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Quản lý thiếu máu bằng các tác nhân kích thích sản xuất erythropoietin ở trẻ em mắc bệnh thận mạn tính
Tóm tắt
Quản lý thiếu máu là một yếu tố quan trọng trong chăm sóc trẻ em mắc bệnh thận mạn tính (CKD) và ảnh hưởng đến cả rủi ro mắc bệnh và tỷ lệ tử vong. Việc giới thiệu erythropoietin tái tổ hợp ở người vào phác đồ điều trị cách đây ba thập kỷ đã cách mạng hóa liệu pháp điều trị và giảm đáng kể nhu cầu truyền máu lặp đi lặp lại cùng với những rủi ro liên quan. Tuy nhiên, dữ liệu gần đây về hiệu quả và các biến chứng liên quan đến việc sử dụng tác nhân kích thích sản xuất erythropoietin (ESA) đã thúc đẩy việc xem xét lại các khuyến nghị liên quan đến điều trị. Bài đánh giá này sẽ đề cập đến những khuyến nghị đó, đồng thời mô tả kết quả điều trị ở trẻ em liên quan đến các ESA hiện tại và cung cấp thông tin về các ESA thay thế, nhiều trong số đó có thể sẽ sớm được đưa vào thực hành lâm sàng.
Từ khóa
#thiếu máu #bệnh thận mạn tính #erythropoietin #tác nhân kích thích sản xuất erythropoietin #trẻ emTài liệu tham khảo
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