Malignancies in HIV/AIDS
Tóm tắt
Từ khóa
Tài liệu tham khảo
Eltom, 2002, Trends in Kaposis sarcoma and non-Hodgkins lymphoma incidence in the United States from 1973 through 1998., J Natl Cancer Inst, 94, 1204, 10.1093/jnci/94.16.1204
Schneider, 2008, Revised surveillance case definitions for HIV infection among adults, adolescents, and children aged18 months and for HIV infection and AIDS among children aged 18 months to 13 years - United States, 2008., MMWR Recomm Rep, 57, 1
Shiels, 2011, Cancer burden in the HIV-infected population in the United States., J Natl Cancer Inst, 103, 753, 10.1093/jnci/djr076
Palella, 1998, Declining morbidity and mortality among patients with advanced human immunodeficiency virus infection. HIV Outpatient Study Investigators., N Engl J Med, 338, 853, 10.1056/NEJM199803263381301
Hall, 2008, Estimation of HIV incidence in the United States., JAMA, 300, 520, 10.1001/jama.300.5.520
Clifford, 2005, Cancer risk in the Swiss HIV Cohort study: associations with immunodeficiency, smoking, and highly active antiretroviral therapy., J Natl Cancer Inst, 97, 425, 10.1093/jnci/dji072
Herida, 2003, Incidence of non-AIDS-defining cancers before and during the highly active antiretroviral therapy era in a cohort of human immunodeficiency virus-infected patients., J Clin Oncol, 21, 3447, 10.1200/JCO.2003.01.096
Patel, 2008, Incidence of types of cancer among HIV-infected persons compared with the general population in the United States, 1992-2003., Ann Int Med, 148, 728, 10.7326/0003-4819-148-10-200805200-00005
Powles, 2009, Highly active antiretroviral therapy and the incidence of non-AIDS-defining cancers in people with HIV infection., J Clin Oncol, 27, 884, 10.1200/JCO.2008.19.6626
Hoffmann, 2005, Malignant melanoma and HIV infection: aggressive course despite immune reconstitution., Onkologie, 28, 35
Lanoy, 2009, Epidemiology of nonkeratinocytic skin cancers among persons with AIDS in the United States., AIDS, 23, 385, 10.1097/QAD.0b013e3283213046
Burgi, 2005, Incidence and risk factors for the occurrence of non-AIDS-defining cancers among human immunodeficiency virus-infected individuals., Cancer, 104, 1505, 10.1002/cncr.21334
Gill, 2010, Causes of death in HIV-1-infected patients treated with antiretroviral therapy, 1996-2006: collaborative analysis of 13 HIV cohort studies., Clin Infect Dis, 50, 1387, 10.1086/652283
Lewden, 2008, Changes in causes of death among adults infected by HIV between 2000 and 2005: the Mortalite 2000 and 2005 surveys (ANRS EN19 and Mortavic)., J Acquir Immune Defic Syndr, 48, 590, 10.1097/QAI.0b013e31817efb54
Biggar, 2005, Survival after cancer diagnosis in persons with AIDS., J Acquir Immune Defic Syndr, 39, 293, 10.1097/01.qai.0000164033.02947.e3
Brock, 2006, Delayed diagnosis and elevated mortality in an urban population with HIV and lung cancer: implications for patient care., J Acquir Immune Defic Syndr, 43, 47, 10.1097/01.qai.0000232260.95288.93
Glaser, 2003, Population-based patterns of human immunodeficiency virus-related Hodgkin lymphoma in the Greater San Francisco Bay Area, 1988-1998., Cancer, 98, 300, 10.1002/cncr.11459
Puoti, 2004, Hepatocellular carcinoma in HIV-infected patients: epidemiological features, clinical presentation and outcome., AIDS, 18, 2285, 10.1097/00002030-200411190-00009
Jones, 1998, Bias in the standardized mortality ratio when using general population rates to estimate expected number of deaths., Am J Epidemiol, 148, 1012, 10.1093/oxfordjournals.aje.a009567
Engels, 2006, Trends in cancer risk among people with AIDS in the United States 1980-2002., AIDS, 20, 1645, 10.1097/01.aids.0000238411.75324.59
