Management of corticosteroid-induced osteoporosis

Seminars in Arthritis and Rheumatism - Tập 29 Số 4 - Trang 228-251 - 2000
Jonathan D. Adachi1, Wojciech P. Olszynski2, David A. Hanley3, Anthony B. Hodsman4, David L. Kendler5, Kerry Siminoski6, Jacques P. Brown7, E.A. Cowden8, David Goltzman9, George Ioannidis1, Robert G. Josse10, Louis‐Georges Ste‐Marie11, Alan Tenenhouse12, Kelly Davison13, Kenneth Blocka14, Accles Pollock14, John Sibley14
1Department of Medicine, St. Joseph's Hospital, McMaster University, Hamilton, Ontario, Canada
2Department ofMedicine, University of Saskatchewan, Saskatoon, Saskatchewan, Canada
3Department ofMedicine, Foothills Hospital, University of Calgary, Calgary, Alberta, Canada
4Department of Medicine, St Joseph's Hospital, University of Western Ontario, London, Ontario, Canada
5Department of Medicine, Vancouver General Hospital, University of British Columbia, Vancouver, British Columbia, Canada
6Endocrine Center of Edmonton and Medical Imaging Consultants, Edmonton, Alberta, Canada
7Department of Rheumatology,Centre Hospitalier de l'Universite Laval, Ste-Foy Quebec, Canada
8Department ofMedicine, Dalhousie University, Halifax Nova Scotia, Canada
9Department of Medicine, Royal Victoria Hospital, McGill University, Montreal, Quebec, Canada
10Department of Medicine, St Michael’s Hospital, University of Toronto, Toronto, Ontario, Canada
11Department of Medicine, Centre Hospitalier de l'Universite Montreal, Montreal, Quebec, Canada
12Department of Medicine,Montreal General Hospital, McGill University, Montreal, Quebec, Canada
13Collegeof Kinesiology, University of Saskatchewan, Saskatoon Saskatchewan, Canada
14Department of Medicine, University of Saskatchewan, Saskatoon, Saskatchewan Canada

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Tài liệu tham khảo

Cushing, 1932, The basophil adenomas of the pituitary body and their clinical manifestations, Bull Johns Hopkins Hosp, 50, 137

Sambrook, 1990, Corticosteroid effects on proximal femur bone loss, J Bone Miner Res, 5, 1211, 10.1002/jbmr.5650051204

Baylink, 1983, Glucocorticoid-induced osteoporosis, N Engl J Med, 309, 306, 10.1056/NEJM198308043090509

Adinoff, 1983, Steroid-induced fractures and bone loss in patients with asthma, N Engl J Med, 309, 265, 10.1056/NEJM198308043090502

Lukert, 1990, Glucocorticoid-induced osteoporosis: pathogenesis and management, Ann Intern Med, 112, 352, 10.7326/0003-4819-112-5-352

Ruegsegger, 1983, Corticosteroid-induced bone loss: a longitudinal study of alternate day therapy in patients with bronchial asthma using quantitative computedtomography, Eur J Clin Pharmacol, 25, 615, 10.1007/BF00542348

Verstraeten, 1986, Vertebral and peripheral bone mineral content and fracture incidence in postmenopausal patients with rheumatoid arthritis: effect of low dosecorticosteroids, Ann Rheum Dis, 45, 852, 10.1136/ard.45.10.852

Gough, 1994, Generalized bone loss in patients with early rheumatoid arthritis, Lancet, 344, 23, 10.1016/S0140-6736(94)91049-9

Bressot, 1979, Histomorphometric profile, pathophysiology and reversibility of corticosteroid induced osteoporosis, Metab Bone Dis Rel Res, 1, 303, 10.1016/0221-8747(79)90024-9

Frost, 1961, The effect of cortisone on lamellar osteoblastic activity, Henry Ford Hosp Med J, 9, 97

Dempster, 1983, Mean wall thickness and formation periods of trabecular bone packets in corticosteroid-induced osteoporosis, Calcif Tissue Int, 35, 410, 10.1007/BF02405069

Ishida, 1998, Glucocorticoid-induced osteoporosis: both in vivo and in vitro concentrations of glucocorticoids higher than physiological levels attenuateosteoblast differentiation, J Bone Miner Res, 13, 1822, 10.1359/jbmr.1998.13.12.1822

