Marine Pharmacology in 2009–2011: Marine Compounds with Antibacterial, Antidiabetic, Antifungal, Anti-Inflammatory, Antiprotozoal, Antituberculosis, and Antiviral Activities; Affecting the Immune and Nervous Systems, and other Miscellaneous Mechanisms of Action

Marine Drugs - Tập 11 Số 7 - Trang 2510-2573
Alejandro M. S. Mayer1, Abimael D. Rodrı́guez, Orazio Taglialatela‐Scafati, Nobuhiro Fusetani
1Department of Pharmacology, Chicago College of Osteopathic Medicine, Midwestern University, 555 31st Street, Downers Grove, Illinois 60515, USA

Tóm tắt

The peer-reviewed marine pharmacology literature from 2009 to 2011 is presented in this review, following the format used in the 1998–2008 reviews of this series. The pharmacology of structurally-characterized compounds isolated from marine animals, algae, fungi and bacteria is discussed in a comprehensive manner. Antibacterial, antifungal, antiprotozoal, antituberculosis, and antiviral pharmacological activities were reported for 102 marine natural products. Additionally, 60 marine compounds were observed to affect the immune and nervous system as well as possess antidiabetic and anti-inflammatory effects. Finally, 68 marine metabolites were shown to interact with a variety of receptors and molecular targets, and thus will probably contribute to multiple pharmacological classes upon further mechanism of action studies. Marine pharmacology during 2009–2011 remained a global enterprise, with researchers from 35 countries, and the United States, contributing to the preclinical pharmacology of 262 marine compounds which are part of the preclinical pharmaceutical pipeline. Continued pharmacological research with marine natural products will contribute to enhance the marine pharmaceutical clinical pipeline, which in 2013 consisted of 17 marine natural products, analogs or derivatives targeting a limited number of disease categories.

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Tài liệu tham khảo

Mayer, 2000, Marine pharmacology in 1998: Marine compounds with antibacterial, anticoagulant, antifungal, anti-inflammatory, anthelmintic, antiplatelet, antiprotozoal, and antiviral activities; with actions on the cardiovascular, endocrine, immune, and nervous systems; and other miscellaneous mechanisms of action, Pharmacologist, 42, 62

Mayer, 2002, Marine pharmacology in 1999: Compounds with antibacterial, anticoagulant, antifungal, anti-inflammatory, anthelmintic, anti-inflammatory, antiplatelet, antiprotozoal and antiviral activities; Affecting the cardiovascular, endocrine, immune, and nervous systems; and other miscellaneous mechanisms of action, Comp. Biochem. Physiol. C, 132, 315

Mayer, 2004, Marine pharmacology in 2000: Marine compounds with antibacterial, anticoagulant, antifungal, anti-inflammatory, antimalarial, antiplatelet, antituberculosis, and antiviral activities; Affecting the cardiovascular, immune, and nervous systems and other miscellaneous mechanisms of action, Mar. Biotechnol., 6, 37, 10.1007/s10126-003-0007-7

Mayer, 2007, Marine pharmacology in 2003–4: Marine compounds with anthelmintic, antibacterial, anticoagulant, antifungal, anti-inflammatory, antimalarial, antiplatelet, antiprotozoal, antituberculosis, and antiviral activities; Affecting the cardiovascular, immune and nervous systems, and other miscellaneous mechanisms of action, Comp. Biochem. Physiol. C, 145, 553

Mayer, 2005, Marine pharmacology in 2001–2002: Marine compounds with anthelmintic, antibacterial, anticoagulant, antidiabetic, antifungal, anti-inflammatory, antimalarial, antiplatelet, antiprotozoal, antituberculosis, and antiviral activities; Affecting the cardiovascular, immune and nervous systems and other miscellaneous mechanisms of action, Comp. Biochem. Physiol. C, 140, 265

Mayer, 2009, Marine pharmacology in 2005–6: Marine compounds with anthelmintic, antibacterial, anticoagulant, antifungal, anti-inflammatory, antimalarial, antiprotozoal, antituberculosis, and antiviral activities; Affecting the cardiovascular, immune and nervous systems, and other miscellaneous mechanisms of action, Biochim. Biophys. Acta, 1790, 283, 10.1016/j.bbagen.2009.03.011

Mayer, 2011, Marine pharmacology in 2007–8: Marine compounds with antibacterial, anticoagulant, antifungal, anti-inflammatory, antimalarial, antiprotozoal, antituberculosis, and antiviral activities; Affecting the immune and nervous system, and other miscellaneous mechanisms of action, Comp. Biochem. Physiol. C, 153, 191

Attaway, D.H., and Zaborsky, O.R. (1993). Antitumor and Cytotoxic Compounds from Marine Organisms, Plenum Press.

Schillaci, 2010, Antimicrobial and antistaphylococcal biofilm activity from the sea urchin Paracentrotus lividus, J. Appl. Microbiol., 108, 17, 10.1111/j.1365-2672.2009.04394.x

Desbois, 2009, A fatty acid from the diatom Phaeodactylum tricornutum is antibacterial against diverse bacteria including multi-resistant Staphylococcus aureus (MRSA), Mar. Biotechnol., 11, 45, 10.1007/s10126-008-9118-5

Costa, 2010, Biological activities of sulfated polysaccharides from tropical seaweeds, Biomed. Pharmacother., 64, 21, 10.1016/j.biopha.2009.03.005

Mao, 2009, Chemical characteristic and anticoagulant activity of the sulfated polysaccharide isolated from Monostroma latissimum (Chlorophyta), Int. J. Biol. Macromol., 44, 70, 10.1016/j.ijbiomac.2008.10.003

Haouas, 2010, Screening of antileishmanial activity from marine sponge extracts collected off the tunisian coast, Parasitol. Res., 106, 1281, 10.1007/s00436-010-1818-x

Lakshmi, 2009, In vitro and in vivo antifilarial potential of marine sponge, Haliclona exigua (Kirkpatrick), against human lymphatic filarial parasite brugia malayi: Antifilarial activity of H. exigua, Parasitol. Res., 105, 1295, 10.1007/s00436-009-1555-1

Harden, 2009, Virucidal activity of polysaccharide extracts from four algal species against herpes simplex virus, Antiviral Res., 83, 282, 10.1016/j.antiviral.2009.06.007

Rashid, 2009, Isolation of a sulphated polysaccharide from a recently discovered sponge species (Celtodoryx girardae) and determination of its anti-herpetic activity, Int. J. Biol. Macromol., 44, 286, 10.1016/j.ijbiomac.2009.01.002

