Management of severe perioperative bleeding

De Robertis, 2016, To streamline the guideline challenge: The European Society of Anaesthesiology policy on guidelines development, Eur J Anaesthesiol, 33, 794, 10.1097/EJA.0000000000000523

Kozek-Langenecker, 2013, Management of severe perioperative bleeding: guidelines from the European Society of Anaesthesiology, Eur J Anaesthesiol, 30, 270, 10.1097/EJA.0b013e32835f4d5b

Farmer, 2013, Drivers for change: Western Australia Patient Blood Management Program (WA PBMP), World Health Assembly (WHA) and Advisory Committee on Blood Safety and Availability (ACBSA), Best Pract Res Clin Anaesthesiol, 27, 43, 10.1016/j.bpa.2012.12.007

Musallam, 2011, Preoperative anaemia and postoperative outcomes in noncardiac surgery: a retrospective cohort study, Lancet, 378, 1396, 10.1016/S0140-6736(11)61381-0

Koch, 2013, Hospital-acquired anemia: prevalence, outcomes, and healthcare implications, J Hosp Med, 8, 506, 10.1002/jhm.2061

Marik, 2008, Efficacy of red blood cell transfusion in the critically ill: a systematic review of the literature, Crit Care Med, 36, 2667, 10.1097/CCM.0b013e3181844677

Shander, 2009, Why an alternative to blood transfusion?, Crit Care Clin, 25, 261, 10.1016/j.ccc.2008.12.012

Vamvakas, 2009, Transfusion-related mortality: the ongoing risks of allogeneic blood transfusion and the available strategies for their prevention, Blood, 113, 3406, 10.1182/blood-2008-10-167643

Clauss, 1957, Rapid physiological coagulation method in determination of fibrinogen, Acta Haematol, 17, 237, 10.1159/000205234

Solomon, 2014, Fibrinogen measurement in cardiac surgery with cardiopulmonary bypass: analysis of repeatability and agreement of Clauss method within and between six different laboratories, Thromb Haemost, 112, 109, 10.1160/TH13-12-0997

Gielen, 2014, The effects of pre and postoperative fibrinogen levels on blood loss after cardiac surgery: a systematic review and meta-analysis, Interact Cardiovasc Thorac Surg, 18, 292, 10.1093/icvts/ivt506

Whiting, 2015, Viscoelastic point-of-care testing to assist with the diagnosis, management and monitoring of haemostasis: a systematic review and cost-effectiveness analysis, Health Technol Assess, 19, 1, 10.3310/hta19580

Erdoes, 2015, Prediction of postweaning fibrinogen status during cardiopulmonary bypass: an observational study in 110 patients, PLoS ONE, 10, e0126692, 10.1371/journal.pone.0126692

Theusinger, 2013, The influence of laboratory coagulation tests and clotting factor levels on Rotation Thromboelastometry (ROTEM(R)) during major surgery with hemorrhage, Anesth Analg, 117, 314, 10.1213/ANE.0b013e31829569ac

Lind, 2014, Comparison of the aPTT with alternative tests for monitoring direct thrombin inhibitors in patient samples, Am J Clin Pathol, 141, 665, 10.1309/AJCPGTCEX7K4GXQO

Kim, 2013, Comparison of prolonged prothrombin and activated partial thromboplastin time results with thrombelastograph parameters, Lab Med, 44, 319, 10.1309/LM2KBXKISKD9B1EA

Ågren, 2013, Thromboelastography (TEG®) compared to conventional coagulation tests in surgical patients – a laboratory evaluation, Scand J Clin Lab Invest, 73, 214, 10.3109/00365513.2013.765960

Acedillo, 2013, The risk of perioperative bleeding in patients with chronic kidney disease: a systematic review and meta-analysis, Ann Surg, 258, 901, 10.1097/SLA.0000000000000244

Lopes, 2015, Excessive bleeding predictors after cardiac surgery in adults: integrative review, J Clin Nurs, 24, 3046, 10.1111/jocn.12936

Levy, 2014, Clinical use of the activated partial thromboplastin time and prothrombin time for screening: a review of the literature and current guidelines for testing, Clin Lab Med, 34, 453, 10.1016/j.cll.2014.06.005

Dutzmann, 2012, On the value of routine prothrombin time screening in elective neurosurgical procedures, Neurosurg Focus, 33, E9, 10.3171/2012.7.FOCUS12219

Townsend, 2012, Usefulness of international normalized ratio to predict bleeding complications in patients with end-stage liver disease who undergo cardiac catheterisation, Am J Cardiol, 110, 1062, 10.1016/j.amjcard.2012.05.043

Huang, 2013, Predictive factors for pediatric patients requiring massive blood transfusion during living donor liver transplantation, Ann Transplant, 18, 443, 10.12659/AOT.889293

Cywinski, 2014, Prediction of intraoperative transfusion requirements during orthotopic liver transplantation and the influence on postoperative patient survival, Anesth Analg, 118, 428, 10.1213/ANE.0b013e3182a76f19

Mitra, 2012, Prospective comparison of point-of-care international normalised ratio measurement versus plasma international normalised ratio for acute traumatic coagulopathy, Emerg Med Australas, 24, 363, 10.1111/j.1742-6723.2012.01556.x

Gozal, 2014, Point-of-care testing in the acute management of mild traumatic brain injury: Identifying the coagulopathic patient, Neurocrit Care, 21, S141

Reinhofer, 2008, The value of rotation thromboelastometry to monitor disturbed perioperative haemostasis and bleeding risk in patients with cardiopulmonary bypass, Blood Coagul Fibrinolysis, 19, 212, 10.1097/MBC.0b013e3282f3f9d4

Haas, 2013, Correlation of activated clotting times and standard laboratory coagulation tests in paediatric noncardiac surgery, Scand J Clin Lab Invest, 73, 29, 10.3109/00365513.2012.732239

Wikkelsoe, 2011, Monitoring patients at risk of massive transfusion with thrombelastography or thromboelastometry: a systematic review, Acta Anaesthesiol Scand, 55, 1174, 10.1111/j.1399-6576.2011.02534.x

Harvey, 2014, Thromboelastography reveals abnormalities not detected by standard coagulation studies after pediatric traumatic brain injury, Pediatr Crit Care Med, 15, 75, 10.1097/01.pcc.0000449049.67825.27

Theusinger, 2015, Changes in coagulation in standard laboratory tests and ROTEM in trauma patients between on-scene and arrival in the emergency department, Anesth Analg, 120, 627, 10.1213/ANE.0000000000000561

Schaden, 2012, Perioperative treatment algorithm for bleeding burn patients reduces allogeneic blood product requirements, Br J Anaesth, 109, 376, 10.1093/bja/aes186

Hunt, 2015, Thromboelastography (TEG) and rotational thromboelastometry (ROTEM) for trauma induced coagulopathy in adult trauma patients with bleeding., Cochrane Database Syst Rev, 2, CD010438

Quinn, 2010, Short course preoperative ferrous sulphate supplementation – is it worthwhile in patients with colorectal cancer?, Ann R Coll Surg Engl, 92, 569, 10.1308/003588410X12699663904277

De Candia, 2014, Viscoelastic versus standard coagulation tests in the management of acute trauma, Thromb Res, 134, S70

Ak, 2009, Thromboelastography-based transfusion algorithm reduces blood product use after elective CABG: a prospective randomized study, J Card Surg, 24, 404, 10.1111/j.1540-8191.2009.00840.x

Avidan, 2004, Comparison of structured use of routine laboratory tests or near-patient assessment with clinical judgement in the management of bleeding after cardiac surgery, Br J Anaesth, 92, 178, 10.1093/bja/aeh037

Cui, 2010, Perioperative monitoring of thromboelastograph on blood protection and recovery for severely cyanotic patients undergoing complex cardiac surgery, Artif Organs, 34, 955, 10.1111/j.1525-1594.2010.01148.x

Girdauskas, 2010, Thromboelastometrically guided transfusion protocol during aortic surgery with circulatory arrest: a prospective, randomized trial, J Thorac Cardiovasc Surg, 140, 1117.e2, 10.1016/j.jtcvs.2010.04.043

Kultufan Turan, 2006, The role of rotational thromboelastgraphy on decision of blood transfusion in open heart surgery, GKD Anest Yog Bak Dern Derg, 12, 154

Nakayama, 2015, Thromboelastometry-guided intraoperative haemostatic management reduces bleeding and red cell transfusion after paediatric cardiac surgery, Br J Anaesth, 114, 91, 10.1093/bja/aeu339

Nuttall, 2001, Efficacy of a simple intraoperative transfusion algorithm for nonerythrocyte component utilization after cardiopulmonary bypass, Anesthesiology, 94, 773, 10.1097/00000542-200105000-00014

Royston, 2001, Reduced haemostatic factor transfusion using heparinase-modified thrombelastography during cardiopulmonary bypass, Br J Anaesth, 86, 575, 10.1093/bja/86.4.575

Shore-Lesserson, 1999, Thromboelastography-guided transfusion algorithm reduces transfusions in complex cardiac surgery, Anesth Analg, 88, 312, 10.1213/00000539-199902000-00016

Weber, 2012, Point-of-care testing: a prospective, randomized clinical trial of efficacy in coagulopathic cardiac surgery patients, Anesthesiology, 117, 531, 10.1097/ALN.0b013e318264c644

Westbrook, 2009, Protocol based on thromboelastograph (TEG) out-performs physician preference using laboratory coagulation tests to guide blood replacement during and after cardiac surgery: a pilot study, Heart Lung Circ, 18, 277, 10.1016/j.hlc.2008.08.016

Afshari, 2011, Thrombelastography, (TEG) or thromboelastometry (ROTEM) to monitor haemotherapy versus usual care in patients with massive transfusion., Cochrane Database Syst Rev, 3, CD007871

Bolliger, 2013, Roles of thrombelastography and thromboelastometry for patient blood management in cardiac surgery, Transfus Med Rev, 27, 213, 10.1016/j.tmrv.2013.08.004

Chowdhury, 2014, Thromboelastograph with Platelet Mapping(TM) predicts postoperative chest tube drainage in patients undergoing coronary artery bypass grafting, J Cardiothorac Vasc Anesth, 28, 217, 10.1053/j.jvca.2013.12.010

Yang, 2013, Postoperative fibrinogen level is associated with postoperative bleeding following cardiothoracic surgery and the effect of fibrinogen replacement therapy remains uncertain, J Thromb Haemost, 11, 1519, 10.1111/jth.12304

Faraoni, 2014, Plasma fibrinogen concentration is correlated with postoperative blood loss in children undergoing cardiac surgery. A retrospective review, Eur J Anaesthesiol, 31, 317, 10.1097/EJA.0000000000000043

Pekelharing, 2014, Comparison between thromboelastography and conventional coagulation tests after cardiopulmonary bypass surgery in the paediatric intensive care unit, Int J Lab Hematol, 36, 465, 10.1111/ijlh.12171

Sharma, 2014, Does incorporation of thromboelastography improve bleeding prediction following adult cardiac surgery?, Blood Coagul Fibrinolysis, 25, 561, 10.1097/MBC.0000000000000095

Allingstrup, 2016, Antithrombin III for critically ill patients: a systematic review with meta-analysis and trial sequential analysis, Intensive Care Med, 42, 505, 10.1007/s00134-016-4225-7

Allingstrup, 2016, Antithrombin III for critically ill patients., Cochrane Database Syst Rev, 2, CD005370

Beattie, 2014, Is there evidence that fresh frozen plasma is superior to antithrombin administration to treat heparin resistance in cardiac surgery?, Interact Cardiovasc Thorac Surg, 18, 117, 10.1093/icvts/ivt327

Quintero, 2014, Low plasma levels of antithrombin III in the early postoperative period following pediatric liver transplantation: should they be replaced? A single-center pilot study, Pediatr Transplant, 18, 185, 10.1111/petr.12217

Vinholt, 2014, An overview of platelet indices and methods for evaluating platelet function in thrombocytopenic patients, Eur J Haematol, 92, 367, 10.1111/ejh.12262

Brophy, 2014, Multimodality monitoring of platelet function in traumatic brain injury patients with trauma induced coagulopathy, J Neurotrauma, 31, 19

Gurbel, 2012, The association of preoperative platelet function testing and bleeding patients undergoing elective coronary artery bypass grafting, J Am Coll Cardiol, 59, E1455, 10.1016/S0735-1097(12)61456-9

Orlov, 2014, Platelet dysfunction as measured by a point-of-care monitor is an independent predictor of high blood loss in cardiac surgery, Anesth Analg, 118, 257, 10.1213/ANE.0000000000000054

Schimmer, 2013, The predictive value of multiple electrode platelet aggregometry (multiplate) in adult cardiac surgery, Thorac Cardiovasc Surg, 61, 733, 10.1055/s-0033-1333659

Corredor, 2015, The role of point-of-care platelet function testing in predicting postoperative bleeding following cardiac surgery: a systematic review and meta-analysis, Anaesthesia, 70, 715, 10.1111/anae.13083

Mahla, 2015, Platelet function testing before CABG is recommended in the guidelines: but do we have enough evidence?, J Interv Cardiol, 28, 233, 10.1111/joic.12194

Aradi, 2014, Expert position paper on the role of platelet function testing in patients undergoing percutaneous coronary intervention, Eur Heart J, 35, 209, 10.1093/eurheartj/eht375

Berger, 2015, Does preoperative platelet function predict bleeding in patients undergoing off pump coronary artery bypass surgery?, J Interv Cardiol, 28, 223, 10.1111/joic.12200

Gandhi, 2014, Platelet function inhibitors and platelet function testing in neurointerventional procedures, J Neurointerv Surg, 6, 567, 10.1136/neurintsurg-2014-011357

Daly, 2014, What is the role of genetic testing in the investigation of patients with suspected platelet function disorders?, Br J Haematol, 165, 193, 10.1111/bjh.12751

Dovlatova, 2014, Evaluation of a whole blood remote platelet function test for the diagnosis of mild bleeding disorders, J Thromb Haemost, 12, 660, 10.1111/jth.12555

Watson, 2013, Genotyping and phenotyping of platelet function disorders, J Thromb Haemost, 11, 351, 10.1111/jth.12199

Leo, 2015, Use of next-generation sequencing and candidate gene analysis to identify underlying defects in patients with inherited platelet function disorders, J Thromb Haemost, 13, 643, 10.1111/jth.12836

Arora, 2012, Preventable risk factors for acute kidney injury in patients undergoing cardiac surgery, J Cardiothorac Vasc Anesth, 26, 687, 10.1053/j.jvca.2012.03.001

Schiergens, 2015, Impact of perioperative allogeneic red blood cell transfusion on recurrence and overall survival after resection of colorectal liver metastases, Dis Colon Rectum, 58, 74, 10.1097/DCR.0000000000000233

Steinbicker, 2015, Patient blood management: Umsetzung im Rahmen der Anaesthesiesprechstunde, Anästh Intensivmed, 56, 64

Bisbe, 2014, Randomized trial comparing ferric carboxymaltose vs oral ferrous glycine sulphate for postoperative anaemia after total knee arthroplasty, Br J Anaesth, 113, 402, 10.1093/bja/aeu092

Gillard, 2014, Influence of haematocrit level on thromboelastometry parameters: 6AP5-10, Eur J Anaesthesiol, 31, 106, 10.1097/00003643-201406001-00291

Solomon, 2013, Effect of haematocrit on fibrin-based clot firmness in the FIBTEM test, Blood Transfus, 11, 412

Allen, 2014, Initial hematocrit predicts the use of blood transfusion in the pediatric trauma patient, J Pediatr Surg, 49, 1678, 10.1016/j.jpedsurg.2014.10.044

Baumann, 2014, Preoperative hemoglobin level, blood volume or circulating red blood cell volume as predictors for perioperative blood transfusion? A retrospective study on 681 patients undergoing orthopedic major joint replacement, Eur J Anaesthesiol, 31, 90, 10.1097/00003643-201406001-00247

Browning, 2012, Preoperative anaemia is common in patients undergoing major gynaecological surgery and is associated with a fivefold increased risk of transfusion, Aust N Z J Obstet Gynaecol, 52, 455, 10.1111/j.1479-828X.2012.01478.x

David, 2013, The prevalence of anaemia, hypochromia and microcytosis in preoperative cardiac surgical patients, Anaesth Intensive Care, 41, 316, 10.1177/0310057X1304100307

Theusinger, 2014, Patient blood management in orthopaedic surgery: a four-year follow-up of transfusion requirements and blood loss from 2008 to 2011 at the Balgrist University Hospital in Zurich, Switzerland, Blood Transfus, 12, 195

Enko, 2013, The impact of an algorithm-guided management of preoperative anemia in perioperative hemoglobin level and transfusion of major orthopedic surgery patients, Anemia, 2013, 641876, 10.1155/2013/641876

Harwin, 2014, Is total hip arthroplasty a successful and safe procedure in Jehovah's Witnesses? Mean five-year results, Hip Int, 24, 69, 10.5301/hipint.5000106

Qureshi, 2012, Erythropoietin provides a useful strategy for treating preoperative anemia in planned elective orthopedic surgery: an analysis of benefit in routine practice, Transfusion, 52, 2063, 10.1111/j.1537-2995.2012.03722.x

Bisbe, 2012, Management of preoperative anemia: the NATA consensus statements, ISBT Sci Ser, 7, 283, 10.1111/j.1751-2824.2012.01607.x

Bruce, 2013, Practical recommendations for patient blood management and the reduction of perioperative transfusion in joint replacement surgery, ANZ J Surg, 83, 222, 10.1111/ans.12000

Gurusamy, 2014, Iron therapy in anaemic adults without chronic kidney disease., Cochrane Database Syst Rev, 12, CD010640

Lakkawar, 2012, Efficacy of intravenous administration of iron sucrose for treatment of iron deficiency anaemia in patients with abnormal uterine bleeding, Acta Facultatis Medicae Naissensis, 29, 59, 10.2478/v10283-012-0009-3

Keeler, 2014, The feasibility and clinical efficacy of intravenous iron administration for preoperative anaemia in patients with colorectal cancer, Colorectal Dis, 16, 794, 10.1111/codi.12683

Lin, 2013, Efficacy and safety of erythropoietin and intravenous iron in perioperative blood management: a systematic review, Transfus Med Rev, 27, 221, 10.1016/j.tmrv.2013.09.001

