Maresin 1 attenuates mitochondrial dysfunction through the ALX/cAMP/ROS pathway in the cecal ligation and puncture mouse model and sepsis patients

Laboratory Investigation - Tập 98 - Trang 715-733 - 2018
Jiaqi Gu1, Lingchun Luo1, Qian Wang1, Songfan Yan1, Jing Lin1, Dan Li1, Bingbing Cao1, Hongxia Mei1, Binyu Ying1, Lu Bin2, Fang Gao Smith1,3,4, Sheng-Wei Jin1
1Department of Anesthesia and Critical Care, the Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, 325027, Zhejiang, China
2School of Laboratory Medicine and Life Science, Wenzhou Medical University, 325027, Zhejiang, China
3Institute of Inflammation and Aging, College of Medical and Dental Sciences, University of Birmingham, Birmingham, UK
4Academic Department of Anesthesia, Critical Care, Pain and Resuscitation, Birmingham Heartlands Hospital, Heart of England NHS Foundation Trust, B9 5SS, Birmingham, UK

Tài liệu tham khảo

Martin, 2003, The epidemiology of sepsis in the United States from 1979 through 2000, N Engl J Med, 348, 1546, 10.1056/NEJMoa022139 Nathan, 2002, Points of control in inflammation, Nature, 420, 846, 10.1038/nature01320 Hotchkiss, 2003, The pathophysiology and treatment of sepsis, N Engl J Med, 348, 138, 10.1056/NEJMra021333 Vaporciyan, 1993, Involvement of plateletendothelial cell adhesion molecule-1 in neutrophil recruitment in vivo, Science, 262, 1580, 10.1126/science.8248808 Ameziane-El-Hassani, 2017, Detection of Reactive Oxygen Species in Cells Undergoing Oncogene-Induced Senescence, Methods Mol Biol, 1534, 139, 10.1007/978-1-4939-6670-7_13 Rani, 2016, Oxidative stress and metabolic disorders: Pathogenesis and therapeutic strategies, Life Sci, 148, 183, 10.1016/j.lfs.2016.02.002 Serhan, 2014, Pro-resolving lipid mediators are leads for resolution physiology, Nature, 510, 92, 10.1038/nature13479 Serhan, 2009, Maresins: novel macrophage mediators with potent antiinflammatory and proresolving actions, J Exp Med, 206, 15, 10.1084/jem.20081880 Serhan, 2012, Macrophage proresolving mediator maresin 1 stimulates tissue regeneration and controls pain, FASEB J, 26, 1755, 10.1096/fj.11-201442 Dalli, 2013, The novel 13S,14S-epoxy-maresin is converted by human macrophages to maresin 1 (MaR1), inhibits leukotriene A4 hydrolase (LTA4H), and shifts macrophage phenotype, FASEB J, 27, 2573, 10.1096/fj.13-227728 Titos, 2016, Signaling and immunoresolving actions of resolvin D1 in inflamed human visceral adipose tissue, J Immunol, 197, 3360, 10.4049/jimmunol.1502522 Spite, 2009, Resolvin D2 is a potent regulator of leukocytes and controls microbial sepsis, Nature, 461, 1287, 10.1038/nature08541 Ueda, 2014, Combination therapy of 15-epi-lipoxin A4 with antibiotics protects mice from Escherichia coli-induced sepsis*, Crit Care Med, 42, e288, 10.1097/CCM.0000000000000162 Chen, 2014, Resolvin D1 improves survival in experimental sepsis through reducing bacterial load and preventing excessive activation of inflammatory response, Eur J Clin Microbiol Infect Dis, 33, 457, 10.1007/s10096-013-1978-6 Chiang, 2012, Infection regulates pro-resolving mediators that lower antibiotic requirements, Nature, 484, 524, 10.1038/nature11042 Rittirsch, 2009, Immunodesign of experimental sepsis by cecal ligation and puncture, Nat Protoc, 4, 31, 10.1038/nprot.2008.214 Mikawa, 2003, Obara, ONO-1714, a nitric oxide synthase inhibitor, attenuates endotoxin-induced acute lung injury in rabbits, Anesth Analg, 97, 1751, 10.1213/01.ANE.0000086896.90343.13 Liu, 2005, Rosiglitazone, a peroxisome proliferator-activated receptorgamma agonist, reduces acute lung injury in endotoxemic rats, Crit Care Med, 33, 2309, 10.1097/01.CCM.0000183161.81503.7D Bouabe, 2011, Novel highly sensitive IL-10-beta-lactamase reporter mouse reveals cells of the innate immune system as a substantial source of IL-10 in vivo, J Immunol, 187, 3165, 10.4049/jimmunol.1101477 Schepetkin, 2007, Highthroughput screening for small-molecule activators of neutrophils: Identification of novel N-formyl peptide receptor agonists, Mol Pharmacol, 71, 1061, 10.1124/mol.106.033100 Abraham, 1995, Efficacy and safety of monoclonal antibody to human tumor necrosis factor alpha in patients with sepsis syndrome. A randomized, controlled, double-blind, multicenter clinical trial, TNF-alpha MAb Sepsis Study Group, JAMA, 273, 934, 10.1001/jama.1995.03520360048038 Muenzer, 2010, Characterization and modulation of the immunosuppressive phase of sepsis, Infect Immun, 78, 1582, 10.1128/IAI.01213-09 Matsutani, 2017, Impact of Pioglitazone on Macrophage Dynamics in Adipose Tissues of Cecal Ligation and Puncture-Treated Mice, Biol Pharm Bull, 40, 638, 10.1248/bpb.b16-00883 Zhang, 2017, Immune intervention of human umbilical cord mesenchymal stem cells on sepsis rats, Zhonghua Wei Zhong Bing Ji Jiu Yi Xue, 29, 705 Zhang, 2017, Effect of Liangge powder on expression of inflammatory mediators and hepatic and renal function in rats with sepsis, Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi, 35, 369 Tanaka H, Nishikawa Y, Fukushima T, et al. Lipopolysaccharide inhibits hepatic gluconeogenesis in rats: the role of immune cells. J Diabetes Invest. 