Peck, 1967, Hydrocortisone-induced inhibition of protein synthesis and uridine incorporation in isolated bone cells in vitro, 57, 1599

Caporali, 1991, Serum osteocalcin (bone gla-protein) and steroid osteoporosis in rheumatoid arthritis, J Rheumatol, 18, 148

Godschalk, 1988, Effect of short-term glucocorticoids on serum osteocalcin in healthy young men, J Bone Miner Res, 3, 113, 10.1002/jbmr.5650030117

Neilsen, 1988, The effects of high-dose glucocorticoid administration on serum bone gamma carboxyglutamic acid-containing protein, serum alkaline phosphatase and vitamin D metabolites in normal subjects, Bone Miner, 4, 105

Prummel, 1991, The course of biochemical parameters of bone turnover during treatment with corticosteroids, J Clin Endocrinol Metab, 72, 382, 10.1210/jcem-72-2-382

Reid, 1986, Low serum osteocalcin levels in glucocorticold-treated asthmatics, J Clin Endocrinol Metab, 62, 379, 10.1210/jcem-62-2-379

Kotowicz, 1990, Relationship of glucocorticoid dosage to serum bone gla-protein concentration in patients with rheumatologic disorders, Arthritis Rheum, 33, 1487, 10.1002/art.1780331005

Eastell, 1998, A UK consensus group on management of glucocorticoid-induced osteoporosis: an update, J Intem Med, 244, 271, 10.1046/j.1365-2796.1998.00408.x

Stellon, 1988, Bone histomorphometry and structure in corticosteroid treated chronic active hepatitis, Gut, 29, 378, 10.1136/gut.29.3.378

Jee, 1970, Corticosteroids and bone, Am J Anat, 129, 477, 10.1002/aja.1001290409

Fucik, 1975, Effect of glucocorticoids on function of the parathyroid glands in man, J Clin Endocrinol Metabol, 40, 152, 10.1210/jcem-40-1-152

Lukert, 1976, Calcium and phosphorus homeostasis in man: effect of corticosteroids, Arch Intern Med, 136, 1249, 10.1001/archinte.136.11.1249

Hahn, 1976, Osteopenia in patients with rheumatic diseases: principles of diagnosis and therapy, Semin Arthritis Rheum, 6, 165, 10.1016/0049-0172(76)90020-2

Hahn, 1979, Altered mineral metabolism in glucocorticoid induced osteopenia: effect of 25-hydroxyvitamin D administration, J Clin Invest, 64, 655, 10.1172/JCI109506

Seeman, 1980, Production, degradation and circulating levels of 1,25-dihydroxyvitamin D in health and chronic glucocorticoid excess, J Clin Invest, 66, 664, 10.1172/JCI109902

Hahn, 1981, Effects of short-term glucocorticoid administration on intestinal calcium absorption and circulating vitamin D metabolite concentrations in man, J Clin Endocrinol Metab, 52, 111, 10.1210/jcem-52-1-111

Klein, 1977, Intestinal calcium absorption in exogenous hypercortisolism: role of 25-hydroxyvitamin D and corticosteroid dose, J Clin Invest, 60, 253, 10.1172/JCI108762

Kimberg, 1973, Effects of cortisone treatment on the active transport of calcium by the small intestine, J Clin Invest, 52, 1680, 10.1172/JCI107349

Favus, 1973, Effects of 1,25-dihydroxycholecalciferol on intestinal calcium transport in cortisone-treated rats, J Clin Invest, 52, 1680, 10.1172/JCI107349

Suzuki, 1983, Importance of increased urinary calcium excretion in the development of secondary hyperparathyroidism of patients under glucocorticoid therapy, Metabol, 32, 151, 10.1016/0026-0495(83)90221-4

Need, 1987, Corticosteroids and osteoporosis, Aust N Z J Med, 17, 257, 10.1111/j.1445-5994.1987.tb00064.x

Reid, 1989, Steroid osteoporosis, Calcif Tissue Int, 45, 63, 10.1007/BF02561402

Pearce, 1998, Corticosteroid-induced bone loss in men, J Clin Endocrinol Metab, 83, 801, 10.1210/jc.83.3.801