Alsaleh, 2013, The use of preoperative erythropoiesis-stimulating agents (ESAs) in patients who underwent knee or hip arthroplasty: a meta-analysis of randomized clinical trials, J Arthroplasty, 28, 1463, 10.1016/j.arth.2013.01.024

Doodeman, 2013, The effect of a preoperative erythropoietin protocol as part of a multifaceted blood management program in daily clinical practice (CME), Transfusion, 53, 1930, 10.1111/trf.12016

van Haelst, 2013, Occurrence and determinants of poor response to short-term preoperative erythropoietin treatment, Acta Anaesthesiol Scand, 57, 350, 10.1111/aas.12029

Tomeczkowski, 2013, Potential cost saving of Epoetin alfa in elective hip or knee surgery due to reduction in blood transfusions and their side effects: a discrete-event simulation model, PLoS ONE, 8, e72949, 10.1371/journal.pone.0072949

Kotze, 2012, Effect of a patient blood management programme on preoperative anaemia, transfusion rate, and outcome after primary hip or knee arthroplasty: a quality improvement cycle, Br J Anaesth, 108, 943, 10.1093/bja/aes135

Cladellas, 2012, Effects of preoperative intravenous erythropoietin plus iron on outcome in anemic patients after cardiac valve replacement, Am J Cardiol, 110, 1021, 10.1016/j.amjcard.2012.05.036

Menkis, 2012, Drug, devices, technologies, and techniques for blood management in minimally invasive and conventional cardiothoracic surgery: a consensus statement from the International Society for Minimally Invasive Cardiothoracic Surgery (ISMICS) 2011, Innovations (Phila, 7, 229, 10.1097/imi.0b013e3182747699

Leahy, 2014, A pragmatic approach to embedding patient blood management in a tertiary hospital, Transfusion, 54, 1133, 10.1111/trf.12362

Munoz, 2014, Cost of postoperative intravenous iron therapy in total lower limb arthroplasty: a retrospective, matched cohort study, Blood Transfus, 12, 40

Crosby, 1994, Iron supplementation for acute blood loss anemia after coronary artery bypass surgery: a randomized, placebo-controlled study, Heart Lung, 23, 493

Garrido-Martin, 2012, The effect of intravenous and oral iron administration on perioperative anaemia and transfusion requirements in patients undergoing elective cardiac surgery: a randomized clinical trial, Interact Cardiovasc Thorac Surg, 15, 1013, 10.1093/icvts/ivs344

Karkouti, 2006, Intravenous iron and recombinant erythropoietin for the treatment of postoperative anemia, Can J Anaesth, 53, 11, 10.1007/BF03021522

Madi-Jebara, 2004, Postoperative intravenous iron used alone or in combination with low-dose erythropoietin is not effective for correction of anemia after cardiac surgery, J Cardiothorac Vasc Anesth, 18, 59, 10.1053/j.jvca.2003.10.012

Parker, 2010, Iron supplementation for anemia after hip fracture surgery: a randomized trial of 300 patients, J Bone Joint Surg Am, 92, 265, 10.2106/JBJS.I.00883

Mundy, 2005, The effect of iron supplementation on the level of haemoglobin after lower limb arthroplasty, J Bone Joint Surg Br, 87, 213, 10.1302/0301-620X.87B2.15122

Sutton, 2004, A randomized trial of rescue angioplasty versus a conservative approach for failed fibrinolysis in ST-segment elevation myocardial infarction: the Middlesbrough Early Revascularization to Limit INfarction (MERLIN) trial, J Am Coll Cardiol, 44, 287, 10.1016/j.jacc.2003.12.059

Zauber, 1992, Iron supplementation after femoral head replacement for patients with normal iron stores, JAMA, 267, 525, 10.1001/jama.1992.03480040073033

Titos-Arcos, 2012, Is intravenous iron useful for reducing transfusions in surgically treated colorectal cancer patients?, World J Surg, 36, 1893, 10.1007/s00268-012-1589-x

van Iperen, 1998, Iron metabolism and erythropoiesis after surgery, Br J Surg, 85, 41, 10.1046/j.1365-2168.1998.00571.x

Abuella, 2012, Meta-analysis of goal directed therapy in high-risk patients undergoing major noncardiac surgery, Intensive Care Med, 38, S120

Benes, 2014, The effects of goal-directed fluid therapy based on dynamic parameters on postsurgical outcome: a meta-analysis of randomized controlled trials, Crit Care, 18, 584, 10.1186/s13054-014-0584-z

Cecconi, 2013, Clinical review: Goal-directed therapy-what is the evidence in surgical patients? The effect on different risk groups, Crit Care, 17, 209, 10.1186/cc11823

Aya, 2013, Goal-directed therapy in cardiac surgery: a systematic review and meta-analysis, Br J Anaesth, 110, 510, 10.1093/bja/aet020

Grocott, 2013, Perioperative increase in global blood flow to explicit defined goals and outcomes after surgery: a Cochrane Systematic Review, Br J Anaesth, 111, 535, 10.1093/bja/aet155

Salzwedel, 2013, Perioperative goal-directed hemodynamic therapy based on radial arterial pulse pressure variation and continuous cardiac index trending reduces postoperative complications after major abdominal surgery: a multicenter, prospective, randomized study, Crit Care, 17, R191, 10.1186/cc12885

Pearse, 2014, Effect of a perioperative, cardiac output-guided hemodynamic therapy algorithm on outcomes following major gastrointestinal surgery: a randomized clinical trial and systematic review, JAMA, 311, 2181, 10.1001/jama.2014.5305

Kehlet, 1997, Multimodal approach to control postoperative pathophysiology and rehabilitation, Br J Anaesth, 78, 606, 10.1093/bja/78.5.606

Cuthbertson, 2013, Goldilocks, elephants, and surgical fluids, Br J Anaesth, 110, 144, 10.1093/bja/aes449

Vaughan-Shaw, 2013, Oedema is associated with clinical outcome following emergency abdominal surgery, Ann R Coll Surg Engl, 95, 390, 10.1308/003588413X13629960046552

Marik, 2013, Does the central venous pressure predict fluid responsiveness? An updated meta-analysis and a plea for some common sense, Crit Care Med, 41, 1774, 10.1097/CCM.0b013e31828a25fd

Cannesson, 2011, Assessing the diagnostic accuracy of pulse pressure variations for the prediction of fluid responsiveness: a ‘gray zone’ approach, Anesthesiology, 115, 231, 10.1097/ALN.0b013e318225b80a

Sondergaard, 2013, Pavane for a pulse pressure variation defunct, Crit Care, 17, 327, 10.1186/cc13109

Marik, 2014, Fluid responsiveness: an evolution of our understanding, Br J Anaesth, 112, 617, 10.1093/bja/aet590

Murphy, 2015, Liberal or restrictive transfusion after cardiac surgery, N Engl J Med, 372, 997, 10.1056/NEJMoa1403612

Villanueva, 2013, Transfusion strategies for acute upper gastrointestinal bleeding, N Engl J Med, 368, 11, 10.1056/NEJMoa1211801

de Almeida, 2015, Transfusion requirements in surgical oncology patients: a prospective, randomized controlled trial, Anesthesiology, 122, 29, 10.1097/ALN.0000000000000511

Rohde, 2014, Healthcare-associated infection after red blood cell transfusion: a systematic review and meta-analysis, JAMA, 311, 1317, 10.1001/jama.2014.2726

Cabello, 2013, Oxygen therapy for acute myocardial infarction., Cochrane Database Syst Rev, 8, CD007160

Wetterslev, 2015, The effects of high perioperative inspiratory oxygen fraction for adult surgical patients., Cochrane Database Syst Rev, 6, CD008884

Andreu, 2002, Hemovigilance network in France: organization and analysis of immediate transfusion incident reports from 1994 to 1998, Transfusion, 42, 1356, 10.1046/j.1537-2995.2002.00202.x

Chung, 2015, How is national recipient hemovigilance conducted in the United States?, Transfusion, 55, 703, 10.1111/trf.12980

Faber, 2004, The European Blood Directive: a new era of blood regulation has begun, Transfus Med, 14, 257, 10.1111/j.0958-7578.2004.00513.x

Watson, 2005, EU tightens rules on blood safety, BMJ, 331, 800, 10.1136/bmj.331.7520.800-c

de Vries, 2011, Board of the International Haemovigilance Network. Haemovigilance: an effective tool for improving transfusion practice, Vox Sang, 100, 60, 10.1111/j.1423-0410.2010.01442.x

Giampaolo, 2007, The first data from the haemovigilance system in Italy, Blood Transfus, 5, 66

Keller-Stanislawski, 2009, The German Haemovigilance System: reports of serious adverse transfusion reactions between 1997 and 2007, Transfus Med, 19, 340, 10.1111/j.1365-3148.2009.00947.x

Bolton-Maggs, 2013, Serious Hazards of Transfusion (SHOT) haemovigilance and progress is improving transfusion safety, Br J Haematol, 163, 303, 10.1111/bjh.12547

Lafeuillade, 2015, Residual risk and retrospective analysis of transfusion-transmitted bacterial infection reported by the French National Hemovigilance Network from 2000 to 2008, Transfusion, 55, 636, 10.1111/trf.12883

Custer, 2015, Risk factors for retrovirus and hepatitis virus infections in accepted blood donors, Transfusion, 55, 1098, 10.1111/trf.12951

Stramer, 2013, Hepatitis B virus testing by minipool nucleic acid testing: does it improve blood safety?, Transfusion, 53, 2449, 10.1111/trf.12213

Bruhn, 2015, Relative efficacy of nucleic acid amplification testing and serologic screening in preventing hepatitis C virus transmission risk in seven international regions, Transfusion, 55, 1195, 10.1111/trf.13024

Zou, 2010, Prevalence, incidence, and residual risk of human immunodeficiency virus and hepatitis C virus infections among United States blood donors since the introduction of nucleic acid testing, Transfusion, 50, 1495, 10.1111/j.1537-2995.2010.02622.x

Arora, 2015, Sensitivity of individual donor nucleic acid testing (NAT) for the detection of hepatitis B infection by studying diluted NAT yield samples, Blood Transfus, 13, 227

Stramer, 2014, Current perspectives in transfusion-transmitted infectious diseases: emerging and re-emerging infections, ISBT Sci Ser, 9, 30, 10.1111/voxs.12070

Seltsam, 2013, Update on the use of pathogen-reduced human plasma and platelet concentrates, Br J Haematol, 162, 442, 10.1111/bjh.12403

Rock, 2011, A comparison of methods of pathogen inactivation of FFP, Vox Sang, 100, 169, 10.1111/j.1423-0410.2010.01374.x

Butler, 2013, Pathogen-reduced platelets for the prevention of bleeding., Cochrane Database Syst Rev, 3, CD009072

Wagner, 2011, Developing pathogen reduction technologies for RBC suspensions, Vox Sang, 100, 112, 10.1111/j.1423-0410.2010.01386.x

Kleinman, 2015, Risks associated with red blood cell transfusions: potential benefits from application of pathogen inactivation, Transfusion, 55, 2983, 10.1111/trf.13259

Gilliss, 2011, Reducing noninfectious risks of blood transfusion, Anesthesiology, 115, 635, 10.1097/ALN.0b013e31822a22d9

Edgeworth, 2011, Detection of prion infection in variant Creutzfeldt-Jakob disease: a blood-based assay, Lancet, 377, 487, 10.1016/S0140-6736(10)62308-2

Lescoutra-Etchegaray, 2014, Removal of exogenous prion infectivity in leukoreduced red blood cells unit by a specific filter designed for human transfusion, Transfusion, 54, 1037, 10.1111/trf.12420

Bilgin, 2004, Double-blind, randomized controlled trial on the effect of leukocyte-depleted erythrocyte transfusions in cardiac valve surgery, Circulation, 109, 2755, 10.1161/01.CIR.0000130162.11925.21

Mendrone, 2014, Is there justification for universal leukoreduction?, Rev Bras Hematol Hemoter, 36, 237, 10.1016/j.bjhh.2014.06.004

Douet, 2015, Leukoreduction and blood-borne vCJD transmission risk, Curr Opin Hematol, 22, 36, 10.1097/MOH.0000000000000101

Carson, 2012, Transfusion thresholds and other strategies for guiding allogeneic red blood cell transfusion., Cochrane Database Syst Rev, 4, CD002042

Holst, 2015, Restrictive versus liberal transfusion strategy for red blood cell transfusion: systematic review of randomised trials with meta-analysis and trial sequential analysis, BMJ, 350, h1354, 10.1136/bmj.h1354

Holst, 2014, Lower versus higher hemoglobin threshold for transfusion in septic shock, N Engl J Med, 371, 1381, 10.1056/NEJMoa1406617

Curley, 2014, Transfusion triggers for guiding RBC transfusion for cardiovascular surgery: a systematic review and meta-analysis, Crit Care Med, 42, 2611, 10.1097/CCM.0000000000000548

Murphy, 2015, Liberal or restrictive transfusion after cardiac surgery, N Engl J Med, 372, 997, 10.1056/NEJMoa1403612

Bolton-Maggs, 2013, Transfusion safety in 2012: main messages from the SHOT Annual Report for 2012, Transfus Med, 23, 217, 10.1111/tme.12060

Ozier, 2011, Transfusion-related acute lung injury: reports to the French Hemovigilance Network 2007 through 2008, Transfusion, 51, 2102, 10.1111/j.1537-2995.2011.03073.x

Muller, 2015, Low-risk transfusion-related acute lung injury donor strategies and the impact on the onset of transfusion-related acute lung injury: a meta-analysis, Transfusion, 55, 164, 10.1111/trf.12816

Kopolovic, 2015, A systematic review of transfusion-associated graft-versus-host disease, Blood, 126, 406, 10.1182/blood-2015-01-620872

Clifford, 2015, Characterizing the epidemiology of perioperative transfusion-associated circulatory overload, Anesthesiology, 122, 21, 10.1097/ALN.0000000000000513

Piccin, 2015, Transfusion-associated circulatory overload in Ireland: a review of cases reported to the National Haemovigilance Office 2000 to 2010, Transfusion, 55, 1223, 10.1111/trf.12965

Alam, 2013, The prevention of transfusion-associated circulatory overload, Transfus Med Rev, 27, 105, 10.1016/j.tmrv.2013.02.001

Ozier, 2014, The prevention of transfusion-associated circulatory overload, Transfus Clin Biol, 21, 153, 10.1016/j.tracli.2014.07.008

Murphy, 2013, Risk factors and outcomes in transfusion-associated circulatory overload, Am J Med, 126, 357, 10.1016/j.amjmed.2012.08.019

Vamvakas, 2010, Meta-analysis of clinical studies of the purported deleterious effects of ‘old’ (versus ‘fresh’) red blood cells: are we at equipoise?, Transfusion, 50, 600, 10.1111/j.1537-2995.2009.02465.x

Lelubre, 2013, Relationship between red cell storage duration and outcomes in adults receiving red cell transfusions: a systematic review, Crit Care, 17, R66, 10.1186/cc12600

Wang, 2012, Transfusion of older stored blood and risk of death: a meta-analysis, Transfusion, 52, 1184, 10.1111/j.1537-2995.2011.03466.x

Fergusson, 2012, Effect of fresh red blood cell transfusions on clinical outcomes in premature, very low-birth-weight infants: the ARIPI randomized trial, JAMA, 308, 1443, 10.1001/2012.jama.11953

Lacroix, 2015, Age of transfused blood in critically ill adults, N Engl J Med, 372, 1410, 10.1056/NEJMoa1500704

Steiner, 2015, Effects of red-cell storage duration on patients undergoing cardiac surgery, N Engl J Med, 372, 1419, 10.1056/NEJMoa1414219

Carless, 2010, Cell salvage for minimising perioperative allogeneic blood transfusion., Cochrane Database Syst Rev, 4, CD001888

van Bodegom-Vos, 2015, Cell salvage in hip and knee arthroplasty: a meta-analysis of randomized controlled trials, J Bone Joint Surg Am, 97, 1012, 10.2106/JBJS.N.00315

Xie, 2015, Is postoperative cell salvage necessary in total hip or knee replacement? A meta-analysis of randomized controlled trials, Int J Surg, 21, 135, 10.1016/j.ijsu.2015.07.700

Shantikumar, 2011, The role of cell salvage autotransfusion in abdominal aortic aneurysm surgery, Eur J Vasc Endovasc Surg, 42, 577, 10.1016/j.ejvs.2011.04.014

Esper, 2011, Intra-operative cell salvage: a fresh look at the indications and contraindications, Blood Transfus, 9, 139

Li, 2015, Cell salvage in emergency trauma surgery., Cochrane Database Syst Rev, 1, CD007379

Trudeau, 2012, Should intraoperative cell-salvaged blood be used in patients with suspected or known malignancy?, Can J Anaesth, 59, 1058, 10.1007/s12630-012-9781-x

Aning, 2012, Towards bloodless cystectomy: a 10-year experience of intra-operative cell salvage during radical cystectomy, BJU Int, 110, E608, 10.1111/j.1464-410X.2012.11338.x

Raval, 2012, Intraoperative cell salvage in radical prostatectomy does not appear to increase long-term biochemical recurrence, metastases, or mortality, Transfusion, 52, 2590, 10.1111/j.1537-2995.2012.03682.x

Gakhar, 2013, Role of intraoperative red cell salvage and autologus transfusion in metastatic spine surgery: a pilot study and review of literature, Asian Spine J, 7, 167, 10.4184/asj.2013.7.3.167

Bowley, 2006, Intraoperative blood salvage in penetrating abdominal trauma: a randomised, controlled trial, World J Surg, 30, 1074, 10.1007/s00268-005-0466-2

Liumbruno, 2011, Intraoperative cell salvage in obstetrics: is it a real therapeutic option?, Transfusion, 51, 2244, 10.1111/j.1537-2995.2011.03116.x

Dhariwal, 2014, Does current evidence support the use of intraoperative cell salvage in reducing the need for blood transfusion in caesarean section?, Curr Opin Obstet Gynecol, 26, 425, 10.1097/GCO.0000000000000116

De Pietri, 2016, Thrombelastography-guided blood product use before invasive procedures in cirrhosis with severe coagulopathy. A randomized controlled trial, Hepatology, 63, 566, 10.1002/hep.28148

Berg, 2013, Acetylsalicylic acid treatment until surgery reduces oxidative stress and inflammation in patients undergoing coronary artery bypass grafting, Eur J Cardiothorac Surg, 43, 1154, 10.1093/ejcts/ezs591

