Maps and legends: The quest for dissociated ligands of the glucocorticoid receptor

Pharmacology & Therapeutics - Tập 134 Số 1 - Trang 54-67 - 2012
Andrew R. Clark1, Maria G. Belvisi2
1Kennedy Institute of Rheumatology, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, 65 Aspenlea Road, Hammersmith, London W6 8LH, United Kingdom
2National Heart and Lung Institute, Imperial College London, Sir Alexander Fleming Building, Exhibition Road, London SW7 2AZ, United Kingdom

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Aagaard, 2011, Molecular basis for gene-specific transactivation by nuclear receptors, Biochim Biophys Acta, 1812, 824, 10.1016/j.bbadis.2010.12.018

Abraham, 2006, Antiinflammatory effects of dexamethasone are partly dependent on induction of dual specificity phosphatase 1, J Exp Med, 203, 1883, 10.1084/jem.20060336

Auphan, 1995, Immunosuppression by glucocorticoids: inhibition of NF-kappa B activity through induction of I kappa B synthesis, Science, 270, 286, 10.1126/science.270.5234.286

Avenant, 2010, Glucocorticoid receptor phosphorylation modulates transcription efficacy through GRIP-1 recruitment, Biochemistry, 49, 972, 10.1021/bi901956s

Barnes, 1995, Anti-inflammatory mechanisms of glucocorticoids, Biochem Soc Trans, 23, 940, 10.1042/bst0230940

Barnes, 2006, Corticosteroids: the drugs to beat, Eur J Pharmacol, 533, 2, 10.1016/j.ejphar.2005.12.052

Baschant, 2011, Glucocorticoid therapy of arthritis depends on the dimerized glucocorticoid receptor in T cells, Proc Natl Acad Sci U S A, 108, 19317, 10.1073/pnas.1105857108

Beaulieu, 2011, Role of GILZ in immune regulation, glucocorticoid actions and rheumatoid arthritis, Nat Rev Rheumatol, 7, 340, 10.1038/nrrheum.2011.59

Beaulieu, 2010, Glucocorticoid-induced leucine zipper is an endogenous antiinflammatory mediator in arthritis, Arthritis Rheum, 62, 2651, 10.1002/art.27566

Beausoleil, 2006, A probability-based approach for high-throughput protein phosphorylation analysis and site localization, Nat Biotechnol, 24, 1285, 10.1038/nbt1240

Beck, 2009, Crosstalk in inflammation: the interplay of glucocorticoid receptor-based mechanisms and kinases and phosphatases, Endocr Rev, 30, 830, 10.1210/er.2009-0013

Belvisi, 2001, Therapeutic benefit of a dissociated glucocorticoid and the relevance of in vitro separation of transrepression from transactivation activity, J Immunol, 166, 1975, 10.4049/jimmunol.166.3.1975

Bergmann, 2004, Glucocorticoid inhibition of granulocyte macrophage-colony-stimulating factor from T cells is independent of control by nuclear factor-kappaB and conserved lymphokine element 0, Am J Respir Cell Mol Biol, 30, 555, 10.1165/rcmb.2003-0295OC

Berlin, 2010, Recent advances in the development of novel glucocorticoid receptor modulators, Expert Opin Ther Pat, 20, 855, 10.1517/13543776.2010.493876

Bhandare, 2010, Glucocorticoid receptor interacting protein-1 restores glucocorticoid responsiveness in steroid-resistant airway structural cells, Am J Respir Cell Mol Biol, 42, 9, 10.1165/rcmb.2009-0239RC

Biddie, 2010, Genome-wide mechanisms of nuclear receptor action, Trends Endocrinol Metab, 21, 3, 10.1016/j.tem.2009.08.006

Biddie, 2011, Transcription factor AP1 potentiates chromatin accessibility and glucocorticoid receptor binding, Mol Cell, 43, 145, 10.1016/j.molcel.2011.06.016

Bilodeau, 2006, Role of Brg1 and HDAC2 in GR trans-repression of the pituitary POMC gene and misexpression in Cushing disease, Genes Dev, 20, 2871, 10.1101/gad.1444606

Bladh, 2009, Inhibition of extracellular signal-regulated kinase (ERK) signaling participates in repression of nuclear factor (NF)-kappaB activity by glucocorticoids, Biochim Biophys Acta, 1793, 439, 10.1016/j.bbamcr.2008.11.013

Bledsoe, 2002, Crystal structure of the glucocorticoid receptor ligand binding domain reveals a novel mode of receptor dimerization and coactivator recognition, Cell, 110, 93, 10.1016/S0092-8674(02)00817-6