Dellai, 2010, Anti-inflammatory and antiproliferative activities of crude extract and its fractions of the defensive secretion from the mediterranean sponge, Spongia officinalis. Drug Dev. Res., 71, 412, 10.1002/ddr.20392

Jung, 2009, Anti-asthmatic effect of marine red alga (Laurencia undulata) polyphenolic extracts in a murine model of asthma, Food Chem. Toxicol., 47, 293, 10.1016/j.fct.2008.11.012

Kim, 2009, Anti-inflammatory effect of Ishige okamurae ethanolic extract via Inhibition of NF-kappaB transcription factor in RAW 264. 7 cells, Phytother. Res., 23, 628, 10.1002/ptr.2674

Braganhol, 2009, Extracts of marine sponge Polymastia janeirensis induce oxidative cell death through a caspase-9 apoptotic pathway in human U138MG glioma cell line, Investig. New Drugs, 27, 440, 10.1007/s10637-008-9198-0

Nappo, 2011, Apoptotic activity of the marine diatom Cocconeis scutellum and eicosapentaenoic acid in BT20 cells, Pharm. Biol., 50, 1

Grunewald, 2009, Optimized and standardized isolation and structural characterization of anti-inflammatory sulfated polysaccharides from the red alga Delesseria sanguinea (Hudson) lamouroux (ceramiales, delesseriaceae), Biomacromolecules, 10, 2998, 10.1021/bm900501g

Je, 2009, Antioxidant activity of a red seaweed Polysiphonia morrowii extract, Food Sci. Biotechnol., 18, 124

Novoa, 2009, Free phenolic acids from the seaweed Halimeda monile with antioxidant effect protecting against liver injury, Z. Naturforsch. C, 64, 657, 10.1515/znc-2009-9-1009

Sun, 2009, Isolation, chemical characteristics and antioxidant properties of the polysaccharides from marine fungus Penicillium sp. F23-2, Carbohydr. Polym., 78, 117, 10.1016/j.carbpol.2009.04.017

Zhang, 2009, In vitro antioxidant activities of acetylated, phosphorylated derivatives of porphyran extracted from Porphyra haitanensis, Carbohydr. Polym., 78, 449, 10.1016/j.carbpol.2009.04.026

Badiu, 2010, Amino acids from Mytilus galloprovincialis (L.) and Rapana venosa molluscs accelerate skin wounds healing via enhancement of dermal and epidermal neoformation, Protein J., 29, 81, 10.1007/s10930-009-9225-9

Suganthy, 2010, Neuroprotective effect of seaweeds inhabiting south indian coastal area (hare island, gulf of mannar marine biosphere reserve): Cholinesterase inhibitory effect of Hypnea valentiae and Ulva reticulata, Neurosci. Lett., 468, 216, 10.1016/j.neulet.2009.11.001

Plaza, 2010, Chrysophaentins A–H, antibacterial bisdiarylbutene macrocycles that inhibit the bacterial cell division protein FtsZ, J. Am. Chem Soc., 132, 9069, 10.1021/ja102100h

Teasdale, 2009, Secondary metabolites produced by the marine bacterium Halobacillus salinus that inhibit quorum sensing-controlled phenotypes in gram-negative bacteria, Appl. Environ. Microbiol., 75, 567, 10.1128/AEM.00632-08

Kwan, 2011, Lyngbyoic acid, a “Tagged” fatty acid from a marine cyanobacterium, disrupts quorum sensing in Pseudomonas aeruginosa, Mol. Biosyst., 7, 1205, 10.1039/c0mb00180e

Jeon, 2010, Discorhabdins from the Korean marine sponge Sceptrella sp., J. Nat. Prod., 73, 258, 10.1021/np9005629

Hertiani, 2010, From anti-fouling to biofilm inhibition: New cytotoxic secondary metabolites from two indonesian Agelas sponges, Bioorg. Med. Chem., 18, 1297, 10.1016/j.bmc.2009.12.028

Laatsch, 2010, Aqabamycins A–G: Novel nitro maleimides from a marine Vibrio species. I. Taxonomy, fermentation, isolation and biological activities, J. Antibiot., 63, 297, 10.1038/ja.2010.34

Pettit, 2009, Antineoplastic agents. 570. Isolation and structure elucidation of bacillistatins 1 and 2 from a marine Bacillus silvestris, J. Nat. Prod., 72, 366, 10.1021/np800603u

Lane, 2009, Antimalarial bromophycolides J–Q from the fijian red alga Callophycus serratus, J. Org. Chem., 74, 2736, 10.1021/jo900008w

Hohmann, 2009, Caboxamycin, a new antibiotic of the benzoxazole family produced by the deep-sea strain Streptomyces sp. NTK 937, J. Antibiot., 62, 99, 10.1038/ja.2008.24

Choi, 2010, Crossbyanols A–D, toxic brominated polyphenyl ethers from the hawai’ian bloom-forming cyanobacterium Leptolyngbya crossbyana, J. Nat. Prod., 73, 517, 10.1021/np900661g

Bontemps, 2010, Structures and antimicrobial activities of pyridoacridine alkaloids isolated from different chromotypes of the ascidian Cystodytes dellechiajei, J. Nat. Prod., 73, 1044, 10.1021/np900751k

Wright, 2011, Anti-malarial, anti-algal, anti-tubercular, anti-bacterial, anti-photosynthetic, and anti-fouling activity of diterpene isonitriles from the tropical marine sponge Cymbastela hooperi, Org. Biomol. Chem., 9, 400, 10.1039/C0OB00326C

Tadesse, 2011, The antibacterial ent-eusynstyelamide B and eusynstyelamides D, E, and F from the arctic bryozoan Tegella cf. spitzbergensis, J. Nat. Prod., 74, 837, 10.1021/np100499c

Tello, 2009, Cembranoid diterpenes from the caribbean sea whip Eunicea knighti, J. Nat. Prod., 72, 1595, 10.1021/np9002492

Isnansetyo, 2009, Anti-methicillin-resistant Staphylococcus aureus (MRSA) activity of MC21-B, an antibacterial compound produced by the marine bacterium Pseudoalteromonas phenolica O-BC30T, Int. J. Antimicrob. Agents, 34, 131, 10.1016/j.ijantimicag.2009.02.009