Shiels, 2011, Proportions of Kaposi sarcoma, selected non-Hodgkin lymphomas, and cervical cancer in the United States occurring in persons with AIDS, 1980-2007., JAMA, 305, 1450, 10.1001/jama.2011.396
Ambinder, 2001, Epstein-Barr virus associated lymphoproliferations in the AIDS setting., Eur J Cancer, 37, 1209, 10.1016/S0959-8049(01)00123-X
Carbone, 1993, Human immunodeficiency virus-associated systemic lymphomas may be subdivided into two main groups according to Epstein-Barr viral latent gene expression., J Clin Oncol, 11, 1674, 10.1200/JCO.1993.11.9.1674
Nador, 1996, Primary effusion lymphoma: a distinct clinicopathologic entity associated with the Kaposis sarcoma-associated herpes virus., Blood, 88, 645, 10.1182/blood.V88.2.645.bloodjournal882645
Guech-Ongey, 2010, AIDS-related Burkitt lymphoma in the United States: what do age and CD4 lymphocyte patterns tell us about etiology andor biology., Blood, 116, 5600, 10.1182/blood-2010-03-275917
Cote, 1997, Non-Hodgkins lymphoma among people with AIDS: incidence, presentation and public health burden. AIDSCancer Study Group., Int J Cancer, 73, 645, 10.1002/(SICI)1097-0215(19971127)73:5<645::AID-IJC6>3.0.CO;2-X
Frisch, 2001, Association of cancer with AIDS-related immunosuppression in adults., JAMA, 285, 1736, 10.1001/jama.285.13.1736
Bedimo, 2004, Trends in AIDS-defining and non-AIDS-defining malignancies among HIV-infected patients: 1989-2002., Clin Infect Dis, 39, 1380, 10.1086/424883
Engels, 2008, Cancer risk in people infected with human immunodeficiency virus in the United States., Int J Cancer, 123, 187, 10.1002/ijc.23487
Biggar, 2004, Cancer risk in elderly persons with HIVAIDS., J Acquir Immune Defic Syndr, 36, 861, 10.1097/00126334-200407010-00014
Hessol, 2007, The impact of highly active antiretroviral therapy on non-AIDS-defining cancers among adults with AIDS., Am J Epidemiol, 165, 1143, 10.1093/aje/kwm017
Biggar, 2006, Hodgkin lymphoma and immunodeficiency in persons with HIVAIDS., Blood, 108, 3786, 10.1182/blood-2006-05-024109
Bini, 2009, Screening colonoscopy for the detection of neoplastic lesions in asymptomatic HIV-infected subjects., Gut, 58, 1129, 10.1136/gut.2008.165985
Shiels, 2010, Reduced risk of prostate cancer in U.S. Men with AIDS., Cancer Epidemiol Biomarkers Prev, 19, 2910, 10.1158/1055-9965.EPI-10-0741
Aberg, 2006, The changing face of HIV care: common things really are common., Ann Int Med, 145, 463, 10.7326/0003-4819-145-6-200609190-00011
Engels, 2006, Elevated incidence of lung cancer among HIV-infected individuals., J Clin Oncol, 24, 1383, 10.1200/JCO.2005.03.4413
Kirk, 2007, HIV infection is associated with an increased risk for lung cancer, independent of smoking., Clin Infect Dis, 45, 103, 10.1086/518606
Piketty, 2012, Incidence of HIV-related anal cancer remains increased despite long-term combined antiretroviral treatment: results from the French hospital database on HIV., J Clin Oncol, 30, 4360, 10.1200/JCO.2012.44.5486
Grulich, 2007, Incidence of cancers in people with HIVAIDS compared with immunosuppressed transplant recipients: a meta-analysis., Lancet, 370, 59, 10.1016/S0140-6736(07)61050-2
Silverberg, 2007, Risk of cancers during interrupted antiretroviral therapy in the SMART study., AIDS, 21, 1957, 10.1097/QAD.0b013e3282ed6338
Kowalska, 2012, Long-term exposure to combination antiretroviral therapy and risk of death from specific causes: no evidence for any previously unidentified increased risk due to antiretroviral therapy., AIDS, 26, 315, 10.1097/QAD.0b013e32834e8805
Rodger, 2013, Mortality in well controlled HIV in the continuous antiretroviral therapy arms of the SMART and ESPRIT trials compared with the general population., AIDS, 27, 973, 10.1097/QAD.0b013e32835cae9c
