Macrophage-Derived Extracellular Succinate Licenses Neural Stem Cells to Suppress Chronic Neuroinflammation

Cell Stem Cell - Tập 22 - Trang 355-368.e13 - 2018
Luca Peruzzotti-Jametti1, Joshua D. Bernstock1,2, Nunzio Vicario1, Ana S.H. Costa3, Chee Keong Kwok4, Tommaso Leonardi1, Lee M. Booty5, Iacopo Bicci1, Beatrice Balzarotti1, Giulio Volpe1, Giulia Mallucci1, Giulia Manferrari1, Matteo Donegà1, Nunzio Iraci1,6, Alice Braga1, John M. Hallenbeck2, Michael P. Murphy5, Frank Edenhofer4,7, Christian Frezza3, Stefano Pluchino1
1Department of Clinical Neurosciences and NIHR Biomedical Research Centre, University of Cambridge, Cambridge, UK
2Stroke Branch, National Institute of Neurological Disorders and Stroke, NIH (NINDS/NIH), Bethesda, MD, USA
3MRC Cancer Unit, Hutchison/MRC Research Centre, University of Cambridge, Cambridge, UK
4Institute of Anatomy and Cell Biology, University of Würzburg, Würzburg, Germany
5MRC Mitochondrial Biology Unit, Hills Road, University of Cambridge, Cambridge, UK
6Department of Biomedical and Biotechnological Sciences (BIOMETEC), University of Catania, Via S. Sofia 97, Catania 95125, Italy
7Institute of Molecular Biology and CMBI, Genomics, Stem Cell Biology and Regenerative Medicine, Leopold-Franzens-University Innsbruck, Innsbruck, Austria

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