Magnetic resonance imaging of Hoffa's fat pad and relevance for osteoarthritis research: a narrative review

Clockaerts, 2010, The infrapatellar fat pad should be considered as an active osteoarthritic joint tissue: a narrative review, Osteoarthritis Cartilage, 18, 876, 10.1016/j.joca.2010.03.014 Saddik, 2004, MRI of Hoffa's fat pad, Skeletal Radiol, 33, 433, 10.1007/s00256-003-0724-z Pan, 2014, A longitudinal study of the association between infrapatellar fat pad maximal area and changes in knee symptoms and structure in older adults, Ann Rheum Dis Ioan-Facsinay, 2013, An emerging player in knee osteoarthritis: the infrapatellar fat pad, Arthritis Res Ther, 15, 225, 10.1186/ar4422 de Lange-Brokaar, 2012, Synovial inflammation, immune cells and their cytokines in osteoarthritis: a review, Osteoarthritis Cartilage, 20, 1484, 10.1016/j.joca.2012.08.027 Benito, 2005, Synovial tissue inflammation in early and late osteoarthritis, Ann Rheum Dis, 64, 1263, 10.1136/ard.2004.025270 Stannus, 2013, Associations between serum levels of inflammatory markers and change in knee pain over 5 years in older adults: a prospective cohort study, Ann Rheum Dis, 72, 535, 10.1136/annrheumdis-2011-201047 Hayashi, 2014, Clinical and translational potential of MRI evaluation in knee osteoarthritis, Curr Rheumatol Rep, 16, 391, 10.1007/s11926-013-0391-6 Hayashi, 2011, Imaging of synovitis in osteoarthritis: current status and outlook, Semin Arthritis Rheum, 41, 116, 10.1016/j.semarthrit.2010.12.003 Peterfy, 2004, Whole-Organ Magnetic Resonance Imaging Score (WORMS) of the knee in osteoarthritis, Osteoarthritis Cartilage, 12, 177, 10.1016/j.joca.2003.11.003 Hunter, 2008, The reliability of a new scoring system for knee osteoarthritis MRI and the validity of bone marrow lesion assessment: BLOKS (Boston Leeds Osteoarthritis Knee Score), Ann Rheum Dis, 67, 206, 10.1136/ard.2006.066183 Ballegaard, 2014, Knee pain and inflammation in the infrapatellar fat pad estimated by conventional and dynamic contrast-enhanced magnetic resonance imaging in obese patients with osteoarthritis: a cross-sectional study, Osteoarthritis Cartilage, 22, 933, 10.1016/j.joca.2014.04.018 Braun, 2012, Diagnosis of osteoarthritis: imaging, Bone, 51, 278, 10.1016/j.bone.2011.11.019 Hunter, 2011, Evolution of semi-quantitative whole joint assessment of knee OA: MOAKS (MRI Osteoarthritis Knee Score), Osteoarthritis Cartilage, 19, 990, 10.1016/j.joca.2011.05.004 Baker, 2010, Relation of synovitis to knee pain using contrast-enhanced MRIs, Ann Rheum Dis, 69, 1779, 10.1136/ard.2009.121426 Loeuille, 2005, Macroscopic and microscopic features of synovial membrane inflammation in the osteoarthritic knee: correlating magnetic resonance imaging findings with disease severity, Arthritis Rheum, 52, 3492, 10.1002/art.21373 Attur, 2010, Targeting the synovial tissue for treating osteoarthritis (OA): where is the evidence?, Best Pract Res Clin Rheumatol, 24, 71, 10.1016/j.berh.2009.08.011 Roemer, 2011, Presence of MRI-detected joint effusion and synovitis increases the risk of cartilage loss in knees without osteoarthritis at 30-month follow-up: the MOST study, Ann Rheum Dis, 70, 1804, 10.1136/ard.2011.150243 Atukorala, 2014, Synovitis in knee osteoarthritis: a precursor of disease?, Ann Rheum Dis Fernandez-Madrid, 1995, Synovial thickening detected by MR imaging in osteoarthritis of the knee confirmed by biopsy as synovitis, Magn Reson Imaging, 13, 177, 10.1016/0730-725X(94)00119-N Hill, 2007, Synovitis detected on magnetic resonance imaging and its relation to pain and cartilage loss in knee osteoarthritis, Ann Rheum Dis, 66, 1599, 10.1136/ard.2006.067470 Hill, 2001, Knee effusions, popliteal cysts, and synovial thickening: association with knee pain in osteoarthritis, J Rheumatol, 28, 1330 Han, 2014, Infrapatellar fat pad in the knee: is local fat good or bad for