Macrophages promote polycystic kidney disease progression

Duffield, 2010, Macrophages and immunologic inflammation of the kidney, Semin Nephrol, 30, 234, 10.1016/j.semnephrol.2010.03.003 Eardley, 2005, Macrophages and progressive tubulointerstitial disease, Kidney Int, 68, 437, 10.1111/j.1523-1755.2005.00422.x Duffield, 2011, Macrophages in kidney repair and regeneration, J Am Soc Nephrol, 22, 199, 10.1681/ASN.2010121301 Lee, 2011, Distinct macrophage phenotypes contribute to kidney injury and repair, J Am Soc Nephrol, 22, 317, 10.1681/ASN.2009060615 Martinez, 2009, Alternative activation of macrophages: an immunologic functional perspective, Annu Rev Immunol, 27, 451, 10.1146/annurev.immunol.021908.132532 Murray, 2011, Obstacles and opportunities for understanding macrophage polarization, J Leukoc Biol, 89, 557, 10.1189/jlb.0710409 Anders, 2011, Renal microenvironments and macrophage phenotypes determine progression or resolution of renal inflammation and fibrosis, Kidney Int, 80, 915, 10.1038/ki.2011.217 Ricardo, 2008, Macrophage diversity in renal injury and repair, J Clin Invest, 118, 3522, 10.1172/JCI36150 Fujiu, 2011, Renal collecting duct epithelial cells regulate inflammation in tubulointerstitial damage in mice, J Clin Invest, 121, 3425, 10.1172/JCI57582 Lin, 2009, Bone marrow Ly6Chigh monocytes are selectively recruited to injured kidney and differentiate into functionally distinct populations, J Immunol, 183, 6733, 10.4049/jimmunol.0901473 Grantham, 2011, Why kidneys fail in autosomal dominant polycystic kidney disease, Nat Rev Nephrol, 7, 556, 10.1038/nrneph.2011.109 Sweeney, 2006, Molecular and cellular pathophysiology of autosomal recessive polycystic kidney disease (ARPKD), Cell Tissue Res, 326, 671, 10.1007/s00441-006-0226-0 Grantham, 2003, Lillian Jean Kaplan International Prize for advancement in the understanding of polycystic kidney disease. Understanding polycystic kidney disease: a systems biology approach, Kidney Int, 64, 1157, 10.1046/j.1523-1755.2003.00242.x Torres, 2007, Autosomal dominant polycystic kidney disease, Lancet, 369, 1287, 10.1016/S0140-6736(07)60601-1 Renal Data System, 2011 Prasad, 2009, Pkd2 dosage influences cellular repair responses following ischemia-reperfusion injury, Am J Pathol, 175, 1493, 10.2353/ajpath.2009.090227 Zeier, 1992, Renal histology in polycystic kidney disease with incipient and advanced renal failure, Kidney Int, 42, 1259, 10.1038/ki.1992.413 Karihaloo, 2011, Macrophages promote cyst growth in polycystic kidney disease, J Am Soc Nephrol, 22, 1809, 10.1681/ASN.2011010084 Mrug, 2008, Overexpression of innate immune response genes in a model of recessive polycystic kidney disease, Kidney Int, 73, 63, 10.1038/sj.ki.5002627 Fry, 1985, A genetically determined murine model of infantile polycystic kidney disease, J Urol, 134, 828, 10.1016/S0022-5347(17)47448-9 Hou, 2002, Cystin, a novel cilia-associated protein, is disrupted in the cpk mouse model of polycystic kidney disease, J Clin Invest, 109, 533, 10.1172/JCI0214099 Preminger, 1982, Murine congenital polycystic kidney disease: a model for studying development of cystic disease, J Urol, 127, 556, 10.1016/S0022-5347(17)53911-7 Yoder, 2002, The polycystic kidney disease proteins, polycystin-1, polycystin-2, polaris, and cystin, are co-localized in renal cilia, J Am Soc Nephrol, 13, 2508, 10.1097/01.ASN.0000029587.47950.25 Gown, 1986, Human atherosclerosis. II. Immunocytochemical analysis of the cellular composition of human atherosclerotic lesions, Am J Pathol, 125, 191 Mantovani, 2002, Macrophage polarization: tumor-associated macrophages as a paradigm for polarized M2 mononuclear phagocytes, Trends Immunol, 23, 549, 10.1016/S1471-4906(02)02302-5 Van Gorp, 2010, Scavenger receptor CD163, a Jack-of-all-trades and potential target for cell-directed therapy, Mol Immunol, 47, 1650, 10.1016/j.molimm.2010.02.008 Ibelgaufts, 2010 Mangoo-Karim, 1989, Renal epithelial fluid secretion and cyst growth: the role of cyclic AMP, FASEB J, 3, 2629, 10.1096/fasebj.3.14.2480260 Van Rooijen, 1994, Liposome mediated depletion of macrophages: mechanism of action, preparation of liposomes and applications, J Immunol Methods, 174, 83, 10.1016/0022-1759(94)90012-4 Van Rooijen, 1996, Apoptosis of macrophages induced by liposome-mediated intracellular delivery of clodronate and propamidine, J Immunol Methods, 193, 93, 10.1016/0022-1759(96)00056-7 Gerdes, 1984, Cell cycle analysis of a cell proliferation-associated human nuclear antigen defined by the monoclonal antibody Ki-67, J Immunol, 133, 1710, 10.4049/jimmunol.133.4.1710 Cowley, 2001, Increased renal expression of monocyte chemoattractant protein-1 and osteopontin in ADPKD in rats, Kidney Int, 60, 2087, 10.1046/j.1523-1755.2001.00065.x Zheng, 2003, Urinary excretion of monocyte chemoattractant protein-1 in autosomal dominant polycystic kidney disease, J Am Soc Nephrol, 14, 2588, 10.1097/01.ASN.0000088720.61783.19 Lanoix, 1996, Dysregulation of cellular proliferation and apoptosis mediates human autosomal dominant polycystic kidney disease (ADPKD), Oncogene, 13, 1153 Lin, 2010, Macrophage Wnt7b is critical for kidney repair and regeneration, Proc Natl Acad Sci USA, 107, 4194, 10.1073/pnas.0912228107 Patel, 2008, Acute kidney injury and aberrant planar cell polarity induce cyst formation in mice lacking renal cilia, Hum Mol Genet, 17, 1578, 10.1093/hmg/ddn045 Takakura, 2009, Renal injury is a third hit promoting rapid development of adult polycystic kidney disease, Hum Mol Genet, 18, 2523, 10.1093/hmg/ddp147 Happe, 2009, Toxic tubular injury in kidneys from Pkd1-deletion mice accelerates cystogenesis accompanied by dysregulated planar cell polarity and canonical Wnt signaling pathways, Hum Mol Genet, 18, 2532, 10.1093/hmg/ddp190