Xiao, 2015, Effect of preoperatively continued aspirin use on early and mid-term outcomes in off-pump coronary bypass surgery: a propensity score-matched study of 1418 patients, PLoS ONE, 10, e0116311, 10.1371/journal.pone.0116311

Vorobcsuk, 2012, Outcomes of patients receiving clopidogrel prior to cardiac surgery, Int J Cardiol, 156, 34, 10.1016/j.ijcard.2010.10.034

Blais, 2012, Bleeding outcomes associated with coronary artery bypass graft surgery and recent clopidogrel exposure, Heart Surgery Forum, 16, E70, 10.1532/HSF98.20121101

Guay, 2014, Continuing antiplatelet therapy before cardiac surgery with cardiopulmonary bypass: a meta-analysis on the need for reexploration and major outcomes, J Cardiothorac Vasc Anesth, 28, 90, 10.1053/j.jvca.2013.03.013

Rossini, 2015, Perioperative management of oral antiplatelet therapy and clinical outcomes in coronary stent patients undergoing surgery. Results of a multicentre registry, Thromb Haemost, 113, 272, 10.1160/TH14-05-0436

Hutton, 2012, Risks of harms using antifibrinolytics in cardiac surgery: systematic review and network meta-analysis of randomised and observational studies, BMJ, 345, e5798, 10.1136/bmj.e5798

Meybohm, 2013, Aprotinin may increase mortality in low and intermediate risk but not in high risk cardiac surgical patients compared to tranexamic acid and (epsilon)-aminocaproic acid: a meta-analysis of randomised and observational trials of over 30,000 patients, PLoS ONE, 8, e58009, 10.1371/journal.pone.0058009

Ranucci, 2013, Preoperative antithrombin supplementation in cardiac surgery: a randomized controlled trial, J Thorac Cardiovasc Surg, 145, 1393, 10.1016/j.jtcvs.2012.09.061

Ranucci, 2015, Preoperative fibrinogen supplementation in cardiac surgery patients: an evaluation of different trigger values, Acta Anaesthesiol Scand, 59, 427, 10.1111/aas.12469

Vonk, 2014, Individualized heparin and protamine management improves rotational thromboelastometric parameters and postoperative hemostasis in valve surgery, J Cardiothorac Vasc Anesth, 28, 235, 10.1053/j.jvca.2013.09.007

Guo, 2012, Protamine dosage based on two titrations reduces blood loss after valve replacement surgery: a prospective, double-blinded, randomized study, Can J Cardiol, 28, 547, 10.1016/j.cjca.2012.03.012

Martin, 2013, Replacement of aprotinin by epsilon-aminocaproic acid in infants undergoing cardiac surgery: consequences for blood loss and outcome, Br J Anaesth, 110, 615, 10.1093/bja/aes430

Makhija, 2013, Comparison of epsilon aminocaproic acid and tranexamic acid in thoracic aortic surgery: clinical efficacy and safety, J Cardiothorac Vasc Anesth, 27, 1201, 10.1053/j.jvca.2013.04.003

Faraoni, 2012, Efficacy of tranexamic acid in paediatric cardiac surgery: a systematic review and meta-analysis, Eur J Cardiothorac Surg, 42, 781, 10.1093/ejcts/ezs127

Mansouri, 2012, Comparative evaluation of the effects of tranexamic acid and low-dose aprotinin on postvalvular heart surgery bleeding and allogenic transfusion, Interact Cardiovasc Thorac Surg, 15, 23, 10.1093/icvts/ivs114

Waldow, 2013, Prospective clinical trial on dosage optimizing of tranexamic acid in nonemergency cardiac surgery procedures, Clin Hemorheol Microcirc, 55, 457, 10.3233/CH-131782

Du, 2014, Comparison of two tranexamic acid dose regimens in patients undergoing cardiac valve surgery, J Cardiothorac Vasc Anesth, 28, 1233, 10.1053/j.jvca.2013.10.006

Sigaut, 2014, Comparison of two doses of tranexamic acid in adults undergoing cardiac surgery with cardiopulmonary bypass, Anesthesiology, 120, 590, 10.1097/ALN.0b013e3182a443e8

Faraoni, 2014, Effect of two doses of tranexamic acid on fibrinolysis evaluated by thromboelastography during cardiac surgery: a randomised, controlled study, Eur J Anaesthesiol, 31, 491, 10.1097/EJA.0000000000000051

Vaněk, 2013, Topical use of tranexamic acid in cardiac surgery—a review and meta-analysis of four randomized controlled trials, Cor Vasa, 55, e184, 10.1016/j.crvasa.2012.10.002

Hosseini, 2014, Evaluations of topical application of tranexamic acid on postoperative blood loss in off-pump coronary artery bypass surgery, Saudi J Anaesth, 8, 224, 10.4103/1658-354X.130724

Mahaffey, 2013, A retrospective analysis of blood loss with combined topical and intravenous tranexamic acid after coronary artery bypass graft surgery, J Cardiothorac Vasc Anesth, 27, 18, 10.1053/j.jvca.2012.08.004

Wang, 2012, Tranexamic acid reduces blood loss after off-pump coronary surgery: a prospective, randomized, double-blind, placebo-controlled study, Anesth Analg, 115, 239, 10.1213/ANE.0b013e3182264a11

Gurian, 2014, A randomized trial of the topical effect of antifibrinolytic epsilon aminocaproic acid on coronary artery bypass surgery without cardiopulmonary bypass, Clin Appl Thromb Hemost, 20, 615, 10.1177/1076029613476338

Lee, 2014, Fibrinogen recovery and changes in fibrin-based clot firmness after cryoprecipitate administration in patients undergoing aortic surgery involving deep hypothermic circulatory arrest, Transfusion, 54, 1379, 10.1111/trf.12479

Doussau, 2014, Fresh-frozen plasma transfusion did not reduce 30-day mortality in patients undergoing cardiopulmonary bypass cardiac surgery with excessive bleeding: the PLASMACARD multicenter cohort study, Transfusion, 54, 1114, 10.1111/trf.12422

Zhou, 2013, Analysis of autologous platelet-rich plasma during ascending and transverse aortic arch surgery, Ann Thorac Surg, 95, 1525, 10.1016/j.athoracsur.2012.09.054

Jin, 2015, Effect of desmopressin on platelet aggregation and blood loss in patients undergoing valvular heart surgery, Chin Med J (Engl, 128, 644, 10.4103/0366-6999.151663

Karkouti, 2013, Efficacy and safety of recombinant factor XIII on reducing blood transfusions in cardiac surgery: a randomized, placebo-controlled, multicenter clinical trial, J Thorac Cardiovasc Surg, 146, 927, 10.1016/j.jtcvs.2013.04.044

Rahe-Meyer, 2013, Fibrinogen concentrate reduces intraoperative bleeding when used as first-line hemostatic therapy during major aortic replacement surgery: results from a randomized, placebo-controlled trial, J Thorac Cardiovasc Surg, 145, S178, 10.1016/j.jtcvs.2012.12.083

Galas, 2014, Hemostatic effects of fibrinogen concentrate compared with cryoprecipitate in children after cardiac surgery: a randomized pilot trial, J Thorac Cardiovasc Surg, 148, 1647, 10.1016/j.jtcvs.2014.04.029

Bilecen, 2013, Fibrinogen concentrate therapy in complex cardiac surgery, J Cardiothorac Vasc Anesth, 27, 12, 10.1053/j.jvca.2012.06.006

Giorni, 2014, Use of Confidex to control perioperative bleeding in pediatric heart surgery: prospective cohort study, Pediatr Cardiol, 35, 208, 10.1007/s00246-013-0760-y

Song, 2014, Safety and efficacy of prothrombin complex concentrates for the treatment of coagulopathy after cardiac surgery, J Thorac Cardiovasc Surg, 147, 1036, 10.1016/j.jtcvs.2013.11.020

Rao, 2014, Factor VIII inhibitor bypass activity and recombinant activated factor VII in cardiac surgery, J Cardiothorac Vasc Anesth, 28, 1221, 10.1053/j.jvca.2014.04.015

Abdel-Meguid, 2013, Prophylactic administration of recombinant activated factor VII in coronary revascularization surgery, Saudi J Anaesth, 7, 301, 10.4103/1658-354X.115364

Singh, 2014, Recombinant activated factor VII in cardiac surgery: single-center experience, Asian Cardiovasc Thorac Ann, 22, 148, 10.1177/0218492312471672

Kurkluoglu, 2015, Single center experience on dosing and adverse events of recombinant factor seven use for bleeding after congenital heart surgery, J Saudi Heart Assoc, 27, 18, 10.1016/j.jsha.2014.05.001

Alfirevic, 2014, Recombinant factor VII is associated with worse survival in complex cardiac surgical patients, Ann Thorac Surg, 98, 618, 10.1016/j.athoracsur.2014.04.126

Clark, 2013, Factor IX complex for the treatment of severe bleeding after cardiac surgery, J Cardiovasc Pharmacol, 62, 67, 10.1097/FJC.0b013e318290922f

Alizadeh Ghavidel, 2014, Haemostatic role of TachoSil surgical patch in cardiac surgery, J Cardiovasc Thorac Res, 6, 91

Agarwal, 2015, Preoperative point-of-care platelet function testing in cardiac surgery, J Cardiothorac Vasc Anesth, 29, 333, 10.1053/j.jvca.2014.06.025

Whitney, 2013, Implementation of a transfusion algorithm to reduce blood product utilization in pediatric cardiac surgery, Paediatr Anaesth, 23, 639, 10.1111/pan.12126

Karkouti, 2015, Evaluation of a novel transfusion algorithm employing point-of-care coagulation assays in cardiac surgery: a retrospective cohort study with interrupted time-series analysis, Anesthesiology, 122, 560, 10.1097/ALN.0000000000000556

Bergmann, 2010, Prevalence and risk factors for early postpartum anemia, Eur J Obstet Gynecol Reprod Biol, 150, 126, 10.1016/j.ejogrb.2010.02.030

Chauleur, 2008, Analysis of the venous thromboembolic risk associated with severe postpartum haemorrhage in the NOHA First cohort, Thromb Haemost, 100, 773, 10.1160/TH08-06-0376

James, 2009, Blood component therapy in postpartum hemorrhage, Transfusion, 49, 2430, 10.1111/j.1537-2995.2009.02318.x

Ehrenthal, 2012, Maternal risk factors for peripartum transfusion, J Women's Health, 21, 792, 10.1089/jwh.2011.3248

Cooper, 2008, Anaesthesia chapter from saving mothers’ lives; reviewing maternal deaths to make pregnancy safer, Br J Anaesth, 100, 17, 10.1093/bja/aem344

Kacmar, 2014, The use of postpartum hemorrhage protocols in United States Academic Obstetric Anesthesia Units, Anesth Analg, 119, 906, 10.1213/ANE.0000000000000399

Gutierrez, 2012, Postpartum hemorrhage treated with a massive transfusion protocol at a tertiary obstetric center: a retrospective study, Int J Obstet Anesth, 21, 230, 10.1016/j.ijoa.2012.03.005

Era, 2014, Usefulness of shock indicators for determining the need for blood transfusion after massive obstetric hemorrhage, J Obstet Gynaecol Res, 41, 39, 10.1111/jog.12480

Steele, 2014, The practical utility of routine postpartum hemoglobin assessment, Am J Obstet Gynecol, 210, 576.e1, 10.1016/j.ajog.2014.02.022

Patterson, 2014, Blood transfusion during pregnancy, birth, and the postnatal period, Obstet Gynecol, 123, 126, 10.1097/AOG.0000000000000054

So-Osman, 2010, Triggers and appropriateness of red blood cell transfusions in the postpartum patient--a retrospective audit, Vox Sang, 98, 65, 10.1111/j.1423-0410.2009.01231.x

Bonnet, 2013, Transfusion practices in postpartum hemorrhage: a population-based study, Acta Obstet Gynecol Scand, 92, 404, 10.1111/aogs.12063

Prick, 2014, Cost-effectiveness of red blood cell transfusion vs. nonintervention in women with acute anaemia after postpartum haemorrhage, Vox Sang, 107, 381, 10.1111/vox.12181

Prick, 2014, Transfusion policy after severe postpartum haemorrhage: a randomised noninferiority trial, BJOG, 121, 1005, 10.1111/1471-0528.12531

Morikawa, 2015, Intraoperative red cell salvage during obstetric surgery in 50 Japanese women, Int J Gynecol Obstet, 128, 256, 10.1016/j.ijgo.2014.09.008

Brearton, 2012, The economic benefits of cell salvage in obstetric haemorrhage, Int J Obstet Anesth, 21, 329, 10.1016/j.ijoa.2012.05.003

Froessler, 2013, Intravenous iron sucrose versus oral iron ferrous sulfate for antenatal and postpartum iron deficiency anemia: a randomized trial, J Matern Fetal Neonatal Med, 26, 654, 10.3109/14767058.2012.746299

De Lloyd, 2012, Early fibrinogen as a predictor of red cell requirements during postpartum haemorrhage, Int J Obstet Anesth, 21, S13

Shibata, 2014, Association between fibrinogen levels and severity of postpartum hemorrhage in singleton vaginal deliveries at a Japanese perinatal center, J Nippon Med Sch, 81, 94, 10.1272/jnms.81.94

Collins, 2014, Fibrin-based clot formation as an early and rapid biomarker for progression of postpartum hemorrhage: a prospective study, Blood, 124, 1727, 10.1182/blood-2014-04-567891

Precious, 2013, A prospective study to evaluate early clauss fibrinogen and fibtem as predictors of progression of major obstetric haemorrhage, J Thromb Haemost, 11, 425

Peyvandi, 2012, Elevated prepartum fibrinogen levels are not associated with a reduced risk of postpartum hemorrhage, J Thromb Haemost, 10, 1451, 10.1111/j.1538-7836.2012.04755.x

Yamada, 2014, Antenatal fibrinogen concentrations and postpartum haemorrhage, Int J Obstet Anesth, 23, 365, 10.1016/j.ijoa.2014.06.004

Karlsson, 2013, Coagulopathies early in postpartum haemorrhage; thromboelastography and haemostatic laboratory analyses, Thromb Res, 131, S94, 10.1016/S0049-3848(13)70115-4

Karlsson, 2014, Major obstetric haemorrhage: monitoring with thromboelastography, laboratory analyses or both?, Int J Obstet Anesth, 23, 10, 10.1016/j.ijoa.2013.07.003

Harrod, 2014, Evaluation of FIBTEM A5 guided fibrinogen concentrate administration in massive obstetric haemorrhage, Int J Obstet Anesth, 23, S16

de Lloyd, 2011, Standard haemostatic tests following major obstetric haemorrhage, Int J Obstet Anesth, 20, 135, 10.1016/j.ijoa.2010.12.002

Ducloy-Bouthors, 2012, Point-of-care prothrombin time testing as an early predictor of severe post partum hemorrhage, Int J Gynaecol Obstet, 119, S822, 10.1016/S0020-7292(12)62086-4

Erhabor, 2013, Some hemostatic parameters in women with obstetric hemorrhage in Sokoto, Nigeria, Int J Womens Health, 5, 285, 10.2147/IJWH.S43503

Chevannes, 2012, Fast rotational thromboelastometry evaluation in major obstetric haemorrhage, Br J Anaesth, 109, 484

Lilley, 2013, A prospective study to evaluate early Clauss fibrinogen and FIBTEM as predictors for major obstetric haemorrhage, Int J Obstet Anesth, 22, S7

de Lange, 2012, Obstetric hemorrhage and coagulation: an update. Thromboelastography, thromboelastometry, and conventional coagulation tests in the diagnosis and prediction of postpartum hemorrhage, Obstet Gynecol Surv, 67, 426, 10.1097/OGX.0b013e3182605861

de Lange, 2014, Peri-partum reference ranges for ROTEM(R) thromboelastometry, Br J Anaesth, 112, 852, 10.1093/bja/aet480

Hill, 2012, Point-of-care testing of coagulation and fibrinolytic status during postpartum haemorrhage: developing a thrombelastography(R)-guided transfusion algorithm, Anaesth Intensive Care, 40, 1007, 10.1177/0310057X1204000612

Butwick, 2011, The association between thromboelastographic parameters and total estimated blood loss in patients undergoing elective cesarean delivery, Anesth Analg, 112, 1041, 10.1213/ANE.0b013e318210fc64

Macafee, 2012, Reference ranges for thromboelastography (TEG®) and traditional coagulation tests in term parturients undergoing caesarean section under spinal anaesthesia, Anaesthesia, 67, 741, 10.1111/j.1365-2044.2012.07101.x

Ekelund, 2013, Thromboelastography and aggregometry guided treatment in a patient with idiopathic thrombocytopenic purpura and postpartum hemorrhage, Acta Anaesthesiol Scand, 57, 16

Susen, 2013, Tranexamic acid inhibits fibrinolysis-induced coagulopathy associated with postpartum hemorrhage, J Thromb Haemost, 11, 221

Aoki, 2014, Use of blood components in major obstetric hemorrhage: Preliminary findings from the Australian and New Zealand massive transfusion registry (ANZ-MTR), Blood, 124, 1563, 10.1182/blood.V124.21.1563.1563

Green, 2014, Transfusion management and haemostatic changes in major obstetric haemorrhage in the UK, Transfus Med, 24, 25

Pasquier, 2013, An observational study of the fresh frozen plasma: red blood cell ratio in postpartum hemorrhage, Anesth Analg, 116, 155, 10.1213/ANE.0b013e31826f084d

Teofili, 2014, Acute lung injury complicating blood transfusion in postpartum hemorrhage: incidence and risk factors, Mediterr J Hematol Infect Dis, 6, e2014069, 10.4084/mjhid.2014.069

Teofili, 2013, Pregnancy-related hypertensive disorders are the major risk factor for TRALI in patients with severe postpartum hemorrhage, Blood, 122, 1159, 10.1182/blood.V122.21.1159.1159

Ickx, 2015, Fibrinogen concentrates for postpartum haemorrhage? Do not miss the most relevant population!, Br J Anaesth, 114, 548, 10.1093/bja/aev033

Onwuemene, 2012, Postpartum hemorrhage management in 2012: predicting the future, Int J Gynaecol Obstet, 119, 3, 10.1016/j.ijgo.2012.07.001

