Management of the patient with incomplete response to PPI therapy

Best Practice & Research Clinical Gastroenterology - Tập 27 - Trang 401-414 - 2013
Peter J. Kahrilas1, Guy Boeckxstaens2, Andre J.P.M. Smout3
1Division of Gastroenterology and Hepatology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA
2Department of Gastroenterology, Translational Research Center for Gastrointestinal Disorders (TARGID), University Hospital Leuven, Catholic University Leuven, Leuven, Belgium
3Department of Gastroenterology and Hepatology, Academic Medical Centre, Amsterdam, The Netherlands

Tài liệu tham khảo

Kahrilas, 2008, AGAI medical position statement: management of gastroesophageal reflux disease, Gastroenterology, 135, 1383, 10.1053/j.gastro.2008.08.045 Numans, 2004, Short-term treatment with proton-pump inhibitors as a test for gastroesophageal reflux disease: a meta-analysis of diagnostic test characteristics, Ann Intern Med, 140, 518, 10.7326/0003-4819-140-7-200404060-00011 Kahrilas, 1997, Treatment vs management of gastroesophageal reflux disease, Am J Gastroenterol, 92, 1959 Vakil, 2006, The Montreal definition and classification of gastro-esophageal reflux disease (GERD) – a global evidence-based consensus, Am J Gastroenterol, 101, 1900, 10.1111/j.1572-0241.2006.00630.x Sandler, 2002, The burden of selected digestive diseases in the United States, Gastroenterology, 122, 1500, 10.1053/gast.2002.32978 Inadomi, 2003, Step-down from multiple- to single-dose proton pump inhibitors (PPIs): a prospective study of patients with heartburn or acid regurgitation completely relieved with PPIs, Am J Gastroenterol, 98, 1940, 10.1111/j.1572-0241.2003.07665.x Dean, 2004, Effectiveness of proton pump inhibitors in nonerosive reflux disease, Clin Gastroenterol Hepatol, 2, 656, 10.1016/S1542-3565(04)00288-5 Kahrilas, 2012, Failure of reflux inhibitors in clinical trials: bad drugs or wrong patients?, Gut, 61, 1501, 10.1136/gutjnl-2011-301898 Jones, 2001, Hiatal hernia size is the dominant determinant of esophagitis presence and severity in gastroesophageal reflux disease, Am J Gastroenterol, 96, 1711, 10.1111/j.1572-0241.2001.03926.x Lin, 1994, Impaired esophageal emptying in reflux disease, Am J Gastroenterol, 89, 1003 Gillen, 1987, Barrett's oesophagus: pH profile, Br J Surg, 74, 774, 10.1002/bjs.1800740906 Singh, 1992, Oesophageal motor function before and after healing of oesophagitis, Gut, 33, 1590, 10.1136/gut.33.12.1590 Mittal, 1987, Identification and mechanism of delayed esophageal acid clearance in subjects with hiatus hernia, Gastroenterology, 92, 130, 10.1016/0016-5085(87)90849-3 Sloan, 1991, Impairment of esophageal emptying with hiatal hernia, Gastroenterology, 100, 596, 10.1016/0016-5085(91)80003-R Smith, 2010, Acoustic cough-reflux associations in chronic cough: potential triggers and mechanisms, Gastroenterology, 139, 754, 10.1053/j.gastro.2010.06.050 Clouse, 2005, Use of psychopharmacological agents for functional gastrointestinal disorders, Gut, 54, 1332, 10.1136/gut.2004.048884 Vaezi, 2006, Treatment of chronic posterior laryngitis with esomeprazole, Laryngoscope, 116, 254, 10.1097/01.mlg.0000192173.00498.ba Kahrilas, 2011, Response of regurgitation to proton pump inhibitor therapy in clinical trials of gastroesophageal reflux disease, Am J Gastroenterol, 106, 1419, 10.1038/ajg.2011.146 Kahrilas, 2012, Regurgitation is less responsive to acid suppression than heartburn in patients with gastroesophageal reflux disease, Clin Gastroenterol Hepatol, 10, 612, 