Keffer, 2009, Motualevic acids A–F, antimicrobial Acids from the Sponge Siliquariaspongia sp., Org. Lett., 11, 1087, 10.1021/ol802890b

Engelhardt, 2010, Production of a new thiopeptide antibiotic, TP-1161, by a marine Nocardiopsis Species, Appl. Environ. Microbiol., 76, 4969, 10.1128/AEM.00741-10

Stout, 2009, Antibacterial neurymenolides from the fijian red alga Neurymenia fraxinifolia, Org. Lett., 11, 225, 10.1021/ol8024814

Feher, 2010, Highly brominated antimicrobial metabolites from a marine Pseudoalteromonas sp., J. Nat. Prod., 73, 1963, 10.1021/np100506z

Correa, 2011, Cytotoxic and antimicrobial activity of pseudopterosins and seco-Pseudopterosins isolated from the octocoral Pseudopterogorgia elisabethae of san andres and providencia islands (Southwest Caribbean Sea), Mar. Drugs, 9, 334, 10.3390/md9030334

Till, 2009, 5-Bromo-8-methoxy-1-methyl-β-carboline, an alkaloid from the New Zealand marine bryozoan Pterocella vesiculosa, J. Nat. Prod., 72, 796, 10.1021/np8007655

Matsuda, 2009, Salinisporamycin, a novel metabolite from Salinispora arenicola, J. Antibiot., 62, 519, 10.1038/ja.2009.75

Tadesse, 2010, Synoxazolidinones A and B: Novel bioactive alkaloids from the ascidian Synoicum pulmonaria, Org. Lett., 12, 4752, 10.1021/ol101707u

DiGirolamo, 2009, Reversal of fluconazole resistance by sulfated sterols from the marine sponge Topsentia sp., J. Nat. Prod., 72, 1524, 10.1021/np900177m

Nishimura, 2010, Marine antifungal theonellamides target 3β-hydroxysterol to activate rho1 signaling, Nat. Chem. Biol., 6, 519, 10.1038/nchembio.387

Carroll, 2009, Citronamides A and B, tetrapeptides from the australian sponge Citronia astra, J. Nat. Prod., 72, 764, 10.1021/np800832w

Yuan, 2009, Antifungal triterpene glycosides from the sea cucumber Bohadschia marmorata, Planta Med., 75, 168, 10.1055/s-0028-1088348

2010, Production and genetic improvement of a novel antimycotic agent, saadamycin, against dermatophytes and other clinical fungi from endophytic Streptomyces sp. Hedaya 48, J. Ind. Microbiol. Biotechnol., 37, 831, 10.1007/s10295-010-0729-2

Plaza, 2009, Celebesides A-C and theopapuamides B-D, depsipeptides from an indonesian sponge that inhibit HIV-1 entry, J. Org. Chem., 74, 504, 10.1021/jo802232u

Fattorusso, 2010, Insight into the mechanism of action of plakortins, Simple 1,2-Dioxane antimalarials, Org. Biomol. Chem., 8, 846, 10.1039/B918600J

Lebouvier, 2009, Antiplasmodial activities of homogentisic acid derivative protein kinase inhibitors isolated from a vanuatu marine sponge Pseudoceratina sp., Mar. Drugs, 7, 640, 10.3390/md7040640

Laville, 2009, Bioactive guanidine alkaloids from two caribbean marine sponges, J. Nat. Prod., 72, 1589, 10.1021/np900244g

Lin, 2010, Bioactive bromophycolides R–U from the Fijian red alga Callophycus serratus, J. Nat. Prod., 73, 275, 10.1021/np900686w

Davis, 2010, (+)-7-bromotrypargine:An antimalarial β-Carboline from the australian marine sponge Ancorina sp., Tetrahedron Lett., 51, 583, 10.1016/j.tetlet.2009.11.055

Wright, 2009, Diterpene formamides from the tropical marine sponge Cymbastela hooperi and their antimalarial activity in vitro, J. Nat. Prod., 72, 492, 10.1021/np800654w

Vicente, 2010, Bioactive cycloperoxides isolated from the puerto rican sponge Plakortis halichondrioides, J. Nat. Prod., 73, 1694, 10.1021/np100461t

Linington, 2009, Antimalarial peptides from marine cyanobacteria: Isolation and structural elucidation of gallinamide A, J. Nat. Prod., 72, 14, 10.1021/np8003529

Ueoka, 2009, Gracilioethers A–C, antimalarial metabolites from the marine sponge Agelas gracilis, J. Org. Chem., 74, 4203, 10.1021/jo900380f

Wattanapiromsakul, 2009, 8-Isocyanoamphilecta-11(20),15-diene, a new antimalarial isonitrile diterpene from the sponge Ciocalapata sp., Can. J. Chem., 87, 612, 10.1139/V09-030

Tripathi, 2010, Lagunamides A and B: Cytotoxic and antimalarial cyclodepsipeptides from the marine cyanobacterium Lyngbya majuscula, J. Nat. Prod., 73, 1810, 10.1021/np100442x

Fattorusso, 2010, Manadoperoxides A–D from the indonesian sponge Plakortis cfr. simplex. Further insights on the structure-activity relationships of simple 1,2-dioxane antimalarials, J. Nat. Prod., 73, 1138, 10.1021/np100196b

Yamada, 2009, Zamamidine C, 3,4-dihydro-6-hydroxy-10,11-Epoxymanzamine A, and 3,4-Dihydromanzamine J N-oxide, new manzamine alkaloids from sponge Amphimedon sp., Tetrahedron, 65, 2313, 10.1016/j.tet.2009.01.032

Wei, 2010, Neopetrosiamine A, biologically active bis-piperidine alkaloid from the caribbean sea sponge Neopetrosia proxima, Bioorg. Med. Chem. Lett., 20, 5905, 10.1016/j.bmcl.2010.07.084

Yang, 2010, Antimalarial bromotyrosine derivatives from the australian marine sponge Hyattella sp., J. Nat. Prod., 73, 985, 10.1021/np900834g

Britta, 2011, 4-Acetoxydolastane diterpene from the brazilian brown alga Canistrocarpus cervicornis as antileishmanial agent, Mar. Drugs, 9, 2369, 10.3390/md9112369

Vik, 2009, Screening of agelasine D and analogs for inhibitory activity against pathogenic protozoa; Identification of hits for visceral leishmaniasis and chagas disease, Molecules, 14, 279, 10.3390/molecules14010279

Sanchez, 2010, Almiramides A–C: Discovery and development of a new class of leishmaniasis lead compounds, J. Med. Chem., 53, 4187, 10.1021/jm100265s