Boldizsar, 2010, Emerging pathways of non-genomic glucocorticoid (GC) signalling in T cells, Immunobiology, 215, 521, 10.1016/j.imbio.2009.10.003

Buckingham, 2006, Glucocorticoids: exemplars of multi-tasking, Br J Pharmacol, 147, S258, 10.1038/sj.bjp.0706456

Caldenhoven, 1995, Negative cross-talk between RelA and the glucocorticoid receptor: a possible mechanism for the antiinflammatory action of glucocorticoids, Mol Endocrinol, 9, 401, 10.1210/me.9.4.401

Cato, 1996, Molecular mechanisms of anti-inflammatory action of glucocorticoids, Bioessays, 18, 371, 10.1002/bies.950180507

Chang, 2001, Mechanism of dexamethasone-mediated interleukin-8 gene suppression in cultured airway epithelial cells, Am J Physiol Lung Cell Mol Physiol, 280, L107, 10.1152/ajplung.2001.280.1.L107

Chaudhary, 1996, Regulation of interleukin-8 gene expression by interleukin-1beta, osteotropic hormones, and protein kinase inhibitors in normal human bone marrow stromal cells, J Biol Chem, 271, 16591, 10.1074/jbc.271.28.16591

Chen, 2008, Glucocorticoid receptor phosphorylation differentially affects target gene expression, Mol Endocrinol, 22, 1754, 10.1210/me.2007-0219

Chen, 2006, MED14 and MED1 differentially regulate target-specific gene activation by the glucocorticoid receptor, Mol Endocrinol, 20, 560, 10.1210/me.2005-0318

Chinenov, 2007, Glucocorticoids and the innate immune system: crosstalk with the toll-like receptor signaling network, Mol Cell Endocrinol, 275, 30, 10.1016/j.mce.2007.04.014

Chinenov, 2008, GRIP1-associated SET-domain methyltransferase in glucocorticoid receptor target gene expression, Proc Natl Acad Sci U S A, 105, 20185, 10.1073/pnas.0810863105

Chivers, 2006, Analysis of the dissociated steroid RU24858 does not exclude a role for inducible genes in the anti-inflammatory actions of glucocorticoids, Mol Pharmacol, 70, 2084, 10.1124/mol.106.025841

Cho, 2009, A novel mitogen-activated protein kinase phosphatase-1 and glucocorticoid receptor (GR) interacting protein-1-dependent combinatorial mechanism of gene transrepression by GR, Mol Endocrinol, 23, 86, 10.1210/me.2008-0257

Chung, 2011, Circadian rhythm of adrenal glucocorticoid: its regulation and clinical implications, Biochim Biophys Acta, 1812, 581, 10.1016/j.bbadis.2011.02.003

Clark, 2007, Anti-inflammatory functions of glucocorticoid-induced genes, Mol Cell Endocrinol, 275, 79, 10.1016/j.mce.2007.04.013

Clarke, 2007, The E3 Ligase MuRF1 degrades myosin heavy chain protein in dexamethasone-treated skeletal muscle, Cell Metab, 6, 376, 10.1016/j.cmet.2007.09.009

Cole, 1995, Targeted disruption of the glucocorticoid receptor gene blocks adrenergic chromaffin cell development and severely retards lung maturation, Genes Dev, 9, 1608, 10.1101/gad.9.13.1608

Conradie, 2011, MKP-1 knockout does not prevent glucocorticoid-induced bone disease in mice, Calcif Tissue Int, 89, 221, 10.1007/s00223-011-9509-x

Conradie, 2007, Vanadate prevents glucocorticoid-induced apoptosis of osteoblasts in vitro and osteocytes in vivo, J Endocrinol, 195, 229, 10.1677/JOE-07-0217

Coutinho, 2011, The anti-inflammatory and immunosuppressive effects of glucocorticoids, recent developments and mechanistic insights, Mol Cell Endocrinol, 335, 2, 10.1016/j.mce.2010.04.005

Dahlman-Wright, 1993, Protein–protein interactions between the DNA-binding domains of nuclear receptors: influence on DNA-binding, J Steroid Biochem Mol Biol, 45, 239, 10.1016/0960-0760(93)90338-W

Dahlman-Wright, 1992, Determinants of high-affinity DNA binding by the glucocorticoid receptor: evaluation of receptor domains outside the DNA-binding domain, Biochemistry, 31, 9040, 10.1021/bi00152a047

Dahlman-Wright, 1991, Interaction of the glucocorticoid receptor DNA-binding domain with DNA as a dimer is mediated by a short segment of five amino acids, J Biol Chem, 266, 3107, 10.1016/S0021-9258(18)49960-7

