Malaria Vaccines: Moving Forward After Encouraging First Steps

Current Tropical Medicine Reports - Tập 2 Số 1 - Trang 1-3 - 2015
Tuan M. Tran1, Sílvia Portugal1, Simon J. Draper2, Peter D. Crompton1
1Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD, USA
2Jenner Institute, University of Oxford, Old Road Campus Research Building, Oxford OX3 7DQ, UK

Tóm tắt

Từ khóa


Tài liệu tham khảo

World Health Organization: World Malaria Report 2013: World Health Organization; 2013.

World Health Organization: Global Plan for Insecticide Resistance Management in malaria vectors: World Health Organization; 2012.

Ashley EA, Dhorda M, Fairhurst RM, et al. Spread of artemisinin resistance in Plasmodium falciparum malaria. N Engl J Med. 2014;371(5):411–23.

Gates MF. Malaria Forum Keynote Address. October 17, 2007. http://www.gatesfoundation.org/media-center/speeches/2007/10/melinda-french-gates-malaria-forum . Accessed October 28, 201.

World Health Organization. Global malaria action plan. http://www.rbm.who.int/gmap/ . Accessed October 28, 2014.

Greenwood B. Can malaria be eliminated? Trans R Soc Trop Med Hyg. 2009;103 Suppl 1:S2–5.

Fauci AS. Ebola—underscoring the global disparities in health care resources. N Engl J Med. 2014;371(12):1084–6.

Check Hayden E. Ebola obstructs malaria control. Nature. 2014;514(7520):15–6.

Riley EM, Stewart VA. Immune mechanisms in malaria: new insights in vaccine development. Nat Med. 2013;19(2):168–78.

Tran TM, Li S, Doumbo S, et al. An intensive longitudinal cohort study of Malian children and adults reveals no evidence of acquired immunity to Plasmodium falciparum infection. Clin Infect Dis. 2013;57(1):40–7.

Agnandji ST, Lell B, Soulanoudjingar SS, et al. First results of phase 3 trial of RTS,S/AS01 malaria vaccine in African children. N Engl J Med. 2011;365(20):1863–75.

SCTP Rts, Agnandji ST, Lell B, et al. A phase 3 trial of RTS,S/AS01 malaria vaccine in African infants. N Engl J Med. 2012;367(24):2284–95.

Rts SCTP. Efficacy and safety of the RTS,S/AS01 malaria vaccine during 18 months after vaccination: a phase 3 randomized, controlled trial in children and young infants at 11 African sites. PLoS Med. 2014;11(7):e1001685.

PATH Malaria Vaccine Initiative. Malaria Vaccine Technology Roadmap. August 2006. http://www.malariavaccine.org/files/Malaria_Vaccine_TRM_Final_000.pdf . Accessed October 28, 2014.

Daily JP. Malaria vaccine trials—beyond efficacy end points. N Engl J Med. 2012;367(24):2349–51.

Tran TM, Samal B, Kirkness E, Crompton PD. Systems immunology of human malaria. Trends Parasitol. 2012;28(6):248–57.

Ewer KJ, O’Hara GA, Duncan CJ, et al. Protective CD8+ T-cell immunity to human malaria induced by chimpanzee adenovirus-MVA immunisation. Nat Commun. 2013;4:2836.

Fowkes FJ, Simpson JA, Beeson JG. Implications of the licensure of a partially efficacious malaria vaccine on evaluating second-generation vaccines. BMC Med. 2013;11:232.

Seder RA, Chang LJ, Enama ME, et al. Protection against malaria by intravenous immunization with a nonreplicating sporozoite vaccine. Science. 2013;341(6152):1359–65.

Barry AE, Schultz L, Buckee CO, Reeder JC. Contrasting population structures of the genes encoding ten leading vaccine-candidate antigens of the human malaria parasite, Plasmodium falciparum. PLoS One. 2009;4(12):e8497.

Heppner Jr DG, Kester KE, Ockenhouse CF, et al. Towards an RTS,S-based, multi-stage, multi-antigen vaccine against falciparum malaria: progress at the Walter Reed Army Institute of Research. Vaccine. 2005;23(17–18):2243–50.

Thompson FM, Porter DW, Okitsu SL, et al. Evidence of blood stage efficacy with a virosomal malaria vaccine in a phase IIa clinical trial. PLoS One. 2008;3(1):e1493.

Douglas AD, Edwards NJ, Duncan CJ, et al. Comparison of modeling methods to determine liver-to-blood inocula and parasite multiplication rates during controlled human malaria infection. J Infect Dis. 2013;208(2):340–5.

Sheehy SH, Douglas AD, Draper SJ. Challenges of assessing the clinical efficacy of asexual blood-stage Plasmodium falciparum malaria vaccines. Hum Vaccin Immunother. 2013;9(9):1831–40.

Wright GJ, Rayner JC. Plasmodium falciparum erythrocyte invasion: combining function with immune evasion. PLoS Pathog. 2014;10(3):e1003943.

Tran TM, Ongoiba A, Coursen J, et al. Naturally acquired antibodies specific for Plasmodium falciparum reticulocyte-binding protein homologue 5 inhibit parasite growth and predict protection from malaria. J Infect Dis. 2014;209(5):789–98.

Douglas AD, Williams AR, Knuepfer E, et al. Neutralization of Plasmodium falciparum merozoites by antibodies against PfRH5. J Immunol. 2014;192(1):245–58.

Srinivasan P, Ekanem E, Diouf A, et al. Immunization with a functional protein complex required for erythrocyte invasion protects against lethal malaria. Proc Natl Acad Sci U S A. 2014;111(28):10311–6.

Raj DK, Nixon CP, Nixon CE, et al. Antibodies to PfSEA-1 block parasite egress from RBCs and protect against malaria infection. Science. 2014;344(6186):871–7.

World Health Organization. Malaria vaccine rainbow tables. [ http://www.who.int/immunization/research/development/Rainbow_tables/en/ ]. Accessed November 7, 2014.