Pantanowitz, 2009, Evolving spectrum and incidence of non-AIDS-defining malignancies., Curr Opin HIV AIDS, 4, 27, 10.1097/COH.0b013e32831a7259
Overton, 2013, Effect of statin therapy in reducing the risk of serious non-AIDS-defining events and nonaccidental death., Clin Infect Dis, 56, 1471, 10.1093/cid/cit053
Sigel, 2011, Cancer screening in patients infected with HIV., Curr HIVAIDS Rep, 8, 142, 10.1007/s11904-011-0085-5
Tyerman, 2012, Review of screening guidelines for non-AIDS-defining malignancies: evolving issues in the era of highly active antiretroviral therapy., AIDS Rev, 14, 3
Palefsky, 1998, Virologic, immunologic, and clinical parameters in the incidence and progression of anal squamous intraepithelial lesions in HIV-positive and HIV-negative homosexual men., J Acquir Immune Defic Syndr Hum Retrovirol, 17, 314, 10.1097/00042560-199804010-00004
McLaughlin-Drubin, 2008, Viruses associated with human cancer., Biochim Biophys Acta, 1782, 127, 10.1016/j.bbadis.2007.12.005
Ateenyi-Agaba, 1995, Conjunctival squamous-cell carcinoma associated with HIV infection in Kampala, Uganda., Lancet, 345, 695, 10.1016/S0140-6736(95)90870-6
Goedert, 1998, Spectrum of AIDS-associated malignant disorders., Lancet, 351, 1833, 10.1016/S0140-6736(97)09028-4
Amini, 2004, Effect of HIV-1 Vpr on cell cycle regulators., DNA Cell Biol, 23, 249, 10.1089/104454904773819833
Corallini, 2002, Inhibition of HIV-1 Tat activity correlates with down-regulation of bcl-2 and results in reduction of angiogenesis and oncogenicity., Virology, 299, 1, 10.1006/viro.2002.1459
Guo, 2004, Tumorigenesis by human herpesvirus 8 vGPCR is accelerated by human immunodeficiency virus type 1 Tat., J Virol, 78, 9336, 10.1128/JVI.78.17.9336-9342.2004
Harrod, 2003, Human immunodeficiency virus type-1 Tatco-activator acetyltransferase interactions inhibit p53Lys-320 acetylation and p53-responsive transcription., J Biol Chem, 278, 12310, 10.1074/jbc.M211167200
Li, 1995, Reciprocal modulations between p53 and Tat of human immunodeficiency virus type 1., Proc Natl Acad Sci U S A, 92, 5461, 10.1073/pnas.92.12.5461
Wright, 1994, Human immunodeficiency virus type 1 tat directs transcription through attenuation sites within the mouse c-myc gene., J Mol Biol, 243, 568, 10.1016/0022-2836(94)90031-0
Bartel, 2009, MicroRNAs: target recognition and regulatory functions., Cell, 136, 215, 10.1016/j.cell.2009.01.002
Qi, 2006, Virus-encoded microRNAs: future therapeutic targets., Cell Mol Immunol, 3, 411
Bartel, 2004, MicroRNAs: genomics, biogenesis, mechanism, and function., Cell, 116, 281, 10.1016/S0092-8674(04)00045-5
Lu, 2005, MicroRNA expression profiles classify human cancers., Nature, 435, 834, 10.1038/nature03702
Besson, 2001, Changes in AIDS-related lymphoma since the era of highly active antiretroviral therapy., Blood, 98, 2339, 10.1182/blood.V98.8.2339
Carbone, 2002, AIDS-related non-Hodgkins lymphomas: from pathology and molecular pathogenesis to treatment., Hum Pathol, 33, 392, 10.1053/hupa.2002.124723
Knowles, 2003, Etiology and pathogenesis of AIDS-related non-Hodgkins lymphoma., HematolOncol Clin North Am, 17, 785, 10.1016/S0889-8588(03)00050-9
Carbone, 2005, AIDS-related lymphomas: from pathogenesis to pathology., Br J Haematol, 130, 662, 10.1111/j.1365-2141.2005.05613.x
Epeldegui, 2006, Pathogenesis of AIDS lymphoma: role of oncogenic viruses and B cell activation-associated molecular lesions., Curr Opin Oncol, 18, 444, 10.1097/01.cco.0000239882.23839.e5
Barclay, 2007, Clinical and immunologic profile of AIDS-related lymphoma in the era of highly active antiretroviral therapy., Clin Lymphoma Myeloma, 7, 272, 10.3816/CLM.2007.n.002