Daub, 2008, Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle, Mol Cell, 31, 438, 10.1016/j.molcel.2008.07.007

De Bosscher, 2010, Targeting inflammation using selective glucocorticoid receptor modulators, Curr Opin Pharmacol, 10, 497, 10.1016/j.coph.2010.04.007

De Bosscher, 2005, A fully dissociated compound of plant origin for inflammatory gene repression, Proc Natl Acad Sci U S A, 102, 15827, 10.1073/pnas.0505554102

Dephoure, 2008, A quantitative atlas of mitotic phosphorylation, Proc Natl Acad Sci U S A, 105, 10762, 10.1073/pnas.0805139105

Dhawan, 2007, A novel role for the glucocorticoid receptor in the regulation of monocyte chemoattractant protein-1 mRNA stability, J Biol Chem, 282, 10146, 10.1074/jbc.M605925200

Dickmeis, 2011, Glucocorticoids and circadian clock control of cell proliferation: at the interface between three dynamic systems, Mol Cell Endocrinol, 331, 11, 10.1016/j.mce.2010.09.001

Diefenbacher, 2008, Restriction to Fos family members of Trip6-dependent coactivation and glucocorticoid receptor-dependent trans-repression of activator protein-1, Mol Endocrinol, 22, 1767, 10.1210/me.2007-0574

Dostert, 2004, Negative glucocorticoid receptor response elements and their role in glucocorticoid action, Curr Pharm Des, 10, 2807, 10.2174/1381612043383601

Draper, 2005, 11beta-hydroxysteroid dehydrogenase and the pre-receptor regulation of corticosteroid hormone action, J Endocrinol, 186, 251, 10.1677/joe.1.06019

Eberhardt, 2005, Dissociated glucocorticoids equipotently inhibit cytokine- and cAMP-induced matrix degrading proteases in rat mesangial cells, Biochem Pharmacol, 70, 433, 10.1016/j.bcp.2005.05.007

Essilfie-Quaye, 2011, Comparison of symbicort versus pulmicort on steroid pharmacodynamic markers in asthma patients, Respir Med, 105, 1784, 10.1016/j.rmed.2011.08.020

Fardet, 2011, Prevalence of long-term oral glucocorticoid prescriptions in UK over the past 20years, Rheumatology (Oxford), 50, 1982, 10.1093/rheumatology/ker017

Flammer, 2010, The type I interferon signaling pathway is a target for glucocorticoid inhibition, Mol Cell Biol, 30, 4564, 10.1128/MCB.00146-10

Flammer, 2011, Minireview: glucocorticoids in autoimmunity: unexpected targets and mechanisms, Mol Endocrinol, 25, 1075, 10.1210/me.2011-0068

Frijters, 2010, Prednisolone-induced differential gene expression in mouse liver carrying wild type or a dimerization-defective glucocorticoid receptor, BMC Genomics, 11, 359, 10.1186/1471-2164-11-359

Furst, 2007, MAPK phosphatase-1 represents a novel anti-inflammatory target of glucocorticoids in the human endothelium, FASEB J, 21, 74, 10.1096/fj.06-6752com

Galliher-Beckley, 2009, Emerging roles of glucocorticoid receptor phosphorylation in modulating glucocorticoid hormone action in health and disease, IUBMB Life, 61, 979, 10.1002/iub.245

Galliher-Beckley, 2008, Glycogen synthase kinase 3{beta}-mediated serine phosphorylation of the human glucocorticoid receptor redirects gene expression profiles, Mol Cell Biol, 28, 7309, 10.1128/MCB.00808-08

Geserick, 2005, The role of DNA response elements as allosteric modulators of steroid receptor function, Mol Cell Endocrinol, 236, 1, 10.1016/j.mce.2005.03.007

Gilson, 2007, Myostatin gene deletion prevents glucocorticoid-induced muscle atrophy, Endocrinology, 148, 452, 10.1210/en.2006-0539

Glass, 2010, Nuclear receptor transrepression pathways that regulate inflammation in macrophages and T cells, Nat Rev Immunol, 10, 365, 10.1038/nri2748

Gorter, 2010, Current evidence for the management of rheumatoid arthritis with glucocorticoids: a systematic literature review informing the EULAR recommendations for the management of rheumatoid arthritis, Ann Rheum Dis, 69, 1010, 10.1136/ard.2009.127332

Gossye, 2009, Differential mechanism of NF-kappaB inhibition by two glucocorticoid receptor modulators in rheumatoid arthritis synovial fibroblasts, Arthritis Rheum, 60, 3241, 10.1002/art.24963

Grad, 2007, The glucocorticoid responses are shaped by molecular chaperones, Mol Cell Endocrinol, 275, 2, 10.1016/j.mce.2007.05.018

Groeneweg, 2011, Rapid non-genomic effects of corticosteroids and their role in the central stress response, J Endocrinol, 209, 153, 10.1530/JOE-10-0472

Gronemeyer, 2009, Allosteric effects govern nuclear receptor action: DNA appears as a player, Sci Signal, 2, pe34, 10.1126/scisignal.273pe34

Haendler, B., & Cleve, A. in press. Recent developments in antiandrogens and selective androgen receptor modulators. Mol Cell Endocrinol.