Davis, 2011, Convolutamines I and J, antitrypanosomal alkaloids from the bryozoan Amathia tortusa, Bioorg. Med. Chem., 19, 6615, 10.1016/j.bmc.2011.06.006

Scala, 2010, Bromopyrrole alkaloids as lead compounds against protozoan parasites, Mar. Drugs, 8, 2162, 10.3390/md8072162

Quijano, 2010, The tropical brown alga Lobophora variegata: A source of antiprotozoal compounds, Mar. Drugs, 8, 1292, 10.3390/md8041292

Rubio, 2009, The marine sponge Diacarnus bismarckensis as a source of peroxiterpene inhibitors of Trypanosoma brucei, the causative agent of sleeping sickness, J. Nat. Prod., 72, 218, 10.1021/np800711a

Ma, 2009, Norselic acids A–E, highly oxidized anti-infective steroids that deter mesograzer predation, from the antarctic sponge Crella sp., J. Nat. Prod., 72, 1842, 10.1021/np900382x

Regalado, 2010, Antiprotozoal steroidal saponins from the marine sponge Pandaros acanthifolium, J. Nat. Prod., 73, 1404, 10.1021/np100348x

Feng, 2010, Antitrypanosomal cyclic polyketide peroxides from the australian marine sponge Plakortis sp., J. Nat. Prod., 73, 716, 10.1021/np900535z

Kozytska, 2010, Anti-parasitic compounds from Streptomyces sp. strains isolated from mediterranean sponges, Mar. Drugs, 8, 373, 10.3390/md8020373

Vicente, 2009, Euryjanicin A: A new cycloheptapeptide from the caribbean marine sponge Prosuberites laughlini, Tetrahedron Lett., 50, 4571, 10.1016/j.tetlet.2009.05.067

Pruksakorn, 2010, Trichoderins, novel aminolipopeptides from a marine sponge-derived Trichoderma sp., are active against dormant mycobacteria, Bioorg. Med. Chem. Lett., 20, 3658, 10.1016/j.bmcl.2010.04.100

Cheng, 2010, Antiviral and anti-inflammatory diterpenoids from the soft coral Sinularia gyrosa, J. Nat. Prod., 73, 1184, 10.1021/np100185a

Cheng, 2010, Cembranoids from the octocoral Sarcophyton ehrenbergi, J. Nat. Prod., 73, 197, 10.1021/np900693r

Palem, 2011, Manzamine a as a novel inhibitor of herpes simplex virus type-1 replication in cultured corneal cells, Planta Med., 77, 46, 10.1055/s-0030-1250093

Ding, 2010, Xiamycin, a pentacyclic indolosesquiterpene with selective anti-HIV activity from a bacterial mangrove endophyte, Bioorg. Med. Chem. Lett., 20, 6685, 10.1016/j.bmcl.2010.09.010

Fan, 2010, Baculiferins A–O, O-Sulfated pyrrole alkaloids with anti-HIV-1 activity, from the chinese marine sponge Iotrochota baculifera, Bioorg. Med. Chem., 18, 5466, 10.1016/j.bmc.2010.06.052

Li, 2010, Rare casbane diterpenoids from the Hainan soft coral Sinularia depressa, J. Nat. Prod., 73, 133, 10.1021/np900484k

Chakraborty, 2010, Guaiane sesquiterpenes from seaweed Ulva fasciata delile and their antibacterial properties, Eur. J. Med. Chem., 45, 2237, 10.1016/j.ejmech.2010.01.065

Wood, 2010, Gymnochromes E and F, cytotoxic phenanthroperylenequinones from a deep-water crinoid, Holopus rangii, J. Nat. Prod., 73, 712, 10.1021/np900526y

Mondol, 2011, Ieodomycins A–D, antimicrobial fatty acids from a marine Bacillus sp., J. Nat. Prod., 74, 1606, 10.1021/np200223r

Yao, 2009, Bioactive sulfated sesterterpene alkaloids and sesterterpene sulfates from the marine sponge Fasciospongia sp., J. Nat. Prod., 72, 319, 10.1021/np8005343

Elsebai, 2011, Antimicrobial phenalenone derivatives from the marine-derived fungus Coniothyrium cereale, Org. Biomol. Chem., 9, 802, 10.1039/C0OB00625D

Devi, 2010, The sponge-associated bacterium Bacillus licheniformis SAB1: A source of antimicrobial compounds, Mar. Drugs, 8, 1203, 10.3390/md8041203

Kamei, 2009, The novel anti-Propionibacterium acnes compound, sargafuran, found in the marine brown alga Sargassum macrocarpum, J. Antibiot., 62, 259, 10.1038/ja.2009.25

Smyrniotopoulos, 2010, Structure and antibacterial activity of brominated diterpenes from the red alga Sphaerococcus coronopifolius, Chem. Biodivers., 7, 186, 10.1002/cbdv.200800309

Mukai, 2009, Tyrokeradines A and B, new bromotyrosine alkaloids with an imidazolyl-quinolinone moiety from a verongid sponge, Bioorg. Med. Chem. Lett., 19, 1337, 10.1016/j.bmcl.2009.01.056

Li, 2010, Centrocins: Isolation and characterization of novel dimeric antimicrobial peptides from the green sea urchin, Strongylocentrotus droebachiensis, Dev. Comp. Immunol., 34, 959, 10.1016/j.dci.2010.04.004

Galinier, 2009, Halocyntin and papillosin, two new antimicrobial peptides isolated from hemocytes of the solitary tunicate, Halocynthia papillosa, J. Pept. Sci., 15, 48, 10.1002/psc.1101

Sperstad, 2009, Hyastatin, a glycine-rich multi-domain antimicrobial peptide isolated from the spider crab (Hyas araneus) hemocytes, Mol. Immunol., 46, 2604, 10.1016/j.molimm.2009.05.002

Heo, 2009, Diphlorethohydroxycarmalol isolated from Ishige okamurae, a brown alga, a potent α-glucosidase and α-amylase inhibitor, alleviates postprandial hyperglycemia in diabetic mice, Eur. J. Pharmacol., 615, 252, 10.1016/j.ejphar.2009.05.017

Li, 2009, A novel sesquiterpene quinone from hainan sponge Dysidea villosa, Bioorg. Med. Chem. Lett., 19, 390, 10.1016/j.bmcl.2008.11.068