Wikkelso, 2015, Preemptive treatment with fibrinogen concentrate for postpartum haemorrhage: randomized controlled trial, Br J Anaesth, 114, 623, 10.1093/bja/aeu444

Collis, 2015, Haemostatic management of obstetric haemorrhage, Anaesthesia, 70, 78, 10.1111/anae.12913

Cunningham, 2015, Disseminated intravascular coagulation syndromes in obstetrics, Obstet Gynecol, 126, 999, 10.1097/AOG.0000000000001110

Mallaiah, 2014, Significant improvement in the management of major obstetric haemorrhage with a ROTEM guided algorithm using fibrinogen concentrate, Transfus Med, 24, 7

Ahmed, 2012, How efficient is fibrinogen concentrate in the management of major obstetric haemorrhage in comparison to cryoprecipitate?, Int J Gynaecol Obstet, 119, S818, 10.1016/S0020-7292(12)62072-4

Ahmed, 2012, The efficacy of fibrinogen concentrate compared with cryoprecipitate in major obstetric haemorrhage: an observational study, Transfus Med, 22, 344, 10.1111/j.1365-3148.2012.01178.x

Wikkelsoe, 2012, The FIB-PPH trial: fibrinogen concentrate as initial treatment for postpartum haemorrhage: study protocol for a randomised controlled trial, Trials, 13, 110, 10.1186/1745-6215-13-110

Mallaiah, 2015, Introduction of an algorithm for ROTEM-guided fibrinogen concentrate administration in major obstetric haemorrhage, Anaesthesia, 70, 166, 10.1111/anae.12859

Hall, 2009, Abruptio placentae and disseminated intravascular coagulopathy, Semin Perinatol, 33, 189, 10.1053/j.semperi.2009.02.005

Mirghafourvand, 2015, The effect of prophylactic intravenous tranexamic acid on blood loss after vaginal delivery in women at low risk of postpartum haemorrhage: a double-blind randomised controlled trial, Aust N Z J Obstet Gynaecol, 55, 53, 10.1111/ajo.12262

Novikova, 2014, Meta-analysis of randomised controlled trials of tranexamic acid for prevention of postpartum haemorrhage, S Afr J Obstet Gynaecol, 20, 71

Xu, 2013, Tranexamic acid for the prevention of postpartum hemorrhage after cesarean section: a double-blind randomization trial, Arch Gynecol Obstet, 287, 463, 10.1007/s00404-012-2593-y

Bouet, 2014, Policy of tranexamic acid for treating postpartum hemorrhage after a vaginal delivery, Am J Obstet Gynecol, 210, S302, 10.1016/j.ajog.2013.10.650

Ducloy-Bouthors, 2012, High dose tranexamic acid reduces blood loss in postpartum haemorrhage, Int J Gynaecol Obstet, 119, S331, 10.1016/S0020-7292(12)60631-6

Faraoni, 2014, Efficacy and safety of tranexamic acid administration for the prevention and/or the treatment of postpartum haemorrhage: a systematic review with meta-analysis, Ann Fr Anesth Reanim, 33, 563, 10.1016/j.annfar.2014.07.748

Heesen, 2014, Prophylactic tranexamic acid in parturients at low risk for postpartum haemorrhage: systematic review and meta-analysis, Acta Anaesthesiol Scand, 58, 1075, 10.1111/aas.12341

Walsh, 2014, Successful thromboelastographic goal-directed blood component therapy, prothrombin complex concentrate, and rFVIIa administration without tranexamic acid for reversal of severe coagulopathy in an obstetrical patient presenting with hemorrhagic cardiac arrest, Am J Hematol, 89, E50

Kayem, 2011, Specific second-line therapies for postpartum haemorrhage: a national cohort study, BJOG, 118, 856, 10.1111/j.1471-0528.2011.02921.x

Magon, 2013, Recombinant activated factor VII in post partum haemorrhage, Niger Med J, 54, 289, 10.4103/0300-1652.122328

Ogawa, 2013, Low-dose recombinant activated factor VII temporally stopped bleeding from small artery in severe postpartum hemorrhage: a case report, Blood Coagul Fibrinolysis, 24, 344, 10.1097/MBC.0b013e32835975b1

Quigley, 2013, Use of recombinant factor VIIa (rFVIIa) in acute life threatening primary postpartum haemorrhage: a case report, Vox Sang, 105, 272

Barillari, 2009, Use of recombinant activated factor VII in severe postpartum haemorrhage: data from the Italian Registry: a multicentric observational retrospective study, Thromb Res, 124, e41, 10.1016/j.thromres.2009.08.018

Mostic, 2008, Our experince with the use of recombinant activated factor VII in postpartum haemorrhage, Srp Arh Celok Lek, 136, 204, 10.2298/SARH08S3204I

Seidlova, 2010, Recombinant activated factor VII in the treatment of life threatening postpartum haemorrhage: Registry UniSeven in the Czech Republic, Ceska Gynekol, 75, 297

Lavigne-Lissalde, 2013, rhuFVIIa in women with a refractory primary postpartum haemorrhage: An international, multicenter, randomised, opened, controlled trial, Thromb Res, 131, S74, 10.1016/S0049-3848(13)70038-0

Fleisher, 2014, 2014 ACC/AHA guideline on perioperative cardiovascular evaluation and management of patients undergoing noncardiac surgery: executive summary: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines, Circulation, 130, 2215, 10.1161/CIR.0000000000000105

Kristensen, 2014, 2014 ESC/ESA Guidelines on noncardiac surgery: cardiovascular assessment and management: The Joint Task Force on noncardiac surgery: cardiovascular assessment and management of the European Society of Cardiology (ESC) and the European Society of Anaesthesiology (ESA), Eur J Anaesthesiol, 31, 517, 10.1097/EJA.0000000000000150

Bidolegui, 2014, Tranexamic acid reduces blood loss and transfusion in patients undergoing total knee arthroplasty without tourniquet: a prospective randomized controlled trial, Open Orthop J, 8, 250, 10.2174/1874325001408010250

Fu, 2013, Use of intravenous tranexamic acid in total knee arthroplasty: a meta-analysis of randomized controlled trials, Chin J Traumatol, 16, 67

Gandhi, 2013, Tranexamic acid and the reduction of blood loss in total knee and hip arthroplasty: a meta-analysis, BMC Res Notes, 6, 184, 10.1186/1756-0500-6-184

Gautam, 2013, The role of tranexamic acid in reducing blood loss in total knee replacement, J Clin Orthop Trauma, 4, 36, 10.1016/j.jcot.2013.01.007

Li, 2013, Is tranexamic acid effective and safe in spinal surgery? A meta-analysis of randomized controlled trials, Eur Spine J, 22, 1950, 10.1007/s00586-013-2774-9

Oremus, 2014, Influence of tranexamic acid on postoperative autologous blood retransfusion in primary total hip and knee arthroplasty: a randomized controlled trial, Transfusion, 54, 31, 10.1111/trf.12224

Pachauri, 2014, The effect of tranexamic acid on hemoglobin levels during total knee arthroplasty, Am J Ther, 21, 366, 10.1097/MJT.0b013e318250f85a

Shen, 2015, Effectiveness and safety of tranexamic acid for total knee arthroplasty: a prospective randomized controlled trial, Med Sci Monit, 21, 576, 10.12659/MSM.892768

Tan, 2013, A meta-analysis of the effectiveness and safety of using tranexamic acid in primary unilateral total knee arthroplasty, J Surg Res, 184, 880, 10.1016/j.jss.2013.03.099

Yang, 2013, Systematic review and meta-analysis of perioperative intravenous tranexamic acid use in spinal surgery, PLoS ONE, 8, e55436, 10.1371/journal.pone.0055436

Zhang, 2014, Effectiveness of tranexamic acid in reducing blood loss in spinal surgery: a meta-analysis, BMC Musculoskelet Disord, 15, 448, 10.1186/1471-2474-15-448

Poeran, 2014, Tranexamic acid use and postoperative outcomes in patients undergoing total hip or knee arthroplasty in the United States: retrospective analysis of effectiveness and safety, BMJ, 349, g4829, 10.1136/bmj.g4829

Goz, 2013, Antifibrinolytics reduce blood loss in adult spinal deformity surgery: a prospective randomized controlled trial, Spine J, 13, S1, 10.1016/j.spinee.2013.07.032

Antonopoulou, 2013, The effectiveness of tranexamic acid in total knee replacement, Reg Anesth Pain Med, 38, E177

Tengborn, 2015, Tranexamic acid: an old drug still going strong and making a revival, Thromb Res, 135, 231, 10.1016/j.thromres.2014.11.012

Alshryda, 2013, Topical (intra-articular) tranexamic acid reduces blood loss and transfusion rates following total hip replacement: a randomized controlled trial (TRANX-H), J Bone Joint Surg Am, 95, 1969, 10.2106/JBJS.L.00908

Alshryda, 2013, Topical (intra-articular) tranexamic acid reduces blood loss and transfusion rates following total knee replacement: a randomized controlled trial (TRANX-K), J Bone Joint Surg Am, 95, 1961, 10.2106/JBJS.L.00907

Alshryda, 2014, A systematic review and meta-analysis of the topical administration of tranexamic acid in total hip and knee replacement, Bone Joint J, 96-B, 1005, 10.1302/0301-620X.96B8.33745

Chang, 2014, Topical tranexamic acid reduces blood loss and transfusion rates associated with primary total hip arthroplasty, Clin Orthop Relat Res, 472, 1552, 10.1007/s11999-013-3446-0

Gilbody, 2014, Topical tranexamic acid reduces transfusion rates in total hip and knee arthroplasty, J Arthroplasty, 29, 681, 10.1016/j.arth.2013.09.005

Gomez-Barrena, 2014, Topical intra-articular compared with intravenous tranexamic acid to reduce blood loss in primary total knee replacement: a double-blind, randomized, controlled, noninferiority clinical trial, J Bone Joint Surg Am, 96, 1937, 10.2106/JBJS.N.00060

Ageno, 2012, Oral anticoagulant therapy: Antithrombotic Therapy and Prevention of Thrombosis, 9th ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines, Chest, 141, e44S, 10.1378/chest.11-2292

Kerebel, 2013, A French multicenter randomised trial comparing two dose-regimens of prothrombin complex concentrates in urgent anticoagulation reversal, Crit Care, 17, R4, 10.1186/cc11923

Spahn, 2013, Management of bleeding and coagulopathy following major trauma: an updated European guideline, Crit Care, 17, R76, 10.1186/cc12685

Tazarourte, 2014, Guideline-concordant administration of prothrombin complex concentrate and vitamin K is associated with decreased mortality in patients with severe bleeding under vitamin K antagonist treatment (EPAHK study), Crit Care, 18, R81, 10.1186/cc13843

Toth, 2013, Real world usage of PCC to ‘rapidly’ correct warfarin induced coagulopathy, Blood Transfus, 11, 500

Goldstein, 2015, Four-factor prothrombin complex concentrate versus plasma for rapid vitamin K antagonist reversal in patients needing urgent surgical or invasive interventions: a phase 3b, open-label, noninferiority, randomised trial, Lancet, 385, 2077, 10.1016/S0140-6736(14)61685-8

Quinlan, 2013, Four-factor prothrombin complex concentrate for urgent reversal of vitamin K antagonists in patients with major bleeding, Circulation, 128, 1179, 10.1161/CIRCULATIONAHA.113.005107

Sarode, 2013, Efficacy and safety of a 4-factor prothrombin complex concentrate in patients on vitamin K antagonists presenting with major bleeding: a randomized, plasma-controlled, phase IIIb study, Circulation, 128, 1234, 10.1161/CIRCULATIONAHA.113.002283

Sarode, 2014, Four-factor prothrombin complex concentrate versus plasma for urgent vitamin K antagonist reversal: new evidence, Clin Lab Med, 34, 613, 10.1016/j.cll.2014.06.002

Hickey, 2013, Outcomes of urgent warfarin reversal with frozen plasma versus prothrombin complex concentrate in the emergency department, Circulation, 128, 360, 10.1161/CIRCULATIONAHA.113.001875

Milling, 2016, Thromboembolic events after vitamin K antagonist reversal with 4-factor prothrombin complex concentrate: exploratory analyses of two randomized, plasma-controlled studies, Ann Emerg Med, 67, 96.e5, 10.1016/j.annemergmed.2015.04.036

Llau, 2015, Multidisciplinary consensus document on the management of massive haemorrhage (HEMOMAS document), Med Intensiva, 39, 483, 10.1016/j.medin.2015.05.002

Sadaka, 2012, Prothrombin complex concentrates for warfarin-related intracranial hemorrhage: should they replace fresh-frozen plasma?, J Blood Disorders Transf, 3, e104, 10.4172/2155-9864.1000e104

Rodgers, 2012, Prothrombin complex concentrates in emergency bleeding disorders, Am J Hematol, 87, 898, 10.1002/ajh.23254

Yates, 2015, New strategies for effective treatment of vitamin K antagonist-associated bleeding, J Thromb Haemost, 13, S180, 10.1111/jth.12970

Schiele, 2015, Structure-guided residence time optimization of a dabigatran reversal agent, MAbs, 7, 871, 10.1080/19420862.2015.1057364

Lu, 2013, A specific antidote for reversal of anticoagulation by direct and indirect inhibitors of coagulation factor Xa, Nat Med, 19, 446, 10.1038/nm.3102

Marlu, 2012, Effect of nonspecific reversal agents on anticoagulant activity of dabigatran and rivaroxaban: a randomised crossover ex vivo study in healthy volunteers, Thromb Haemost, 108, 217, 10.1160/TH12-03-0179

Whalley, 2014, The need to clot: a review of current management strategies for adverse bleeding events with new oral anticoagulants, Minerva Anestesiol, 80, 821

Lazo-Langner, 2009, Intrahospital correlation of the international normalized ratio, Clin Appl Thromb Hemost, 15, 220, 10.1177/1076029608315167

Dickneite, 2014, Prothrombin complex concentrates as reversal agents for new oral anticoagulants: lessons from preclinical studies with Beriplex, Clin Lab Med, 34, 623, 10.1016/j.cll.2014.06.001

Herzog, 2015, Four-factor prothrombin complex concentrate reverses apixaban-associated bleeding in a rabbit model of acute hemorrhage, J Thromb Haemost, 13, 2220, 10.1111/jth.13165

Herzog, 2015, Effective reversal of edoxaban-associated bleeding with four-factor prothrombin complex concentrate in a rabbit model of acute hemorrhage, Anesthesiology, 122, 387, 10.1097/ALN.0000000000000520

Hoffman, 2015, Reversal of dabigatran effects in models of thrombin generation and hemostasis by factor VIIa and prothrombin complex concentrate, Anesthesiology, 122, 353, 10.1097/ALN.0000000000000540

Pragst, 2012, Reversal of dabigatran anticoagulation by prothrombin complex concentrate (Beriplex P/N) in a rabbit model, J Thromb Haemost, 10, 1841, 10.1111/j.1538-7836.2012.04859.x

Godier, 2015, Management of direct oral anticoagulants for invasive procedures, J Mal Vasc, 40, 173, 10.1016/j.jmv.2015.02.004

Grottke, 2014, Prothrombin complex concentrates and a specific antidote to dabigatran are effective ex-vivo in reversing the effects of dabigatran in an anticoagulation/liver trauma experimental model, Crit Care, 18, R27, 10.1186/cc13717

Zhou, 2013, Hemostatic therapy in experimental intracerebral hemorrhage associated with rivaroxaban, Stroke, 44, 771, 10.1161/STROKEAHA.112.675231

Zhou, 2011, Hemostatic therapy in experimental intracerebral hemorrhage associated with the direct thrombin inhibitor dabigatran, Stroke, 42, 3594, 10.1161/STROKEAHA.111.624650

Miesbach, 2012, New direct oral anticoagulants: current therapeutic options and treatment recommendations for bleeding complications, Thromb Haemost, 108, 625, 10.1160/TH12-05-0319

Dickneite, 2014, Reversing the new oral anticoagulants with prothrombin complex concentrates (PCCs): what is the evidence?, Thromb Haemost, 111, 189, 10.1160/TH13-05-0431

Liotta, 2015, Reversal of the novel oral anticoagulants dabigatran, rivoraxaban, and apixaban, Curr Opin Crit Care, 21, 127, 10.1097/MCC.0000000000000181

Levy, 2013, Managing new oral anticoagulants in the perioperative and intensive care unit setting, Anesthesiology, 118, 1466, 10.1097/ALN.0b013e318289bcba

Haas, 2008, Fibrinogen in craniosynostosis surgery, Anesth Analg, 106, 725, 10.1213/ane.0b013e318163fb26

El Kady, 2009, Perioperative assessment of coagulation in paediatric neurosurgical patients using thromboelastography, Eur J Anaesthesiol, 26, 293, 10.1097/EJA.0b013e32831c8b5f

Miller, 2003, Tissue factor-activated thromboelastograms in children undergoing cardiac surgery: baseline values and comparisons, Anesth Analg, 97, 1289, 10.1213/01.ANE.0000085635.68556.22

Haizinger, 2006, Activated thrombelastogram in neonates and infants with complex congenital heart disease in comparison with healthy children, Br J Anaesth, 97, 545, 10.1093/bja/ael206

Romlin, 2011, Intraoperative thromboelastometry is associated with reduced transfusion prevalence in pediatric cardiac surgery, Anesth Analg, 112, 30, 10.1213/ANE.0b013e3181fe4674

Haas, 2015, Higher fibrinogen concentrations for reduction of transfusion requirements during major paediatric surgery: a prospective randomised controlled trial, Br J Anaesth, 115, 234, 10.1093/bja/aev136

Haas, 2012, Management of dilutional coagulopathy during pediatric major surgery, Transfus Med Hemother, 39, 114, 10.1159/000337245

Niebler, 2012, Thromboelastography in the assessment of bleeding following surgery for congenital heart disease, World J Pediatr Congenit Heart Surg, 3, 433, 10.1177/2150135112447540

Romlin, 2013, Earlier detection of coagulopathy with thromboelastometry during pediatric cardiac surgery: a prospective observational study, Paediatr Anaesth, 23, 222, 10.1111/pan.12116

Ziegler, 2013, Severe pediatric blunt trauma: successful ROTEM-guided hemostatic therapy with fibrinogen concentrate and no administration of fresh frozen plasma or platelets, Clin Appl Thromb Hemost, 19, 453, 10.1177/1076029612458149