Jennings, 1991, The assessment of the systemic effects of inhaled glucocorticosteroids: the effects of inhaled budesonide vs. oral prednisolone on calcium metabolism, Eur J Clin Pharmacol, 41, 11, 10.1007/BF00280099

Bikle, 1993, Elevated 1,25-dihydroxyvitamin-D levels in patients with chronic obstructive pulmonary disease treated with prednisone, J Clin Endocrinol Metab, 76, 456, 10.1210/jc.76.2.456

Williams, 1960, Calcium absorption in the rat in relation to excessive vitamin D and cortisone, 5, 354

Hahn, 1980, Comparison of subacute effects of oxazacort and prednisone on mineral metabolism in man, Calcif Tissue Int, 31, 109, 10.1007/BF02407171

Lekkerkerker, 1972, Influence of low dose of sterol therapy on calcium absorption, Acta Endocrinol (Copenh), 69, 488, 10.1530/acta.0.0690488

Sjoberg, 1970, Retention of orally administered 47-calcium in man under normal diseased conditions studies with a wholebody counter technique, Acta Med Scand, 509, 1

Lindgren, 1978, Short-term effects of 1-alpha-hydroxy-vitamin D3 in patients on corticosteroid treatment and in patients with senile osteoporosis, Acta Med Scand, 204, 89, 10.1111/j.0954-6820.1978.tb08404.x

Adams, 1981, Effects of hydrochlorothiazide and dietary sodium restriction on calcium metabolism in corticosteroid treated patients, Metabol, 30, 217, 10.1016/0026-0495(81)90144-X

Findling, 1982, Vitamin D metabolites and parathyroid hormone in Cushing's syndrome: relationship to calcium and phosphorus homeostasis, J Clin Endocrinol Metab, 52, 1680

Lee, 1983, Unanticipated stimulatory action of glucocorticoids on epithelial calcium absorption: effect of dexamethasone on rat distal colon, J Clin Invest, 71, 322, 10.1172/JCI110772

Binder, 1978, Effect of dexamethasone on electrolyte transport in the large intestine of the rat, Gastroenterology, 75, 212, 10.1016/0016-5085(78)90404-3

Ferretti, 1978, The intestinal handling of calcium by the rat in vivo, as affected by cortisol: effect of dietary calcium supplements, Calcif Tissue Res, 251, 1, 10.1007/BF02010743

Hahn, 1977, Serum 25 hydroxyvitamin D concentrations in patients receiving chronic corticosteroid therapy, J Lab Clin Med, 90, 399

Chesney, 1978, Reduction of serum 1,25-dihydroxyvitamin D3 in children receiving glucocordeoids, Lancet, ii, 1123, 10.1016/S0140-6736(78)92277-8

Godschalk, 1992, Glucocorticoids decrease vitamin D receptor numbers and gene expression in human osteosarcoma cells, J Bone Miner Res, 7, 21, 10.1002/jbmr.5650070105

Sakakura, 1975, Inhibition of luteinizing hormone secretion induced by synthetic LRH by long-term treatment with glucocorticoids in human subjects, J Clin Endocrinol Metab, 40, 774, 10.1210/jcem-40-5-774

Luton, 1977, Reversible gonadotrophin deficiency in male Cushing's disease, J Clin Endocrinol Metab, 45, 488, 10.1210/jcem-45-3-488

Hsueh, 1978, Glucocorticoid inhibition of FSH-induced estrogen production in cultured rat granulosa cells, Steroids, 32, 639, 10.1016/0039-128X(78)90074-0

Doerr, 1976, Cortisol-induced suppression of plasma testosterone in normal adult males, J Clin Endocrinol Metab, 43, 622, 10.1210/jcem-43-3-622

Schaison, 1987, Effect of glucocorticoids on plasma testosterone in men, Acta Endocrinol (Copenh), 89, 126, 10.1530/acta.0.0890126

MacAdams, 1986, Reduction of serum testosterone levels during chronic glucocorticoid therapy, Ann Intern Med, 104, 648, 10.7326/0003-4819-104-5-648

