Management von entzündlich rheumatischen Erkrankungen während und nach Malignomen
Tóm tắt
Das Management von entzündlich rheumatischen Erkrankungen bei gleichzeitiger oder stattgehabter maligner Erkrankung ist mit komplexen Fragestellungen verbunden. Schwierigkeiten und Lösungsmöglichkeiten bei der Interpretation aussagekräftiger Studien werden dargestellt. Empfehlungen in Leitlinien zu diesem Thema werden diskutiert. Nationale Register und Versicherungsdatenbanken wurden mit der Frage nach Tumorrezidivrisiko unter Basistherapeutika untersucht; diese Analysen beziehen sich aber v. a. auf TNF(Tumornekrosefaktor)-Inhibitoren und Rituximab. Zu den gängigen Substanzen der Basistherapie werden Daten zur Tumorinzidenz und – wenn vorhanden – zum Tumorrezidivrisiko zusammengefasst. Abschließend wird der Versuch unternommen, Vorschläge zur rheumatologischen Therapie bei Malignomanamnese zu formulieren.
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