Mammalian Homologues of Drosophila Fused Kinase
Tài liệu tham khảo
Ahantarig, 2009, Molecular characterization of Pegarn: A Drosophila homolog of UNC-51 kinase, Mol. Biol. Rep., 36, 1311, 10.1007/s11033-008-9314-4
Alves, 1998, Modulation of Hedgehog target gene expression by the Fused serine-threonine kinase in wing imaginal discs, Mech. Dev., 78, 17, 10.1016/S0925-4773(98)00130-0
Ascano, 2004, An intramolecular association between two domains of the protein kinase Fused is necessary for Hedgehog signaling, Mol. Cell. Biol., 24, 10397, 10.1128/MCB.24.23.10397-10405.2004
Aza-Blanc, 2000, Expression of the vertebrate Gli proteins in Drosophila reveals a distribution of activator and repressor activities, Development, 127, 4293, 10.1242/dev.127.19.4293
Bai, 2001, Gli1 can rescue the in vivo function of Gli2, Development, 128, 5161, 10.1242/dev.128.24.5161
Bai, 2002, Gli2, but not Gli1, is required for initial Shh signaling and ectopic activation of the Shh pathway, Development, 129, 4753, 10.1242/dev.129.20.4753
Canestro, 2007, Evolutionary developmental biology and genomics, Nat. Rev. Genet., 8, 932, 10.1038/nrg2226
Chan, 2009, Evolution of Atg1 function and regulation, Autophagy, 5, 758, 10.4161/auto.8709
Chan, 2009, Kinase-inactivated ULK proteins inhibit autophagy via their conserved C-terminal domains using an Atg13-independent mechanism, Mol. Cell. Biol., 29, 157, 10.1128/MCB.01082-08
Chen, 1998, Protein kinase A directly regulates the activity and proteolysis of cubitus interruptus, Proc. Natl. Acad. Sci. USA, 95, 2349, 10.1073/pnas.95.5.2349
Chen, 2005, Mice deficient in the fused homolog do not exhibit phenotypes indicative of perturbed hedgehog signaling during embryonic development, Mol. Cell. Biol., 25, 7042, 10.1128/MCB.25.16.7042-7053.2005
Chen, 2009, Cilium-independent regulation of Gli protein function by Sufu in Hedgehog signaling is evolutionarily conserved, Genes Dev., 23, 1910, 10.1101/gad.1794109
Claret, 2007, Evidence for a novel feedback loop in the Hedgehog pathway involving Smoothened and Fused, Curr. Biol., 17, 1326, 10.1016/j.cub.2007.06.059
Clark, 2000, Desert hedgehog (Dhh) gene is required in the mouse testis for formation of adult-type Leydig cells and normal development of peritubular cells and seminiferous tubules, Biol. Reprod., 63, 1825, 10.1095/biolreprod63.6.1825
Cooper, 2005, Cardiac and CNS defects in a mouse with targeted disruption of suppressor of fused, Development, 132, 4407, 10.1242/dev.02021
Dai, 1999, Sonic Hedgehog-induced activation of the Gli1 promoter is mediated by GLI3, J. Biol. Chem., 274, 8143, 10.1074/jbc.274.12.8143
Daoud, 2005, Expression of the human FUSED protein in Drosophila, Dev. Genes Evol., 215, 230, 10.1007/s00427-005-0469-x
Dierks, 2007, Essential role of stromally induced hedgehog signaling in B-cell malignancies, Nat. Med., 13, 944, 10.1038/nm1614
Ding, 1998, Diminished Sonic hedgehog signaling and lack of floor plate differentiation in Gli2 mutant mice, Development, 125, 2533, 10.1242/dev.125.14.2533
Ding, 1999, Mouse suppressor of fused is a negative regulator of sonic hedgehog signaling and alters the subcellular distribution of Gli1, Curr. Biol., 9, 1119, 10.1016/S0960-9822(99)80482-5
Dorsey, 2009, Mapping the phosphorylation sites of Ulk1, J. Proteome Res., 8, 5253, 10.1021/pr900583m