Faraoni, 2015, Development of a specific algorithm to guide haemostatic therapy in children undergoing cardiac surgery: a single-centre retrospective study, Eur J Anaesthesiol, 32, 320, 10.1097/EJA.0000000000000179

Haas, 2014, Improvements in patient blood management for pediatric craniosynostosis surgery using a ROTEM((R))-assisted strategy: feasibility and costs, Paediatr Anaesth, 24, 774, 10.1111/pan.12341

Hazle, 2013, Fluid overload in infants following congenital heart surgery, Pediatr Crit Care Med, 14, 44, 10.1097/PCC.0b013e3182712799

Hassinger, 2014, Early postoperative fluid overload precedes acute kidney injury and is associated with higher morbidity in pediatric cardiac surgery patients, Pediatr Crit Care Med, 15, 131, 10.1097/PCC.0000000000000043

Seguin, 2014, Extent, risk factors, and outcome of fluid overload after pediatric heart surgery*, Crit Care Med, 42, 2591, 10.1097/CCM.0000000000000517

Bolliger, 2010, Pathophysiology and treatment of coagulopathy in massive hemorrhage and hemodilution, Anesthesiology, 113, 1205, 10.1097/ALN.0b013e3181f22b5a

Goobie, 2013, Population pharmacokinetics of tranexamic acid in paediatric patients undergoing craniosynostosis surgery, Clin Pharmacokinet, 52, 267, 10.1007/s40262-013-0033-1

Wesley, 2015, Pharmacokinetics of tranexamic acid in neonates, infants, and children undergoing cardiac surgery with cardiopulmonary bypass, Anesthesiology, 122, 746, 10.1097/ALN.0000000000000570

Faraoni, 2015, Experimental model of hyperfibrinolysis designed for rotational thromboelastometry in children with congenital heart disease, Blood Coagul Fibrinolysis, 26, 290, 10.1097/MBC.0000000000000238

Huntington, 2014, Minimizing blood loss during hepatectomy: a literature review, J Surg Oncol, 109, 81, 10.1002/jso.23455

Li, 2014, Controlled low central venous pressure reduces blood loss and transfusion requirements in hepatectomy, World J Gastroenterol, 20, 303, 10.3748/wjg.v20.i1.303

Lekerika, 2014, Predicting fluid responsiveness in patients undergoing orthotopic liver transplantation: effects on intraoperative blood transfusion and postoperative complications, Transplant Proc, 46, 3087, 10.1016/j.transproceed.2014.10.005

Massicotte, 2014, Relationship between conventional coagulation tests and bleeding for 600 consecutive liver transplantations, Transplantation, 98, e13, 10.1097/TP.0000000000000253

Krzanicki, 2013, Intraoperative hypercoagulability during liver transplantation as demonstrated by thromboelastography, Liver Transpl, 19, 852, 10.1002/lt.23668

Leon-Justel, 2015, Point-of-care haemostasis monitoring during liver transplantation reduces transfusion requirements and improves patient outcome, Clin Chim Acta, 446, 277, 10.1016/j.cca.2015.04.022

Fayed, 2014, Therapeutic rather than prophylactic platelet transfusion policy for severe thrombocytopenia during liver transplantation, Platelets, 25, 576, 10.3109/09537104.2013.849335

Schofield, 2014, No increase in blood transfusions during liver transplantation since the withdrawal of aprotinin, Liver Transpl, 20, 584, 10.1002/lt.23839

Roberts, 2014, HALT-IT – tranexamic acid for the treatment of gastrointestinal bleeding: study protocol for a randomised controlled trial, Trials, 15, 450, 10.1186/1745-6215-15-450

Corbett, 2012, The role of transjugular intrahepatic portosystemic stent-shunt (TIPSS) in the management of variceal hemorrhage, Liver Int, 32, 1493, 10.1111/j.1478-3231.2012.02861.x

Garcia-Pagan, 2013, Use of early-TIPS for high-risk variceal bleeding: results of a post-RCT surveillance study, J Hepatol, 58, 45, 10.1016/j.jhep.2012.08.020

Al-Jaghbeer, 2013, Blood transfusion for upper gastrointestinal bleeding: is less more again?, Crit Care, 17, 325, 10.1186/cc13020

Jairath, 2015, Restrictive versus liberal blood transfusion for acute upper gastrointestinal bleeding (TRIGGER): a pragmatic, open-label, cluster randomised feasibility trial, Lancet, 386, 137, 10.1016/S0140-6736(14)61999-1

de Franchis, 2015, Expanding consensus in portal hypertension: Report of the Baveno VI Consensus Workshop: Stratifying risk and individualizing care for portal hypertension, J Hepatol, 63, 743, 10.1016/j.jhep.2015.05.022

Tripathi, 2015, U.K. guidelines on the management of variceal haemorrhage in cirrhotic patients, Gut, 64, 1680, 10.1136/gutjnl-2015-309262

Ranghino, 2014, Assessment of platelet function analyzer (PFA-100) in kidney transplant patients before renal allograft biopsy: a retrospective single-center analysis, Transplant Proc, 46, 2259, 10.1016/j.transproceed.2014.07.052

Mannucci, 1997, Desmopressin (DDAVP) in the treatment of bleeding disorders: the first 20 years, Blood, 90, 2515, 10.1182/blood.V90.7.2515

Manno, 2011, Desmopressin acetate in percutaneous ultrasound-guided kidney biopsy: a randomized controlled trial, Am J Kidney Dis, 57, 850, 10.1053/j.ajkd.2010.12.019

Anandagoda, 2014, Desmopressin use prior to renal transplant biopsy-does it fit?, Clin Kidney J, 7, 602, 10.1093/ckj/sfu110

Devereaux, 2014, Aspirin in patients undergoing noncardiac surgery, N Engl J Med, 370, 1494, 10.1056/NEJMoa1401105

Au, 2012, Preoperative thienopyridine use and outcomes after surgery: a systematic review, Am J Med, 125, 87, 10.1016/j.amjmed.2011.07.038

Smith, 2012, Mortality benefit with prasugrel in the TRITON-TIMI 38 coronary artery bypass grafting cohort: risk-adjusted retrospective data analysis, J Am Coll Cardiol, 60, 388, 10.1016/j.jacc.2012.03.030

Price, 2012, Recovery of platelet function after discontinuation of prasugrel or clopidogrel maintenance dosing in aspirin-treated patients with stable coronary disease: the recovery trial, J Am Coll Cardiol, 59, 2338, 10.1016/j.jacc.2012.02.042

Godier, 2015, Inefficacy of platelet transfusion to reverse ticagrelor, N Engl J Med, 372, 196, 10.1056/NEJMc1409373

Baber, 2011, Impact of the everolimus-eluting stent on stent thrombosis: a meta-analysis of 13 randomized trials, J Am Coll Cardiol, 58, 1569, 10.1016/j.jacc.2011.06.049

Feres, 2013, Three vs twelve months of dual antiplatelet therapy after zotarolimus-eluting stents: the OPTIMIZE randomized trial, JAMA, 310, 2510

Hawn, 2013, Risk of major adverse cardiac events following noncardiac surgery in patients with coronary stents, JAMA, 310, 1462, 10.1001/jama.2013.278787

Fazavana, 2013, A chemically-modified inactive antithrombin as a potent antagonist of fondaparinux and heparin anticoagulant activity, J Thromb Haemost, 11, 1128, 10.1111/jth.12249

Elmer, 2012, Emergency reversal of pentasaccharide anticoagulants: a systematic review of the literature, Transfus Med, 22, 108, 10.1111/j.1365-3148.2011.01125.x

Clark, 2015, Bleeding, recurrent venous thromboembolism, and mortality risks during warfarin interruption for invasive procedures, JAMA Intern Med, 175, 1163, 10.1001/jamainternmed.2015.1843

Douketis, 2015, Perioperative bridging anticoagulation in patients with atrial fibrillation, N Engl J Med, 373, 823, 10.1056/NEJMoa1501035

Kim, 2015, Heparin bridging in warfarin anticoagulation therapy initiation could increase bleeding in nonvalvular atrial fibrillation patients: a multicenter propensity-matched analysis, J Thromb Haemost, 13, 182, 10.1111/jth.12810

Douketis, 2012, Perioperative management of antithrombotic therapy: Antithrombotic Therapy and Prevention of Thrombosis, 9th ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines, Chest, 141, e326S, 10.1378/chest.11-2298

Colomina, 2012, Perioperative use of prothrombin complex concentrates, Minerva Anestesiol, 78, 358

Makris, 2013, Guideline on the management of bleeding in patients on antithrombotic agents, Br J Haematol, 160, 35, 10.1111/bjh.12107

Pernod, 2010, French clinical practice guidelines on the management of patients on vitamin K antagonists in at-risk situations (overdose, risk of bleeding, and active bleeding), Thromb Res, 126, e167, 10.1016/j.thromres.2010.06.017

Tran, 2013, An update of consensus guidelines for warfarin reversal, Med J Aust, 198, 198, 10.5694/mja12.10614

Buller, 2012, Oral rivaroxaban for the treatment of symptomatic pulmonary embolism, N Engl J Med, 366, 1287, 10.1056/NEJMoa1113572

Cohen, 2013, Rivaroxaban for thromboprophylaxis in acutely ill medical patients, N Engl J Med, 368, 513, 10.1056/NEJMoa1111096

Mega, 2012, Rivaroxaban in patients with a recent acute coronary syndrome, N Engl J Med, 366, 9, 10.1056/NEJMoa1112277

Agnelli, 2013, Oral apixaban for the treatment of acute venous thromboembolism, N Engl J Med, 369, 799, 10.1056/NEJMoa1302507

Goldhaber, 2011, Apixaban versus enoxaparin for thromboprophylaxis in medically ill patients, N Engl J Med, 365, 2167, 10.1056/NEJMoa1110899

Alexander, 2011, Apixaban with antiplatelet therapy after acute coronary syndrome, N Engl J Med, 365, 699, 10.1056/NEJMoa1105819

Giugliano, 2013, Edoxaban versus warfarin in patients with atrial fibrillation, N Engl J Med, 369, 2093, 10.1056/NEJMoa1310907

Buller, 2013, Edoxaban versus warfarin for the treatment of symptomatic venous thromboembolism, N Engl J Med, 369, 1406, 10.1056/NEJMoa1306638

Wang, 2014, Effect of activated charcoal on apixaban pharmacokinetics in healthy subjects, Am J Cardiovasc Drugs, 14, 147, 10.1007/s40256-013-0055-y

Lehmann, 2014, Massive human rivaroxaban overdose, Thromb Haemost, 112, 834, 10.1160/TH14-02-0138

Eerenberg, 2011, Reversal of rivaroxaban and dabigatran by prothrombin complex concentrate: a randomized, placebo-controlled, crossover study in healthy subjects, Circulation, 124, 1573, 10.1161/CIRCULATIONAHA.111.029017

Glund, 2015, Safety, tolerability, and efficacy of idarucizumab for the reversal of the anticoagulant effect of dabigatran in healthy male volunteers: a randomised, placebo-controlled, double-blind phase 1 trial, Lancet, 386, 680, 10.1016/S0140-6736(15)60732-2

Pollack, 2015, Idarucizumab for dabigatran reversal, N Engl J Med, 373, 511, 10.1056/NEJMoa1502000

Siegal, 2015, Andexanet alfa for the reversal of factor Xa inhibitor activity, N Engl J Med, 373, 2413, 10.1056/NEJMoa1510991

Sie, 2011, Surgery and invasive procedures in patients on long-term treatment with direct oral anticoagulants: thrombin or factor-Xa inhibitors. Recommendations of the Working Group on Perioperative Haemostasis and the French Study Group on Thrombosis and Haemostasis, Arch Cardiovasc Dis, 104, 669, 10.1016/j.acvd.2011.09.001

Heidbuchel, 2015, Updated European Heart Rhythm Association Practical Guide on the use of nonvitamin K antagonist anticoagulants in patients with nonvalvular atrial fibrillation, Europace, 17, 1467, 10.1093/europace/euv309

Thompson, 2010, Systemic AL amyloidosis with acquired factor X deficiency: a study of perioperative bleeding risk and treatment outcomes in 60 patients, Am J Hematol, 85, 171, 10.1002/ajh.21603

Franchini, 2009, Hemostatic abnormalities in endocrine and metabolic disorders, Eur J Endocrinol, 162, 439, 10.1530/EJE-09-0958

Vescovi, 2011, The spectrum of coagulation abnormalities in thyroid disorders, Semin Thromb Hemost, 37, 007, 10.1055/s-0030-1270065

Michiels, 2001, Acquired von Willebrand syndrome type 1 in hypothyroidism: reversal after treatment with thyroxine, Clin Appl Thromb Hemost, 7, 113, 10.1177/107602960100700206

Chadarevian, 2001, Components of the fibrinolytic system are differently altered in moderate and severe hypothyroidism, J Clin Endocrinol Metab, 86, 732, 10.1210/jcem.86.2.7221

Akinci, 2007, Elevated Thrombin Activatable Fibrinolysis Inhibitor (TAFI) antigen levels in overt and subclinical hypothyroid patients were reduced by levothyroxine replacement, Endocr J, 54, 45, 10.1507/endocrj.K06-062

Chadarevian, 2005, Effect of levothyroxine replacement therapy on coagulation and fibrinolysis in severe hypothyroidism, J Endocrinol Investig, 28, 398, 10.1007/BF03347217

Franchini, 2004, High prevalence of acquired von Willebrand's syndrome in patients with thyroid diseases undergoing thyroid surgery, Haematologica, 89, 1341

Franchini, 2015, Acquired inhibitors of clotting factors: AICE recommendations for diagnosis and management, Blood Transfus, 13, 498

Kennedy, 2008, Polypharmacy in a general surgical unit and consequences of drug withdrawal, Br J Clin Pharmacol, 49, 353, 10.1046/j.1365-2125.2000.00145.x

McCloskey, 2008, Selective serotonin reuptake inhibitors: measurement of effect on platelet function, Transl Res, 151, 168, 10.1016/j.trsl.2007.10.004

de Abajo, 2011, Effects of selective serotonin reuptake inhibitors on platelet function, Drugs Aging, 28, 345, 10.2165/11589340-000000000-00000

Meijer, 2004, Association of risk of abnormal bleeding with degree of serotonin reuptake inhibition by antidepressants, Arch Intern Med, 164, 2367, 10.1001/archinte.164.21.2367

Castanheira, 2011, Chronic medication in the perioperative period: usage profile and risk management, Acta Med Port, 24, 893, 10.20344/amp.1428

Sayadipour, 2012, Antidepressants and the risk of abnormal bleeding during spinal surgery: a case–control study, Eur Spine J, 21, 2070, 10.1007/s00586-011-2132-8

van Haelst, 2010, Use of serotonergic antidepressants and bleeding risk in orthopedic patients, Anesthesiology, 112, 631, 10.1097/ALN.0b013e3181cf8fdf

Seitz, 2013, Risk of perioperative blood transfusions and postoperative complications associated with serotonergic antidepressants in older adults undergoing hip fracture surgery, J Clin Psychopharmacol, 33, 790, 10.1097/JCP.0b013e3182a58dce

Dall, 2014, The association between use of serotonergic antidepressants and perioperative bleeding during total hip arthroplasty: a cohort study, Basic Clin Pharmacol Toxicol, 115, 277, 10.1111/bcpt.12218

Schutte, 2014, SSRIs increase risk of blood transfusion in patients admitted for hip surgery, PLoS ONE, 9, e95906, 10.1371/journal.pone.0095906

Jeong, 2014, Use of serotonergic antidepressants and bleeding risk in patients undergoing surgery, Psychosomatics, 55, 213, 10.1016/j.psym.2013.08.011

Gahr, 2015, Risk of bleeding related to selective and nonselective serotonergic antidepressants: a case/noncase approach using data from two pharmacovigilance databases, Pharmacopsychiatry, 48, 19

Mahdanian, 2014, Serotonergic antidepressants and perioperative bleeding risk: a systematic review, Expert Opin Drug Saf, 13, 695

Gahr, 2015, Association between haemorrhages and treatment with selective and nonselective serotonergic antidepressants: possible implications of quantitative signal detection, Psychiatry Res, 229, 257, 10.1016/j.psychres.2015.07.024

Maschino, 2012, Bleeding adverse drug reactions (ADRs) in patients exposed to antiplatelet plus serotonin reuptake inhibitor drugs: analysis of the French Spontaneous Reporting Database for a controversial ADR, Eur J Clin Pharmacol, 68, 1557, 10.1007/s00228-012-1268-8

Montastruc, 2011, The importance of drug–drug interactions as a cause of adverse drug reactions: a pharmacovigilance study of serotoninergic reuptake inhibitors in France, Eur J Clin Pharmacol, 68, 767, 10.1007/s00228-011-1156-7

Nadkarni, 2012, Drug-drug interactions between warfarin and psychotropics: updated review of the literature, Pharmacotherapy, 32, 932, 10.1002/j.1875-9114.2012.01119

Cheng, 2015, Use of SSRI, but not SNRI, increased upper and lower gastrointestinal bleeding, Medicine, 94, e2022, 10.1097/MD.0000000000002022

Anglin, 2014, Risk of upper gastrointestinal bleeding with selective serotonin reuptake inhibitors with or without concurrent nonsteroidal anti-inflammatory use: a systematic review and meta-analysis, Am J Gastroenterol, 109, 811, 10.1038/ajg.2014.82

Jiang, 2015, Use of selective serotonin reuptake inhibitors and risk of upper gastrointestinal bleeding: a systematic review and meta-analysis, Clin Gastroenterol Hepatol, 13, 42.e3, 10.1016/j.cgh.2014.06.021

Wang, 2014, Short-term use of serotonin reuptake inhibitors and risk of upper gastrointestinal bleeding, Am J Psychiatry, 171, 54, 10.1176/appi.ajp.2013.12111467

Yoon, 2011, Valproic acid and warfarin: an underrecognized drug interaction, Neurocrit Care, 15, 182, 10.1007/s12028-011-9544-5

Kose, 2009, Valproate-associated coagulopathies in children during short-term treatment, J Child Neurol, 24, 1493, 10.1177/0883073808331084

Gerstner, 2006, Valproate-associated coagulopathies are frequent and variable in children, Epilepsia, 47, 1136, 10.1111/j.1528-1167.2006.00587.x

