Mapping metabolome changes in Luffa aegyptiaca Mill fruits at different maturation stages via MS-based metabolomics and chemometrics

Lawal, 2010, Ethno medicinal information on collation and identification of some medicinal plants in Research Institutes of South-west Nigeria, Afr J Pharm Pharmacol, 4, 001 Oboh, 2009, Luffa cylindrica-an emerging cash crop, Afr J Agric Res, 4, 684 Demir, 2008, Dye adsorption behavior of Luffa cylindrica fibers, J Hazard Mater, 153, 389, 10.1016/j.jhazmat.2007.08.070 Azeez, 2013, Traditional and medicinal uses of Luffa cylindrica: a review, J Med Plants, 1, 102 Partap, 2012, Luffa Cylindrica : An important medicinal plant, J Nat Prod Plant Resour, 2, 127 Lee S, Yoo J. Method for preparing transformed Luffa cylindrica Roem (World Intellectual property organization); 2006. Du, 2006, Preparative separation of Saponins from the Luffa Cylindeica (L.) Roem. by slow rotary countercurrent chromatography, J Liq Chromatogr Relat Technol, 29, 2451, 10.1080/10826070600864924 Irshad IA, 2010, Phytochemical screening and high performance TLC analysis of some cucurbits, Res J Phytochem, 4, 242, 10.3923/rjphyto.2010.242.247 Du, 2006, Antioxidant constituents in the fruits of Luffa cylindrica (L.) Roem, J Agric Food Chem, 54, 4186, 10.1021/jf0604790 Bor, 2006, Evaluation of antioxidant activity and inhibitory effect on nitric oxide production of some common vegetables, J Agric Food Chem, 54, 1680, 10.1021/jf0527448 Ismail, 2010, Phytochemical and antimicrobial investigation of Luffa cylindrica, Boletín Latinoamericano y del Caribe de Plantas Medicinales y Aromáticas., 9 Ng, 1992, Two proteins with ribosome-inactivating, cytotoxic and abortifacient activities from seeds of Luffa cylindrica roem (Cucurbitaceae), Biochem Int, 27, 197 Parkash, 2002, Isolation and characterization of luffacylin, a ribosome inactivating peptide with anti-fungal activity from sponge gourd (Luffa cylindrica) seeds, Peptides, 23, 1019, 10.1016/S0196-9781(02)00045-1 Khajuria, 2007, Immunomodulatory effects of two sapogenins 1 and 2 isolated from Luffa cylindrica in Balb/C mice, Bioorg Med Chem Lett, 17, 1608, 10.1016/j.bmcl.2006.12.091 Muthumani, 2010, Phytochemical screening and anti inflammatory, bronchodilator and antimicrobial activities of the seeds of Luffa cylindrica, Res J Pharmaceut, Biol Chem Sci, 1, 11 Ng, 2011, Structural characterization and anti-HIV-1 activities of arginine/glutamate-rich polypeptide Luffin P1 from the seeds of sponge gourd (Luffa cylindrica), J Struct Biol, 174, 164, 10.1016/j.jsb.2010.12.007 Kao, 2012, Functional components in Luffa cylindrica and their effects on anti-inflammation of macrophage cells, Food Chem, 135, 386, 10.1016/j.foodchem.2012.04.128 Farag, 2017, Assessment of sensory metabolites distribution in 3 cactus Opuntia ficus-indica fruit cultivars using UV fingerprinting and GC/MS profiling techniques, LWT, 80, 145, 10.1016/j.lwt.2017.02.014 Farag, 2015, Volatiles and primary metabolites profiling in two Hibiscus sabdariffa (roselle) cultivars via headspace SPME-GC-MS and chemometrics, Food Res Int, 78, 327, 10.1016/j.foodres.2015.09.024 Khalil, 2017, Metabolome based volatiles profiling in 13 date palm fruit varieties from Egypt via SPME GC–MS and chemometrics, Food Chem, 217, 171, 10.1016/j.foodchem.2016.08.089 Gumustas, 2013, UPLC versus HPLC on drug analysis: advantageous, applications and their validation parameters, Chromatographia, 76, 1365, 10.1007/s10337-013-2477-8 Farag, 2012, Volatiles profiling in medicinal licorice roots using steam distillation and solid-phase microextraction (SPME) coupled to chemometrics, J Food Sci, 77, C1179, 10.1111/j.1750-3841.2012.02927.x Goodacre, 2000, Detection of the dipicolinic acid biomarker in Bacillus spores using Curie-point pyrolysis mass spectrometry and Fourier transform infrared spectroscopy, Anal Chem, 72, 119, 10.1021/ac990661i Farag, 2018, Salicylic acid and its derivatives elicit the production of diterpenes and sterols in corals and their algal symbionts: a metabolomics approach to elicitor SAR, Metabolomics, 14, 127, 10.1007/s11306-018-1416-y Smith, 2006, XCMS: processing mass spectrometry data for metabolite profiling using nonlinear peak alignment, matching, and identification, Anal Chem, 78, 779, 10.1021/ac051437y Fernando, 2005, Identification and use of potential bacterial organic antifungal volatiles in biocontrol, Soil Biol Biochem, 37, 955, 10.1016/j.soilbio.2004.10.021 Burdock, 2010, 2159 Simon C. Hexenal - Molecule of the Month March 2005 [Archived version]; 2017. Buescher, 2001, Production and stability of (E, Z)-2, 6-Nonadienal, the major flavor volatile of cucumbers, J Food Sci, 66, 357, 10.1111/j.1365-2621.2001.tb11346.x Scriven R, Meloan CE. (E, Z)-2, 6-nonadien-1-al and (E)-2-nonen-1-al Present in Crushed Cucumbers