Drossopoulou, 2000, A model for anteroposterior patterning of the vertebrate limb based on sequential long- and short-range Shh signalling and Bmp signalling, Development, 127, 1337, 10.1242/dev.127.7.1337
Dunaeva, 2003, Characterization of the physical interaction of Gli proteins with SUFU proteins, J. Biol. Chem., 278, 5116, 10.1074/jbc.M209492200
Dussillol-Godar, 2006, Modulation of the Suppressor of fused protein regulates the Hedgehog signaling pathway in Drosophila embryo and imaginal discs, Dev. Biol., 291, 53, 10.1016/j.ydbio.2005.12.004
El Andaloussi, 2006, Hedgehog signaling controls thymocyte progenitor homeostasis and differentiation in the thymus, Nat. Immunol., 7, 418, 10.1038/ni1313
Endoh-Yamagami, 2009, The mammalian Cos2 homolog Kif7 plays an essential role in modulating Hh signal transduction during development, Curr. Biol., 19, 1320, 10.1016/j.cub.2009.06.046
Evangelista, 2008, Kinome siRNA screen identifies regulators of ciliogenesis and hedgehog signal transduction, Sci. Signal., 1, ra7, 10.1126/scisignal.1162925
Fukumoto, 2001, The fused protein kinase regulates Hedgehog-stimulated transcriptional activation in Drosophila Schneider 2 cells, J. Biol. Chem., 276, 38441, 10.1074/jbc.M105871200
Goodrich, 1996, Conservation of the hedgehog/patched signaling pathway from flies to mice: Induction of a mouse patched gene by Hedgehog, Genes Dev., 10, 301, 10.1101/gad.10.3.301
Grindley, 1997, Evidence for the involvement of the Gli gene family in embryonic mouse lung development, Dev. Biol., 188, 337, 10.1006/dbio.1997.8644
Haycraft, 2005, Gli2 and Gli3 localize to cilia and require the intraflagellar transport protein polaris for processing and function, PLoS Genet., 1, e53, 10.1371/journal.pgen.0010053
Huangfu, 2005, Cilia and Hedgehog responsiveness in the mouse, Proc. Natl. Acad. Sci. USA, 102, 11325, 10.1073/pnas.0505328102
Humke, 2010, The output of Hedgehog signaling is controlled by the dynamic association between Suppressor of Fused and the Gli proteins, Genes Dev., 24, 670, 10.1101/gad.1902910
Ikram, 2004, GLI2 is expressed in normal human epidermis and BCC and induces GLI1 expression by binding to its promoter, J. Invest. Dermatol., 122, 1503, 10.1111/j.0022-202X.2004.22612.x
Incardona, 2002, Sonic hedgehog induces the segregation of patched and smoothened in endosomes, Curr. Biol., 12, 983, 10.1016/S0960-9822(02)00895-3
Jia, 2002, Shaggy/GSK3 antagonizes Hedgehog signalling by regulating Cubitus interruptus, Nature, 416, 548, 10.1038/nature733
Jia, 2003, Smoothened transduces Hedgehog signal by physically interacting with Costal2/Fused complex through its C-terminal tail, Genes Dev., 17, 2709, 10.1101/gad.1136603
Jia, 2009, Suppressor of Fused inhibits mammalian Hedgehog signaling in the absence of cilia, Dev. Biol., 330, 452, 10.1016/j.ydbio.2009.04.009
Jiang, 1998, Regulation of the Hedgehog and Wingless signalling pathways by the F-box/WD40-repeat protein Slimb, Nature, 391, 493, 10.1038/35154
Kise, 2006, Fused kinase is stabilized by Cdc37/Hsp90 and enhances Gli protein levels, Biochem. Biophys. Res. Commun., 351, 78, 10.1016/j.bbrc.2006.10.036
Lee, 2011, The requirement of uncoordinated 51-like kinase 1 (ULK1) and ULK2 in the regulation of autophagy, Autophagy, 7, 689, 10.4161/auto.7.7.15450
Lee, 1997, Gli1 is a target of Sonic hedgehog that induces ventral neural tube development, Development, 124, 2537, 10.1242/dev.124.13.2537