Montecucco, 1992, Sex hormones and bone metabolism in postmenopausal rheumatoid arthritis treated with two different glucocorticoids, J Rheumatol, 19, 1895

Goulding, 1988, Effects of chronic prednisolone treatment on bone resorption and bone composition in intact and ovariectomized rats and in ovariectomized rats receiving Bestradiol, Endocrinology, 122, 482, 10.1210/endo-122-2-482

Hahn, 1974, Effect of chronic corticosteroid administration on diaphyseal and metaphyseal bone mass, J Clin Endocrinol Metab, 39, 274, 10.1210/jcem-39-2-274

Maldague, 1984, Radiologic aspects of glucocorfcoid-induced bone disease, Adv Exp Med Biol, 171, 155

Saito, 1995, Users of low-dose glucocorticoids have increased bone loss rates: a longitudinal study, Calcif Tissue Int, 57, 115, 10.1007/BF00298431

Gennari, 1985, Glucocorticoids and bone, 213

Adachi, 1990, Corticosteroid induced osteoporosis: follow-up over 3 years, 1745

Aman, 1998, Low incidence of osteoporosis in a two year follow-up of early community based patients with rheumatoid arthritis, Scand J Rheumatol, 27, 188, 10.1080/030097498440796

Kroger, 1994, Decreased axial bone mineral density in perimenopausal women with rheumatoid arthritis: a population based study, Ann Rheum Dis, 53, 18, 10.1136/ard.53.1.18

Sambrook, 1987, Determinants of axial bone loss in rheumatoid arthritis, Arthritis Rheum, 30, 721, 10.1002/art.1780300701

Flicker, 1995, Bone density determinants in elderly women: a twin study, J Bone Miner Res, 10, 1607, 10.1002/jbmr.5650101102

Arden, 1996, The heritability of bone mineral density, ultrasound of the calcaneus and hip axis length: a study of postmenopausal twins, J Bone Miner Res, 11, 530, 10.1002/jbmr.5650110414

Morrison, 1994, Testosterone levels during systemic and inhaled corticosteroid therapy, Respir Med, 88, 659, 10.1016/S0954-6111(05)80062-9

Ross, 1991, Preexisting fractures and bone mass predict vertebral fracture incidence in women, Ann Intern Med, 114, 919, 10.7326/0003-4819-114-11-919

Kimble, 1997, Alcohol, cytokines, and estrogen in the control of bone remodeling, Alcohol Clin Exp Res, 21, 385, 10.1111/j.1530-0277.1997.tb03780.x

Klein, 1997, Alcohol-induced bone disease: impact of ethanol on osteoblast proliferation, Alcohol Clin Exp Res, 21, 329, 10.1111/j.1530-0277.1997.tb03781.x

Ernst, 1998, Exercise for female osteoporosis: a systematic review of randomized clinical trials, Sports Med, 25, 359, 10.2165/00007256-199825060-00002

Kano, 1998, Relationship between exercise and bone mineral density among over 5,000 women aged 40 years and above, J Epidemiol, 8, 28, 10.2188/jea.8.28

Egger, 1996, Cigarette smoking and bone mineral density in the elderly, J Epidemiol Commun Health, 50, 47, 10.1136/jech.50.1.47

Law, 1997, Cigarette smoking, sex hormones and bone density in women, Eur J Epidemiol, 13, 553, 10.1023/A:1007389712487

Nielsen, 1988, The effect of single oral doses of prednisone on the circadian rhythm of serum osteocalcin in normal subjects, J Clin Endocrinol Metab, 67, 1025, 10.1210/jcem-67-5-1025

Need, 1986, Calcium metabolism and osteoporosis in corticosteroid-treated postmenopausal women, Aust N Z J Med, 16, 341, 10.1111/j.1445-5994.1986.tb01183.x

Garnero, 1994, Comparison of new biochemical markers of bone turnover in late postmenopausal osteoporosic women in response to alendronate treatment, J Clin Endocrinol Metabol, 79, 1693, 10.1210/jc.79.6.1693

Seeman, 1982, Differential effects of endocrine dysfunction on the axial and appendicular skeleton, J Clin Invest, 69, 1302, 10.1172/JCI110570

