Managing Delirium in the Emergency Department: An Updated Narrative Review

April Ehrlich1, Esther S. Oh1,2,3,4, Shaista Ahmed1
1Division of Geriatric Medicine and Gerontology, Department of Medicine, The Johns Hopkins University, 5200, Baltimore, USA
2Department of Psychiatry and Behavioral Sciences, The Johns Hopkins University, Baltimore, USA
3The Johns Hopkins University School of Nursing, Baltimore, USA
4Division of Neuropathology, Department of Pathology, The Johns Hopkins University, Baltimore, USA

Tóm tắt

Emergency departments (EDs) are facing an epidemic of overcrowding and ED boarding, particularly of older adults who often present with, or develop, delirium in the ED. Delirium is associated with increased complications, longer hospital length of stay, mortality, and costs to the healthcare system. However, we only have limited knowledge of how to successfully prevent and treat delirium in the ED in a pragmatic, sustainable, and cost-effective way. We present a narrative review of recent literature of delirium prevention and treatment programs in the ED. We aim to describe the components of successful delirium management strategies to be used by EDs in building delirium management programs. We reviewed 10 studies (2005-2023) that report delirium interventions in the ED, and describe the different components of these interventions that have been studied. These interventions included: optimizing hemodynamics and oxygenation, treating pain, hydration and nutrition support, avoiding sedative hypnotics, antipsychotics and anticholinergics, promoting sleep, sensory stimulation, limiting the time spent in the ED, educating providers and staff, and developing multidisciplinary delirium protocols integrated into the electronic health record. Through our narrative review of the recent literature on delirium prevention and treatment programs in the ED, we have identified nine components of successful delirium prevention strategies in the ED. We also discuss three high priority areas for further research including identification of most effective components of delirium prevention strategies, conduct of additional high-quality trials in non-hip

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Tài liệu tham khảo

Institute for Healthcare Improvement. Age-Friendly Health Systems. [Internet]. [cited 2024 March 5]. Available from https://www.ihi.org/initiatives/age-friendly-health-systems.

Hoogendijk EO, Afilalo J, Ensrud KE, Kowal P, Onder G, Fried LP. Frailty: Implications for clinical practice and public health. Lancet. 2019;394(10206):1365–75. https://doi.org/10.1016/S0140-6736(19)31786-6.

Nidadavolu LS, Ehrlich AL, Sieber FE, Oh ES. Preoperative evaluation of the frail patient. Anesth Analg. 2020;130(6):1493–503. https://doi.org/10.1213/ANE.0000000000004735.

Sieber F, Gearhart S, Bettick D, Wang N. Edmonton frailty scale score predicts postoperative delirium: A retrospective cohort analysis. BMC Geriatr. 2022;22(1):585–8. https://doi.org/10.1186/s12877-022-03252-8.

Muscedere J, Waters B, Varambally A, et al. The impact of frailty on intensive care unit outcomes: A systematic review and meta-analysis. Intensive Care Med. 2017;43(8):1105–22. https://doi.org/10.1007/s00134-017-4867-0.

Imam T, Konstant-Hambling R, Fluck R, Hall N, Palmer J, Conroy S. The hospital frailty risk score-outcomes in specialised services. Age Ageing. 2021;50(2):511–8. https://doi.org/10.1093/ageing/afaa156.

Oh ES, Fong TG, Hshieh TT, Inouye SK. Delirium in older persons: Advances in diagnosis and treatment. JAMA. 2017;318(12):1161–74. https://doi.org/10.1001/jama.2017.12067.

Carpenter CR, Hammouda N, Linton EA, et al. Delirium prevention, detection, and treatment in emergency medicine settings: A geriatric emergency care applied research (GEAR) network scoping review and consensus statement. Acad Emerg Med. 2021;28(1):19–35. https://doi.org/10.1111/acem.14166.

Kenny JF, Chang BC, Hemmert KC. Factors affecting emergency department crowding. Emerg Med Clin North Am. 2020;38(3):573–87. https://doi.org/10.1016/j.emc.2020.04.001.

Kelen GD, Wolfe R, Gail D’Onofrio, et al. Emergency department crowding: The canary in the health care system. Catalyst non-issue content. 2021;2(5). https://doi.org/10.1056/CAT.21.0217.

Ma IC, Chen KC, Chen WT, et al. Increased readmission risk and healthcare cost for delirium patients without immediate hospitalization in the emergency department. Clin Psychopharmacol Neurosci. 2018;16(4):398–406. https://doi.org/10.9758/cpn.2018.16.4.398.