Lefers, 2001, Genetic dissection of the Drosophila Cubitus interruptus signaling complex, Dev. Biol., 236, 411, 10.1006/dbio.2001.0345
Lum, 2003, Hedgehog signal transduction via Smoothened association with a cytoplasmic complex scaffolded by the atypical kinesin, Costal-2, Mol. Cell, 12, 1261, 10.1016/S1097-2765(03)00426-X
Maloverjan, 2010, Dual function of UNC-51-like kinase 3 (Ulk3) in the Sonic hedgehog signaling pathway, J. Biol. Chem., 285, 30079, 10.1074/jbc.M110.133991
Maloverjan, 2010, Identification of a novel serine/threonine kinase ULK3 as a positive regulator of Hedgehog pathway, Exp. Cell Res., 316, 627, 10.1016/j.yexcr.2009.10.018
Maloveryan, 2007, A possible role of mouse Fused (STK36) in Hedgehog signaling and Gli transcription factor regulation, J. Cell Commun. Signal., 1, 165, 10.1007/s12079-007-0014-y
Malpel, 2007, The last 59 amino acids of Smoothened cytoplasmic tail directly bind the protein kinase Fused and negatively regulate the Hedgehog pathway, Dev. Biol., 303, 121, 10.1016/j.ydbio.2006.10.042
Mao, 2002, Regulation of Gli1 transcriptional activity in the nucleus by Dyrk1, J. Biol. Chem., 277, 35156, 10.1074/jbc.M206743200
Marigo, 1996, Sonic hedgehog differentially regulates expression of GLI and GLI3 during limb development, Dev. Biol., 180, 273, 10.1006/dbio.1996.0300
Merchant, 2005, Loss of the serine/threonine kinase fused results in postnatal growth defects and lethality due to progressive hydrocephalus, Mol. Cell. Biol., 25, 7054, 10.1128/MCB.25.16.7054-7068.2005
Methot, 2000, Suppressor of fused opposes hedgehog signal transduction by impeding nuclear accumulation of the activator form of Cubitus interruptus, Development, 127, 4001, 10.1242/dev.127.18.4001
Milenkovic, 2009, Lateral transport of Smoothened from the plasma membrane to the membrane of the cilium, J. Cell Biol., 187, 365, 10.1083/jcb.200907126
Monnier, 1998, Suppressor of fused links fused and Cubitus interruptus on the hedgehog signalling pathway, Curr. Biol., 8, 583, 10.1016/S0960-9822(98)70227-1
Monnier, 2002, Hedgehog signal transduction proteins: Contacts of the Fused kinase and Ci transcription factor with the kinesin-related protein Costal2, BMC Dev. Biol., 2, 4, 10.1186/1471-213X-2-4
Motoyama, 1998, Essential function of Gli2 and Gli3 in the formation of lung, trachea, and oesophagus, Nat. Genet., 20, 54, 10.1038/1711
Murone, 2000, Gli regulation by the opposing activities of fused and suppressor of fused, Nat. Cell Biol., 2, 310, 10.1038/35010610
Narita, 2009, Autophagy facilitates oncogene-induced senescence, Autophagy, 5, 1046, 10.4161/auto.5.7.9444
Nybakken, 2002, Hedgehog-stimulated phosphorylation of the kinesin-related protein Costal2 is mediated by the serine/threonine kinase fused, J. Biol. Chem., 277, 24638, 10.1074/jbc.M110730200
Ogura, 1994, Caenorhabditis elegans unc-51 gene required for axonal elongation encodes a novel serine/threonine kinase, Genes Dev., 8, 2389, 10.1101/gad.8.20.2389
Ohlmeyer, 1998, Hedgehog stimulates maturation of Cubitus interruptus into a labile transcriptional activator, Nature, 396, 749, 10.1038/25533
Osterlund, 2004, The FU gene and its possible protein isoforms, BMC Genomics, 5, 49, 10.1186/1471-2164-5-49
Park, 2000, Mouse Gli1 mutants are viable but have defects in SHH signaling in combination with a Gli2 mutation, Development, 127, 1593, 10.1242/dev.127.8.1593