Brenchley, 2004, T-cell subsets that harbor human immunodeficiency virus (HIV) in vivo: implications for HIV pathogenesis., J Virol, 78, 1160, 10.1128/JVI.78.3.1160-1168.2004
Levesque, 2009, Polyclonal B cell differentiation and loss of gastrointestinal tract germinal centers in the earliest stages of HIV-1 infection., PLoS Med, 6, e1000107, 10.1371/journal.pmed.1000107
Mosmann, 1989, TH1 and TH2 cells: different patterns of lymphokine secretion lead to different functional properties., Ann Rev Immunol, 7, 145, 10.1146/annurev.iy.07.040189.001045
Pantaleo, 1991, Lymphoid organs function as major reservoirs for human immunodeficiency virus., Proc Natl Acad Sci U S A, 88, 9838, 10.1073/pnas.88.21.9838
Thorbecke, 1994, Biology of germinal centers in lymphoid tissue., FASEB J, 8, 832, 10.1096/fasebj.8.11.8070632
Kuppers, 1994, Hodgkin disease: Hodgkin and Reed-Sternberg cells picked from histological sections show clonal immunoglobulin gene rearrangements and appear to be derived from B cells at various stages of development., Proc Natl Acad Sci U S A, 91, 10962, 10.1073/pnas.91.23.10962
Buri, 2001, CC chemokines and the receptors CCR3 and CCR5 are differentially expressed in the nonneoplastic leukocytic infiltrates of Hodgkin disease., Blood, 97, 1543, 10.1182/blood.V97.6.1543
Kapp, 1999, Interleukin 13 is secreted by and stimulates the growth of Hodgkin and Reed-Sternberg cells., J Exp Med, 189, 1939, 10.1084/jem.189.12.1939
Klein, 1992, Production of multiple cytokines by Hodgkins disease derived cell lines., Hematol Oncol, 10, 319, 10.1002/hon.2900100605
Skinnider, 2002, Signal transducer and activator of transcription 6 is frequently activated in Hodgkin and Reed-Sternberg cells of Hodgkin lymphoma., Blood, 99, 618, 10.1182/blood.V99.2.618
Skinnider, 2002, The role of cytokines in classical Hodgkin lymphoma., Blood, 99, 4283, 10.1182/blood-2002-01-0099
Teruya-Feldstein, 1999, Differential chemokine expression in tissues involved by Hodgkins disease: direct correlation of eotaxin expression and tissue eosinophilia., Blood, 93, 2463, 10.1182/blood.V93.8.2463
van den Berg, 1999, High expression of the CC chemokine TARC in Reed-Sternberg cells. A possible explanation for the characteristic T-cell infiltratein Hodgkins lymphoma., Am J Pathol, 154, 1685, 10.1016/S0002-9440(10)65424-7
Shedlock, 2003, Requirement for CD4 T cell help in generating functional CD8 T cell memory., Science, 300, 337, 10.1126/science.1082305
Sun, 2003, Defective CD8 T cell memory following acute infection without CD4 T cell help., Science, 300, 339, 10.1126/science.1083317
Zloza, 2012, NKG2D signaling on CD8() T cells represses T-bet and rescues CD4-unhelped CD8() T cell memory recall but not effector responses., Nat Med, 18, 422, 10.1038/nm.2683
Appay, 2002, Characterization of CD4() CTLs ex vivo., J Immunol, 168, 5954, 10.4049/jimmunol.168.11.5954
Belkaid, 2002, CD4CD25 regulatory T cells control Leishmania major persistence and immunity., Nature, 420, 502, 10.1038/nature01152
Chaturvedi, 2011, Cutting edge: human regulatory T cells require IL-35 to mediate suppression and infectious tolerance., J Immunol, 186, 6661, 10.4049/jimmunol.1100315
Collison, 2010, IL-35-mediated induction of a potent regulatory T cell population., Nat Immunol, 11, 1093, 10.1038/ni.1952
Curotto de Lafaille, 2009, Natural and adaptive foxp3 regulatory T cells: more of the same or a division of labor., Immunity, 30, 626, 10.1016/j.immuni.2009.05.002
Dardalhon, 2008, IL-4 inhibits TGF-beta-induced Foxp3 T cells and, together with TGF-beta, generates IL-9 IL-10 Foxp3(-) effector T cells., Nat Immunol, 9, 1347, 10.1038/ni.1677
Duhen, 2009, Production of interleukin 22 but not interleukin 17 by a subset of human skin-homing memory T cells., Nat Immunol, 10, 857, 10.1038/ni.1767