Elder NM, Mumma BE, Maeda MY, Tancredi DJ, Tyler KR. Emergency department length of stay is associated with delirium in older adults. West J Emerg Med. 2023;24(3):532–7. https://doi.org/10.5811/westjem.59383.

Moura Junior V, Westover MB, Li F, et al. Hospital complications among older adults: Better processes could reduce the risk of delirium. Health Serv Manage Res. 2022;35(3):154–63. https://doi.org/10.1177/09514848211028707.

Ehrlich A, Erickson M, Oh E, James T, Saxena S. Prioritizing care of older adults in times of emergency department overcrowding. JGEM. 2023;4(3):1–6. https://institutionalrepository.aah.org/cgi/viewcontent.cgi?article=1067&context=jgem. https://doi.org/10.17294/2694-4715.1067.

•• Lee S, Chen H, Hibino S, et al. Can we improve delirium prevention and treatment in the emergency department? A systematic review. J Am Geriatr Soc. 2022;70(6):1838–49. https://doi.org/10.1111/jgs.17740. Initial systematic review of delirium management in the emergency department.

Al-Aama T, Brymer C, Gutmanis I, Woolmore-Goodwin SM, Esbaugh J, Dasgupta M. Melatonin decreases delirium in elderly patients: A randomized, placebo-controlled trial. Int J Geriatr Psychiatry. 2011;26(7):687–94. https://doi.org/10.1002/gps.2582.

Bjorkelund KB, Hommel A, Thorngren K, Gustafson L, Larsson S, Lundberg D. Reducing delirium in elderly patients with hip fracture: A multi-factorial intervention study. Acta Anaesthesiol Scand. 2010;54(6):678–88. https://doi.org/10.1111/j.1399-6576.2010.02232.x.

Naughton BJ, Saltzman S, Ramadan F, Chadha N, Priore R, Mylotte JM. A multifactorial intervention to reduce prevalence of delirium and shorten hospital length of stay. J Am Geriatr Soc. 2005;53(1):18–23. https://doi.org/10.1111/j.1532-5415.2005.53005.x.

• Filiatreault S, Grimshaw JM, Kreindler SA, et al. A critical appraisal and recommendation synthesis of delirium clinical practice guidelines relevant to the care of older adults in the emergency department: An umbrella review. J Eval Clin Pract. 2023;29(6):1039–53. https://doi.org/10.1111/jep.13883. Outlines and discusses current delirium clinical practice guidelines that may be relevant to the emergency department setting.

Keene S, Balasundaram A, Cameron-Comasco L, Otero R. Feasibility of light and music therapy in the elderly for the prevention of hospital-associated delirium. R I Med J (2013). 2023;106(4):35–9.

Park C, Bharija A, Mesias M, et al. Association between implementation of a geriatric trauma clinical pathway and changes in rates of delirium in older adults with traumatic injury. JAMA Surg. 2022;157(8):676–83. https://doi.org/10.1001/jamasurg.2022.1556.

Maher S, Moore Z, Avsar P, Patton D. What is the impact of a fast-track pathway on length of stay for adult patients with a hip fracture? A systematic review. Arch Orthop Trauma Surg. 2022;142(12):3803–16. https://doi.org/10.1007/s00402-021-04248-6.

Makkar JK, Singh NP, Bhatia N, Samra T, Singh PM. Fascia iliaca block for hip fractures in the emergency department: Meta-analysis with trial sequential analysis. Am J Emerg Med. 2021;50:654–60. https://doi.org/10.1016/j.ajem.2021.09.038.

Simic A, Nesek Adam V, Rosic D, et al. Peripheral nerve blocks for hip fractures in emergency medicine. Acta Clin Croat. 2022;61(Suppl 1):78–83. https://doi.org/10.20471/acc.2022.61.s1.13.

Larsson G, Holgers K. Fast-track care for patients with suspected hip fracture. Injury. 2011;42(11):1257–61. https://doi.org/10.1016/j.injury.2011.01.001.

Hao J, Dong B, Zhang J, Luo Z. Pre-emptive analgesia with continuous fascia iliaca compartment block reduces postoperative delirium in elderly patients with hip fracture. A randomized controlled trial. Saudi Med J. 2019;40(9):901–6. https://doi.org/10.15537/smj.2019.9.24483.