Zhang, 2009, A sesquiterpene quinone, dysidine, from the sponge Dysidea villosa, activates the insulin pathway through inhibition of PTP ases, Acta Pharmacol. Sin., 30, 333, 10.1038/aps.2009.5

Asolkar, 2009, Arenamides A–C, cytotoxic NFκB inhibitors from the marine actinomycete Salinispora arenicola, J. Nat. Prod., 72, 396, 10.1021/np800617a

Youssef, 2010, New anti-inflammatory sterols from the red sea sponges Scalarispongia aqabaensis and Callyspongia siphonella, Nat. Prod. Commun., 5, 27

Jean, 2009, Capnellene, a natural marine compound derived from soft coral, attenuates chronic constriction injury-induced neuropathic pain in rats, Br. J. Pharmacol., 158, 713, 10.1111/j.1476-5381.2009.00323.x

Shi, 2009, New terpenoid constituents of the Southwestern Caribbean sea whip Pseudopterogorgia elisabethae (Bayer) including a unique pentanorditerpene, Eur. J. Org. Chem., 4, 493, 10.1002/ejoc.200800795

Li, 2010, Inhibitors of oxidation and matrix metalloproteinases, floridoside, and d-isofloridoside from marine red alga Laurencia undulata, J. Agric. Food Chem., 58, 578, 10.1021/jf902811j

Malloy, 2011, Malyngamide 2, an oxidized lipopeptide with nitric oxide inhibiting activity from a papua new guinea marine cyanobacterium, J. Nat. Prod., 74, 95, 10.1021/np1005407

Villa, 2010, Selective MyD88-dependent pathway inhibition by the cyanobacterial natural product malyngamide F acetate, Eur. J. Pharmacol., 629, 140, 10.1016/j.ejphar.2009.12.002

Kim, 2009, Isolation and identification of phlorotannins from Ecklonia stolonifera with antioxidant and anti-inflammatory properties, J. Agric. Food Chem., 57, 3483, 10.1021/jf900820x

Belmiro, 2009, Unfractionated heparin and new heparin analogues from ascidians (chordate-tunicate) ameliorate colitis in rats, J. Biol. Chem., 284, 11267, 10.1074/jbc.M807211200

Hanif, 2010, Symbiopolyol, a VCAM-1 inhibitor from a symbiotic dinoflagellate of the jellyfish Mastigias papua, J. Nat. Prod., 73, 1318, 10.1021/np100221k

Costantino, 2009, Tedanol: A potent anti-inflammatory ent-pimarane diterpene from the caribbean sponge Tedania ignis, Bioorg. Med. Chem., 17, 7542, 10.1016/j.bmc.2009.09.010

Liu, 2010, Carijoside A, a bioactive sterol glycoside from an octocoral Carijoa sp. (Clavulariidae), Mar. Drugs, 8, 2014, 10.3390/md8072014

Cheng, 2009, Novel sesquiterpenes and norergosterol from the soft corals Nephthea erecta and Nephthea chabroli, Tetrahedron Lett., 50, 802, 10.1016/j.tetlet.2008.12.002

Festa, 2009, Coscinolactams A and B: New nitrogen-containing sesterterpenoid from the marine sponge Coscinoderma mathewsi exerting anti-inflammatory Properties, Tetrahedron, 65, 2905, 10.1016/j.tet.2009.02.016

Cheng, 2009, Unprecedented hemiketal cembranolides with anti-inflammatory activity from the soft coral Lobophytum durum, J. Nat. Prod., 72, 152, 10.1021/np800686k

Cheng, 2009, Anti-inflammatory cembranolides from the soft coral Lobophytum durum, Bioorg. Med. Chem., 17, 3763, 10.1016/j.bmc.2009.04.053

Cheng, 2010, Bioactive norditerpenoids from the soft coral Sinularia gyrosa, Bioorg. Med. Chem., 18, 3379, 10.1016/j.bmc.2010.04.012

Chen, 2010, Anti-inflammatory eunicellin-based diterpenoids from the cultured soft coral Klyxum simplex, Org. Biomol. Chem., 8, 2363, 10.1039/b926353e

Wanzola, 2010, Four new cembrane diterpenes isolated from an okinawan soft coral Lobophytum crassum with inhibitory effects on nitric oxide production, Chem. Pharm. Bull., 58, 1203, 10.1248/cpb.58.1203

Festa, 2009, Perthamides C and D, two new potent anti-inflammatory cyclopeptides from a solomon lithistid sponge Theonella swinhoei, Tetrahedron, 65, 10424, 10.1016/j.tet.2009.10.026

Appleton, 2009, Rossinones A and B, biologically active meroterpenoids from the antarctic ascidian, Aplidium species, J. Org. Chem., 74, 9195, 10.1021/jo901846j

Cheng, 2009, New 19-oxygenated and 4-methylated steroids from the formosan soft coral Nephthea chabroli, Steroids, 74, 543, 10.1016/j.steroids.2009.02.004

Cheng, 2009, Ceramide and cerebrosides from the octocoral Sarcophyton ehrenbergi, J. Nat. Prod., 72, 465, 10.1021/np800362g

Lin, 2010, Cytotoxic and anti-inflammatory cembranoids from the dongsha atoll soft coral Sarcophyton crassocaule, Bioorg. Med. Chem., 18, 1936, 10.1016/j.bmc.2010.01.036

Wu, 2009, Simplexins A–I, eunicellin-based diterpenoids from the soft coral Klyxum simplex, J. Nat. Prod., 72, 994, 10.1021/np900064a

Costantino, 2010, Terpioside B, a difucosyl GSL from the marine sponge Terpios sp. is a potent inhibitor of NO release, Bioorg. Med. Chem., 18, 5310, 10.1016/j.bmc.2010.05.048

Kwan, 2009, Grassystatins A–C from marine cyanobacteria, potent cathepsin E inhibitors that reduce antigen presentation, J. Med. Chem., 52, 5732, 10.1021/jm9009394

Takei, 2010, Polyacetylenediols regulate the function of human monocyte-derived dendritic cells, Int. Immunopharmacol., 10, 913, 10.1016/j.intimp.2010.05.002

Shim, 2009, Inhibitory effects of phloroglucinol derivatives isolated from Ecklonia stolonifera on FcεRI expression, Bioorg. Med. Chem., 17, 4734, 10.1016/j.bmc.2009.04.050

Strangman, 2009, Potent inhibitors of pro-inflammatory cytokine production produced by a marine-derived bacterium, J. Med. Chem., 52, 2317, 10.1021/jm801110j

