Male circumcision for HIV prevention in men in Rakai, Uganda: a randomised trial

The Lancet - Tập 369 Số 9562 - Trang 657-666 - 2007
Ronald H. Gray1, Godfrey Kigozi2, David Serwadda3, Frederick Makumbi3, Stephen Watya4, Fred Nalugoda2, Noah Kiwanuka2, Lawrence H. Moulton1, M.A. Chaudhary1, Michael Z. Chen1, Nelson Sewankambo5, Fred Wabwire‐Mangen3, Melanie C. Bacon6, Carolyn Williams6, Pius Opendi2, Steven J. Reynolds7,6, Oliver Laeyendecker7,6, Thomas C. Quinn7,6, Maria J. Wawer1
1Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD, USA
2Rakai Health Sciences Program, Entebbe, Uganda
3Makerere University Institute of Public Health, Kampala, Uganda
4Makerere University, Mulago Hospital, Department of Surgery, Urology Unit, Kampala, Uganda
5Makerere University, Department of Medicine, Kampala, Uganda
6National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA
7Johns Hopkins Medical Institutions, Baltimore, Md. USA

Tóm tắt

Từ khóa


Tài liệu tham khảo

Weiss, 2000, Male circumcision and risk of HIV infection in sub-Saharan Africa: a systematic review and meta-analysis, AIDS, 14, 2361, 10.1097/00002030-200010200-00018

Gray, 2000, Male circumcision and HIV acquisition and transmission: cohort studies in Rakai, Uganda. Rakai Project Team, AIDS, 14, 2371, 10.1097/00002030-200010200-00019

Reynolds, 2004, Male circumcision and risk of HIV-1 and other sexually transmitted infections in India, Lancet, 363, 1039, 10.1016/S0140-6736(04)15840-6

Lavreys, 1999, Effect of circumcision on incidence of human immunodeficiency virus type 1 and other sexually transmitted diseases: a prospective cohort study of trucking company employees in Kenya, J Infect Dis, 180, 330, 10.1086/314884

Baeten, 2005, Female-to-male infectivity of HIV-1 among circumcised and uncircumcised Kenyan men, J Infect Dis, 191, 546, 10.1086/427656

Auvert, 2005, Randomized, controlled intervention trial of male circumcision for reduction of HIV infection risk: the ANRS 1265 Trial, PLoS Med, 2, e298, 10.1371/journal.pmed.0020298

1992, 2972

Zablotska, 2006, Alcohol use before sex and HIV acquisition: a longitudinal study in Rakai, Uganda, AIDS, 20, 1, 10.1097/01.aids.0000226960.25589.72

Lan, 1983, Discrete sequential boundaries for clinical trials, Biometrika, 70, 659, 10.2307/2336502

O'Brien, 1979, A multiple testing procedure for clinical trials, Biometrics, 35, 549, 10.2307/2530245

Bailey, 2007, Male circumcision for HIV prevention in young men in Kisumu, Kenya: a randomised controlled trial, Lancet, 369, 643, 10.1016/S0140-6736(07)60312-2

Gray RH, Li X, Kigozi G, et al. The impact of male circumcision on HIV incidence, and cost-per infection prevented: a stochastic simulation model from Rakai, Uganda. AIDS (in press).

Weiss, 2006, Male circumcision and risk of syphilis, chancroid, and genital herpes: a systematic review and meta-analysis, Sex Transm Infect, 82, 101, 10.1136/sti.2005.017442

Freeman, 2006, Herpes simplex virus 2 infection increases HIV acquisition in men and women: systematic review and meta-analysis of longitudinal studies, AIDS, 20, 73, 10.1097/01.aids.0000198081.09337.a7

Reynolds, 2003, Recent herpes simplex virus type 2 infection and the risk of human immunodeficiency virus type 1 acquisition in India, J Infect Dis, 187, 1513, 10.1086/368357

Rottingen, 2001, A systematic review of the epidemiologic interactions between classic sexually transmitted diseases and HIV, Sex Transm Dis, 28, 579, 10.1097/00007435-200110000-00005

Gray, 2004, Male circumcision and the risk of sexually transmitted infections and HIV in Rakai, Uganda, AIDS, 18, 2428

Hussain, 1995, Comparative investigation of Langerhans' cells and potential receptors for HIV in oral, genitourinary and rectal epithelia, Immunology, 85, 475

Donoval, 2006, HIV-1 target cells in foreskins of African men with varying histories of sexually transmitted infections, Am J Clin Pathol, 125, 386, 10.1309/JVHQVDJDYKM58EPH

McCoombe, 2006, Potential HIV-1 target cells in the human penis, AIDS, 20, 1491, 10.1097/01.aids.0000237364.11123.98

Patterson, 2002, Susceptibility to human immunodeficiency virus-1 infection of human foreskin and cervical tissue grown in explant culture, Am J Pathol, 161, 867, 10.1016/S0002-9440(10)64247-2

Szabo, 2000, How does male circumcision protect against HIV infection?, BMJ, 320, 1592, 10.1136/bmj.320.7249.1592

Kahn, 2006, Cost-effectiveness of male circumcision for HIV prevention in a South African setting, PLoS Med, 3, e517, 10.1371/journal.pmed.0030517

Bailey, 2006, 1

Kabra, 1990, Sterilisation camps in India, Lancet, 335, 224, 10.1016/0140-6736(90)90314-U

Kumar, 1999, Health-care camps for the poor provide mass sterilisation quota, Lancet, 353, 1251, 10.1016/S0140-6736(05)66920-6

Montori, 2005, Randomized trials stopped early for benefit: a systematic review, JAMA, 294, 2203, 10.1001/jama.294.17.2203