Josefowicz, 2009, Control of regulatory T cell lineage commitment and maintenance., Immunity, 30, 616, 10.1016/j.immuni.2009.04.009
Romagnani, 1994, Lymphokine production by human T cells in disease states., Annu Rev Immunol, 12, 227, 10.1146/annurev.iy.12.040194.001303
Wilson, 2007, Development, cytokine profile and function of human interleukin 17-producing helper T cells., Nat Immunol, 8, 950, 10.1038/ni1497
Zhou, 2009, Plasticity of CD4 T cell lineage differentiation., Immunity, 30, 646, 10.1016/j.immuni.2009.05.001
Burns, 1996, Cigarette smoking, bacterial pneumonia, and other clinical outcomes in HIV-1 infection. Terry Beirn Community Programs for Clinical Research on AIDS., J Acquir Immune Defic Syndr Hum Retrovirol, 13, 374, 10.1097/00042560-199612010-00012
Niaura, 2000, Human immunodeficiency virus infection, AIDS, and smoking cessation: the time is now., Clin Infect Dis, 31, 808, 10.1086/314048
Galvan, 2002, The prevalence of alcohol consumption and heavy drinking among people with HIV in the United States: results from the HIV Cost and Services Utilization Study., J Stud Alcohol, 63, 179, 10.15288/jsa.2002.63.179
Helleberg, 2013, Mortality attributable to smoking among HIV-1-infected individuals: a nationwide, population-based cohort study., Clin Infect Dis, 56, 727, 10.1093/cid/cis933
Kaplan, 2005, Rituximab does not improve clinical outcome in a randomized phase 3 trial of CHOP with or without rituximab in patients with HIV-associated non-Hodgkin lymphoma: AIDS-Malignancies Consortium Trial 010., Blood, 106, 1538, 10.1182/blood-2005-04-1437
Thun, 1997, Alcohol consumption and mortality among middle-aged and elderly U.S. adults., N Engl J Med, 337, 1705, 10.1056/NEJM199712113372401
Gebo, 2005, Racial and gender disparities in receipt of highly active antiretroviral therapy persist in a multistate sample of HIV patients in 2001., J Acquir Immune Defic Syndr, 38, 96, 10.1097/00126334-200501010-00017
Hardy, 2009, Racial disparities and survival for nonsmall-cell lung cancer in a large cohort of black and white elderly patients., Cancer, 115, 4807, 10.1002/cncr.24521
Hentrich, 2012, Stage-adapted treatment of HIV-associated Hodgkin lymphoma: results of a prospective multicenter study., J Clin Oncol, 30, 4117, 10.1200/JCO.2012.41.8137
Levine, 2000, Chemotherapy consisting of doxorubicin, bleomycin, vinblastine, and dacarbazine with granulocyte-colony-stimulating factor in HIV-infected patients with newly diagnosed Hodgkins disease: a prospective, multiinstitutional AIDS clinical trials group study (ACTG 149)., J Acquir Immune Defic Syndr, 24, 444, 10.1097/00042560-200008150-00009
Xicoy, 2007, Results of treatment with doxorubicin, bleomycin, vinblastine and dacarbazine and highly active antiretroviral therapy in advanced stage, human immunodeficiency virus-related Hodgkins lymphoma., Haematologica, 92, 191, 10.3324/haematol.10479
Dunleavy, 2010, The role of tumor histogenesis, FDG-PET, and short-course EPOCH with dose-dense rituximab (SC-EPOCH-RR) in HIV-associated diffuse large B-cell lymphoma., Blood, 115, 3017, 10.1182/blood-2009-11-253039
Lim, 2005, AIDS-related Burkitts lymphoma versus diffuse large-cell lymphoma in the prehighly active antiretroviral therapy (HAART) and HAART eras: significant differences in survival with standard chemotherapy., J Clin Oncol, 23, 4430, 10.1200/JCO.2005.11.973
Little, 2003, Highly effective treatment of acquired immunodeficiency syndrome-related lymphoma with dose-adjusted EPOCH: impact of antiretroviral therapy suspension and tumor biology., Blood, 101, 4653, 10.1182/blood-2002-11-3589