Koenig, 2008, High incidence of vaproate-induced coagulation disorders in children receiving valproic acid: a prospective study, Blood Coagul Fibrinolysis, 19, 375, 10.1097/MBC.0b013e3282f3f9ec

Zighetti, 2015, Effects of chronic administration of valproic acid to epileptic patients on coagulation tests and primary hemostasis, Epilepsia, 56, e49, 10.1111/epi.12952

Manohar, 2011, The effect of antiepileptic drugs on coagulation and bleeding in the perioperative period of epilepsy surgery: The Cleveland Clinic experience, J Clin Neurosci, 18, 1180, 10.1016/j.jocn.2011.02.018

Cordier, 2011, Herbal remedies affecting coagulation: a review, Pharm Biol, 50, 443, 10.3109/13880209.2011.611145

Tsai, 2013, A Review of potential harmful interactions between anticoagulant/antiplatelet agents and chinese herbal medicines, PLoS ONE, 8, e64255, 10.1371/journal.pone.0064255

McEwen, 2015, The influence of herbal medicine on platelet function and coagulation: a narrative review, Semin Thromb Hemost, 41, 300, 10.1055/s-0035-1549089

Bent, 2005, Spontaneous bleeding associated with Ginkgo biloba, J Gen Intern Med, 20, 657, 10.1007/s11606-005-0114-4

Kohler, 2004, Influence of a 7-day treatment with Ginkgo biloba special extract EGb 761 on bleeding time and coagulation: a randomized, placebo-controlled, double-blind study in healthy volunteers, Blood Coagul Fibrinolysis, 15, 303, 10.1097/00001721-200406000-00003

Kellermann, 2011, Is there a risk of bleeding associated with standardized ginkgo biloba extract therapy? A systematic review and meta-analysis, Pharmacotherapy, 31, 490, 10.1592/phco.31.5.490

Wolf, 2006, Does ginkgo biloba special extract EGb 761 Provide additional effects on coagulation and bleeding when added to acetylsalicylic acid 500 mg daily?, Drugs R&D, 7, 163, 10.2165/00126839-200607030-00003

Gardner, 2007, Effect of Ginkgo biloba (EGb 761) and aspirin on platelet aggregation and platelet function analysis among older adults at risk of cardiovascular disease: a randomized clinical trial, Blood Coagul Fibrinolysis, 18, 787, 10.1097/MBC.0b013e3282f102b1

Kim, 2014, The effect of Ginkgo biloba extracts on the pharmacokinetics and pharmacodynamics of cilostazol and its active metabolites in healthy Korean subjects, Br J Clin Pharmacol, 77, 821, 10.1111/bcp.12236

Kim, 2010, Influence of Ginkgo biloba extract on the pharmacodynamic effects and pharmacokinetic properties of ticlopidine: an open-label, randomized, two-period, two-treatment, two-sequence, single-dose crossover study in healthy Korean male volunteers, Clin Ther, 32, 380, 10.1016/j.clinthera.2010.01.027

McEwen, 2014, The influence of diet and nutrients on platelet function, Semin Thromb Hemost, 40, 214, 10.1055/s-0034-1365839

McEwen, 2015, The effect of omega-3 polyunsaturated fatty acids on fibrin and thrombin generation in healthy subjects and subjects with cardiovascular disease, Semin Thromb Hemost, 41, 315, 10.1055/s-0034-1395352

Mensah, 2015, Surgery in patients with inherited bleeding disorders, Anaesthesia, 70, 112, 10.1111/anae.12899

Rodeghiero, 2005, The discriminant power of bleeding history for the diagnosis of type 1 von Willebrand disease: an international, multicenter study, J Thromb Haemost, 3, 2619, 10.1111/j.1538-7836.2005.01663.x

Azzam, 2012, The condensed MCMDM-1 VWD bleeding questionnaire as a predictor of bleeding disorders in women with unexplained menorrhagia, Blood Coagul Fibrinolysis, 23, 311, 10.1097/MBC.0b013e32835274d9

Bidlingmaier, 2012, Prospective evaluation of a pediatric bleeding questionnaire and the ISTH bleeding assessment tool in children and parents in routine clinical practice, J Thromb Haemost, 10, 1335, 10.1111/j.1538-7836.2012.04775.x

Lowe, 2013, Utility of the ISTH bleeding assessment tool in predicting platelet defects in participants with suspected inherited platelet function disorders, J Thromb Haemost, 11, 1663, 10.1111/jth.12332

Bowman, 2008, Generation and validation of the Condensed MCMDM-1VWD Bleeding Questionnaire for von Willebrand disease, J Thromb Haemost, 6, 2062, 10.1111/j.1538-7836.2008.03182.x

Hyatt, 2009, Applying diagnostic criteria for type 1 von Willebrand disease to a pediatric population, Pediatr Blood Cancer, 52, 102, 10.1002/pbc.21755

Rodeghiero, 2007, How to estimate bleeding risk in mild bleeding disorders, J Thromb Haemost, 5, 157, 10.1111/j.1538-7836.2007.02520.x

Mauer, 2011, Impact of sex, age, race, ethnicity and aspirin use on bleeding symptoms in healthy adults, J Thromb Haemost, 9, 100, 10.1111/j.1538-7836.2010.04105.x

Quiroga, 2007, High prevalence of bleeders of unknown cause among patients with inherited mucocutaneous bleeding. A prospective study of 280 patients and 299 controls, Haematologica, 92, 357, 10.3324/haematol.10816

Tosetto, 2013, The role of bleeding history and clinical markers for the correct diagnosis of VWD, Mediterr J Hematol Infect Dis, 5, e2013051, 10.4084/mjhid.2013.051

Mittal, 2015, Utility of a Paediatric Bleeding Questionnaire as a screening tool for von Willebrand disease in apparently healthy children, Haemophilia, 21, 806, 10.1111/hae.12689

Federici, 2014, The bleeding score predicts clinical outcomes and replacement therapy in adults with von Willebrand disease, Blood, 123, 4037, 10.1182/blood-2014-02-557264

Castaman, 2012, Different bleeding risk in type 2A and 2 M von Willebrand disease: a 2-year prospective study in 107 patients, J Thromb Haemost, 10, 632, 10.1111/j.1538-7836.2012.04661.x

Ahmad, 2013, Surgeon and haematologist: a review of comprehensive care for patients with inherited bleeding disorders in Northern Ireland, Int J Surg, 11, 22, 10.1016/j.ijsu.2012.12.005

Chevalier, 2013, Seventy-two total knee arthroplasties performed in patients with haemophilia using continuous infusion, Vox Sang, 104, 135, 10.1111/j.1423-0410.2012.01653.x

Kulkarni, 2013, Comprehensive care of the patient with haemophilia and inhibitors undergoing surgery: practical aspects, Haemophilia, 19, 2, 10.1111/j.1365-2516.2012.02922.x

Lingohr, 2014, Value and risk of laparoscopic surgery in hemophiliacs – experiences from a tertiary referral center for hemorrhagic diatheses, Langenbecks Arch Surg, 399, 609, 10.1007/s00423-014-1185-7

Poenaru, 2014, Orthopaedic and surgical features in the management of patients with haemophilia, Eur J Orthop Surg Traumatol, 24, 685, 10.1007/s00590-013-1361-4

Hart, 2015, A standardized treatment regimen for patients with severe haemophilia A undergoing orthopaedic or trauma surgery: a single centre experience, Blood Coagul Fibrinolysis, 26, 396, 10.1097/MBC.0000000000000281

Serban, 2014, Risks and challenges of orthopaedic invasive interventions in haemophilia in a low-resource country. A single-center experience, Hamostaseologie, 34, S30, 10.5482/HAMO-14-01-0007

Hermans, 2009, Replacement therapy for invasive procedures in patients with haemophilia: literature review, European survey and recommendations, Haemophilia, 15, 639, 10.1111/j.1365-2516.2008.01950.x

Sikkema, 2011, A comparison between the complications and long-term outcome of hip and knee replacement therapy in patients with and without haemophilia; a controlled retrospective cohort study, Haemophilia, 17, 300, 10.1111/j.1365-2516.2010.02408.x

Jenkins, 2013, Total knee replacement in patients with haemophilia: the Scottish experience, Scott Med J, 58, 223, 10.1177/0036933013507870

Rogenhofer, 2013, Urological surgery in patients with hemorrhagic bleeding disorders Hemophilia A, Hemophilia B, von Willebrand disease: a retrospective study with matched pairs analysis, World J Urol, 31, 703, 10.1007/s00345-012-0988-9

Karaman, 2014, Circumcision in bleeding disorders: improvement of our cost effective method with diathermic knife, Urol J, 11, 1406

Barg, 2015, Total ankle replacement in patients with bleeding disorders, Orthopade, 44, 623, 10.1007/s00132-015-3107-y

Westberg, 2014, Haemophilic arthropathy: long-term outcomes in 107 primary total knee arthroplasties, Knee, 21, 147, 10.1016/j.knee.2013.09.010

Cancienne, 2015, Complications after TKA in patients with hemophilia or Von Willebrand's disease, J Arthroplasty, 30, 2285, 10.1016/j.arth.2015.06.015

Aryal, 2011, General surgery in patients with a bleeding diathesis: how we do it, World J Surg, 35, 2603, 10.1007/s00268-011-1265-6

Goldmann, 2010, Perioperative management and outcome of general and abdominal surgery in hemophiliacs, Am J Surg, 199, 702, 10.1016/j.amjsurg.2009.02.018

Panotopoulos, 2012, Surgical treatment of the haemophilic pseudotumour: a single centre experience, Int Orthop, 36, 2157, 10.1007/s00264-012-1593-7

Lim, 2014, Clinical features and management of haemophilic pseudotumours: a single US centre experience over a 30-year period, Haemophilia, 20, e58, 10.1111/hae.12295

Inokawa, 2014, Hepatectomy for hepatocellular carcinoma in patients with hemophilia, J Hepatobiliary Pancreat Sci, 21, 824, 10.1002/jhbp.142

Lim, 2012, Outcomes of management of acute coronary syndrome in patients with congenital bleeding disorders: a single center experience and review of the literature, Thromb Res, 130, 316, 10.1016/j.thromres.2012.02.050

Tuinenburg, 2013, Cardiac catheterization and intervention in haemophilia patients: prospective evaluation of the 2009 institutional guideline, Haemophilia, 19, 370, 10.1111/hae.12109

Fogarty, 2015, Presentation and management of acute coronary syndromes among adult persons with haemophilia: results of an international, retrospective, 10-year survey, Haemophilia, 21, 589, 10.1111/hae.12652

Tintillier, 2013, Colonoscopy in patients with haemophilia: the duration of clotting factor coverage must be adjusted to suit the procedure, Haemophilia, 19, e296, 10.1111/hae.12174

Escobar, 2012, Multidisciplinary management of patients with haemophilia with inhibitors undergoing surgery in the United States: perspectives and best practices derived from experienced treatment centres, Haemophilia, 18, 971, 10.1111/j.1365-2516.2012.02894.x

Shapiro, 2012, U.S. survey of surgical capabilities and experience with surgical procedures in patients with congenital haemophilia with inhibitors, Haemophilia, 18, 400, 10.1111/j.1365-2516.2011.02698.x

Caviglia, 2015, Haemophilia pseudotumours in patients with inhibitors, Haemophilia, 21, 681, 10.1111/hae.12632

Stoof, 2015, Primary postpartum haemorrhage in women with von Willebrand disease or carriership of haemophilia despite specialised care: a retrospective survey, Haemophilia, 21, 505, 10.1111/hae.12635

Ljung, 2012, How to manage invasive procedures in children with haemophilia, Br J Haematol, 157, 519, 10.1111/j.1365-2141.2012.09089.x

Sun, 2013, Posttonsillectomy hemorrhage in children with von Willebrand disease or hemophilia, JAMA Otolaryngol Head Neck Surg, 139, 245, 10.1001/jamaoto.2013.1821

Watts, 2012, Operative management and outcomes in children with congenital bleeding disorders: a retrospective review at a single haemophilia treatment centre, Haemophilia, 18, 421, 10.1111/j.1365-2516.2011.02667.x

Garcia-Matte, 2012, Management of children with inherited mild bleeding disorders undergoing adenotonsillar procedures, Int J Pediatr Otorhinolaryngol, 76, 291, 10.1016/j.ijporl.2011.11.024

Santoro, 2012, Haemostasis prophylaxis using single dose desmopressin acetate and extended use epsilon aminocaproic acid for adenotonsillectomy in patients with type 1 von Willebrand disease, Haemophilia, 18, 200, 10.1111/j.1365-2516.2011.02619.x

Jimenez-Yuste, 2002, Otolaryngologic surgery in children with von Willebrand disease, Arch Otolaryngol Head Neck Surg, 128, 1365, 10.1001/archotol.128.12.1365

Sanchez-Luceros, 2010, Biological and clinical response to desmopressin (DDAVP) in a retrospective cohort study of children with low von Willebrand factor levels and bleeding history, Thromb Haemost, 104, 984, 10.1160/TH10-04-0220

Dunn, 2010, Adenotonsillectomy in patients with desmopressin responsive mild bleeding disorders: a review of the literature, Haemophilia, 16, 711, 10.1111/j.1365-2516.2009.02145.x

Rodriguez, 2010, Posttonsillectomy bleeding in children with von Willebrand disease: a single-institution experience, Otolaryngol Head Neck Surg, 142, 715, 10.1016/j.otohns.2010.01.029

Witmer, 2009, Incidence of bleeding complications in pediatric patients with type 1 von Willebrand disease undergoing adenotonsillar procedures, J Pediatr, 155, 68, 10.1016/j.jpeds.2009.01.051

Kearney, 2015, Neonatal circumcision in severe haemophilia: a survey of paediatric haematologists at United States Hemophilia Treatment Centers, Haemophilia, 21, 52, 10.1111/hae.12528

Elalfy, 2012, Risk of bleeding and inhibitor development after circumcision of previously untreated or minimally treated severe hemophilia A children, Pediatr Hematol Oncol, 29, 485, 10.3109/08880018.2012.704624

Rodriguez, 2010, To circumcise or not to circumcise? Circumcision in patients with bleeding disorders, Haemophilia, 16, 272, 10.1111/j.1365-2516.2009.02119.x

Yilmaz, 2010, A single centre experience in circumcision of haemophilia patients: Izmir protocol, Haemophilia, 16, 888, 10.1111/j.1365-2516.2010.02324.x

Sasmaz, 2012, Circumcision and complications in patients with haemophilia in southern part of Turkey: Cukurova experience, Haemophilia, 18, 426, 10.1111/j.1365-2516.2011.02706.x

Mansouritorghabeh, 2013, Circumcision in males with bleeding disorders, Mediterr J Hematol Infect Dis, 5, e2013004, 10.4084/mjhid.2013.004

Peisker, 2014, Management of dental extraction in patients with haemophilia A and B: a report of 58 extractions, Med Oral Patol Oral Cir Bucal, 19, e55, 10.4317/medoral.19191

Zanon, 2000, Proposal of a standard approach to dental extraction in haemophilia patients. A case-control study with good results, Haemophilia, 6, 533, 10.1046/j.1365-2516.2000.00423.x

Frachon, 2005, Management options for dental extraction in hemophiliacs: a study of 55 extractions (2000-2002), Oral Surg Oral Med Oral Pathol Oral Radiol Endod, 99, 270, 10.1016/j.tripleo.2004.06.071

Franchini, 2005, Dental procedures in adult patients with hereditary bleeding disorders: 10 years experience in three Italian Hemophilia Centers, Haemophilia, 11, 504, 10.1111/j.1365-2516.2005.01132.x

Anderson, 2013, Guidance on the dental management of patients with haemophilia and congenital bleeding disorders, Br Dent J, 215, 497, 10.1038/sj.bdj.2013.1097

Hewson, 2011, Dental surgery with minimal factor support in the inherited bleeding disorder population at the Alfred Hospital, Haemophilia, 17, e185, 10.1111/j.1365-2516.2010.02346.x

Givol, 2015, Oral surgery-associated postoperative bleeding in haemophilia patients: a tertiary centre's two decade experience, Haemophilia, 21, 234, 10.1111/hae.12573

Hirose, 2013, The risk of elective orthopaedic surgery for haemophilia patients: Japanese single-centre experience, Haemophilia, 19, 951, 10.1111/hae.12209

Wallny, 2014, Elective total knee arthroplasty in haemophilic patients. Proposal for a clinical pathway, Hamostaseologie, 34, S23, 10.5482/HAMO-14-01-0004

Solimeno, 2009, Factors influencing the long-term outcome of primary total knee replacement in haemophiliacs: a review of 116 procedures at a single institution, Br J Haematol, 145, 227, 10.1111/j.1365-2141.2009.07613.x

Bolton-Maggs, 2006, A review of inherited platelet disorders with guidelines for their management on behalf of the UKHCDO, Br J Haematol, 135, 603, 10.1111/j.1365-2141.2006.06343.x

Keeling, 2008, Guideline on the selection and use of therapeutic products to treat haemophilia and other hereditary bleeding disorders. A United Kingdom Haemophilia Center Doctors’ Organisation (UKHCDO) guideline approved by the British Committee for Standards in Haematology, Haemophilia, 14, 671, 10.1111/j.1365-2516.2008.01695.x

Nichols, 2008, von Willebrand disease (VWD): evidence-based diagnosis and management guidelines, the National Heart, Lung, and Blood Institute (NHLBI) Expert Panel report (USA), Haemophilia, 14, 171, 10.1111/j.1365-2516.2007.01643.x

Habermann, 2007, Total hip replacement in patients with severe bleeding disorders. A 30 years single center experience, Int Orthop, 31, 17, 10.1007/s00264-006-0136-5

Srivastava, 2013, Guidelines for the management of hemophilia, Haemophilia, 19, e1, 10.1111/j.1365-2516.2012.02909.x

Giangrande, 2014, The European standards of Haemophilia Centres, Blood Transfus, 12, s525

Candura, 2014, The methodology for defining the European standards for the certification of Haemophilia Centres in Europe, Blood Transfus, 12, s519

Coppola, 2015, Treatment for preventing bleeding in people with haemophilia or other congenital bleeding disorders undergoing surgery., Cochrane Database Syst Rev, 2, CD009961

Laffan, 2014, The diagnosis and management of von Willebrand disease: a United Kingdom Haemophilia Centre Doctors Organization guideline approved by the British Committee for Standards in Haematology, Br J Haematol, 167, 453, 10.1111/bjh.13064