knee osteoarthritis?, Arthritis Res Ther, 16, R145, 10.1186/ar4607 Jacobson, 1997, MR imaging of the infrapatellar fat pad of Hoffa, RadioGraphics, 17, 675, 10.1148/radiographics.17.3.9153705 Viegas, 2007, Deep and superficial infrapatellar bursae: cadaveric investigation of regional anatomy using magnetic resonance after ultrasound-guided bursography, Skeletal Radiol, 36, 41, 10.1007/s00256-006-0142-0 LaPrade, 1998, The anatomy of the deep infrapatellar bursa of the knee, Am J Sports Med, 26, 129, 10.1177/03635465980260010501 Biedert, 2002, Sources of anterior knee pain, Clin Sports Med, 21, 335, 10.1016/S0278-5919(02)00026-1 Witonski, 1999, Distribution of substance-P nerve fibers in the knee joint in patients with anterior knee pain syndrome. A preliminary report, Knee Surg Sports Traumatol Arthrosc, 7, 177, 10.1007/s001670050144 Dye, 1998, Conscious neurosensory mapping of the internal structures of the human knee without intraarticular anesthesia, Am J Sports Med, 26, 773, 10.1177/03635465980260060601 Vahlensieck, 2002, Hoffa's recess: incidence, morphology and differential diagnosis of the globular-shaped cleft in the infrapatellar fat pad of the knee on MRI and cadaver dissections, Eur Radiol, 12, 90, 10.1007/s003300100982 Wenham, 2014, The responsiveness of novel, dynamic, contrast-enhanced magnetic resonance measures of total knee synovitis after intra-articular corticosteroid for painful osteoarthritis, Osteoarthritis Cartilage, 22, 1614, 10.1016/j.joca.2014.05.024 Sharif, 2000, Increased serum C reactive protein may reflect events that precede radiographic progression in osteoarthritis of the knee, Ann Rheum Dis, 59, 71, 10.1136/ard.59.1.71 Stannus, 2010, Circulating levels of IL-6 and TNF-alpha are associated with knee radiographic osteoarthritis and knee cartilage loss in older adults, Osteoarthritis Cartilage, 18, 1441, 10.1016/j.joca.2010.08.016 Livshits, 2009, Interleukin-6 is a significant predictor of radiographic knee osteoarthritis: the Chingford Study, Arthritis Rheum, 60, 2037, 10.1002/art.24598 Orita, 2011, Associations between proinflammatory cytokines in the synovial fluid and radiographic grading and pain-related scores in 47 consecutive patients with osteoarthritis of the knee, BMC Musculoskelet Disord, 12, 144, 10.1186/1471-2474-12-144 Conde, 2014, Differential expression of adipokines in infrapatellar fat pad (IPFP) and synovium of osteoarthritis patients and healthy individuals, Ann Rheum Dis, 73, 631, 10.1136/annrheumdis-2013-204189 Klein-Wieringa, 2011, The infrapatellar fat pad of patients with osteoarthritis has an inflammatory phenotype, Ann Rheum Dis, 70, 851, 10.1136/ard.2010.140046 Eymard, 2014, Induction of an inflammatory and prodegradative phenotype in autologous fibroblast-like synoviocytes by the infrapatellar fat pad from patients with knee osteoarthritis, Arthritis Rheumatol, 66, 2165, 10.1002/art.38657 Wickham, 2003, Multipotent stromal cells derived from the infrapatellar fat pad of the knee, Clin Orthop Relat Res, 196, 10.1097/01.blo.0000072467.53786.ca Diepold, 2015, Sex-differences of the healthy infra-patellar (Hoffa) fat pad in relation to intermuscular and subcutaneous fat content – data from the osteoarthritis initiative, Ann Anat, 200C, 30, 10.1016/j.aanat.2014.12.004 Roemer, 2009, Hoffa's fat pad: evaluation on unenhanced MR images as a measure of patellofemoral synovitis in osteoarthritis, AJR Am J Roentgenol, 192, 1696, 10.2214/AJR.08.2038 Krasnokutsky, 2011, Quantitative magnetic resonance imaging evidence of synovial proliferation is associated with radiographic severity of knee osteoarthritis, Arthritis Rheum, 63, 2983, 10.1002/art.30471 Loeuille, 2011, Comparing non-enhanced and enhanced sequences in the assessment of effusion and synovitis in knee OA: associations with clinical, macroscopic and microscopic features, Osteoarthritis