Marshall, 1996, Meta-analysis of how well measures of bone mineral density predict occurrence of osteoporosis fractures, Br Med J, 312, 1254, 10.1136/bmj.312.7041.1254

Luengo, 1991, Vertebral fractures in steroid dependent asthma and involutional osteoporosis: a comparative study, Thorax, 46, 803, 10.1136/thx.46.11.803

Hough, 1981, Isolated skeletal involvement in Cushing's syndrome: response to therapy, J Clin Endocrin Metab, 52, 1033, 10.1210/jcem-52-5-1033

Riggs, 1966, Quantitative microradiographic study of bone remodelling in Cushing's syndrome, Metabol, 15, 773, 10.1016/0026-0495(66)90169-7

Sheagren, 1977, Effect on bone growth of daily versus alternate day corticosteroid administration: an experimental study, J Lab Clin Med, 89, 120

Gluck, 1981, Bone loss in adults receiving alternate day glucccorticoid therapy, Arthritis Rheum, 24, 892, 10.1002/art.1780240705

Tucci, 1996, Effect of three years of oral alendronate treatment in postmenopausal women with osteoporosis, Am J Med, 101, 488, 10.1016/S0002-9343(96)00282-3

Watts, 1990, Intermittent cyclical etidronate treatment of postmenopausal osteoporosis, N Engl J Med, 323, 73, 10.1056/NEJM199007123230201

Devogelaer, 1996, Oral alendronate induces progressive increases in bone mass of the spine, hip, and total body over 3 years in postmenopausal women withosteoporosis, Bone, 18, 141, 10.1016/8756-3282(95)00436-X

Liberman, 1995, Effect of oral alendronate on bone mineral density and the incidence of fractures in postmenopausal osteoporosis, N Engl J Med, 333, 1437, 10.1056/NEJM199511303332201

Black, 1997, Randomised trial of effect of alendronate on risk of fracture in women with existing vertebral fractures, Lancet, 348, 1535, 10.1016/S0140-6736(96)07088-2

Storm, 1990, Effect of intermittent cyclical etidronate therapy on bone mass and fracture rate in women with postmenopausal osteoporosis, N Engl J Med, 322, 1265, 10.1056/NEJM199005033221803

Amin, 1998, A meta-analysis ranking efficacy of treatments for corticosteroid-induced osteoporosis (CSOP), Arthritis Rheum, 41, S137

Roux, 1998, Randomized trial of effect of cyclical etidronate in the prevention of corticosteroid-induced bone loss, J Clin Endocrinol Metabol, 83, 1128, 10.1210/jc.83.4.1128

Adachi, 1997, Intermittent cyclical etidronate therapy in the prevention of corticosteroid-iuduced-osteoporosis, N Engl J Med, 337, 382, 10.1056/NEJM199708073370603

Wolfhagen, 1997, Cyclical etidronate in the prevention of bone loss in corticosteroid-treated primary biliary cirrhosis, J Hepatol, 26, 325, 10.1016/S0168-8278(97)80048-7

Jenkins, 1997, The prevention of corticosteroid induced osteoporosis with intermittent cyclical etidronate, Bone, 20, 103S

Skingle, 1994, Increased bone density in patients on steroids with etidronate, Lancet, 344, 543, 10.1016/S0140-6736(94)91932-1

Mulder, 1994, Intermittent cyclical etidronate in the prevention of corticosteroid-induced bone loss, Br J Rheumatol, 33, 348, 10.1093/rheumatology/33.4.348

Cohen, 1998, Risedronate prevents bone loss and decreases the risk of vertebral fractures in corticosteroid-induced osteoporosis, Bone, 23, S595

Boutsen, 1997, Primary prevention of glucocorticoid-induced osteoporosis with intermittent intravenous pamidronate: a randomized trial, Calcif Tissue Int, 61, 266, 10.1007/s002239900334

Gonnelli, 1997, Prevention of corticosteroid-induced with alendronate in sarcoid patients, Calcif Tissue Int, 61, 382, 10.1007/s002239900352

Nordborg, 1997, The ineffectiveness of cyclical oral clodronate on bone mineral density in glucocorticoid-treated patients with giant cell arteritis, J Intern Med, 242, 367, 10.1046/j.1365-2796.1997.00210.x