Preat, 1990, A putative serine/threonine protein kinase encoded by the segment-polarity fused gene of Drosophila, Nature, 347, 87, 10.1038/347087a0
Preat, 1993, Segmental polarity in Drosophila melanogaster: Genetic dissection of fused in a Suppressor of fused background reveals interaction with costal-2, Genetics, 135, 1047, 10.1093/genetics/135.4.1047
Price, 2002, Proteolysis of the Hedgehog signaling effector Cubitus interruptus requires phosphorylation by Glycogen Synthase Kinase 3 and Casein Kinase 1, Cell, 108, 823, 10.1016/S0092-8674(02)00664-5
Raisin, 2010, Dynamic phosphorylation of the kinesin Costal-2 in vivo reveals requirement of fused kinase activity for all levels of hedgehog signalling, Dev. Biol., 344, 119, 10.1016/j.ydbio.2010.04.021
Riobo, 2006, Protein kinase C-delta and mitogen-activated protein/extracellular signal-regulated kinase-1 control GLI activation in hedgehog signaling, Cancer Res., 66, 839, 10.1158/0008-5472.CAN-05-2539
Riobo, 2006, Phosphoinositide 3-kinase and Akt are essential for Sonic Hedgehog signaling, Proc. Natl. Acad. Sci. USA, 103, 4505, 10.1073/pnas.0504337103
Robbins, 1997, Hedgehog elicits signal transduction by means of a large complex containing the kinesin-related protein costal2, Cell, 90, 225, 10.1016/S0092-8674(00)80331-1
Ruel, 2003, Stability and association of Smoothened, Costal2, and Fused with Cubitus interruptus are regulated by Hedgehog, Nat. Cell Biol., 5, 907, 10.1038/ncb1052
Ruel, 2007, Phosphorylation of the atypical kinesin Costal2 by the kinase Fused induces the partial disassembly of the Smoothened-Fused-Costal2-Cubitus interruptus complex in Hedgehog signalling, Development, 134, 3677, 10.1242/dev.011577
Ruiz i Altaba, 1998, Combinatorial Gli gene function in floor plate and neuronal inductions by Sonic hedgehog, Development, 125, 2203, 10.1242/dev.125.12.2203
Sacedon, 2003, Expression of hedgehog proteins in the human thymus, J. Histochem. Cytochem., 51, 1557, 10.1177/002215540305101115
Sasaki, 1999, Regulation of Gli2 and Gli3 activities by an amino-terminal repression domain: Implication of Gli2 and Gli3 as primary mediators of Shh signaling, Development, 126, 3915, 10.1242/dev.126.17.3915
Sheng, 2006, Regulation of Gli1 localization by the cAMP/protein kinase A signaling axis through a site near the nuclear localization signal, J. Biol. Chem., 281, 9, 10.1074/jbc.C500300200
Sisson, 1997, Costal2, a novel kinesin-related protein in the Hedgehog signaling pathway, Cell, 90, 235, 10.1016/S0092-8674(00)80332-3
Smelkinson, 2007, Regulation of Ci-SCFSlimb binding, Ci proteolysis, and hedgehog pathway activity by Ci phosphorylation, Dev. Cell, 13, 481, 10.1016/j.devcel.2007.09.006
Stecca, 2009, A GLI1-p53 inhibitory loop controls neural stem cell and tumour cell numbers, EMBO J., 28, 663, 10.1038/emboj.2009.16
Stegman, 2000, Identification of a tetrameric hedgehog signaling complex, J. Biol. Chem., 275, 21809, 10.1074/jbc.C000043200
Svärd, 2006, Genetic elimination of Suppressor of fused reveals an essential repressor function in the mammalian Hedgehog signaling pathway, Dev. Cell, 10, 187, 10.1016/j.devcel.2005.12.013
Taipale, 2002, Patched acts catalytically to suppress the activity of Smoothened, Nature, 418, 892, 10.1038/nature00989
te Welscher, 2002, Progression of vertebrate limb development through SHH-mediated counteraction of GLI3, Science, 298, 827, 10.1126/science.1075620