Rocino, 2014, Principles of treatment and update of recommendations for the management of haemophilia and congenital bleeding disorders in Italy, Blood Transfus, 12, 575

Federici, 2011, Management of inherited von Willebrand disease in Italy: results from the retrospective study on 1234 patients, Semin Thromb Hemost, 37, 511, 10.1055/s-0031-1281037

Nitu-Whalley, 2001, Retrospective review of the management of elective surgery with desmopressin and clotting factor concentrates in patients with von Willebrand disease, Am J Hematol, 66, 280, 10.1002/ajh.1058

Morimoto, 2005, Haemostatic management of intraoral bleeding in patients with von Willebrand disease, Oral Dis, 11, 243, 10.1111/j.1601-0825.2005.01111.x

Revel-Vilk, 2003, Desmopressin (DDAVP) responsiveness in children with von Willebrand disease, J Pediatr Hematol Oncol, 25, 874, 10.1097/00043426-200311000-00010

Garcia-Matte, 2012, Use of desmopressin in children with inherited platelet dysfunctions undergoing adenotonsillar procedures, Acta Otorrinolaringol Esp, 63, 115, 10.1016/j.otoeng.2012.03.009

Leissinger, 2014, Desmopressin (DDAVP) in the management of patients with congenital bleeding disorders, Haemophilia, 20, 158, 10.1111/hae.12254

Trigg, 2012, A systematic review: the use of desmopressin for treatment and prophylaxis of bleeding disorders in pregnancy, Haemophilia, 18, 25, 10.1111/j.1365-2516.2011.02573.x

Windyga, 2016, Practical aspects of DDAVP use in patients with von Willebrand Disease undergoing invasive procedures: a European survey, Haemophilia, 22, 110, 10.1111/hae.12763

Sharma, 2014, Hyponatremia after desmopressin (DDAVP) use in pediatric patients with bleeding disorders undergoing surgeries, J Pediatr Hematol Oncol, 36, e371, 10.1097/MPH.0000000000000185

Gill, 2015, Hemostatic efficacy, safety, and pharmacokinetics of a recombinant von Willebrand factor in severe von Willebrand disease, Blood, 126, 2038, 10.1182/blood-2015-02-629873

Neff, 2014, Management of VWD, Hematology Am Soc Hematol Educ Program, 2014, 536, 10.1182/asheducation-2014.1.536

Castaman, 2011, Treatment of von Willebrand disease with FVIII/VWF concentrates, Blood Transfus, 9, s9

Lillicrap, 2002, Efficacy and safety of the factor VIII/von Willebrand factor concentrate, Haemate-P/Humate-P: ristocetin cofactor unit dosing in patients with von Willebrand disease, Thromb Haemost, 87, 224, 10.1055/s-0037-1612977

Howman, 2011, The clinical efficacy and safety of the FVIII/VWF concentrate, BIOSTATE(R), in children with von Willebrand disorder: a multicentre retrospective review, Haemophilia, 17, 463, 10.1111/j.1365-2516.2010.02445.x

Gill, 2011, von Willebrand factor/factor VIII concentrate (Humate-P) for management of elective surgery in adults and children with von Willebrand disease, Haemophilia, 17, 895, 10.1111/j.1365-2516.2011.02534.x

Mannucci, 2013, Prophylactic efficacy and pharmacokinetically guided dosing of a von Willebrand factor/factor VIII concentrate in adults and children with von Willebrand's disease undergoing elective surgery: a pooled and comparative analysis of data from USA and European Union clinical trials, Blood Transfus, 11, 533

Khair, 2015, Wilate use in 47 children with von Willebrand disease: the North London paediatric haemophilia network experience, Haemophilia, 21, e44, 10.1111/hae.12497

Franchini, 2003, Efficacy and safety of factor VIII/von Willebrand's factor concentrate (Haemate-P) in preventing bleeding during surgery or invasive procedures in patients with von Willebrand disease, Haematologica, 88, 1279

Thompson, 2004, Successful treatment for patients with von Willebrand disease undergoing urgent surgery using factor VIII/VWF concentrate (Humate-P), Haemophilia, 10, 42, 10.1046/j.1351-8216.2003.00809.x

Federici, 2007, Clinical use of Haemate P in inherited von Willebrand's disease: a cohort study on 100 Italian patients, Haematologica, 92, 944, 10.3324/haematol.11124

Lethagen, 2007, von Willebrand factor/factor VIII concentrate (Haemate P) dosing based on pharmacokinetics: a prospective multicenter trial in elective surgery, J Thromb Haemost, 5, 1420, 10.1111/j.1538-7836.2007.02588.x

Hernandez-Navarro, 2008, Clinical efficacy in bleeding and surgery in von Willebrand patients treated with Fanhdi a highly purified, doubly inactivated FVIII/VWF concentrate, Haemophilia, 14, 963, 10.1111/j.1365-2516.2008.01784.x

Rivard, 2008, Efficacy of factor VIII/von Willebrand factor concentrate Alphanate in preventing excessive bleeding during surgery in subjects with von Willebrand disease, Haemophilia, 14, 271, 10.1111/j.1365-2516.2007.01616.x

Viswabandya, 2008, Successful surgical haemostasis in patients with von Willebrand disease with Koate DVI, Haemophilia, 14, 763, 10.1111/j.1365-2516.2008.01755.x

Dunkley, 2010, Clinical efficacy and safety of the factor VIII/von Willebrand factor concentrate BIOSTATE in patients with von Willebrand's disease: a prospective multicentre study, Haemophilia, 16, 615, 10.1111/j.1365-2516.2010.02206.x

Federici, 2010, Efficacy and safety of highly purified, doubly virus-inactivated VWF/FVIII concentrates in inherited von Willebrand's disease: results of an Italian cohort study on 120 patients characterized by bleeding severity score, Haemophilia, 16, 101, 10.1111/j.1365-2516.2009.02088.x

Windyga, 2014, Efficacy and safety of a recombinant factor IX (Bax326) in previously treated patients with severe or moderately severe haemophilia B undergoing surgical or other invasive procedures: a prospective, open-label, uncontrolled, multicentre, phase III study, Haemophilia, 20, 651, 10.1111/hae.12419

Castaman, 2013, Efficacy and safety during formulation switch of a pasteurized VWF/FVIII concentrate: results from an Italian prospective observational study in patients with von Willebrand disease, Haemophilia, 19, 82, 10.1111/hae.12005

Batty, 2014, Safety and efficacy of a von Willebrand factor/factor VIII concentrate (Wilate(R)): a single centre experience, Haemophilia, 20, 846, 10.1111/hae.12496

Siboni, 2014, Orthopaedic surgery in patients with von Willebrand disease, Haemophilia, 20, 133, 10.1111/hae.12258

Michiels, 2009, Managing patients with von Willebrand disease type 1, 2 and 3 with desmopressin and von Willebrand factor-factor VIII concentrate in surgical settings, Acta Haematol, 121, 167, 10.1159/000214857

Di Paola, 2011, Presurgical pharmacokinetic analysis of a von Willebrand factor/factor VIII (VWF/FVIII) concentrate in patients with von Willebrand's disease (VWD) has limited value in dosing for surgery, Haemophilia, 17, 752, 10.1111/j.1365-2516.2011.02583.x

van Vliet, 2008, PFA-100 monitoring of von Willebrand factor (VWF) responses to desmopressin (DDAVP) and factor VIII/VWF concentrate substitution in von Willebrand disease type 1 and 2, Thromb Haemost, 100, 462, 10.1160/TH07-08-0527

Makris, 2002, Venous thrombosis following the use of intermediate purity FVIII concentrate to treat patients with von Willebrand's disease, Thromb Haemost, 88, 387, 10.1055/s-0037-1613227

Girolami, 2015, Venous thrombosis in von Willebrand disease as observed in one centre and as reported in the literature, Blood Coagul Fibrinolysis, 26, 54, 10.1097/MBC.0000000000000179

Gill, 2014, Thromboembolic incidence with transiently elevated levels of coagulation factors in patients with von Willebrand disease treated with VWF:FVIII concentrate during surgery, Haemophilia, 20, e404, 10.1111/hae.12498

Mannucci, 2009, Evidence-based recommendations on the treatment of von Willebrand disease in Italy, Blood Transfus, 7, 117

Gresele, 2014, Diagnosis of suspected inherited platelet function disorders: results of a worldwide survey, J Thromb Haemost, 12, 1562, 10.1111/jth.12650

Coppola, 2008, Desmopressin in inherited disorders of platelet function, Haemophilia, 14, 31, 10.1111/j.1365-2516.2007.01607.x

Alamelu, 2010, Modern management of severe platelet function disorders, Br J Haematol, 149, 813, 10.1111/j.1365-2141.2010.08191.x

Karger, 2007, Diagnostic performance of the platelet function analyzer (PFA-100) for the detection of disorders of primary haemostasis in patients with a bleeding history-a systematic review and meta-analysis, Platelets, 18, 249, 10.1080/09537100601100366

Podda, 2007, Usefulness of PFA-100 testing in the diagnostic screening of patients with suspected abnormalities of hemostasis: comparison with the bleeding time, J Thromb Haemost, 5, 2393, 10.1111/j.1538-7836.2007.02752.x

Marcus, 2011, The power of a standardized bleeding score in diagnosing paediatric type 1 von Willebrand's disease and platelet function defects, Haemophilia, 17, 223, 10.1111/j.1365-2516.2010.02390.x

Gresele, 2015, Diagnosis of inherited platelet function disorders: guidance from the SSC of the ISTH, J Thromb Haemost, 13, 314, 10.1111/jth.12792

Tosetto, 2009, Management of bleeding and of invasive procedures in patients with platelet disorders and/or thrombocytopenia: Guidelines of the Italian Society for Haemostasis and Thrombosis (SISET), Thromb Res, 124, e13, 10.1016/j.thromres.2009.06.009

Rao, 1995, Mechanisms of platelet dysfunction and response to DDAVP in patients with congenital platelet function defects. A double-blind placebo-controlled trial, Thromb Haemost, 74, 1071, 10.1055/s-0038-1649884

Koscielny, 2004, A practical concept for preoperative management of patients with impaired primary hemostasis, Clin Appl Thromb Hemost, 10, 155, 10.1177/107602960401000206

Siegmund, 2011, Desmopressin parenteral in patients with VWD1, VWD 2A and thrombocytopathy, Hamostaseologie, 31, S29, 10.1055/s-0037-1619746

Tauer, 2011, Evaluation of desmopressin effect on primary haemostasis in pediatric patients with aspirin-like defect as hereditary thrombocytopathy, Klin Padiatr, 223, 169, 10.1055/s-0031-1275347

Colucci, 2014, The effect of desmopressin on platelet function: a selective enhancement of procoagulant COAT platelets in patients with primary platelet function defects, Blood, 123, 1905, 10.1182/blood-2013-04-497123

Rajpurkar, 2014, Use of recombinant activated factor VII in patients with Glanzmann's thrombasthenia: a review of the literature, Haemophilia, 20, 464, 10.1111/hae.12473

Poon, 2015, The international, prospective Glanzmann Thrombasthenia Registry: treatment and outcomes in surgical intervention, Haematologica, 100, 1038

Di Minno, 2015, The international, prospective Glanzmann Thrombasthenia Registry: treatment modalities and outcomes of nonsurgical bleeding episodes in patients with Glanzmann thrombasthenia, Haematologica, 100, 1031

Balduini, 2013, Inherited thrombocytopenias frequently diagnosed in adults, J Thromb Haemost, 11, 1006, 10.1111/jth.12196

Weber, 2011, Tranexamic acid partially improves platelet function in patients treated with dual antiplatelet therapy, Eur J Anaesthesiol, 28, 57, 10.1097/EJA.0b013e32834050ab

Hennewig, 2005, Bleeding and surgery in children with Glanzmann thrombasthenia with and without the use of recombinant factor VII a, Klin Padiatr, 217, 365, 10.1055/s-2005-872523

Blanchette, 2014, Definitions in hemophilia: communication from the SSC of the ISTH, J Thromb Haemost, 12, 1935, 10.1111/jth.12672

Franchini, 2010, Mild hemophilia A, J Thromb Haemost, 8, 421, 10.1111/j.1538-7836.2009.03717.x

Franchini, 2015, Acquired inhibitors of clotting factors: AICE recommendations for diagnosis and management, Blood Transfus, 13, 498

Young, 2013, Thrombin generation and whole blood viscoelastic assays in the management of hemophilia: current state of art and future perspectives, Blood, 121, 1944, 10.1182/blood-2012-08-378935

Srivastava, 1998, Low-dose intermittent factor replacement for postoperative haemostasis in haemophilia, Haemophilia, 4, 799, 10.1046/j.1365-2516.1998.00161.x

Wong, 2012, Perioperative clotting factor replacement and infection in total knee arthroplasty, Haemophilia, 18, 607, 10.1111/j.1365-2516.2011.02728.x

Franchini, 2010, Plasma-derived versus recombinant Factor VIII concentrates for the treatment of haemophilia A: recombinant is better, Blood Transfus, 8, 292

Mannucci, 2010, Plasma-derived versus recombinant factor VIII concentrates for the treatment of haemophilia A: plasma-derived is better, Blood Transfus, 8, 288

Fischer, 2015, Inhibitor development in haemophilia according to concentrate. Four-year results from the European HAemophilia Safety Surveillance (EUHASS) project, Thromb Haemost, 113, 968, 10.1160/TH14-10-0826

Windyga, 2010, BDDrFVIII (Moroctocog alfa [AF-CC]) for surgical haemostasis in patients with haemophilia A: results of a pivotal study, Haemophilia, 16, 731, 10.1111/j.1365-2516.2010.02239.x

Santagostino, 2015, Safety and efficacy of turoctocog alfa (NovoEight(R)) during surgery in patients with haemophilia A: results from the multinational guardian clinical trials, Haemophilia, 21, 34, 10.1111/hae.12518

Mancuso, 2012, Source and purity of factor VIII products as risk factors for inhibitor development in patients with hemophilia A, J Thromb Haemost, 10, 781, 10.1111/j.1538-7836.2012.04691.x

Marcucci, 2015, Type and intensity of FVIII exposure on inhibitor development in PUPs with haemophilia A. A patient-level meta-analysis, Thromb Haemost, 113, 958, 10.1160/TH14-07-0621

Ragni, 2002, Use of recombinant factor IX in subjects with haemophilia B undergoing surgery, Haemophilia, 8, 91, 10.1046/j.1365-2516.2002.00587.x

Lissitchkov, 2011, A clinical study assessing the pharmacokinetics, efficacy and safety of AlphaNine((R)), a high-purity factor IX concentrate, in patients with severe haemophilia B, Haemophilia, 17, 590, 10.1111/j.1365-2516.2010.02470.x

Mauser-Bunschoten, 2011, An ultrapure plasma-derived monoclonal antibody-purified factor IX concentrate (Nonafact(R)), results of phase III and IV clinical studies, Haemophilia, 17, 439, 10.1111/j.1365-2516.2010.02453.x

Quon, 2011, Safety and efficacy of plasma-derived coagulation factor IX concentrate (AlphaNine(R) SD) in patients with haemophilia B undergoing surgical intervention: a single institution retrospective analysis, Haemophilia, 17, e196, 10.1111/j.1365-2516.2010.02354.x

Perez-Garrido, 2012, Efficacy of factor IX Grifols((R)) in surgery: experience of an international multicentre retrospective study, Haemophilia, 18, e372, 10.1111/j.1365-2516.2012.02919.x

Uprichard, 2012, Factor IX replacement to cover total knee replacement surgery in haemophilia B: a single-centre experience, 2000-2010, Haemophilia, 18, 46, 10.1111/j.1365-2516.2011.02552.x

Powell, 2015, Long-acting recombinant factor IX Fc fusion protein (rFIXFc) for perioperative management of subjects with haemophilia B in the phase 3 B-LONG study, Br J Haematol, 168, 124, 10.1111/bjh.13112

Batorova, 2000, Intermittent injections vs. continuous infusion of factor VIII in haemophilia patients undergoing major surgery, Br J Haematol, 110, 715, 10.1046/j.1365-2141.2000.02226.x

Schulman, 2004, Minimizing factor requirements for surgery without increased risk, Haemophilia, 10, 35, 10.1111/j.1745-6584.2005.0048.x

Stieltjes, 2004, Continuous infusion of B-domain deleted recombinant factor VIII (ReFacto) in patients with haemophilia A undergoing surgery: clinical experience, Haemophilia, 10, 452, 10.1111/j.1365-2516.2004.01013.x

Negrier, 2008, Surgical evaluation of a recombinant factor VIII prepared using a plasma/albumin-free method: efficacy and safety of Advate in previously treated patients, Thromb Haemost, 100, 217, 10.1160/TH08-02-0117

Auerswald, 2014, Prospective study of continuous infusion with Beriate(R) P in patients with severe haemophilia A undergoing surgery: a subgroup analysis, Thromb Res, 134, S43, 10.1016/j.thromres.2013.10.009

Eckhardt, 2009, Intensive peri-operative use of factor VIII and the Arg593-->Cys mutation are risk factors for inhibitor development in mild/moderate hemophilia A, J Thromb Haemost, 7, 930, 10.1111/j.1538-7836.2009.03357.x

Auerswald, 2013, No inhibitor development after continuous infusion of factor concentrates in subjects with bleeding disorders undergoing surgery: a prospective study, Haemophilia, 19, 438, 10.1111/hae.12075

Meijer, 2015, Continuous infusion of recombinant factor VIII formulated with sucrose in surgery: noninterventional, observational study in patients with severe haemophilia A, Haemophilia, 21, e19, 10.1111/hae.12530

Boban, 2015, The use of short-term central venous catheters for optimizing continuous infusion of coagulation factor concentrate in haemophilia patients undergoing major surgical procedures, Haemophilia, 21, e364, 10.1111/hae.12722

Iorio, 2010, Recombinant Factor VIIa concentrate versus plasma derived concentrates for the treatment of acute bleeding episodes in people with haemophilia and inhibitors., Cochrane Database Syst Rev, 8, CD004449

Johansson, 2010, Evidence supporting the use of recombinant activated factor VII in congenital bleeding disorders, Drug Des Devel Ther, 4, 107, 10.2147/DDDT.S11764