Sparano, 2010, Rituximab plus concurrent infusional EPOCH chemotherapy is highly effective in HIV-associated B-cell non-Hodgkin lymphoma., Blood, 115, 3008, 10.1182/blood-2009-08-231613
Kachnic, 2012, Dose-painted intensity-modulated radiation therapy for anal cancer: a multiinstitutional report of acute toxicity and response to therapy., Int J Radiat Oncol Biol Physics, 82, 153, 10.1016/j.ijrobp.2010.09.030
Oehler-Janne, 2008, HIV-specific differences in outcome of squamous cell carcinoma of the anal canal: a multicentric cohort study of HIV-positive patients receiving highly active antiretroviral therapy., J Clin Oncol, 26, 2550, 10.1200/JCO.2007.15.2348
Antoniou, 2005, Interactions between antiretrovirals and antineoplastic drug therapy., Clin Pharmacokinet, 44, 111, 10.2165/00003088-200544020-00001
Deeken, 2009, Targeted therapies to treat non-AIDS-defining cancers in patients with HIV on HAART therapy: treatment considerations and research outlook., Curr Opin Oncol, 21, 445, 10.1097/CCO.0b013e32832f3e04
Rudek, 2011, Use of antineoplastic agents in patients with cancer who have HIVAIDS., Lancet Oncol, 12, 905, 10.1016/S1470-2045(11)70056-0
Schwartz, 1999, Potential interaction of antiretroviral therapy with paclitaxel in patients with AIDS-related Kaposis sarcoma., AIDS, 13, 283, 10.1097/00002030-199902040-00019
Walubo, 2007, The role of cytochrome P450 in antiretroviral drug interactions., Exp Opin Drug Metab Toxicol, 3, 583, 10.1517/17425255.3.4.583
Ling, 2010, The large intestine as a major reservoir for simian immunodeficiency virus in macaques with long-term, nonprogressing infection., J Infect Dis, 202, 1846, 10.1086/657413
Rubinstein, 2010, Ritonavir based highly active retroviral therapy (HAART) correlates with early neurotoxicity when combined with ABVD treated HIV associated Hodgkin lymphoma but not non-Hodgkin lymphoma. A retrospective study., Blood, 116, 2807, 10.1182/blood.V116.21.2807.2807
Ezzat, 2012, Incidence, predictors and significance of severe toxicity in patients with human immunodeficiency virus-associated Hodgkin lymphoma., Leuk Lymph, 53, 2390, 10.3109/10428194.2012.697560
Powles, 2002, Effects of combination chemotherapy and highly active antiretroviral therapy on immune parameters in HIV-1 associated lymphoma., AIDS, 16, 531, 10.1097/00002030-200203080-00003
Alfa-Wali, 2012, Chemoradiotherapy for anal cancer in HIV patients causes prolonged CD4 cell count suppression., Ann Oncol, 23, 141, 10.1093/annonc/mdr050
Bouma, 2003, The immunological and genetic basis of inflammatory bowel disease., Nat Rev Immunol, 3, 521, 10.1038/nri1132
Chun, 1999, Effect of interleukin-2 on the pool of latently infected, resting CD4 T cells in HIV-1-infected patients receiving highly active antiretroviral therapy., Nat Med, 5, 651, 10.1038/9498
Spina, 2005, Rituximab plus infusional cyclophosphamide, doxorubicin, and etoposide in HIV-associated non-Hodgkin lymphoma: pooled results from 3 phase 2 trials., Blood, 105, 1891, 10.1182/blood-2004-08-3300
Boue, 2006, Phase II trial of CHOP plus rituximab in patients with HIV-associated non-Hodgkins lymphoma., J Clin Oncol, 24, 4123, 10.1200/JCO.2005.05.4684
Rothe, 2012, Brentuximab vedotin for relapsed or refractory CD30 hematologic malignancies: the German Hodgkin Study Group experience., Blood, 120, 1470, 10.1182/blood-2012-05-430918
Hodi, 2010, Improved survival with ipilimumab in patients with metastatic melanoma., N Engl J Med, 363, 711, 10.1056/NEJMoa1003466
Kantoff, 2010, Sipuleucel-T immunotherapy for castration-resistant prostate cancer., N Engl J Med, 363, 411, 10.1056/NEJMoa1001294
Zhu, 1998, An African HIV-1 sequence from 1959 and implications for the origin of the epidemic., Nature, 391, 594, 10.1038/35400