Hakim, 2009, Glucocorticoid receptor activation of the Ciz1-Lcn2 locus by long range interactions, J Biol Chem, 284, 6048, 10.1074/jbc.C800212200

Han, 2009, Multi-modulation of nuclear receptor coactivators through posttranslational modifications, Trends Endocrinol Metab, 20, 8, 10.1016/j.tem.2008.10.001

Hargreaves, 2009, Control of inducible gene expression by signal-dependent transcriptional elongation, Cell, 138, 129, 10.1016/j.cell.2009.05.047

Heck, 1997, I kappaB alpha-independent downregulation of NF-kappaB activity by glucocorticoid receptor, EMBO J, 16, 4698, 10.1093/emboj/16.15.4698

Heck, 1994, A distinct modulating domain in glucocorticoid receptor monomers in the repression of activity of the transcription factor AP-1, EMBO J, 13, 4087, 10.1002/j.1460-2075.1994.tb06726.x

Hench, 1964, 312

Hillier, 2007, Diamonds are forever: the cortisone legacy, J Endocrinol, 195, 1, 10.1677/JOE-07-0309

Hoes, 2010, Current view of glucocorticoid co-therapy with DMARDs in rheumatoid arthritis, Nat Rev Rheumatol, 6, 693, 10.1038/nrrheum.2010.179

Hofbauer, 2009, Minireview: live and let die: molecular effects of glucocorticoids on bone cells, Mol Endocrinol, 23, 1525, 10.1210/me.2009-0069

Horsch, 2007, Mitogen-activated protein kinase phosphatase 1/dual specificity phosphatase 1 mediates glucocorticoid inhibition of osteoblast proliferation, Mol Endocrinol, 21, 2929, 10.1210/me.2007-0153

Hudson, 2008, Recent developments in the discovery of selective glucocorticoid receptor modulators (SGRMs), Curr Top Med Chem, 8, 750, 10.2174/156802608784535048

Ishmael, 2008, Role of the RNA-binding protein tristetraprolin in glucocorticoid-mediated gene regulation, J Immunol, 180, 8342, 10.4049/jimmunol.180.12.8342

Ishmael, 2011, The human glucocorticoid receptor as an RNA-binding protein: global analysis of glucocorticoid receptor-associated transcripts and identification of a target RNA motif, J Immunol, 186, 1189, 10.4049/jimmunol.1001794

Islam, 2008, Glucocorticoid/glucocorticoid receptor inhibition of surfactant protein-A (SP-A) gene expression in lung type II cells is mediated by repressive changes in histone modification at the SP-A promoter, Mol Endocrinol, 22, 585, 10.1210/me.2007-0412

Ismaili, 2005, Stabilization of the unliganded glucocorticoid receptor by TSG101, J Biol Chem, 280, 11120, 10.1074/jbc.M500059200

Ito, 2000, Glucocorticoid receptor recruitment of histone deacetylase 2 inhibits interleukin-1beta-induced histone H4 acetylation on lysines 8 and 12, Mol Cell Biol, 20, 6891, 10.1128/MCB.20.18.6891-6903.2000

Janka-Junttila, 2006, The glucocorticoid RU24858 does not distinguish between transrepression and transactivation in primary human eosinophils, J Inflamm (Lond), 3, 10, 10.1186/1476-9255-3-10

Joanny, 2012, Anti-inflammatory effects of selective glucocorticoid receptor modulators (SGRMs) are partially dependent on upregulation of dual specificity phosphatase 1 (DUSP1), Br J Pharmacol, 65, 1124, 10.1111/j.1476-5381.2011.01574.x

John, 2008, Interaction of the glucocorticoid receptor with the chromatin landscape, Mol Cell, 29, 611, 10.1016/j.molcel.2008.02.010

John, 2011, Chromatin accessibility pre-determines glucocorticoid receptor binding patterns, Nat Genet, 43, 264, 10.1038/ng.759

