Manufacturing mesenchymal stromal cells for phase I clinical trials

Cytotherapy - Tập 15 Số 4 - Trang 416-422 - 2013
Patrick J. Hanley1, Zhuyong Mei1, Maria da Graça Cabreira-Hansen2, Mariola Klis1, Wei Li1, Yali Zhao1, April Durett1, Xingwu Zheng3, Yongping Wang3,4, Adrian P. Gee1, Edwin M. Horwitz3,4
1Center for Cell and Gene Therapy, Baylor College of Medicine, Texas Children's Hospital and The Methodist Hospital, Houston, Texas, USA
2The Texas Heart Institute, St Luke's Episcopal Hospital, Houston, Texas, USA
3The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania USA
4The University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA

Tóm tắt

Từ khóa


Tài liệu tham khảo

Friedenstein, 1974, Precursors for fibroblasts in different populations of hematopoietic cells as detected by the in vitro colony assay method, Exp Hematol, 2, 83

Pittenger, 1999, Multilineage potential of adult human mesenchymal stem cells, Science, 284, 143, 10.1126/science.284.5411.143

Caplan, 1991, Mesenchymal stem cells, J Orthop Res, 9, 641, 10.1002/jor.1100090504

Fossett, 2012, Optimising human mesenchymal stem cell numbers for clinical application: a literature review, Stem Cells Int, 2012, 465259, 10.1155/2012/465259

D'Ippolito, 1999, Age-related osteogenic potential of mesenchymal stromal stem cells from human vertebral bone marrow, J Bone Miner Res, 14, 1115, 10.1359/jbmr.1999.14.7.1115

Malgieri, 2010, Bone marrow and umbilical cord blood human mesenchymal stem cells: state of the art, Int J Clin Exp Med, 3, 248

Campagnoli, 2001, Identification of mesenchymal stem/progenitor cells in human first-trimester fetal blood, liver, and bone marrow, Blood, 98, 2396, 10.1182/blood.V98.8.2396

Gotherstrom, 2003, Immunomodulatory effects of human foetal liver-derived mesenchymal stem cells, Bone Marrow Transplant, 32, 265, 10.1038/sj.bmt.1704111

Nauta, 2007, Immunomodulatory properties of mesenchymal stromal cells, Blood, 110, 3499, 10.1182/blood-2007-02-069716

Sensebe, 2011, Good manufacturing practices production of mesenchymal stem/stromal cells, Hum Gene Ther, 22, 19, 10.1089/hum.2010.197

Bieback, 2011, Translating research into clinical scale manufacturing of mesenchymal stromal cells, Stem Cells Int, 2010, 193519

Vidal, 2012, Evaluation of senescence in mesenchymal stem cells isolated from equine bone marrow, adipose tissue, and umbilical cord tissue, Stem Cells Dev, 21, 273, 10.1089/scd.2010.0589

Muller, 2006, Animal serum-free culture conditions for isolation and expansion of multipotent mesenchymal stromal cells from human BM, Cytotherapy, 8, 437, 10.1080/14653240600920782

Horwitz, 2002, Isolated allogeneic bone marrow-derived mesenchymal cells engraft and stimulate growth in children with osteogenesis imperfecta: implications for cell therapy of bone, Proc Natl Acad Sci U S A, 99, 8932, 10.1073/pnas.132252399

Horwitz, 1999, Transplantability and therapeutic effects of bone marrow-derived mesenchymal cells in children with osteogenesis imperfecta, Nat Med, 5, 309, 10.1038/6529

Krampera, 2003, Bone marrow mesenchymal stem cells inhibit the response of naive and memory antigen-specific T cells to their cognate peptide, Blood, 101, 3722, 10.1182/blood-2002-07-2104

Dominici, 2006, Minimal criteria for defining multipotent mesenchymal stromal cells: the International Society for Cellular Therapy position statement, Cytotherapy, 8, 315, 10.1080/14653240600855905

Pytlik, 2009, The cultivation of human multipotent mesenchymal stromal cells in clinical grade medium for bone tissue engineering, Biomaterials, 30, 3415, 10.1016/j.biomaterials.2009.03.001

Philippe, 2010, Culture and use of mesenchymal stromal cells in phase I and II clinical trials, Stem Cells Int, 2010, 503593, 10.4061/2010/503593

Abumaree, 2012, Immunosuppressive properties of mesenchymal stem cells, Stem Cell Rev, 8, 375, 10.1007/s12015-011-9312-0

Tu, 2010, Mesenchymal stem cells inhibit complement activation by secreting factor H, Stem Cells Dev, 19, 1803, 10.1089/scd.2009.0418

Newman, 2009, Treatment of inflammatory diseases with mesenchymal stem cells, Inflamm Allergy Drug Targets, 8, 110, 10.2174/187152809788462635

Tarte, 2010, Clinical-grade production of human mesenchymal stromal cells: occurrence of aneuploidy without transformation, Blood, 115, 1549, 10.1182/blood-2009-05-219907

Battula, 2009, Isolation of functionally distinct mesenchymal stem cell subsets using antibodies against CD56, CD271, and mesenchymal stem cell antigen-1, Haematologica, 94, 173, 10.3324/haematol.13740

Wagner, 2005, Toward closed-system culture of blood origin endothelial cells, Transfusion, 45, 1201, 10.1111/j.1537-2995.2005.00180.x

Kedong, 2010, Simultaneous expansion and harvest of hematopoietic stem cells and mesenchymal stem cells derived from umbilical cord blood, J Mater Sci Mater Med, 21, 3183, 10.1007/s10856-010-4167-5

Nguyen, 2008, Reproducible growth and expansion of bone marrow derived mesenchymal stem cells (MSC), using a novel, automated and closed cell expansion system (CES) [abstract], Cytotherapy, 10