Cartilage, 19, 1433, 10.1016/j.joca.2011.08.010 Crema, 2013, Peripatellar synovitis: comparison between non-contrast-enhanced and contrast-enhanced MRI and association with pain. The MOST study, Osteoarthritis Cartilage, 21, 413, 10.1016/j.joca.2012.12.006 Guermazi, 2011, Assessment of synovitis with contrast-enhanced MRI using a whole-joint semiquantitative scoring system in people with, or at high risk of, knee osteoarthritis: the MOST study, Ann Rheum Dis, 70, 805, 10.1136/ard.2010.139618 Eshed, 2015, Influence of field strength, coil type and image resolution on assessment of synovitis by unenhanced MRI – a comparison with contrast-enhanced MRI, Eur Radiol, 25, 1059, 10.1007/s00330-014-3470-9 MacIsaac, 2014, Pre-treatment whole blood gene expression is associated with 14-week response assessed by dynamic contrast enhanced magnetic resonance imaging in infliximab-treated rheumatoid arthritis patients, PLos One, 9, e113937, 10.1371/journal.pone.0113937 Workie, 2005, Quantifying dynamic contrast-enhanced MRI of the knee in children with juvenile rheumatoid arthritis using an arterial input function (AIF) extracted from popliteal artery enhancement, and the effect of the choice of the AIF on the kinetic parameters, Magn Reson Med, 54, 560, 10.1002/mrm.20597 Sakai, 1999, Para-articular chondroma and osteochondroma of the infrapatellar fat pad: a report of three cases, Int Orthop, 23, 114, 10.1007/s002640050322 Helpert, 2004, Differential diagnosis of tumours and tumour-like lesions of the infrapatellar (Hoffa's) fat pad: pictorial review with an emphasis on MR imaging, Eur Radiol, 14, 2337, 10.1007/s00330-004-2491-1 Masih, 2003, Imaging of pigmented villonodular synovitis, Semin Musculoskelet Radiol, 7, 205, 10.1055/s-2003-43231 Jaffe, 1941, Pigmented villonodular synovitis, bursitis, tenosynovitis, Arch Pathol, 31, 731 Fletcher, 2002, Diffuse-type giant cell tumour, 112 2013, 100 Aynaci, 2001, Synovial hemangioma in Hoffa's fat pad (case report), Knee Surg Sports Traumatol Arthrosc, 9, 355, 10.1007/s001670100234 Ryd, 1989, Hemangioma mimicking meniscal injury. A report on 10 years of knee pain, Acta Orthop Scand, 60, 230, 10.3109/17453678909149264 Perdikakis, 2013, MRI characteristics of cysts and “cyst-like” lesions in and around the knee: what the radiologist needs to know, Insights Imaging, 4, 257, 10.1007/s13244-013-0240-1 Kim, 2001, Intra-articular ganglion cysts of the knee: clinical and MR imaging features, Eur Radiol, 11, 834, 10.1007/s003300000713 Pedowitz, 1996, A surgical algorithm for treatment of cystic degeneration of the meniscus, Arthroscopy, 12, 209, 10.1016/S0749-8063(96)90012-2 Lantz, 1990, Meniscal cysts, Clin Sports Med, 9, 707, 10.1016/S0278-5919(20)30718-3 Howe, 2007, Arthroscopic internal marsupialization of meniscal cysts, Knee, 14, 408, 10.1016/j.knee.2007.05.005 Anderson, 2010, New observations on meniscal cysts, Skeletal Radiol, 39, 1187, 10.1007/s00256-010-0993-2 De Smet, 2011, Association of parameniscal cysts with underlying meniscal tears as identified on MRI and arthroscopy, AJR Am J Roentgenol, 196, W180, 10.2214/AJR.10.4754 Parisien, 1990, Arthroscopic treatment of cysts of the menisci. A preliminary report, Clin Orthop Relat Res, 257, 154, 10.1097/00003086-199008000-00027 Hulet, 2004, Arthroscopic treatment of 105 lateral meniscal cysts with 5-year average follow-up, Arthroscopy, 20, 831, 10.1016/S0749-8063(04)00599-7 Bisicchia, 2013, Infra-patellar fat pad cysts: a case report and review of the literature, Muscles Ligaments Tendons J, 2, 305 Aydingoz, 2004, The deep infrapatellar bursa: prevalence and morphology on routine magnetic resonance imaging of the knee, J Comput Assist Tomogr, 28, 557, 10.1097/00004728-200407000-00020 Tschirch, 2003, Prevalence and size of meniscal cysts, ganglionic cysts, synovial cysts of the popliteal space, fluid-filled bursae, and