Pitt, 1998, A double blind placebo controlled study to determine the effects of intermittent cyclical etidronate on bone mineral density in patients on long term oral corticosteroid treatment, Thorax, 53, 351, 10.1136/thx.53.5.351

Guesens, 1998, Cyclic etidronate increases bone density in the spine and hip of postmenopausal women receiving long term corticosteroid treatment: a double-blind,randomized placebo controlled study, Ann Rheum Dis, 57, 724, 10.1136/ard.57.12.724

Worth, 1994, Therapy of steroidinduced bone loss in adult asthmatics with calcium, vitamin D, and a diphosphonate, Am J Respir Crit Care Med, 150, 394, 10.1164/ajrccm.150.2.8049820

Saag, 1998, Alendronate for the prevention and treatment of glucocorticoid-induced osteoporosis, N Engl J Med, 339, 292, 10.1056/NEJM199807303390502

Saag, 1998, Effects of alendronate for two years and BMD and fractures in patients receiving glucocorticoids, Bone, 23, S182

Reid, 1998, Risedronate is an effective and well-tolerated therapy in both the treatment and prevention of corticosteroid-induced osteoporosis, Bone, 23, S402

Reid, 1988, Prevention of steroid-induced osteoporosis with (3-amino-l-hydroxypropylidene)-1, 1-bisphosphonate (APD), Lancet, 23, 143, 10.1016/S0140-6736(88)92721-3

Adachi, 1997, Intermittent etidronate and corticosteroid-induced osteoporosis, N Engl J Med, 337, 1921, 10.1056/NEJM199708073370603

Lukert, 1992, Estrogen and progesterone replacement therapy reduces glucocorticoid-induced bone loss, J Bone Miner Res, 7, 1063, 10.1002/jbmr.5650070909

Hall, 1994, Effect of hormone replacement therapy on bone mass in rheumatoid arthritis treated with and without steroids, Arthritis Rheum, 37, 1499, 10.1002/art.1780371014

Delmas, 1997, Effects of raloxifene on bone mineral density, serum cholesterol concentrations, and uterine endometrium in postmenopausal women, N Engl J Med, 337, 1641, 10.1056/NEJM199712043372301

Adachi, 1997, Salmon calcitonin nasal spray in the prevention of corticosteroid-induced osteoporosis, Br J Rheum, 36, 255, 10.1093/rheumatology/36.2.255

Healy, 1996, A randomized controlled trial of salmon calcitonin to prevent bone loss in corticosteroid-treated temporal arteritis and polymyalgia rheumatica, Calcif Tissue Int, 58, 73, 10.1007/BF02529727

Sambrook, 1993, Prevention of corticosteroid osteoporosis: a comparison of calcium, calcitriol, and calcitonin, N Engl J Med, 328, 1747, 10.1056/NEJM199306173282404

Kotaniemi, 1996, Is continuous intranasal salmon calcitonin effective in treating axial bone loss in patients with active rheumatoid arthritis receiving low dose glucocorticoid therapy?, J Rheumatol, 23, 1875

Luengo, 1994, Prevention of further bone mass loss by nasal calcitonin in patients on long term glucocorticoid therapy for asthma: a two year follow up study, Thorax, 49, 1099, 10.1136/thx.49.11.1099

Luengo, 1990, Treatment of steroid-induced osteopenia with calcitonin in corticosteroid-dependent asthma, Am Rev Respir Dis, 142, 104, 10.1164/ajrccm/142.1.104

Ringe, 1987, Salmon calcitonin in the therapy of corticosteroid-induced osteoporosis, Eur J Clin Pharmacol, 33, 35, 10.1007/BF00610377

Lems, 1997, Effect of sodium fluoride on the prevention of corticosteroid-induced osteoporosis, Osteoporos Int, 7, 575, 10.1007/BF02652565

Lems, 1997, Is addition of sodium fluoride to cyclical etidronate beneficial in the treatment of corticosteroid induced osteoporosis?, Ann Rheum Dis, 56, 357, 10.1136/ard.56.6.357

Guaydier-Souquieres, 1996, In corticosteroid-treated respiratory diseases, monofluorophosphate increases lumbar bone density: a double-masked randomized study, Osteoporosis Int, 6, 171, 10.1007/BF01623943