Valentino, 2010, Assessing the benefits of FEIBA prophylaxis in haemophilia patients with inhibitors, Haemophilia, 16, 263, 10.1111/j.1365-2516.2009.02126.x

Birschmann, 2013, Results of the WIRK prospective, noninterventional observational study of recombinant activated factor VII (rFVIIa) in patients with congenital haemophilia with inhibitors and other bleeding disorders, Haemophilia, 19, 679, 10.1111/hae.12156

Rangarajan, 2011, Experience of four UK comprehensive care centres using FEIBA(R) for surgeries in patients with inhibitors, Haemophilia, 17, 28, 10.1111/j.1365-2516.2010.02360.x

Zulfikar, 2012, Efficacy of FEIBA for acute bleeding and surgical haemostasis in haemophilia A patients with inhibitors: a multicentre registry in Turkey, Haemophilia, 18, 383, 10.1111/j.1365-2516.2011.02693.x

Rangarajan, 2013, Consensus recommendations for the use of FEIBA((R)) in haemophilia A patients with inhibitors undergoing elective orthopaedic and nonorthopaedic surgery, Haemophilia, 19, 294, 10.1111/hae.12028

Holmstrom, 2012, Combined treatment with APCC (FEIBA(R)) and tranexamic acid in patients with haemophilia A with inhibitors and in patients with acquired haemophilia A – a two-centre experience, Haemophilia, 18, 544, 10.1111/j.1365-2516.2012.02748.x

Valentino, 2011, Surgical experience with rFVIIa (NovoSeven) in congenital haemophilia A and B patients with inhibitors to factors VIII or IX, Haemophilia, 17, 579, 10.1111/j.1365-2516.2010.02460.x

Takedani, 2015, Ten-year experience of recombinant activated factor VII use in surgical patients with congenital haemophilia with inhibitors or acquired haemophilia in Japan, Haemophilia, 21, 374, 10.1111/hae.12611

Boadas, 2011, Elective surgery in patients with congenital coagulopathies and inhibitors: experience of the National Haemophilia Centre of Venezuela, Haemophilia, 17, 422, 10.1111/j.1365-2516.2010.02427.x

Young, 2012, Dosing and effectiveness of recombinant activated factor VII (rFVIIA) in congenital haemophilia with inhibitors by bleed type and location: the experience of the Haemophilia and Thrombosis Research Society (HTRS) Registry (2004-2008), Haemophilia, 18, 990, 10.1111/j.1365-2516.2012.02864.x

Santagostino, 2015, Recombinant activated factor VII in the treatment of bleeds and for the prevention of surgery-related bleeding in congenital haemophilia with inhibitors, Blood Rev, 29, S9, 10.1016/S0268-960X(15)30003-5

Shapiro, 2014, Safety of recombinant activated factor VII (rFVIIa) in patients with congenital haemophilia with inhibitors: overall rFVIIa exposure and intervals following high (>240 mug kg(-)(1)) rFVIIa doses across clinical trials and registries, Haemophilia, 20, e23, 10.1111/hae.12329

Valentino, 2015, Should antiinhibitor coagulant complex and tranexamic acid be used concomitantly?, Haemophilia, 21, 709, 10.1111/hae.12723

Matino, 2015, Recombinant factor VIIa concentrate versus plasma-derived concentrates for treating acute bleeding episodes in people with haemophilia and inhibitors., Cochrane Database Syst Rev, 12, CD004449

Treur, 2009, Efficacy of recombinant activated factor VII vs. activated prothrombin complex concentrate for patients suffering from haemophilia complicated with inhibitors: a Bayesian meta-regression, Haemophilia, 15, 420, 10.1111/j.1365-2516.2008.01956.x

Collins, 2013, Diagnosis and treatment of factor VIII and IX inhibitors in congenital haemophilia: (4th edition). UK Haemophilia Centre Doctors Organization, Br J Haematol, 160, 153, 10.1111/bjh.12091

Caviglia, 2011, Elective orthopaedic surgery for haemophilia patients with inhibitors: single centre experience of 40 procedures and review of the literature, Haemophilia, 17, 910, 10.1111/j.1365-2516.2011.02504.x

Ju, 2015, The efficacy of bypassing agents in surgery of hemophilia patients with inhibitors, Blood Res, 50, 173, 10.5045/br.2015.50.3.173

Teitel, 2009, Orthopaedic surgery in haemophilia patients with inhibitors: a practical guide to haemostatic, surgical and rehabilitative care, Haemophilia, 15, 227, 10.1111/j.1365-2516.2008.01840.x

Hay, 2011, Systematic literature review of economics analysis on treatment of mild-to-moderate bleeds with aPCC versus rFVIIa, J Med Econ, 14, 516, 10.3111/13696998.2011.595462

Knight, 2009, A systematic review of the cost-effectiveness of rFVIIa and APCC in the treatment of minor/moderate bleeding episodes for haemophilia patients with inhibitors, Haemophilia, 15, 405, 10.1111/j.1365-2516.2008.01969.x

Jimenez-Yuste, 2013, Cost-effectiveness of recombinant activated factor VII vs. plasma-derived activated prothrombin complex concentrate in the treatment of mild-to-moderate bleeding episodes in patients with severe haemophilia A and inhibitors in Spain, Haemophilia, 19, 841, 10.1111/hae.12199

Giangrande, 2009, Consensus protocol for the use of recombinant activated factor VII [eptacog alfa (activated); NovoSeven] in elective orthopaedic surgery in haemophilic patients with inhibitors, Haemophilia, 15, 501, 10.1111/j.1365-2516.2008.01952.x

Dargaud, 2010, Prospective assessment of thrombin generation test for dose monitoring of bypassing therapy in hemophilia patients with inhibitors undergoing elective surgery, Blood, 116, 5734, 10.1182/blood-2010-06-291906

Furukawa, 2015, Systematic monitoring of hemostatic management in hemophilia A patients with inhibitor in the perioperative period using rotational thromboelastometry, J Thromb Haemost, 13, 1279, 10.1111/jth.12987

Aledort, 2004, Comparative thrombotic event incidence after infusion of recombinant factor VIIa versus factor VIII inhibitor bypass activity, J Thromb Haemost, 2, 1700, 10.1111/j.1538-7836.2004.00944.x

O’Connell, 2008, Recombinant factor VIIa to prevent surgical bleeding in factor XI deficiency, Haemophilia, 14, 775, 10.1111/j.1365-2516.2008.01663.x

Neufeld, 2015, Safety update on the use of recombinant activated factor VII in approved indications, Blood Rev, 29, S34, 10.1016/S0268-960X(15)30006-0

Aledort, 2008, Factor VIII inhibitor bypassing activity (FEIBA): addressing safety issues, Haemophilia, 14, 39, 10.1111/j.1365-2516.2007.01594.x

Cromwell, 2012, FEIBA: a prohemostatic agent, Semin Thromb Hemost, 38, 265, 10.1055/s-0032-1309286

Knofler, 2012, Desmopressin testing in haemophilia A patients and carriers: results of a multi centre survey, Hamostaseologie, 32, 271, 10.5482/HAMO-12-06-0012

Seary, 2012, DDAVP responsiveness in children with mild or moderate haemophilia A correlates with age, endogenous FVIII:C level and with haemophilic genotype, Haemophilia, 18, 50, 10.1111/j.1365-2516.2011.02572.x

Di Perna, 2013, Clinical efficacy and determinants of response to treatment with desmopressin in mild hemophilia A, Semin Thromb Hemost, 39, 732, 10.1055/s-0033-1354418

Nance, 2013, Factor VIII mutation and desmopressin-responsiveness in 62 patients with mild haemophilia A, Haemophilia, 19, 720, 10.1111/hae.12173

Stoof, 2013, Response to desmopressin is strongly dependent on F8 gene mutation type in mild and moderate haemophilia A, Thromb Haemost, 109, 440, 10.1160/TH12-06-0383

Stoof, 2014, Desmopressin response in hemophilia A patients with FVIII:C < 0.10 IU mL(-1.), J Thromb Haemost, 12, 110, 10.1111/jth.12439

Tran, 2014, Tranexamic acid as adjunct therapy to bypassing agents in haemophilia A patients with inhibitors, Haemophilia, 20, 369, 10.1111/hae.12318

Rea, 2014, An in-vitro assessment of tranexamic acid as an adjunct to rFVIII or rFVIIa treatment in haemophilia A, Ann Hematol, 93, 683, 10.1007/s00277-013-1921-z

Dai, 2011, Stabilization of fibrin clots by activated prothrombin complex concentrate and tranexamic acid in FVIII inhibitor plasma, Haemophilia, 17, e944, 10.1111/j.1365-2516.2011.02491.x

Ghosh, 2004, Role of epsilon amino caproic acid in the management of haemophilic patients with inhibitors, Haemophilia, 10, 58, 10.1046/j.1351-8216.2003.00839.x

Davis, 2013, Tranexamic acid without prophylactic factor replacement for prevention of bleeding in hereditary bleeding disorder patients undergoing endoscopy: a pilot study, Haemophilia, 19, 583, 10.1111/hae.12146

Hermans, 2010, Subclinical deep venous thrombosis observed in 10% of hemophilic patients undergoing major orthopedic surgery, J Thromb Haemost, 8, 1138, 10.1111/j.1538-7836.2010.03829.x

Perez Botero, 2015, Incidence of symptomatic venous thromboembolism in patients with hemophilia undergoing joint replacement surgery: a retrospective study, Thromb Res, 135, 109, 10.1016/j.thromres.2014.11.010

Pradhan, 2009, Venous thrombosis prophylaxis in haemophilics undergoing major orthopaedic surgery: a survey of haemophilia treatment centres, Haemophilia, 15, 1337, 10.1111/j.1365-2516.2009.02084.x

Raza, 2016, Thromboprophylaxis and incidence of venous thromboembolism in patients with hemophilia A or B who underwent high-risk orthopedic surgeries, Clin Appl Thromb Hemost, 22, 161, 10.1177/1076029614543139

Mannucci, 2010, Cardiovascular disease in haemophilia patients: a contemporary issue, Haemophilia, 16, 58, 10.1111/j.1365-2516.2010.02262.x

Palla, 2015, Rare bleeding disorders: diagnosis and treatment, Blood, 125, 2052, 10.1182/blood-2014-08-532820

Peyvandi, 2012, Rare bleeding disorders, Haemophilia, 18, 148, 10.1111/j.1365-2516.2012.02841.x

Castaman, 2008, Prophylaxis of bleeding episodes and surgical interventions in patients with rare inherited coagulation disorders, Blood Transfus, 6, s39

Kadir, 2009, Pregnancy and rare bleeding disorders, Haemophilia, 15, 990, 10.1111/j.1365-2516.2009.01984.x

Van Geffen, 2012, Retrospective evaluation of bleeding tendency and simultaneous thrombin and plasmin generation in patients with rare bleeding disorders, Haemophilia, 18, 630, 10.1111/j.1365-2516.2012.02759.x

Rugeri, 2010, Thrombin generation in patients with factor XI deficiency and clinical bleeding risk, Haemophilia, 16, 771, 10.1111/j.1365-2516.2010.02246.x

Zia, 2015, Thromboelastography identifies children with rare bleeding disorders and predicts bleeding phenotype, Haemophilia, 21, 124, 10.1111/hae.12481

Mumford, 2014, Guideline for the diagnosis and management of the rare coagulation disorders: a United Kingdom Haemophilia Centre Doctors’ Organization guideline on behalf of the British Committee for Standards in Haematology, Br J Haematol, 167, 304, 10.1111/bjh.13058

Bolton-Maggs, 2004, The rare coagulation disorders – review with guidelines for management from the United Kingdom Haemophilia Centre Doctors’ Organisation, Haemophilia, 10, 593, 10.1111/j.1365-2516.2004.00944.x

Lobel, 2004, Successful prophylactic treatment for bleeding in a girl with severe hereditary prothrombin deficiency using a prothrombin complex concentrate (Bebulin VH), J Pediatr Hematol Oncol, 26, 480, 10.1097/01.mph.0000130220.33907.5a

Mathias, 2011, Prophylaxis in severe prothrombin deficiency, Br J Haematol, 152, 243, 10.1111/j.1365-2141.2010.08352.x

van Veen, 2007, Blood product support for delivery in severe factor X deficiency: the use of thrombin generation to guide therapy, Blood Transfus, 5, 204

Barillari, 2011, Prothrombin complex concentrate such as therapy and prophylaxis in factor X-deficient patient (Friuli variant), Clin Appl Thromb Hemost, 17, 332, 10.1177/1076029610365331

Peyvandi, 2012, Coagulation factor activity and clinical bleeding severity in rare bleeding disorders: results from the European Network of Rare Bleeding Disorders, J Thromb Haemost, 10, 615, 10.1111/j.1538-7836.2012.04653.x

Peyvandi, 2012, Classification of rare bleeding disorders (RBDs) based on the association between coagulant factor activity and clinical bleeding severity, J Thromb Haemost, 10, 1938, 10.1111/j.1538-7836.2012.04844.x

Salomon, 2005, Plasma replacement therapy during labor is not mandatory for women with severe factor XI deficiency, Blood Coagul Fibrinolysis, 16, 37, 10.1097/00001721-200501000-00006

Baumann Kreuziger, 2013, Is prophylaxis required for delivery in women with factor VII deficiency?, Haemophilia, 19, 827, 10.1111/hae.12167

Siboni, 2014, Management of orthopaedic surgery in rare bleeding disorders, Haemophilia, 20, 693, 10.1111/hae.12387

Santoro, 2015, Bleeding phenotype and correlation with factor XI (FXI) activity in congenital FXI deficiency: results of a retrospective study from a single centre, Haemophilia, 21, 496, 10.1111/hae.12628

Kreuz, 2005, Efficacy and tolerability of a pasteurised human fibrinogen concentrate in patients with congenital fibrinogen deficiency, Transfus Apher Sci, 32, 247, 10.1016/j.transci.2004.08.003

Peyvandi, 2006, Incidence of bleeding symptoms in 100 patients with inherited afibrinogenemia or hypofibrinogenemia, J Thromb Haemost, 4, 1634, 10.1111/j.1538-7836.2006.02014.x

Peyvandi, 2009, Results of an international, multicentre pharmacokinetic trial in congenital fibrinogen deficiency, Thromb Res, 124, S9, 10.1016/S0049-3848(09)70158-6

Bornikova, 2011, Fibrinogen replacement therapy for congenital fibrinogen deficiency, J Thromb Haemost, 9, 1687, 10.1111/j.1538-7836.2011.04424.x

Benlakhal, 2011, A retrospective analysis of 157 surgical procedures performed without replacement therapy in 83 unrelated factor VII-deficient patients, J Thromb Haemost, 9, 1149, 10.1111/j.1538-7836.2011.04291.x

Mariani, 2011, Recombinant, activated factor VII for surgery in factor VII deficiency: a prospective evaluation: the surgical STER, Br J Haematol, 152, 340, 10.1111/j.1365-2141.2010.08287.x

Mariani, 2012, Invasive procedures and minor surgery in factor VII deficiency, Haemophilia, 18, e63, 10.1111/j.1365-2516.2012.02751.x

Mariani, 2013, Replacement therapy for bleeding episodes in factor VII deficiency. A prospective evaluation, Thromb Haemost, 109, 238, 10.1160/TH12-07-0476

Mathias, 2013, Management of surgical procedures in children with severe FV deficiency: experience of 13 surgeries, Haemophilia, 19, 256, 10.1111/hae.12053

Napolitano, 2013, Prophylaxis in congenital factor VII deficiency: indications, efficacy and safety. Results from the Seven Treatment Evaluation Registry (STER), Haematologica, 98, 538, 10.3324/haematol.2012.074039

Windyga, 2013, Management of factor VII-deficient patients undergoing joint surgeries – preliminary results of locally developed treatment regimen, Haemophilia, 19, 89, 10.1111/j.1365-2516.2012.02921.x

Ashley, 2015, Efficacy and safety of prophylactic treatment with plasma-derived factor XIII concentrate (human) in patients with congenital factor XIII deficiency, Haemophilia, 21, 102, 10.1111/hae.12524

Brenner, 2007, Experience with recombinant-activated factor VII in 30 patients with congenital factor VII deficiency, Hematology, 12, 55, 10.1080/10245330601111573

Busani, 2008, Recombinant activated factor VII in critical bleeding after orthotopic liver transplantation, Transplant Proc, 40, 1989, 10.1016/j.transproceed.2008.05.021

Schulman, 2005, Continuous infusion of recombinant factor VIIa for surgery in patients with deficiency of factor VII, Thromb Haemost, 94, 1177, 10.1160/TH05-05-0342

Tran, 2011, rFVIIa administered by continuous infusion during surgery in patients with severe congenital FVII deficiency, Haemophilia, 17, 764, 10.1111/j.1365-2516.2011.02596.x

Napolitano, 2015, Replacement therapy in inherited factor VII deficiency: occurrence of adverse events and relation with surgery, Haemophilia, 21, e513, 10.1111/hae.12782

Kenet, 2009, Lower doses of rFVIIa therapy are safe and effective for surgical interventions in patients with severe FXI deficiency and inhibitors, Haemophilia, 15, 1065, 10.1111/j.1365-2516.2009.02043.x

Chi, 2009, The obstetric experience of women with factor XI deficiency, Acta Obstet Gynecol Scand, 88, 1095, 10.1080/00016340903144238

Livnat, 2009, Recombinant activated factor VII and tranexamic acid are haemostatically effective during major surgery in factor XI-deficient patients with inhibitor antibodies, Thromb Haemost, 102, 487, 10.1160/TH09-03-0172

Franchini, 2009, The use of desmopressin in congenital factor XI deficiency: a systematic review, Ann Hematol, 88, 931, 10.1007/s00277-009-0792-9

Marty, 2008, The paradoxical association between inherited factor VII deficiency and venous thrombosis, Haemophilia, 14, 564, 10.1111/j.1365-2516.2007.01647.x

Girolami, 2012, Recombinant FVIIa concentrate-associated thrombotic events in congenital bleeding disorders other than hemophilias, Hematology, 17, 346, 10.1179/1607845412Y.0000000027

Batty, 2015, Ongoing risk of thrombosis with factor XI concentrate: 5 years experience in two centres, Haemophilia, 21, 490, 10.1111/hae.12682

Ruiz-Saez, 2013, Occurrence of thrombosis in rare bleeding disorders, Semin Thromb Hemost, 39, 684, 10.1055/s-0033-1353391