2017. 10.1111/jdi.12729. [Epub ahead of print] Thomson, 2017, The role of IL17-A in the second hit of acute pancreatitis, S Afr J Surg, 55, 51 Souza, 2007, The required role of endogenously produced lipoxin A4 and annexin-1 for the production of IL-10 and inflammatory hyporesponsiveness in mice, J Immunol, 179, 8533, 10.4049/jimmunol.179.12.8533 Walker, 2011, Lipoxin a4 increases survival by decreasing systemic inflammation and bacterial load in sepsis, Shock, 36, 410, 10.1097/SHK.0b013e31822798c1 Serhan, 2010, Novel lipid mediators and resolution mechanisms in acute inflammation: to resolve or not?, Am J Pathol, 177, 1576, 10.2353/ajpath.2010.100322 Chiang, 2006, The lipoxin receptor ALX: potent ligand-specific and stereoselective actions in vivo, Pharmacol Rev, 58, 463, 10.1124/pr.58.3.4 Colas, 2016, Identification and Actions of the Maresin 1 Metabolome in Infectious Inflammation, J Immunol, 197, 4444, 10.4049/jimmunol.1600837 Haworth, 2008, Resolvin E1 regulates interleukin 23, interferon-gamma and lipoxin A4 to promote the resolution of allergic airway inflammation, Nat Immunol, 9, 873, 10.1038/ni.1627 Zhang, 2017, Maresin 1 stimulates alveolar fluid clearance through the alveolar epithelial sodium channel Na,K-ATPase via the ALX/PI3K/Nedd4-2 pathway, Lab Invest, 97, 543, 10.1038/labinvest.2016.150 Wang, 2014, Resolvin D1 stimulates alveolar fluid clearance through alveolar epithelial sodium channel, Na,K- ATPase via ALX/cAMP/PI3K pathway in lipopolysaccharide-induced acute lung injury, J Immunol, 192, 3765, 10.4049/jimmunol.1302421 Koyama, 2001, Molecular pathways of cyclic nucleotide-induced inhibition of arterial smooth muscle cell proliferation, J Cell Physiol, 186, 1, 10.1002/1097-4652(200101)186:1<1::AID-JCP1012>3.0.CO;2-D Chevtzoff, 2010, Reactive oxygen species- mediated regulation of mitochondrial biogenesis in the yeast Saccharomyces cerevisiae, J Biol Chem, 285, 1733, 10.1074/jbc.M109.019570 Angelova, 2016, Functional role of mitochondrial reactive oxygen species in physiology, Free Radic Biol Med, 100, 81, 10.1016/j.freeradbiomed.2016.06.005 Yoshida, 2011, Cross-talk between the cellular redox state and the circadian system in Neurospora, PLoS ONE, 6, e28227, 10.1371/journal.pone.0028227 Sun, 2017, Maresin 1 ameliorates lung ischemia/reperfusion injury by suppressing oxidative stress via activation of the Nrf-2-mediated HO-1 signaling pathway, Oxid Med Cell Longev, 2017, 9634803, 10.1155/2017/9634803 Tang, 2017, Maresin 1 mitigates high glucose-induced mouse glomerular mesangial cell injury by inhibiting inflammation and fibrosis, Mediat Inflamm, 2017, 2438247, 10.1155/2017/2438247 Li, 2016, Maresin 1, a proresolving lipid mediator, mitigates carbon tetrachloride-induced liver injury in mice, Oxid Med Cell Longev, 2016, 9203716 Wen, 2015, Denatonium inhibits growth and induces apoptosis of airway epithelial cells through mitochondrial signaling pathways, Respir Res, 16, 13, 10.1186/s12931-015-0183-9 Callahan, 2001, Free radicals alter maximal diaphragmatic mitochondrial oxygen consumption in endotoxin-induced sepsis, Free Radic Biol Med, 30, 129, 10.1016/S0891-5849(00)00454-8 Markley, 2002, Hepatocyte mitochondrial metabolism is inhibited in neonatal rat endotoxaemia: effects of glutamine, Clin Sci (Lond), 102, 337, 10.1042/CS20010185 Crouser, 1999, Ileal VO(2)-O(2) alterations induced by endotoxin correlate with severity of mitochondrial injury, Am J Respir Crit Care Med, 160, 1347, 10.1164/ajrccm.160.4.9810116 Crouser, 2000, Endotoxininduced ileal mucosal injury and nitric oxide dysregulation are temporally dissociated, Am J Respir Crit Care Med, 161, 1705, 10.1164/ajrccm.161.5.9907043 Crouser, 2002, Endotoxininduced mitochondrial damage correlates with impaired respiratory activity, Crit Care Med, 30, 276, 10.1097/00003246-200202000-00002