Jones, 2009, Improving selective androgen receptor modulator discovery and preclinical evaluation, Curr Opin Drug Discov, 4, 981, 10.1517/17460440903206957

Kang, 2008, Glucocorticoid regulation of CD38 expression in human airway smooth muscle cells: role of dual specificity phosphatase 1, Am J Physiol Lung Cell Mol Physiol, 295, L186, 10.1152/ajplung.00352.2007

Kanis, 2007, Glucocorticoid-induced osteoporosis: a systematic review and cost-utility analysis, Health Technol Assess, 11, iii, 10.3310/hta11070

Kelly, M., King, E., Rider, C., Gwozd, C., Holden, N., Eddleston, J., Zuraw, B., Leigh, R., O'Byrne, P., & Newton, R. (in press) Corticosteroid-induced gene expression in allergen-challenged asthmatic subjects taking inhaled budesonide. Br J Pharmacol, doi: 10.1111/j.1476-5381.2011.01620.x.

King, 2009, Inhibition of NF-kappaB-dependent transcription by MKP-1: transcriptional repression by glucocorticoids occurring via p38 MAPK, J Biol Chem, 284, 26803, 10.1074/jbc.M109.028381

Kino, 2011, Circadian CLOCK-mediated regulation of target-tissue sensitivity to glucocorticoids: implications for cardiometabolic diseases, Endocr Dev, 20, 116, 10.1159/000321232

Kirwan, 2007, Effects of glucocorticoids on radiological progression in rheumatoid arthritis, Cochrane Database Syst Rev, 10.1002/14651858.CD006356

Kleiman, 2007, Glucocorticoid receptor action in beneficial and side effects of steroid therapy: lessons from conditional knockout mice, Mol Cell Endocrinol, 275, 98, 10.1016/j.mce.2007.05.009

Kleiman, A., Hubner, S., Rodriguez Parkitna, J. M., Neumann, A., Hofer, S., Weigand, M. A., Bauer, M., Schmid, W., Schutz, G., Libert, C., Reichardt, H. M., & Tuckermann, J. P. (in press). Glucocorticoid receptor dimerization is required for survival in septic shock via suppression of interleukin-1 in macrophages. FASEB J.

Lefstin, 1994, Influence of a steroid receptor DNA-binding domain on transcriptional regulatory functions, Genes Dev, 8, 2842, 10.1101/gad.8.23.2842

Leitman, 2010, Regulation of specific target genes and biological responses by estrogen receptor subtype agonists, Curr Opin Pharmacol, 10, 629, 10.1016/j.coph.2010.09.009

Li, 2011, Inhibition of p38 MAPK-dependent bronchial contraction after ozone by corticosteroids, Eur Respir J, 37, 933, 10.1183/09031936.00021110

Liden, 1997, A new function for the C-terminal zinc finger of the glucocorticoid receptor. Repression of RelA transactivation, J Biol Chem, 272, 21467, 10.1074/jbc.272.34.21467

Lopez, 2008, LGD-5552, an antiinflammatory glucocorticoid receptor ligand with reduced side effects, in vivo, Endocrinology, 149, 2080, 10.1210/en.2007-1353

Luecke, 2005, The glucocorticoid receptor blocks P-TEFb recruitment by NFkappaB to effect promoter-specific transcriptional repression, Genes Dev, 19, 1116, 10.1101/gad.1297105

Ma, 2004, Dexamethasone inhibits IL-12p40 production in lipopolysaccharide-stimulated human monocytic cells by down-regulating the activity of c-Jun N-terminal kinase, the activation protein-1, and NF-kappa B transcription factors, J Immunol, 172, 318, 10.4049/jimmunol.172.1.318

Malovannaya, 2011, Analysis of the human endogenous coregulator complexome, Cell, 145, 787, 10.1016/j.cell.2011.05.006

Martens, 2011, Genome-wide interplay of nuclear receptors with the epigenome, Biochim Biophys Acta, 1812, 818, 10.1016/j.bbadis.2010.10.005

McDonnell, 2010, The molecular mechanisms underlying the pharmacological actions of ER modulators: implications for new drug discovery in breast cancer, Curr Opin Pharmacol, 10, 620, 10.1016/j.coph.2010.09.007

McEwan, 1997, Mechanism of gene expression by the glucocorticoid receptor: role of protein–protein interactions, Bioessays, 19, 153, 10.1002/bies.950190210

McKenna, 2009, Minireview: evolution of NURSA, the Nuclear Receptor Signaling Atlas, Mol Endocrinol, 23, 740, 10.1210/me.2009-0135

