Macrofilaricidal effect of 4 weeks of treatment with doxycycline on <i>Wuchereria bancrofti</i>

Tropical Medicine and International Health - Tập 12 Số 12 - Trang 1433-1441 - 2007
Alexander Yaw Debrah1,2,3, Sabine Mand2, Yeboah Marfo‐Debrekyei3, Linda Batsa Debrah3, Kenneth Pfarr2, Marcelle Büttner4, Ohene Adjei5, Dietrich W. Büttner4, Achim Hoerauf2
1Faculty of Allied Health Sciences, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana
2Institute for Medical Microbiology, Immunology and Parasitology, University of Bonn, Bonn, Germany
3Kumasi Centre for Collaborative Research in Tropical Medicine, Kumasi, Ghana
4Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany
5School of Medical Sciences, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana

Tóm tắt

SummaryObjective  To evaluate the efficacy of doxycycline as a macrofilaricidal agent against Wuchereria bancrofti.Method  In the Western Region of Ghana, 18 patients infected with W. bancrofti were recruited and treated with 200 mg doxycycline per day for 4 weeks. Seven untreated patients served as controls. Four months after doxycycline treatment, all patients received 150 μg/kg ivermectin. Patients were monitored for Wolbachia and microfilaria loads, antigenaemia and filarial dance sign (FDS).Results  Four months after doxycycline treatment, cases had a significantly lower Wolbachia load than controls; and 24 months after treatment, microfilaraemia, antigenaemia and frequency of FDS were significantly lower in cases than controls. Most importantly, 4 weeks of doxycycline killed 80% of macrofilariae, which is comparable with the results of a 6‐week regimen. Circulating filarial antigenaemia and FDS were strongly correlated.Conclusion  A 4‐week regimen of doxycycline seems sufficient to kill adult W. bancrofti and could be advantageous for the treatment of individual patients, e.g. in outpatient clinics.

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Thông tin xuất bản

Tropical Medicine and International Health

Tập 12 Số 12

1433-1441

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