Therond, 1993, Molecular organisation and expression pattern of the segment polarity gene fused of Drosophila melanogaster, Mech. Dev., 44, 65, 10.1016/0925-4773(93)90017-R
Therond, 1996, Phosphorylation of the fused protein kinase in response to signaling from hedgehog, Proc. Natl. Acad. Sci. USA, 93, 4224, 10.1073/pnas.93.9.4224
Therond, 1999, Differential requirements of the fused kinase for hedgehog signalling in the Drosophila embryo, Development, 126, 4039, 10.1242/dev.126.18.4039
Tomoda, 1999, A mouse serine/threonine kinase homologous to C. elegans UNC51 functions in parallel fiber formation of cerebellar granule neurons, Neuron, 24, 833, 10.1016/S0896-6273(00)81031-4
Tomoda, 2004, Role of Unc51.1 and its binding partners in CNS axon outgrowth, Genes Dev., 18, 541, 10.1101/gad.1151204
Turner, 2004, Sonic hedgehog pathway genes are expressed and transcribed in the adult mouse epididymis, J. Androl., 25, 514, 10.1002/j.1939-4640.2004.tb02822.x
Varjosalo, 2008, Application of active and kinase-deficient kinome collection for identification of kinases regulating hedgehog signaling, Cell, 133, 537, 10.1016/j.cell.2008.02.047
Wang, 2000, Nuclear import of cubitus interruptus is regulated by hedgehog via a mechanism distinct from Ci stabilization and Ci activation, Development, 127, 3131, 10.1242/dev.127.14.3131
Wang, 1999, Protein kinase A antagonizes Hedgehog signaling by regulating both the activator and repressor forms of Cubitus interruptus, Genes Dev., 13, 2828, 10.1101/gad.13.21.2828
Wang, 2000, Hedgehog-regulated processing of Gli3 produces an anterior/posterior repressor gradient in the developing vertebrate limb, Cell, 100, 423, 10.1016/S0092-8674(00)80678-9
Wang, 2000, Interactions with Costal2 and suppressor of fused regulate nuclear translocation and activity of cubitus interruptus, Genes Dev., 14, 2893, 10.1101/gad.843900
Wen, 2010, Kinetics of hedgehog-dependent full-length Gli3 accumulation in primary cilia and subsequent degradation, Mol. Cell. Biol., 30, 1910, 10.1128/MCB.01089-09
Wilson, 2009, Fused has evolved divergent roles in vertebrate Hedgehog signalling and motile ciliogenesis, Nature, 459, 98, 10.1038/nature07883
Wolff, 2003, Multiple muscle cell identities induced by distinct levels and timing of hedgehog activity in the zebrafish embryo, Curr. Biol., 13, 1169, 10.1016/S0960-9822(03)00461-5
Yan, 1999, Mouse ULK2, a novel member of the UNC-51-like protein kinases: Unique features of functional domains, Oncogene, 18, 5850, 10.1038/sj.onc.1202988
Young, 2009, Autophagy mediates the mitotic senescence transition, Genes Dev., 23, 798, 10.1101/gad.519709
Zhang, 2004, Extensive phosphorylation of Smoothened in Hedgehog pathway activation, Proc. Natl. Acad. Sci. USA, 101, 17900, 10.1073/pnas.0408093101
Zhang, 2005, Hedgehog-regulated Costal2-kinase complexes control phosphorylation and proteolytic processing of Cubitus interruptus, Dev. Cell, 8, 267, 10.1016/j.devcel.2005.01.001
Zhang, 2006, A hedgehog-induced BTB protein modulates hedgehog signaling by degrading Ci/Gli transcription factor, Dev. Cell, 10, 719, 10.1016/j.devcel.2006.05.004
Zhao, 2007, Hedgehog regulates smoothened activity by inducing a conformational switch, Nature, 450, 252, 10.1038/nature06225
Zhou, 2011, Hedgehog activates fused through phosphorylation to elicit a full spectrum of pathway responses, Dev. Cell, 20, 802, 10.1016/j.devcel.2011.04.020