Dai, 2009, Chemical properties and immunostimulatory activity of a water-soluble polysaccharide from the clam of Hyriopsis cumingii lea, Carbohydr. Polym., 77, 365, 10.1016/j.carbpol.2009.01.003

Orsi, 2010, Yessotoxin inhibits phagocytic activity of macrophages, Toxicon, 55, 265, 10.1016/j.toxicon.2009.07.033

Inutsuka, 2009, Calyculin A-induced neurite retraction is critically dependent on actomyosin activation but not on polymerization state of microtubules, Biochem. Biophys. Res. Commun., 390, 1160, 10.1016/j.bbrc.2009.10.108

Sakurada, 2010, Novel N-methylated 8-oxoisoguanines from pacific sponges with diverse neuroactivities, J. Med. Chem., 53, 6089, 10.1021/jm100490m

Choi, 2010, The hoiamides, structurally intriguing neurotoxic lipopeptides from papua new guinea marine cyanobacteria, J. Nat. Prod., 73, 1411, 10.1021/np100468n

Pereira, 2010, Palmyrolide A, an unusually stabilized neuroactive macrolide from palmyra atoll cyanobacteria, Org. Lett., 12, 4490, 10.1021/ol101752n

Zhao, 2009, Marine compound xyloketal B protects PC12 cells against OGD-induced cell damage, Brain Res., 1302, 240, 10.1016/j.brainres.2009.09.034

Pereira, 2009, Alotamide A, a novel neuropharmacological agent from the marine cyanobacterium Lyngbya bouillonii, Org. Lett., 11, 4704, 10.1021/ol901438b

Davis, 2009, (−)-Dibromophakellin: An α2B adrenoceptor agonist isolated from the australian marine sponge, Acanthella costata, Bioorg. Med. Chem., 17, 2497, 10.1016/j.bmc.2009.01.065

Suna, 2009, Dysideamine, a new sesquiterpene aminoquinone, protects hippocampal neuronal cells against iodoacetic acid-induced cell death, Bioorg. Med. Chem., 17, 3968, 10.1016/j.bmc.2009.04.025

Balansa, 2010, Ircinialactams: Subunit-selective glycine receptor modulators from Australian sponges of the family irciniidae, Bioorg. Med. Chem., 18, 2912, 10.1016/j.bmc.2010.03.002

Tapiolas, 2009, Eusynstyelamides A, B, and C, nNOS inhibitors, from the Ascidian Eusynstyela latericius, J. Nat. Prod., 72, 1115, 10.1021/np900099j

Tseng, 2009, Nanolobatolide, a new C18 metabolite from the formosan soft coral Sinularia nanolobata, Org. Lett., 11, 5030, 10.1021/ol901990c

Lin, 2010, Pulicatins A–E, neuroactive thiazoline metabolites from cone snail-associated bacteria, J. Nat. Prod., 73, 1922, 10.1021/np100588c

Perry, 2010, Microglia in neurodegenerative disease, Nat. Rev. Neurol., 6, 193, 10.1038/nrneurol.2010.17

Teruya, 2009, Bisebromoamide, a potent cytotoxic peptide from the marine cyanobacterium Lyngbya sp.: Isolation, stereostructure, and biological activity, Org. Lett., 11, 5062, 10.1021/ol9020546

Henrich, 2009, Botryllamides: Natural product inhibitors of ABCG2, ACS Chem. Biol., 4, 637, 10.1021/cb900134c

Li, 2009, Chemical components and its antioxidant properties in vitro: An edible marine brown alga, Ecklonia cava, Bioorg. Med. Chem., 17, 1963, 10.1016/j.bmc.2009.01.031

Parys, 2010, In vitro chemopreventive potential of fucophlorethols from the brown alga Fucus vesiculosus L. by anti-oxidant activity and inhibition of selected cytochrome P450 enzymes, Phytochemistry, 71, 221, 10.1016/j.phytochem.2009.10.020

Mita, 2009, A relaxin-like peptide purified from radial nerves induces oocyte maturation and ovulation in the starfish, Asterina pectinifera, Proc. Natl. Acad. Sci. USA, 106, 9507, 10.1073/pnas.0900243106

Tsubosaka, 2010, Halichlorine is a novel L-type Ca2+ channel inhibitor isolated from the marine sponge Halichondria okadai Kadota, Eur. J. Pharmacol., 628, 128, 10.1016/j.ejphar.2009.11.026

Pereira, 2009, Hoiamide A, a sodium channel activator of unusual architecture from a consortium of two papua new guinea cyanobacteria, Chem. Biol., 16, 893, 10.1016/j.chembiol.2009.06.012

Ohkawa, 2010, Antiangiogenic metabolites from a marine-derived fungus, Hypocrea vinosa, J. Nat. Prod., 73, 579, 10.1021/np900698p

Morgan, 2010, The marine sponge metabolite mycothiazole: A novel prototype mitochondrial complex I inhibitor, Bioorg. Med. Chem., 18, 5988, 10.1016/j.bmc.2010.06.072

Mao, 2009, Lipophilic 2,5-disubstituted pyrroles from the marine sponge Mycale sp. Inhibit mitochondrial respiration and HIF-1 Activation, J. Nat. Prod., 72, 1927, 10.1021/np900444m

Nakamura, 2010, Neocomplanines A and B, a complanine family isolated from the marine fireworm, J. Nat. Prod., 73, 303, 10.1021/np900694j

Dang, 2009, Inhibition of nonsense-mediated mRNA decay by the natural product pateamine a through eukaryotic initiation factor 4AIII, J. Biol. Chem., 284, 23613, 10.1074/jbc.M109.009985

Iwamoto, 2010, Cytotoxic peptide from a marine sponge exhibits ion channel activity through vectorial-insertion into the membrane, FEBS Lett., 584, 3995, 10.1016/j.febslet.2010.08.007

Field, 2009, Microtubule-stabilizing activity of zampanolide, a potent macrolide isolated from the tongan marine sponge Cacospongia mycofijiensis, J. Med. Chem., 52, 7328, 10.1021/jm901249g

Forestier, 2009, Aloketals A and B, sesterterpenoids from the marine sponge Hamigera species that activate the cAMP cell signalings pathway, Org. Lett., 11, 5166, 10.1021/ol902066e