10.1016/j.cgh.2012.01.022 Kahrilas, 2011, Response of unexplained chest pain to proton pump inhibitor treatment in patients with and without objective evidence of gastro-oesophageal reflux disease, Gut, 60, 1473, 10.1136/gut.2011.241307 Chang, 2011, Cochrane Database Syst Rev, CD004823 Kahrilas, 2013, Response of chronic cough to acid-suppressive therapy in patients with gastroesophageal reflux disease, Chest, 143, 605, 10.1378/chest.12-1788 Dickman, 2011, Comparison of clinical characteristics of patients with gastroesophageal reflux disease who failed proton pump inhibitor therapy versus those who fully responded, J Neurogastroenterol Motil, 17, 387, 10.5056/jnm.2011.17.4.387 Bytzer, 2012, Partial symptom-response to proton pump inhibitors in patients with non-erosive reflux disease or reflux oesophagitis – a post hoc analysis of 5796 patients, Aliment Pharmacol Ther, 36, 635, 10.1111/apt.12007 Aanen, 2006, Diagnostic value of the Reflux Disease Questionnaire in general practice, Digestion, 74, 162, 10.1159/000100511 Miyamoto, 2010, Efficacy of the addition of prokinetics for proton pump inhibitor (PPI) resistant non-erosive reflux disease (NERD) patients: significance of frequency scale for the symptom of GERD (FSSG) on decision of treatment strategy, Intern Med, 49, 1469, 10.2169/internalmedicine.49.3615 Kahrilas, 2012, Concomitant symptoms itemized in the Reflux Disease Questionnaire are associated with attenuated heartburn response to acid suppression, Am J Gastroenterol, 107, 1354, 10.1038/ajg.2012.197 Lichtenstein, 2007, Role of endoscopy in the management of GERD, Gastrointest Endosc, 66, 219, 10.1016/j.gie.2007.05.027 Poh, 2010, Upper GI tract findings in patients with heartburn in whom proton pump inhibitor treatment failed versus those not receiving antireflux treatment, Gastrointest Endosc, 71, 28, 10.1016/j.gie.2009.08.024 Shaheen, 2013, Esophageal mucosal breaks in gastroesophageal reflux disease partially responsive to proton pump inhibitor therapy, Am J Gastroenterol, 108, 529, 10.1038/ajg.2012.447 Ismail-Beigi, 1970, Histological consequences of gastroesophageal reflux in man, Gastroenterology, 58, 163, 10.1016/S0016-5085(70)80004-X Tobey, 1996, Dilated intercellular spaces: a morphological feature of acid reflux – damaged human esophageal epithelium, Gastroenterology, 111, 1200, 10.1053/gast.1996.v111.pm8898633 Vela, 2011, Refractory heartburn: comparison of intercellular space diameter in documented GERD vs. functional heartburn, Am J Gastroenterol, 106, 844, 10.1038/ajg.2010.476 Pandolfino, 2005, Comparison of the Bravo wireless and Digitrapper catheter-based pH monitoring systems for measuring esophageal acid exposure, Am J Gastroenterol, 100, 1466, 10.1111/j.1572-0241.2005.41719.x Hakanson, 2009, Comparison of wireless 48-h (Bravo) versus traditional ambulatory 24-h esophageal pH monitoring, Scand J Gastroenterol, 44, 276, 10.1080/00365520802588109 Wiener, 1988, The symptom index: a clinically important parameter of ambulatory 24-hour esophageal pH monitoring, Am J Gastroenterol, 83, 358 Weusten, 1994, The symptom-association probability: an improved method for symptom analysis of 24-hour esophageal pH data, Gastroenterology, 107, 1741, 10.1016/0016-5085(94)90815-X Galmiche, 2006, Functional esophageal disorders, Gastroenterology, 130, 1459, 10.1053/j.gastro.2005.08.060 Sifrim, 2001, Acid, nonacid, and gas reflux in patients with gastroesophageal reflux disease during ambulatory 24-hour pH-impedance recordings, Gastroenterology, 120, 1588, 10.1053/gast.2001.24841 