other fluid collections in asymptomatic knees on MR imaging, AJR Am J Roentgenol, 180, 1431, 10.2214/ajr.180.5.1801431 McCarthy, 2004, The MRI appearance of cystic lesions around the knee, Skeletal Radiol, 33, 187, 10.1007/s00256-003-0741-y Schweitzer, 1992, Knee effusion: normal distribution of fluid, AJR Am J Roentgenol, 159, 361, 10.2214/ajr.159.2.1632356 Aydingoz, 2005, Recesses along the posterior margin of the infrapatellar (Hoffa's) fat pad: prevalence and morphology on routine MR imaging of the knee, Eur Radiol, 15, 988, 10.1007/s00330-004-2457-3 Patel, 1998, Anatomy and clinical significance of the horizontal cleft in the infrapatellar fat pad of the knee: MR imaging, AJR Am J Roentgenol, 170, 1551, 10.2214/ajr.170.6.9609172 Abreu, 2008, Hoffa's fat pad injuries and their relationship with anterior cruciate ligament tears: new observations based on MR imaging in patients and MR imaging and anatomic correlation in cadavers, Skeletal Radiol, 37, 301, 10.1007/s00256-007-0427-y Apostolaki, 1999, MRI appearances of the infrapatellar fat pad in occult traumatic patellar dislocation, Clin Radiol, 54, 743, 10.1016/S0009-9260(99)91177-7 Cothran, 2003, MR imaging of infrapatellar plica injury, AJR Am J Roentgenol, 180, 1443, 10.2214/ajr.180.5.1801443 Sonin, 1995, MR imaging appearance of the extensor mechanism of the knee: functional anatomy and injury patterns, RadioGraphics, 15, 367, 10.1148/radiographics.15.2.7761641 Hoffa, 1904, Influence of adipose tissue with regard to the pathology of the knee joint, JAMA, 43, 795, 10.1001/jama.1904.92500120002h Turhan, 2008, A giant extrasynovial osteochondroma in the infrapatellar fat pad: end stage Hoffa's disease, Arch Orthop Trauma Surg, 128, 515, 10.1007/s00402-007-0397-5 von Engelhardt, 2010, Hoffa's fat pad impingement treated arthroscopically: related findings on preoperative MRI in a case series of 62 patients, Arch Orthop Trauma Surg, 130, 1041, 10.1007/s00402-010-1133-0 Chung, 2001, Patellar tendon-lateral femoral condyle friction syndrome: MR imaging in 42 patients, Skeletal Radiol, 30, 694, 10.1007/s002560100409 Chhabra, 2011, A systematised MRI approach to evaluating the patellofemoral joint, Skeletal Radiol, 40, 375, 10.1007/s00256-010-0909-1 Subhawong, 2010, Superolateral Hoffa's fat pad edema: association with patellofemoral maltracking and impingement, AJR Am J Roentgenol, 195, 1367, 10.2214/AJR.10.4668 Campagna, 2012, Is superolateral Hoffa fat pad edema a consequence of impingement between lateral femoral condyle and patellar ligament?, Radiology, 263, 469, 10.1148/radiol.12111066 De Smet, 2012, Is there an association between superolateral Hoffa fat pad edema on MRI and clinical evidence of fat pad impingement?, AJR Am J Roentgenol, 199, 1099, 10.2214/AJR.12.8798 Jibri, 2012, The association of infrapatellar fat pad oedema with patellar maltracking: a case-control study, Skeletal Radiol, 41, 925, 10.1007/s00256-011-1299-8 Matcuk, 2014, Superolateral Hoffa fat-pad edema and patellofemoral maltracking: predictive modeling, AJR Am J Roentgenol, 203, W207, 10.2214/AJR.13.11848 Ward, 2007, Patella alta: association with patellofemoral alignment and changes in contact area during weight-bearing, J Bone Surg Am, 89, 1749 Subhawong, 2014, Patellofemoral friction syndrome: magnetic resonance imaging correlation of morphologic and T2 cartilage imaging, J Comput Assist Tomogr, 38, 308, 10.1097/RCT.0b013e3182aab187 Kim, 1996, Arthroscopic anatomy of the infrapatellar plica, Arthroscopy, 12, 561, 10.1016/S0749-8063(96)90195-4 Discepola, 2012, Valid MR imaging predictors of prior knee arthroscopy, Skeletal Radiol, 41, 67, 10.1007/s00256-011-1121-7 Tang, 2000, Fibrous scar in the infrapatellar fat pad after arthroscopy: MR imaging, Radiat Med, 18, 1 Bradley, 2000, MR imaging of cyclops lesions, AJR Am J Roentgenol, 174, 719, 10.2214/ajr.174.3.1740719