are Natural Repellents for the American Cockroach (Periplaneta Americana); 1984. Kula, 1993, Unsaturated aliphatic C9-aldehydes as natural flavorants:(E, Z)-2, 6-nonadienal, Perfumer Flavorist, 18, 23 Fan, 2006, Identification of aroma compounds in Chinese ‘Yanghe Daqu’liquor by normal phase chromatography fractionation followed by gas chromatography [sol] olfactometry, Flavour Fragrance J, 21, 333, 10.1002/ffj.1621 Schieberle, 1990, Evaluation of potent odorants in cucumbers (Cucumis sativus) and muskmelons (Cucumis melo) by aroma extract dilution analysis, J Food Sci, 55, 193, 10.1111/j.1365-2621.1990.tb06050.x Combet, 2006, Eight-carbon volatiles in mushrooms and fungi: properties, analysis, and biosynthesis, Mycoscience., 47, 317, 10.1007/S10267-006-0318-4 Park, 2012, Antimicrobial effect of linalool and α-terpineol against periodontopathic and cariogenic bacteria, Anaerobe, 18, 369, 10.1016/j.anaerobe.2012.04.001 Herman, 2016, Linalool affects the antimicrobial efficacy of essential oils, Curr Microbiol, 72, 165, 10.1007/s00284-015-0933-4 Langhans V, Hedin P, Graves Jr C. Fungitoxic chemicals in pecan tissue [Fusicladium effusum, Carya illinoensis]. Plant Disease Reporter; 1978. Zhang, 2006, Antifungal activities of major tea leaf volatile constituents toward Colletorichum camelliae Massea, J Agric Food Chem, 54, 3936, 10.1021/jf060017m Krist, 2007, Effects of scents on airborne microbes, part I: thymol, eugenol, trans-cinnamaldehyde and linalool, Flavour Fragrance J, 22, 44, 10.1002/ffj.1750 Högnadóttir, 2003, Identification of aroma active compounds in orange essence oil using gas chromatography–olfactometry and gas chromatography–mass spectrometry, J Chromatogr A, 998, 201, 10.1016/S0021-9673(03)00524-7 Griego, 2008, Exposure, epidemiology and human cancer incidence of naphthalene, Regul Toxicol Pharm, 51, 22, 10.1016/j.yrtph.2008.02.003 Rasheed, 2018, Comparative analysis of Hibiscus sabdariffa (roselle) hot and cold extracts in respect to their potential for α-glucosidase inhibition, Food Chem, 250, 236, 10.1016/j.foodchem.2018.01.020 Shmuel Y. Dictionary of food compounds with CD-ROM, 2nd ed: CRC Press, Taylor and Francis Group; 2012. 2346 p. Zhou J, Xie G, Yan X. Encyclopedia of Traditional Chinese Medicines - Molecular Structures, Pharmacological Activities, Natural Sources and Applications: Springer-Verlag Berlin Heidelberg; 2011. 730 p. Kanwal, 2013, Antiemetic and anti-inflammaotry activity of fruit peel of Luffa cylindrica (L.) Roem, J Ethno Trad Med Photon, 118, 258 Liang L, E Lu L, C Cai Y. [Studies on the chemical components from leaves of Luffa cylinderica Roem]; 1993. 836–9 p. Farag, 2015, Metabolomic fingerprint classification of Brachychiton acerifolius organs via UPLC-qTOF-PDA-MS analysis and chemometrics, Nat Prod Res, 29, 116, 10.1080/14786419.2014.964710 Farag, 2019, UPLC-MS metabolome based classification of Lupinus and Lens seeds: A prospect for phyto-equivalency of its different accessions, Food Res Int, 115, 379, 10.1016/j.foodres.2018.11.003 Tang W, GE. Luffa cylindrica (L.) Roem. In: Chinese Drugs of Plant Origin: Springer, Berlin, Heidelberg; 1992. Azimova S. Physicochemical and Pharmacological Properties of Triterpene Glycosides. Tanaka, 1991, Anti-allergic effect of bryonolic acid from Luffa cylindrica cell suspension cultures, Planta Med, 57, 527, 10.1055/s-2006-960199 Salmerón, 2001, Dietary fat intake and risk of type 2 diabetes in women, Am J Clin Nutrit, 73, 1019, 10.1093/ajcn/73.6.1019 Abou-ElWafa, 2009, Three new unsaturated fatty acids from the marine green alga ulva fasciata delile, Zeitschrift Fur Naturforschung Section B J Chem Sci, 64, 1199, 10.1515/znb-2009-1014 Muthumani, 2010, Phytochemical screening and anti inflammatory, bronchodilator and antimicrobial activities of the seeds of Luffa cylindrica, Res J Pharmaceut, Biol Chem Sci, 1, 11 Urbanová, 2013, Analysis of gibberellins as free acids by ultra performance liquid chromatography–tandem mass spectrometry, Talanta, 112, 85, 10.1016/j.talanta.2013.03.068 Hsu, 2014, Multiple-stage linear ion-trap with high resolution mass spectrometry towards complete structural characterization of phosphatidylethanolamines containing cyclopropane fatty acyl chain in Leishmania infantum, J Mass Spectrometry: JMS, 49, 201, 10.1002/jms.3327 Hsu, 2000, Characterization of phosphatidylinositol, phosphatidylinositol-4-phosphate, and phosphatidylinositol-4,5-bisphosphate by electrospray ionization tandem mass spectrometry: a mechanistic study, J Am Soc Mass Spectrom, 11, 986, 10.1016/S1044-0305(00)00172-0 Kinsky, 1987, Circumvention of the methotrexate transport system by methotrexate-phosphatidylethanolamine derivatives: effect of fatty acid chain length, Biochim Biophys Acta (BBA)-Lipids Lipid Metabolism, 921, 96, 10.1016/0005-2760(87)90175-5