Mammalian Sperm Energy Resources Management and Survival during Conservation in Refrigeration

Reproduction in Domestic Animals - Tập 41 Số s2 - Trang 11-20 - 2006
Joan E. Rodríguez‐Gil1
1Unit of Animal Reproduction, Department Animal Medicine and Surgery, School of Veterinary Medicine, Autonomous University of Barcelona, Bellaterra, Spain.

Tóm tắt

ContentsThe present review has as its main aim to present an overview regarding the mechanisms utilized by mammalian sperm to manage its intracellular energy levels. This management will strongly influence the sperm's ability to maintain its overall function during its entire life span. Thus, the precise knowledge of these mechanisms will be of the utmost interest to optimize the systems utilized to conserve mammalian sperm for a medium‐to‐long time‐lapse. Briefly, utilization of hexoses as energy substrates by mammalian sperm is very finely regulated from the very first step of its metabolization. Furthermore, the equilibrium among the separate, monosaccharide metabolization pathways in mammalian sperm depends on many factors. This prevents the possibility to draw a general vision of sperm energy utilization, which explains the results of all mammalian species in all points of the sperm life‐cycle. To complicate the matter further, there are separate energy phenotypes among mammalian spermatozoa. The precise knowledge of these phenotypes is of the greatest importance in order to optimize the design of new extenders for sperm conservation in refrigerated conditions. Moreover, sugars can act on sperm not only as passive metabolic substrates, but also as direct function activators through mechanisms like specific changes in the tyrosine phosphorylation status of distinct proteins. Finally, mammalian sperm utilizes non‐glucidic substrates like citrate and lactate to obtain energy in a regular form. This utilization is also finely regulated and of importance to maintain overall sperm function. This implies that the exact proportion of glucidic and non‐glucidic energy substrates could be very important to optimize the survival ability of these cells in conservation.

Từ khóa


Tài liệu tham khảo

10.1002/(SICI)1097-4644(19981101)71:2<189::AID-JCB5>3.0.CO;2-R

10.1016/j.mce.2003.10.068

10.1002/(SICI)1098-2795(200006)56:2<207::AID-MRD12>3.0.CO;2-4

10.1016/S0378-4320(01)00155-5

10.1021/bi00157a032

Burant CF, 1992, Fructose transporter in human spermatozoa and small intestine is GLUT‐5, J Biol Chem, 267, 14523, 10.1016/S0021-9258(18)42067-4

10.1530/reprod/120.2.325

10.1016/S0167-4889(97)00150-X

10.1002/jez.1402250305

10.1095/biolreprod41.4.635

10.1007/s000180300025

Feldman EC, 1987, Canine and Feline Endocrinology and Reproduction, 420

10.1042/bj3210227

10.1016/S0014-5793(99)01249-1

10.1016/j.febslet.2004.06.015

Fernández‐Novell JM, 2005, Hexose‐specific protein phosphorylation: a feasible system to modulate overall function of dog spermatozoa, Reprod Domest Anim, 40, 350

10.1093/oxfordjournals.humrep.a137950

10.1530/jrf.0.0730197

10.1530/jrf.0.0880611

10.1016/0005-2728(85)90014-3

Hammersted RH, 1983, The effects of substrate cycling on the ATP yield of sperm glycolysis, J Biol Chem, 258, 8759, 10.1016/S0021-9258(18)32121-5

10.1016/B978-0-408-10768-6.50008-3

10.1111/j.1439-0531.1988.tb01080.x

10.1016/S0378-4320(00)00200-1

10.1071/R96102

10.1530/reprod/119.1.129

10.1530/jrf.0.0940129

Linde‐Forsberg C, 2000, Advances in Dog, Cat and Exotic Carnivore Reproduction, 120

Mann T, 1975, Handbook of Physiology, 321

10.1016/S0014-5793(03)01185-2

McGilvery RW, 1983, Biochemistry: a Functional Approach, 539

10.1111/j.1439-0531.2005.00599.x

10.1002/mrd.20480

10.1002/mrd.20414

10.1093/oxfordjournals.humrep.a137050

Mueckler M, 1990, Facilitative glucose transporters, Eur J Biochem, 291, 713

10.1095/biolreprod.103.026054

10.1530/jrf.0.0220109

Pan YC, 1983, Amino acid sequence studies on lactate dehydrogenase C4 isozymes from mouse and rat testes, J Biol Chem, 258, 7005, 10.1016/S0021-9258(18)32325-1

10.1007/BF02340837

10.1002/jcp.20582

10.1530/rep.0.1230579

10.1095/biolreprod43.6.1064

Ruíz‐Pesini E, 1998, Correlation of sperm motility with mitochondrial enzymatic activities, Clin Chem, 44, 1616, 10.1093/clinchem/44.8.1616

Salisbury GW, 1978, Physiology of Reproduction and Artificial Insemination of Cattle, 394

Setchell BP, 1988, The Physiology of Reproduction, 813

10.1002/pro.5560070922

Stryer L, 1995, Biochemistry, 763

Stryer L, 1995, Biochemistry, 509

Stryer L, 1995, Biochemistry, 474

Stryer L, 1995, Biochemistry, 244

10.1095/biolreprod60.4.973

10.1016/S0378-4320(96)01586-2

Yanagimachi R, 1988, The Physiology of Reproduction, 152

Thông tin
Thông tin xuất bản

Reproduction in Domestic Animals

Tập 41 Số s2

11-20

Thông tin tác giả