Bredenoord, 2005, Determinants of perception of heartburn and regurgitation, Gut, 55, 313, 10.1136/gut.2005.074690 Hemmink, 2008, Esophageal pH-impedance monitoring in patients with therapy-resistant reflux symptoms: ‘on’ or ‘off’ proton pump inhibitor?, Am J Gastroenterol, 103, 2446, 10.1111/j.1572-0241.2008.02033.x Kessing, 2011, Erroneous diagnosis of gastroesophageal reflux disease in achalasia, Clin Gastroenterol Hepatol, 9, 1020, 10.1016/j.cgh.2011.04.022 Ponce, 2011, High prevalence of heartburn and low acid sensitivity in patients with idiopathic achalasia, Dig Dis Sci, 56, 773, 10.1007/s10620-010-1343-x Bredenoord, 2007, Technology review: esophageal impedance monitoring, Am J Gastroenterol, 102, 187, 10.1111/j.1572-0241.2006.00966.x Hatlebakk, 2000, Proton pump inhibitors: better acid suppression when taken before a meal than without a meal, Aliment Pharmacol Ther, 14, 1267, 10.1046/j.1365-2036.2000.00829.x Gunaratnam, 2006, Sub-optimal proton pump inhibitor dosing is prevalent in patients with poorly controlled gastro-oesophageal reflux disease, Aliment Pharmacol Ther, 23, 1473, 10.1111/j.1365-2036.2006.02911.x Orlando, 2010, Relationship between esomeprazole dose and timing to heartburn resolution in selected patients with gastroesophageal reflux disease, Clin Exp Gastroenterol, 3, 117, 10.2147/CEG.S12333 Fass, 2006, Treatment of patients with persistent heartburn symptoms: a double-blind, randomized trial, Clin Gastroenterol Hepatol, 4, 50, 10.1016/S1542-3565(05)00860-8 Dent, 2008, A randomized, comparative trial of a potassium-competitive acid blocker (AZD0865) and esomeprazole for the treatment of patients with nonerosive reflux disease, Am J Gastroenterol, 103, 20, 10.1111/j.1572-0241.2007.01544.x Kahrilas, 2007, A randomized, comparative study of three doses of AZD0865 and esomeprazole for healing of reflux esophagitis, Clin Gastroenterol Hepatol, 5, 1385, 10.1016/j.cgh.2007.08.014 Leite, 1996, Persistent acid secretion during omeprazole therapy: a study of gastric acid profiles in patients demonstrating failure of omeprazole therapy, Am J Gastroenterol, 91, 1527 Mainie, 2008, Addition of a H2 receptor antagonist to PPI improves acid control and decreases nocturnal acid breakthrough, J Clin Gastroenterol, 42, 676, 10.1097/MCG.0b013e31814a4e5c Fackler, 2002, Long-term effect of H2RA therapy on nocturnal gastric acid breakthrough, Gastroenterology, 122, 625, 10.1053/gast.2002.31876 Vigneri, 1995, A comparison of five maintenance therapies for reflux esophagitis, N Engl J Med, 333, 1106, 10.1056/NEJM199510263331703 Miwa, 2011, Randomised clinical trial: efficacy of the addition of a prokinetic, mosapride citrate, to omeprazole in the treatment of patients with non-erosive reflux disease – a double-blind, placebo-controlled study, Aliment Pharmacol Ther, 33, 323, 10.1111/j.1365-2036.2010.04517.x Fletcher, 2001, Unbuffered highly acidic gastric juice exists at the gastroesophageal junction after a meal, Gastroenterology, 121, 775, 10.1053/gast.2001.27997 Beaumont, 2010, The position of the acid pocket as a major risk factor for acidic reflux in healthy subjects and patients with GORD, Gut, 59, 441, 10.1136/gut.2009.178061 Rohof, 2012, Effect of azithromycin on acid reflux, hiatus hernia and proximal acid pocket in the postprandial period, Gut, 61, 1670, 10.1136/gutjnl-2011-300926 Kahrilas, 2013, The acid pocket: a target for treatment in reflux disease?, Am J Gastroenterol, 10.1038/ajg.2013.132 Savarino, 2012, Alginate controls heartburn in patients