Seo, 2009, Isolation of the protein tyrosine phosphatase 1B inhibitory metabolite from the marine-derived fungus Cosmospora sp. SF-5060, Bioorg. Med. Chem. Lett., 19, 6095, 10.1016/j.bmcl.2009.09.025

Williams, 2010, Australin E isolated from the soft coral Cladiella sp. collected in pohnpei activates the inositol 5-phosphatase SHIP1, Aust. J. Chem., 63, 895, 10.1071/CH10053

Rubio, 2010, Depsipeptides from a guamanian marine cyanobacterium, Lyngbya bouillonii, with selective inhibition of serine proteases, Tetrahedron Lett., 51, 6718, 10.1016/j.tetlet.2010.10.062

Sisay, 2009, Inhibition of human leukocyte elastase by brunsvicamides A–C: Cyanobacterial cyclic peptides, Chem. Med. Chem., 4, 1425, 10.1002/cmdc.200900139

McCulloch, 2009, Carteriosulfonic acids A–C, GSK-3β inhibitors from a Carteriospongia sp., J. Nat. Prod., 72, 1651, 10.1021/np900336f

Williams, 2009, Scalarane-based sesterterpenoid RCE-protease inhibitors isolated from the indonesian marine sponge Carteriospongia foliascens, J. Nat. Prod., 72, 1106, 10.1021/np900042r

Buchanan, 2009, Clavatadines C–E, guanidine alkaloids from the australian sponge Suberea clavata, J. Nat. Prod., 72, 973, 10.1021/np8008013

Whitson, 2009, Fibrosterol sulfates from the philippine sponge Lissodendoryx (Acanthodoryx) fibrosa: Sterol dimers that inhibit PKCzeta, J. Org. Chem., 74, 5902, 10.1021/jo900844r

Rateb, 2009, Bioactive diterpene derivatives from the marine sponge Spongionella sp., J. Nat. Prod., 72, 1471, 10.1021/np900233c

Cui, 2009, Benzodiazepine alkaloids from marine-derived endophytic fungus Aspergillus ochraceus, Helv. Chim. Acta, 92, 1366, 10.1002/hlca.200900084

Robinson, 2009, Using enzyme assays to evaluate the structure and bioactivity of sponge-derived meroterpenes, J. Nat. Prod., 72, 1857, 10.1021/np900465e

Matthew, 2009, Largamides A–C, tiglic acid-containing cyclodepsipeptides with elastase-inhibitory activity from the marine cyanobacterium Lyngbya confervoides, Planta Med., 75, 528, 10.1055/s-0029-1185332

Matthew, 2010, Intramolecular modulation of serine protease inhibitor activity in a marine cyanobacterium with antifeedant properties, Mar. Drugs, 8, 1803, 10.3390/md8061803

Qin, 2010, Highly brominated metabolites from marine red alga Laurencia similis inhibit protein tyrosine phosphatase 1B, Bioorg. Med. Chem. Lett., 20, 7152, 10.1016/j.bmcl.2010.08.144

Gunasekera, 2010, Molassamide, a depsipeptide serine protease inhibitor from the marine cyanobacterium Dichothrix utahensis, J. Nat. Prod., 73, 459, 10.1021/np900603f

Feng, 2009, Bioactive cyclopentenone derivatives from marine isolates of fungi, Bull. Korean Chem. Soc., 30, 2345, 10.5012/bkcs.2009.30.10.2345

Ciminiello, 2009, Stereostructure and biological activity of 42-Hydroxy-palytoxin: A new palytoxin analogue from Hawaiian Palythoa subspecies, Chem. Res. Toxicol., 22, 1851, 10.1021/tx900259v

Carr, 2009, Plectosphaeroic Acids A, B, and C, indoleamine 2,3-Dioxygenase inhibitors produced in culture by a marine isolate of the fungus Plectosphaerella cucumerina, Org. Lett., 11, 2996, 10.1021/ol900972j

Yamashita, 2009, A new antiangiogenic C24 oxylipin from the soft coral Sinularia numerosa, Bioorg. Med. Chem., 17, 2181, 10.1016/j.bmc.2008.10.083

Jain, 2009, Sipholane triterpenoids: Chemistry, reversal of ABCB1/P-Glycoprotein-Mediated multidrug resistance, and pharmacophore modeling, J. Nat. Prod., 72, 1291, 10.1021/np900091y

Elsebai, 2010, Spartinoxide, a new enantiomer of A82775C with inhibitory activity toward HLE from the marine-derived fungus Phaeosphaeria spartinae, Nat. Prod. Commun., 5, 1071

Ankisetty, 2010, Chemical constituents of the deep reef caribbean sponges Plakortis angulospiculatus and Plakortis halichondrioides and their anti-inflammatory activities, J. Nat. Prod., 73, 1494, 10.1021/np100233d

Gutierrez, 2009, Structural and synthetic investigations of tanikolide dimer, a SIRT2 selective inhibitor, and tanikolide seco-acid from the madagascar marine cyanobacterium Lyngbya majuscula, J. Org. Chem., 74, 5267, 10.1021/jo900578j

Truxal, 2010, Characterization of tamulamides A and B, polyethers isolated from the marine dinoflagellate Karenia brevis, J. Nat. Prod., 73, 536, 10.1021/np900541w

Cabedo, 2009, Terretonins E and F, inhibitors of the mitochondrial respiratory chain from the marine-derived fungus Aspergillus insuetus, J. Nat. Prod., 72, 1348, 10.1021/np900085n

Choi, 2011, Screening natural products for inhibitors of quinone reductase-2 using ultrafiltration LC-MS, Anal. Chem., 83, 1048, 10.1021/ac1028424

Kwan, 2009, Lyngbyastatins 8–10, elastase inhibitors with cyclic depsipeptide scaffolds isolated from the marine cyanobacterium Lyngbya semiplena, Mar. Drugs, 7, 528, 10.3390/md7040528

Glaser, 2009, A renaissance in marine pharmacology: From preclinical curiosity to clinical reality, Biochem. Pharmacol., 78, 440, 10.1016/j.bcp.2009.04.015

Nakamura, 2009, Biologically active marine natural products, Heterocycles, 78, 1, 10.3987/REV-08-637

Molinski, 2009, Drug development from marine natural products, Nat. Rev. Drug Discov., 8, 69, 10.1038/nrd2487

Fusetani, 2010, Biotechnological potential of marine natural products, Pure Appl. Chem., 82, 17, 10.1351/PAC-CON-09-01-11

