Nghiên cứu tính chất từ tính và Mössbauer của các hạt nano magnetit được phủ fucan phục vụ cho hoạt động chống bướu

Springer Science and Business Media LLC - Tập 224 - Trang 227-238 - 2013
V. A. J. Silva1,2, P. L. Andrade1,2, Angel Bustamante3, L. de los Santos Valladares4,5, M. Mejia3, I. A. Souza6, K. P. S. Cavalcanti7, M. P. C. Silva2, J. Albino Aguiar1,4
1Programa de Pós-Graduação em Ciências de Materiais – CCEN, Universidade Federal de Pernambuco, Recife, Brazil
2Laboratório de Imunopatologia Keizo Asami (LIKA), Departamento de Bioquímica, Universidade Federal de Pernambuco, Recife, Brazil
3Laboratorio de Cerámicos y Nanomateriales, Facultad de Ciencias Físicas, Universidad Nacional Mayor de San Marcos, Lima, Peru
4Departamento de Física, Universidade Federal de Pernambuco, Recife, Brazil
5Cavendish Laboratory, Department of Physics, University of Cambridge, Cambridge, UK
6Departamento de Antibióticos, Universidade Federal de Pernambuco, Recife, Brazil
7Hospital das Clínicas, Universidade Federal de Pernambuco, Recife, Brazil

Tóm tắt

Các hạt nano magnetit (Fe3O4) được phủ fucan đã được tổng hợp bằng phương pháp kết tủa đồng thời và được nghiên cứu bằng quang phổ Mössbauer cũng như đo các tính chất từ tính. Kích thước của các hạt nano này là 8-9 nm. Các phép đo từ hóa và quang phổ Mössbauer ở nhiệt độ 300 K cho thấy hành vi siêu từ. Mô men từ của Fe3O4 một phần bị che chắn bởi sự ngưng tụ của lớp phủ fucan. Khi các hạt nano magnetit được bao phủ bằng axit oleic hoặc fucan, sự tương tác giữa các hạt giảm đi được phát hiện thông qua các nghiên cứu bằng quang phổ Mössbauer và kính hiển vi điện tử truyền qua (TEM). Hoạt động chống bướu của các hạt nano được phủ fucan đã được thử nghiệm trên Sarcoma 180, cho thấy hiệu quả giảm kích thước khối u.

Từ khóa

#hạt nano magnetit #fucan #từ tính #quang phổ Mössbauer #hoạt động chống bướu

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