Rizzoli, 1995, Sodium monofluorophosphate increases vertebral bone mineral density in patients with corticosteroid-induced osteoporosis, Osteoporos Int, 5, 39, 10.1007/BF01623657

Lane, 1998, Parathyroid hormone treatment can reverse corticosteroid-induced osteoporosis: results of a randomized controlled clinical trial, J Clin Invest, 102, 1627, 10.1172/JCI3914

Reid, 1996, Testosterone therapy in glucocorticoid-treated men, Arch Intern Med, 156, 1173, 10.1001/archinte.156.11.1173

Adami, 1992, The prevention of corticosteroid-induced osteoporosis with nandrolone decanoate, Bone Miner, 15, 72

Adachi, 1996, Vitamin D and calcium in the prevention of corticosteroid-induced osteoporosis: a 3 year follow-up, J Rheum, 23, 995

Buckley, 1996, Calcium and vitamin D3 supplementation prevents bone loss in the spine secondary to low-dose corticosteroids in patients with rheumatoid arthritis: a randomized, double-blind placebo controlled trial, Ann Intern Med, 125, 961, 10.7326/0003-4819-125-12-199612150-00004

Bernstein, 1996, A randomized, placebo-controlled trial of calcium supplementation for decreased bone density in corticosteroid-using patients with inflammatorybowel disease: a pilot study, Aliment Pharmacol Ther, 10, 777, 10.1046/j.1365-2036.1996.63205000.x

Bijlsma, 1988, Effect of oral calcium and vitamin D on glucocorticoid-induced osteopenia, Clin Exp Rheumatol, 6, 113

Dykman, 1984, Effect of oral 1,25-dihydoxy vitamin D and calcium on glucocorticoid-induced osteopenia in patients with rheumatic diseases, Arthritis Rheum, 27, 1336, 10.1002/art.1780271203

Wasnich, 1995, A randomized, double-masked, placebo-controlled trial of chlorthalidone and bone loss in elderly women, Osteoporos Int, 5, 247, 10.1007/BF01774014

Alon, 1984, Additive hypocalciuric effects of amiloride and hydrochlorothiazide in patients treated with calcitriol, Miner Electrolyte Metab, 10, 379

Condon, 1978, Possible prevention and treatment of steroid-induced osteoporosis, Postgrad Med J, 54, 249, 10.1136/pgmj.54.630.249

Federal Register, 1998, Medicare program, Medicare coverage of and payment for bone mass measurements: rules and regulations, 63, 34320

Shaw, 1998, Weighted vest exercise improves indices of fall risk in older women, J Gerontol Biol Sci Med Sci, 53, 1153

Nelson, 1994, Effects of high-intensity strength training on multiple risk factors for osteoporosic fractures: a randomized controlled trial, JAMA, 272, 1909, 10.1001/jama.272.24.1909

Hickson, 1981, Partial prevention of glucocorticoid-induced muscle atrophy by endurance training, Am J Physiol, 241, E226

Hickson, 1986, Glucocorticoid cytosol binding in exerciseinduced sparing of muscle atrophy, J Appl Physiol, 60, 1413, 10.1152/jappl.1986.60.4.1413

Czerwinski, 1987, Initiating regular exercise protects against muscle atrophy from glucocorticoids, J Appl Physiol, 63, 1504, 10.1152/jappl.1987.63.4.1504

Schwid, 1996, Sporadic corticosteroid pulses and osteoporosis in multiple sclerosis, Arch Neurol, 53, 753, 10.1001/archneur.1996.00550080071014

Lems, 1996, Changes in (markers of) bone metabolism during high dose corticosteroid pulse treatment in patients with rheumatoid arthritis, Ann Rheum Dis, 55, 288, 10.1136/ard.55.5.288

Lems, 1993, Transient decrease in osteocalcin and markers of type 1 collagen turnover during high-dose corticosteroid pulse therapy in rheumatoid arthritis, Br J Rheumatol, 32, 787, 10.1093/rheumatology/32.9.787

van der Veen, 1992, Effects of different regime of corticosteroid treatment on calcium and hone metabolism in rheumatoid arthritis, Clin Rheumatol, 11, 388, 10.1007/BF02207199