Monzon D, Iserson K, Vasquez J. Single fascia iliaca compartment block for post-hip fracture pain relief. J Emerg Med. 2007;32(3):257–62.

• Kim C, Yang JY, Min CH, Shon H, Kim JW, Lim EJ. The effect of regional nerve block on perioperative delirium in hip fracture surgery for the elderly: A systematic review and meta-analysis of randomized controlled trials. Orthop Traumatol Surg Res. 2022;108(1):103151. https://doi.org/10.1016/j.otsr.2021.103151. Meta-analysis of delirium incidence following regional nerve blocks for hip fracture pain.

Schrijver EJM, de Vries OJ, van de Ven PM, et al. Haloperidol versus placebo for delirium prevention in acutely hospitalised older at-risk patients: A multi-centre double-blind randomised controlled clinical trial. Age Ageing. 2018;47(1):48–55. https://doi.org/10.1093/ageing/afx124.

Hshieh TT, Inouye SK, Oh ES. Delirium in the elderly. Psychiatr Clin North Am. 2018;41(1):1–17. https://doi.org/10.1016/j.psc.2017.10.001.

Burton JK, Craig L, Yong SQ, et al. Non-pharmacological interventions for preventing delirium in hospitalised non-ICU patients. Cochrane Database Syst Rev. 2021;11(11):CD013307. https://doi.org/10.1002/14651858.CD013307.pub3.

•• Oliveira JE, Silva L, Berning MJ, Stanich JA, et al. Risk factors for delirium in older adults in the emergency department: A systematic review and meta-analysis. Ann Emerg Med. 2021;78(4):549–65. https://doi.org/10.1016/j.annemergmed.2021.03.005. Outlines risk factors for incident delirium in the emergency department which may benefit from targeted interventions.

American Geriatrics Society Beers Criteria(R) Update Expert Panel. American geriatrics society 2023 updated AGS beers criteria(R) for potentially inappropriate medication use in older adults. J Am Geriatr Soc. 2023;71(7):2052–81.

Inouye SK, Bogardus STJ, Charpentier PA, et al. A multicomponent intervention to prevent delirium in hospitalized older patients. N Engl J Med. 1999;340(9):669–76. https://doi.org/10.1056/NEJM199903043400901.

Dent E, Wright ORL, Woo J, Hoogendijk EO. Malnutrition in older adults. Lancet. 2023;401(10380):951–66. https://doi.org/10.1016/S0140-6736(22)02612-5.

Burry L, Mehta S, Perreault MM, et al. Antipsychotics for treatment of delirium in hospitalised non-ICU patients. Cochrane Database Syst Rev. 2018;6(6):CD005594. https://doi.org/10.1002/14651858.CD005594.pub3.

Nikooie R, Neufeld KJ, Oh ES, et al. Antipsychotics for treating delirium in hospitalized adults: A systematic review. Ann Intern Med. 2019;171(7):485–95. https://doi.org/10.7326/M19-1860.

American Geriatrics Society Expert panel on postoperative delirium in older adults. American geriatrics society abstracted clinical practice guideline for postoperative delirium in older adults. J Am Geriatr Soc. 2015;63(1):142–50. https://doi.org/10.1111/jgs.13281.

Oh ES, Leoutsakos J, Rosenberg PB, et al. Effects of ramelteon on the prevention of postoperative delirium in older patients undergoing orthopedic surgery: The RECOVER randomized controlled trial. Am J Geriatr Psychiatry. 2021;29(1):90–100. https://doi.org/10.1016/j.jagp.2020.05.006.

Khaing K, Nair BR. Melatonin for delirium prevention in hospitalized patients: A systematic review and meta-analysis. J Psychiatr Res. 2021;133:181–90. https://doi.org/10.1016/j.jpsychires.2020.12.020.

•• Ottens T, Hermes C, Page V, et al. The delphi delirium management algorithms. A practical tool for clinicians, the result of a modified delphi expert consensus approach. Delirium. 2024. https://deliriumjournal.com/article/90652-the-delphi-delirium-management-algorithms-a-practical-tool-for-clinicians-the-result-of-a-modified-delphi-expert-consensus-approach. https://doi.org/10.56392/001c.90652. Discusses expert consensus for how to manage delirium including useful mnemonics for diagnosing the underlying cause of delirium.

Martin L, Lyons M, Patton A, et al. Implementing delirium screening in the emergency department: A quality improvement project. BMJ Open Qual. 2022;11(2):e001676. https://doi.org/10.1136/bmjoq-2021-001676.