with erosive and nonerosive reflux disease, World J Gastroenterol, 18, 4371, 10.3748/wjg.v18.i32.4371 Rohof, 2013, An alginate-antacid formulation localizes to the acid pocket to reduce acid reflux in patients with gastroesophageal reflux disease, Clin Gastroenterol Hepatol, 10.1016/j.cgh.2013.04.046 Manabe, 2012, Efficacy of adding sodium alginate to omeprazole in patients with nonerosive reflux disease: a randomized clinical trial, Dis Esophagus, 25, 373, 10.1111/j.1442-2050.2011.01276.x Chey, 2009, Treatment patterns and symptom control in patients with GERD: US community-based survey, Curr Med Res Opin, 25, 1869, 10.1185/03007990903035745 Vela, 2003, Baclofen decreases acid and non-acid post-prandial gastro-oesophageal reflux measured by combined multichannel intraluminal impedance and pH, Aliment Pharmacol Ther, 17, 243, 10.1046/j.1365-2036.2003.01394.x Boeckxstaens, 2010, Systematic review: role of acid, weakly acidic and weakly alkaline reflux in gastro-oesophageal reflux disease, Aliment Pharmacol Ther, 32, 334, 10.1111/j.1365-2036.2010.04358.x Boeckxstaens, 2011, A novel reflux inhibitor lesogaberan (AZD3355) as add-on treatment in patients with GORD with persistent reflux symptoms despite proton pump inhibitor therapy: a randomised placebo-controlled trial, Gut, 60, 1182, 10.1136/gut.2010.235630 Shaheen, 2012, Efficacy and safety of lesogaberan in gastro-oesophageal reflux disease: a randomised controlled trial, Gut Koek, 2003, Effect of the GABA(B) agonist baclofen in patients with symptoms and duodeno-gastro-oesophageal reflux refractory to proton pump inhibitors, Gut, 52, 1397, 10.1136/gut.52.10.1397 Prakash, 1999, Long-term outcome from tricyclic antidepressant treatment of functional chest pain, Dig Dis Sci, 44, 2373, 10.1023/A:1026645914933 Clouse, 1987, Low-dose trazodone for symptomatic patients with esophageal contraction abnormalities. A double-blind, placebo-controlled trial, Gastroenterology, 92, 1027, 10.1016/0016-5085(87)90979-6 Broekaert, 2006, Influence of citalopram, a selective serotonin reuptake inhibitor, on oesophageal hypersensitivity: a double-blind, placebo-controlled study, Aliment Pharmacol Ther, 23, 365, 10.1111/j.1365-2036.2006.02772.x Dickman, 2007, Clinical trial: acupuncture vs. doubling the proton pump inhibitor dose in refractory heartburn, Aliment Pharmacol Ther, 26, 1333, 10.1111/j.1365-2036.2007.03520.x Nojkov, 2008, The influence of co-morbid IBS and psychological distress on outcomes and quality of life following PPI therapy in patients with gastro-oesophageal reflux disease, Aliment Pharmacol Ther, 27, 473, 10.1111/j.1365-2036.2008.03596.x Kiebles, 2010, Do patients with globus sensation respond to hypnotically assisted relaxation therapy? A case series report, Dis Esophagus, 23, 545, 10.1111/j.1442-2050.2010.01064.x Lundell, 2008, Comparing laparoscopic antireflux surgery with esomeprazole in the management of patients with chronic gastro-oesophageal reflux disease: a 3-year interim analysis of the LOTUS trial, Gut, 57, 1207, 10.1136/gut.2008.148833 Galmiche, 2011, Laparoscopic antireflux surgery vs esomeprazole treatment for chronic GERD. The LOTUS randomized clinical trial, J Am Med Assoc, 305, 1969, 10.1001/jama.2011.626 Vakil, 2003, Clinical effectiveness of laparoscopic fundoplication in a U.S. community, Am J Med, 114, 1, 10.1016/S0002-9343(02)01390-6 Hunter, 1999, Laparoscopic fundoplication failures: patterns of failure and response to fundoplication revision, Ann Surg, 230, 595, 10.1097/00000658-199910000-00015