Malleable Penile Implant Is an Effective Therapeutic Option in Men With Peyronie’s Disease and Erectile Dysfunction

Sexual Medicine - Tập 6 - Trang 24-29 - 2018
Mohamad Habous1, Alaa Tealab2, Mohammed Farag3, Tarek Soliman4, Ben Williamson5, Saad Mahmoud1, Amin Elserafy1, Zenhom Mekawi1, Abdallah Remeah1, Mohammed Nassar1, Osama Laban6, Osama Abdelwahab4, Saleh Binsaleh7, Simone Giona8, David Ralph9, John Mulhall10
1Elaj Medical Centers, Jeddah, Saudi Arabia
2Urology Department, Zagazig University, Zagazig, Egypt
3Urology Department, Al-Azhar Faculty of Medicine, Assiut, Egypt
4Urology Department, Benha University, Benha, Egypt
5University Hospitals Birmingham, Birmingham, UK
6Urology Department, King Khaled Hospital, Tabouk, Saudi Arabia
7Division of Urology, Department of Surgery, Faculty of Medicine, King Saud University, Riyadh, Saudi Arabia
8King's College Hospital, London, UK
9St Peter's Andrology Centre & The Institute of Urology, UCLH, London, UK
10Sexual and Reproductive Medicine Program, Memorial Sloan Kettering Cancer Center, NY, USA

Tóm tắt

Abstract Background The inflatable penile prosthesis (IPP) is typically the preferred implant for Peyronie’s disease (PD) and malleable penile prostheses (MPPs) have been discouraged. Aims To evaluate the effectiveness and patient satisfaction of the MPP vs IPP in patients with PD. Methods Men with PD and erectile dysfunction who elected for penile implant surgery constituted the study population. Preoperatively, demographic and comorbidity parameters were recorded. Curvature was measured with a goniometer at maximum rigidity after intracavernosal injection of a vasoactive agent. Postoperatively, overall satisfaction was measured at 3, 6, 12, and 24 months on 5-point Likert scale from 1 (dissatisfied) to 5 (very satisfied). Results 166 men with a mean age of 59 ± 10 years were analyzed. The mean preoperative curvature in the entire cohort was 65° (range = 30–130°). 94% of patients with MPP had total resolution of their curvature at the end of the operation, whereas 8 patients (6%) had residual curvature (25–40°). In the IPP group 25 of 30 (83.3%) had a straight penis at the end of surgery, whereas 5 of 30 (16.7%) had residual curvature, with the mean magnitude being 33° in the MPP group and 30° in the IPP group. 86% of all patients had diabetes. There were no differences between the 2 implant groups in age, hemoglobin A1c, body mass index, or smoking status. The mean patient satisfaction was 4.42 ± 0.70 (range = 2–5) and there was no difference between the 2 groups. The mean follow-up period was 23.4 months (range = 6–29 months). Conclusion We found that the MPP is as effective as the IPP in curvature correction in patients with PD, with similar patient satisfaction for the 2 groups.

Tài liệu tham khảo

Carson, 2003, Penile prostheses: are they still relevant?, BJU Int, 91, 176, 10.1046/j.1464-410X.2003.t01-1-03064.x Ralph, 2010, The management of Peyronie’s disease: evidence-based 2010 guidelines, J Sex Med, 7, 2359 Levine, 2013, Surgery for Peyronie’s disease, Asian J Androl, 15, 27, 10.1038/aja.2012.92 Chaudhary, 2005, Peyronie’s disease with erectile dysfunction: penile modeling over inflatable penile prostheses, Urology, 65, 760, 10.1016/j.urology.2004.10.039 Wilson, 1994, A new treatment for Peyronie’s disease: modeling the penis over an inflatable penile prosthesis, J Urol, 152, 1121 Garaffa, 2011, The management of residual curvature after penile prosthesis implantation in men with Peyronie’s disease, BJU Int, 108, 1152, 10.1111/j.1464-410X.2010.10023.x Levine, 2010, Inflatable penile prosthesis placement in men with Peyronie’s disease and drug-resistant erectile dysfunction: a single-center study, J Sex Med, 7, 3775 Wilson, 2007, Surgical techniques: modeling technique for penile curvature, J Sex Med, 4, 231 Carson, 2000, Penile prosthesis implantation in the treatment of Peyronie’s disease and erectile dysfunction, Int J Impot Res, 12, 122, 10.1038/sj.ijir.3900590 Montorsi, 1993, Patient-partner satisfaction with semirigid penile prosthesis for Peyronie’s disease: a 5-year follow-up study, J Urol, 150, 1819 Levine, 2016, Penile prosthesis surgery: current recommendations from the International Consultation on Sexual Medicine, J Sex Med, 13, 489 Mulcahy, 2002, Management of Peyronie’s disease with penile prostheses, Int J Impot Res, 14, 384, 10.1038/sj.ijir.3900865 Sommer, 2002, Epidemiology of Peyronie’s disease, Int J Impot Res, 14, 379, 10.1038/sj.ijir.3900863 Ralph, 2011, Long-term results of the surgical treatment of Peyronie’s disease with plaque incision and grafting, Asian J Androl, 13, 797, 10.1038/aja.2011.117 Usta, 2004, Stratification of penile vascular pathologies in patients with Peyronie’s disease and in man with erectile dysfunction according to age: a comparative study, J Urol, 172, 259 Segal, 2013, Surgical management for Peyronie’s disease, World J Mens Health, 31, 1, 10.5534/wjmh.2013.31.1.1 Kowalczyk, 1996, Penile curvatures and aneurysmal defects with the Ultrex penile prosthesis corrected with insertion of the AMS 700 CX, J Urol, 156, 398 Nehra, 2015, Peyronie’s disease: AUA guideline, J Urol, 194, 745 Ghanem, 1998, Malleable penile implants without plaque surgery in the treatment of Peyronie’s disease, Int J Impot Res, 10, 171, 10.1038/sj.ijir.3900324