Management of patients with high-risk and advanced prostate cancer in the Middle East: resource-stratified consensus recommendations

Springer Science and Business Media LLC - Tập 38 - Trang 681-693 - 2019
Deborah Mukherji1, Bassem Youssef2, Christelle Dagher1, Albert El-Hajj3, Rami Nasr3, Fadi Geara2, Danny Rabah4, Saad Al Dousari5, Rabih Said6, Raja Ashou7, Wassim Wazzan2, Michel Jabbour8, George Farha9, Nibras Al Hamdani10, Yousuf Al Hallaq10, Hassan Ghazal11, Haifa Dbouk12, Bassel Bachir2, Clement El Khoury13, Ghazi Sakr14, Hero K. Hussain15, Khaled Sayyid16, Khaled Ibrahim17, Mohammad Haidar15, Nicolas Zouain18, Nizar Bitar19, Walid Alameh20, Fadi Abbas21, Sami Faddoul22, Elie Nemer23, Georges Assaf8, Fadi Farhat17, Muhammad Bulbul2, Sally Temraz24, Ali Shamseddine1, Silke Gillessen25,26, Aurelius Omlin26, Raja Khauli3
1Division of Hematology-Oncology, Department of Internal Medicine, American University of Beirut Medical Center, Beirut, Lebanon
2Department of Radiation Oncology, American University of Beirut Medical Center, Beirut, Lebanon
3Division of Urology, Department of Surgery, American University of Beirut Medical Center, Beirut, Lebanon
4Department of Surgery, College of Medicine, King Saud University, Riyadh, Saudi Arabia
5Department of Surgery, Faculty of Medicine, Kuwait University, Kuwait city, Kuwait
6Division of Hematology/Oncology, Department of Internal Medicine, Saint Georges Hospital University Medical Center, Beirut, Lebanon
7Department of Radiology, Saint Georges Hospital University Medical Center, Beirut, Lebanon
8Division of Urology, Department of Surgery, Saint Georges Hospital University Medical Center, Beirut, Lebanon
9Department of Radiation Oncology, Mount Lebanon Hospital, Faculty of Medicine-University of Balamand, Beirut, Lebanon
10Department of Surgery, Medical City Teaching Hospital Baghdad, Baghdad, Iraq
11Division of Hematology/Oncology, Department of Internal Medicine, Clemenceau Medical Center, Beirut, Lebanon
12Division of Oncology, Jamal Amel Hospital, Tyre, Lebanon
13Department of Radiation Oncology, Hotel Dieu de France, Saint Joseph University Faculty of Medicine, Beirut, Lebanon
14Division of Urology, Department of Surgery, Mount Lebanon Hospital, Beirut, Lebanon
15Department of Radiology, American University of Beirut Medical Center, Beirut, Lebanon
16Department of Surgery, Makassed Hospital, Beirut, Lebanon
17Division of Hematology/Oncology, Department of Internal Medicine, Hammoud Hospital University Medical Center, Saida, Lebanon
18Department of Radiation Oncology, Clemenceau Medical Center, Beirut, Lebanon
19Division of Hematology/Oncology, Department of Internal Medicine, Sahel General Hospital, Beirut, Lebanon
20Department of Surgery, Sahel General Hospital, Beirut, Lebanon
21Middle East Tumor Institute, Beirut, Lebanon
22Doctors Center Radiology, Beirut, Lebanon
23Department of Urology, Saint Joseph University, Beirut, Lebanon
24Division of Hematology Oncology, Department of Internal Medicine, American University of Beirut Medical Center, Beirut, Lebanon
25Division of Cancer Sciences, University of Manchester and the Christie, Manchester, UK
26Department of Medical Oncology and Haematology, Cantonal Hospital Saint Gallen, University of Bern, Bern, Switzerland

Tóm tắt

Prostate cancer care in the Middle East is highly variable and access to specialist multidisciplinary management is limited. Academic tertiary referral centers offer cutting-edge diagnosis and treatment; however, in many parts of the region, patients are managed by non-specialists with limited resources. Due to many factors including lack of awareness and lack of prostate-specific antigen (PSA) screening, a high percentage of men present with locally advanced and metastatic prostate cancer at diagnosis. The aim of these recommendations is to assist clinicians in managing patients with different levels of access to diagnostic and treatment modalities. The first Advanced Prostate Cancer Consensus Conference (APCCC) satellite meeting for the Middle East was held in Beirut, Lebanon, November 2017. During this meeting a consortium of urologists, medical oncologists, radiation oncologist and imaging specialists practicing in Lebanon, Syria, Iraq, Kuwait and Saudi Arabia voted on a selection of consensus questions. An additional workshop to formulate resource-stratified consensus recommendations was held in March 2019. Variations in practice based on available resources have been proposed to form resource-stratified recommendations for imaging at diagnosis, initial management of localized prostate cancer requiring therapy, treatment of castration-sensitive/naïve advanced prostate cancer and treatment of castration-resistant prostate cancer. This is the first regional consensus on prostate cancer management from the Middle East. The following recommendations will be useful to urologists and oncologists practicing in all areas with limited access to specialist multi-disciplinary teams, diagnostic modalities and treatment resources.

Tài liệu tham khảo

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