McMaster, 2008, Drug insight: selective agonists and antagonists of the glucocorticoid receptor, Nat Clin Pract Endocrinol Metab, 4, 91, 10.1038/ncpendmet0745

Meijsing, 2009, DNA binding site sequence directs glucocorticoid receptor structure and activity, Science, 324, 407, 10.1126/science.1164265

Miner, 2007, Antiinflammatory glucocorticoid receptor ligand with reduced side effects exhibits an altered protein–protein interaction profile, Proc Natl Acad Sci U S A, 104, 19244, 10.1073/pnas.0705517104

Miner, 2005, New and improved glucocorticoid receptor ligands, Expert Opin Investig Drugs, 14, 1527, 10.1517/13543784.14.12.1527

Mukaida, 1994, Novel mechanism of glucocorticoid-mediated gene repression. Nuclear factor-kappa B is target for glucocorticoid-mediated interleukin 8 gene repression, J Biol Chem, 269, 13289, 10.1016/S0021-9258(17)36831-X

Nader, 2010, Interactions of the circadian CLOCK system and the HPA axis, Trends Endocrinol Metab, 21, 277, 10.1016/j.tem.2009.12.011

Newton, 2000, Molecular mechanisms of glucocorticoid action: what is important?, Thorax, 55, 603, 10.1136/thorax.55.7.603

Newton, 2007, Separating transrepression and transactivation: a distressing divorce for the glucocorticoid receptor?, Mol Pharmacol, 72, 799, 10.1124/mol.107.038794

Newton, 2010, Glucocorticoids inhibit IL-1beta-induced GM-CSF expression at multiple levels: roles for the ERK pathway and repression by MKP-1, Biochem J, 427, 113, 10.1042/BJ20091038

Newton, 1998, Repression of cyclooxygenase-2 and prostaglandin E2 release by dexamethasone occurs by transcriptional and post-transcriptional mechanisms involving loss of polyadenylated mRNA, J Biol Chem, 273, 32312, 10.1074/jbc.273.48.32312

Nie, 2005, Beta2-adrenoceptor agonists, like glucocorticoids, repress eotaxin gene transcription by selective inhibition of histone H4 acetylation, J Immunol, 175, 478, 10.4049/jimmunol.175.1.478

Nilsson, 2011, Estrogen receptors: therapies targeted to receptor subtypes, Clin Pharmacol Ther, 89, 44, 10.1038/clpt.2010.226

Nissen, 2000, The glucocorticoid receptor inhibits NFkappaB by interfering with serine-2 phosphorylation of the RNA polymerase II carboxy-terminal domain, Genes Dev, 14, 2314, 10.1101/gad.827900

Oakley, 2011, Cellular processing of the glucocorticoid receptor gene and protein: new mechanisms for generating tissue-specific actions of glucocorticoids, J Biol Chem, 286, 3177, 10.1074/jbc.R110.179325

Ogawa, 2005, Molecular determinants of crosstalk between nuclear receptors and toll-like receptors, Cell, 122, 707, 10.1016/j.cell.2005.06.029

O'Malley, 2008, Coactivators and corepressors: what's in a name?, Mol Endocrinol, 22, 2213, 10.1210/me.2008-0201

Qiu, 2011, Dynamic interaction of HDAC1 with a glucocorticoid receptor-regulated gene is modulated by the activity state of the promoter, J Biol Chem, 286, 7641, 10.1074/jbc.M110.185488

Quante, 2008, Corticosteroids reduce IL-6 in ASM cells via up-regulation of MKP-1, Am J Respir Cell Mol Biol, 39, 208, 10.1165/rcmb.2007-0014OC

Rao, 2011, Coactivation of GR and NFKB alters the repertoire of their binding sites and target genes, Genome Res, 21, 1404, 10.1101/gr.118042.110

Rauch, 2011, An anti-inflammatory selective glucocorticoid receptor modulator preserves osteoblast differentiation, FASEB J, 25, 1323, 10.1096/fj.10-173393

Rauch, 2010, Glucocorticoids suppress bone formation by attenuating osteoblast differentiation via the monomeric glucocorticoid receptor, Cell Metab, 11, 517, 10.1016/j.cmet.2010.05.005

Rauner, 2011, Dissociation of osteogenic and immunological effects by the selective glucocorticoid receptor agonist, compound A, in human bone marrow stromal cells, Endocrinology, 152, 103, 10.1210/en.2010-0456

Reddy, 2009, Genomic determination of the glucocorticoid response reveals unexpected mechanisms of gene regulation, Genome Res, 19, 2163, 10.1101/gr.097022.109