Hill, 2010, Pharmaceuticals from marine natural products: Surge or Ebb?, Curr. Opin. Biotechnol., 21, 777, 10.1016/j.copbio.2010.10.007

Rae, 2010, Marine pharmacology in Australia. The roche research institute at dee why, new South Wales, 1974–81, Aust. J. Chem., 63, 855, 10.1071/CH10073

Mayer, 2010, The odyssey of marine pharmaceuticals: A current pipeline perspective, Trends Pharmacol. Sci., 31, 255, 10.1016/j.tips.2010.02.005

Thomas, 2010, Marine drugs from sponge-microbe association—A review, Mar. Drugs, 8, 1417, 10.3390/md8041417

Singh, 2011, Cyanobacteria: An emerging source for drug discovery, J. Antibiot., 64, 401, 10.1038/ja.2011.21

Park, 2011, Mining invertebrate natural products for future therapeutic treasure, Nat. Prod. Commun., 6, 1403

Kingston, 2011, Modern natural products drug discovery and its relevance to biodiversity conservation, J. Nat. Prod., 74, 496, 10.1021/np100550t

Ebada, 2011, Chemical and pharmacological significance of natural guanidines from marine invertebrates, Mini-Rev. Med. Chem., 11, 225, 10.2174/138955711795049862

Montaser, 2011, Marine natural products: A new wave of drugs?, Future Med. Chem., 3, 1475, 10.4155/fmc.11.118

Hughes, 2010, Antibacterials from the Sea, Chem. Eur J., 16, 12512, 10.1002/chem.201001279

Waters, 2010, The expanding role of marine microbes in pharmaceutical development, Curr. Opin. Biotechnol., 21, 780, 10.1016/j.copbio.2010.09.013

Lu, 2010, Marine microbes-derived anti-bacterial agents, Mini-Rev. Med. Chem., 10, 1077, 10.2174/1389557511009011077

Magalhaes, 2010, Antimicrobial peptides from marine invertebrates as a new frontier for microbial infection control, FASEB J., 24, 1320, 10.1096/fj.09-143388

Rahman, 2010, Novel anti-infective compounds from marine bacteria, Mar. Drugs, 8, 498, 10.3390/md8030498

Smith, 2010, Conventional and unconventional antimicrobials from fish, marine invertebrates and micro-algae, Mar. Drugs, 8, 1213, 10.3390/md8041213

Sagar, 2010, Antiviral lead compounds from marine sponges, Mar. Drugs, 8, 2619, 10.3390/md8102619

Vo, 2010, Potential anti-HIV agents from marine resources: An overview, Mar. Drugs, 8, 2871, 10.3390/md8122871

Lu, 2010, Marine compounds and their antiviral activities, Antiviral Res., 86, 231, 10.1016/j.antiviral.2010.03.009

Vo, 2011, Marine organisms as a therapeutic source against herpes simplex virus infection, Eur. J. Pharm. Sci., 44, 11, 10.1016/j.ejps.2011.07.005

Watts, 2010, The structural diversity and promise of antiparasitic marine invertebrate-derived small molecules, Curr. Opin. Biotechnol., 21, 808, 10.1016/j.copbio.2010.09.015

Tempone, 2011, Current approaches to discover marine antileishmanial natural products, Planta Med., 77, 572, 10.1055/s-0030-1250663

Ashforth, 2010, Bioprospecting for antituberculosis leads from microbial metabolites, Nat. Prod. Rep., 27, 1709, 10.1039/c0np00008f

Peach, 2009, New innovations for an old infection: Antimalarial lead discovery from marine natural products during the period 2003–2008, Future Med. Chem., 1, 593, 10.4155/fmc.09.56

Gademann, 2009, Antimalarial natural products of marine and freshwater origin, Chem. Rec., 9, 187, 10.1002/tcr.200900001

Fattorusso, 2009, Marine antimalarials, Mar. Drugs, 7, 130, 10.3390/md7020130

Villa, 2010, Marine natural product drug discovery: Leads for treatment of inflammation, cancer, infections, and neurological disorders, Immunopharmacol. Immunotoxicol., 32, 228, 10.3109/08923970903296136

Folmer, 2010, Marine natural products targeting phospholipases A2, Biochem. Pharmacol., 80, 1793, 10.1016/j.bcp.2010.08.024

Berrue, 2011, Marine diterpene glycosides, Bioorg. Med. Chem., 19, 6702, 10.1016/j.bmc.2011.06.083

Jaswir, 2011, Anti-inflammatory compounds of macro algae origin: A review, J. Med. Plants Res., 5, 7146

Wijesekara, 2010, Angiotensin-I-converting Enzyme (ACE) inhibitors from marine resources: Prospects in the pharmaceutical industry, Mar. Drugs, 8, 1080, 10.3390/md8041080

Halai, 2009, Conotoxins: Natural product drug leads, Nat. Prod. Rep., 26, 526, 10.1039/b819311h

Hamann, 2010, Marine indole alkaloids: Potential new drug leads for the control of depression and anxiety, Chem. Rev., 110, 4489, 10.1021/cr900211p

Teichert, 2010, Natural products and ion channel pharmacology, Future Med. Chem., 2, 731, 10.4155/fmc.10.31

Pangestuti, 2011, Neuroprotective effects of marine algae, Mar. Drugs, 9, 803, 10.3390/md9050803

Daly, 2011, Conopeptides as novel options for pain management, Drugs Future, 36, 25, 10.1358/dof.2011.36.1.1561066

Muttenthaler, 2011, Structure-activity studies on alpha-conotoxins, Curr. Pharm. Des., 17, 4226, 10.2174/138161211798999384

Fagerholm, 2010, Calyculins and related marine natural products as serine-threonine protein phosphatase PP1 and PP2A inhibitors and total syntheses of calyculin A, B, and C, Mar. Drugs, 8, 122, 10.3390/md80100122

Folmer, 2009, The inhibition of TNF-α-induced NF-κB activation by marine natural products, Biochem. Pharmacol., 78, 592, 10.1016/j.bcp.2009.05.009

Skropeta, 2011, Kinase inhibitors from marine sponges, Mar. Drugs, 9, 2131, 10.3390/md9102131

Senter, 2012, The discovery and development of brentuximab vedotin for use in relapsed Hodgkin lymphoma and systemic anaplastic large cell lymphoma, Nat. Biotechnol., 30, 631, 10.1038/nbt.2289

The Global Marine Pharmaceutical Pipeline. Available online:http://marinepharmacology.midwestern.edu/.