experiences. Immunol Rev 280:249–279

De Meerleer G, Khoo V, Escudier B et al (2014) Radiotherapy for renal-cell carcinoma. Lancet Oncol 15:e170–e177

Xie G, Gu D, Zhang L et al (2017) A rapid and systemic complete response to stereotactic body radiation therapy and pembrolizumab in a patient with metastatic renal cell carcinoma. Cancer Biol Ther 18:547–551

Adashek JJ, Salgia M, Dizman N et al (2018) Concomitant Radioembolization and Immune Checkpoint Inhibition in Metastatic Renal Cell Carcinoma. Case Rep Oncol 11:276–280

Wong AS, Thian YL, Kapur J et al (2018) Pushing the limits of immune-related response: a case of “extreme pseudoprogression”. Cancer Immunol Immunother 67:1105–1111