Reichardt, 1998, DNA binding of the glucocorticoid receptor is not essential for survival, Cell, 93, 531, 10.1016/S0092-8674(00)81183-6

Reichardt, 2001, Repression of inflammatory responses in the absence of DNA binding by the glucocorticoid receptor, EMBO J, 20, 7168, 10.1093/emboj/20.24.7168

Reily, 2006, The GRIP1:IRF3 interaction as a target for glucocorticoid receptor-mediated immunosuppression, EMBO J, 25, 108, 10.1038/sj.emboj.7600919

Robertson, 2010, Abrogation of glucocorticoid receptor dimerization correlates with dissociated glucocorticoid behavior of compound A, J Biol Chem, 285, 8061, 10.1074/jbc.M109.087866

Rogatsky, 2002, Alternate surfaces of transcriptional coregulator GRIP1 function in different glucocorticoid receptor activation and repression contexts, Proc Natl Acad Sci U S A, 99, 16701, 10.1073/pnas.262671599

Rogatsky, 2003, Target-specific utilization of transcriptional regulatory surfaces by the glucocorticoid receptor, Proc Natl Acad Sci U S A, 100, 13845, 10.1073/pnas.2336092100

Rogatsky, 2001, Factor recruitment and TIF2/GRIP1 corepressor activity at a collagenase-3 response element that mediates regulation by phorbol esters and hormones, EMBO J, 20, 6071, 10.1093/emboj/20.21.6071

Ronacher, 2009, Ligand-selective transactivation and transrepression via the glucocorticoid receptor: role of cofactor interaction, Mol Cell Endocrinol, 299, 219, 10.1016/j.mce.2008.10.008

Sahu, 2011, Dual role of FoxA1 in androgen receptor binding to chromatin, androgen signalling and prostate cancer, EMBO J, 30, 3962, 10.1038/emboj.2011.328

Santos, 2011, Negative regulation by nuclear receptors: a plethora of mechanisms, Trends Endocrinol Metab, 22, 87, 10.1016/j.tem.2010.11.004

Schacke, 2007, Selective glucocorticoid receptor agonists (SEGRAs): novel ligands with an improved therapeutic index, Mol Cell Endocrinol, 275, 109, 10.1016/j.mce.2007.05.014

Schacke, 2002, Mechanisms involved in the side effects of glucocorticoids, Pharmacol Ther, 96, 23, 10.1016/S0163-7258(02)00297-8

Schacke, 2005, Dissociated glucocorticoid receptor ligands: compounds with an improved therapeutic index, Curr Opin Investig Drugs, 6, 503

Scheinman, 1995, Role of transcriptional activation of I kappa B alpha in mediation of immunosuppression by glucocorticoids, Science, 270, 283, 10.1126/science.270.5234.283

Siersbaek, 2011, Extensive chromatin remodelling and establishment of transcription factor ‘hotspots’ during early adipogenesis, EMBO J, 30, 1459, 10.1038/emboj.2011.65

Simons, 2008, What goes on behind closed doors: physiological versus pharmacological steroid hormone actions, Bioessays, 30, 744, 10.1002/bies.20792

Smoak, 2006, Glucocorticoids regulate tristetraprolin synthesis and posttranscriptionally regulate tumor necrosis factor alpha inflammatory signaling, Mol Cell Biol, 26, 9126, 10.1128/MCB.00679-06

So, 2009, Glucocorticoid regulation of the circadian clock modulates glucose homeostasis, Proc Natl Acad Sci U S A, 106, 17582, 10.1073/pnas.0909733106

So, 2007, Determinants of cell- and gene-specific transcriptional regulation by the glucocorticoid receptor, PLoS Genet, 3, e94, 10.1371/journal.pgen.0030094

So, 2008, Conservation analysis predicts in vivo occupancy of glucocorticoid receptor-binding sequences at glucocorticoid-induced genes, Proc Natl Acad Sci U S A, 105, 5745, 10.1073/pnas.0801551105

Staples, 2003, Evidence for post-transcriptional regulation of interleukin-5 by dexamethasone, Immunology, 109, 527, 10.1046/j.1365-2567.2003.01679.x

Stellato, 2004, Post-transcriptional and nongenomic effects of glucocorticoids, Proc Am Thorac Soc, 1, 255, 10.1513/pats.200402-015MS

Surjit, 2011, Widespread negative response elements mediate direct repression by agonist-liganded glucocorticoid receptor, Cell, 145, 224, 10.1016/j.cell.2011.03.027

Tanigawa, 2002, Cell type-dependent divergence of transactivation by glucocorticoid receptor ligand, Biol Pharm Bull, 25, 1619, 10.1248/bpb.25.1619

Taves, 2011, Extra-adrenal glucocorticoids and mineralocorticoids: evidence for local synthesis, regulation, and function, Am J Physiol Endocrinol Metab, 301, E11, 10.1152/ajpendo.00100.2011

Tsaprouni, 2007, Suppression of lipopolysaccharide- and tumour necrosis factor-alpha-induced interleukin (IL)-8 expression by glucocorticoids involves changes in IL-8 promoter acetylation, Clin Exp Immunol, 150, 151, 10.1111/j.1365-2249.2007.03484.x

Tuckermann, 2007, Macrophages and neutrophils are the targets for immune suppression by glucocorticoids in contact allergy, J Clin Invest, 117, 1381, 10.1172/JCI28034

Tuckermann, 1999, The DNA binding-independent function of the glucocorticoid receptor mediates repression of AP-1-dependent genes in skin, J Cell Biol, 147, 1365, 10.1083/jcb.147.7.1365

van der Laan, 2008, Pharmacology of glucocorticoids: beyond receptors, Eur J Pharmacol, 585, 483, 10.1016/j.ejphar.2008.01.060

van Loo, 2010, Antiinflammatory properties of a plant-derived nonsteroidal, dissociated glucocorticoid receptor modulator in experimental autoimmune encephalomyelitis, Mol Endocrinol, 24, 310, 10.1210/me.2009-0236

van Raalte, 2009, Novel insights into glucocorticoid-mediated diabetogenic effects: towards expansion of therapeutic options?, Eur J Clin Invest, 39, 81, 10.1111/j.1365-2362.2008.02067.x

van Staa, 2000, Use of oral corticosteroids in the United Kingdom, QJM, 93, 105, 10.1093/qjmed/93.2.105

Vayssiere, 1997, Synthetic glucocorticoids that dissociate transactivation and AP-1 transrepression exhibit antiinflammatory activity in vivo, Mol Endocrinol, 11, 1245, 10.1210/me.11.9.1245

Visser, 2010, Interplay of the inflammatory and stress systems in a hepatic cell line: interactions between glucocorticoid receptor agonists and interleukin-6, Endocrinology, 151, 5279, 10.1210/en.2010-0368

Waddell, 2008, The glucocorticoid receptor and FOXO1 synergistically activate the skeletal muscle atrophy-associated MuRF1 gene, Am J Physiol Endocrinol Metab, 295, E785, 10.1152/ajpendo.00646.2007

Wang, 2004, Chromatin immunoprecipitation (ChIP) scanning identifies primary glucocorticoid receptor target genes, Proc Natl Acad Sci U S A, 101, 15603, 10.1073/pnas.0407008101

Wang, 2008, The role of MAP kinase phosphatase-1 in the protective mechanism of dexamethasone against endotoxemia, Life Sci, 83, 671, 10.1016/j.lfs.2008.09.003

Webster, 1997, Mouse glucocorticoid receptor phosphorylation status influences multiple functions of the receptor protein, J Biol Chem, 272, 9287, 10.1074/jbc.272.14.9287

Weinstein, 2011, Clinical practice. Glucocorticoid-induced bone disease, N Engl J Med, 365, 62, 10.1056/NEJMcp1012926

Whitehouse, 2011, Anti-inflammatory glucocorticoid drugs: reflections after 60years, Inflammopharmacology, 19, 1, 10.1007/s10787-010-0056-2

Wiench, 2011, DNA methylation status predicts cell type-specific enhancer activity, EMBO J, 30, 3028, 10.1038/emboj.2011.210

Wu, 2005, Glucocorticoid receptor-induced MAPK phosphatase-1 (MPK-1) expression inhibits paclitaxel-associated MAPK activation and contributes to breast cancer cell survival, J Biol Chem, 280, 4117, 10.1074/jbc.M411200200

Wust, 2009, Therapeutic and adverse effects of a non-steroidal glucocorticoid receptor ligand in a mouse model of multiple sclerosis, PLoS One, 4, e8202, 10.1371/journal.pone.0008202

Yemelyanov, 2008, Novel steroid receptor phyto-modulator compound A inhibits growth and survival of prostate cancer cells, Cancer Res, 68, 4763, 10.1158/0008-5472.CAN-07-6104

York, 2010, Steroid receptor coactivator (SRC) family: masters of systems biology, J Biol Chem, 285, 38743, 10.1074/jbc.R110.193367

Yu, 2011, MKP-1 regulates cytokine mRNA stability through selectively modulation subcellular translocation of AUF1, Cytokine, 56, 245, 10.1016/j.cyto.2011.06.006