Maceration of the skin and wound bed 1: its nature and causes
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Mosby-Year Book Inc, 1998.
Charcot J.M, 1877, New Sydenham Society, 63, 126
Falanga V., 2000, www.bu.edu/ woundbiotech/woundcare/ Woundbedpr.html
Cocke W.M., 1984, Wound Care
Harding K.G., 1986, Cardiff: Department of Surgery
Jordan M.M., 1977, Report on Incidence of Pressure Sore in the Patient Community of the Greater Glasgow Health Board Area
Keith F., Principal Lecturer
moisture.1Originally described by Charcot in 18772it occurs typically in and around the wound bed in acute and chronic wounds. Maceration can complicate the healing of chronic wounds.
Exudates have a high protein content and a specific gravity greater than 1.020. They contain inflammatory components, such as leukocytes, fibrinogen, fibrin, and will thus promote clotting.10Exudate varies in appearance and composition according to the aetiology and condition of the wound. It is normally a pale straw colour and watery in appearance but may become discoloured and viscous in the presence of infection. Different types of exudate may be seen in Box 1.11-13
London, 1990, Macmillan
1992, Price, S.A.,Wilson, L.M. Pathophysiology., 4
Vickery, C. 1997.
Exudate, 1997, Proceedings Joint Meeting European Wound Management Association and European Tissue Repair Society. London: Churchill Communications
Chen J., 1998, Aquacel hydrofibre dressing: the next step in wound dressing technology. Monograph
Harding K., 1997, Proceedings Joint Meeting European Wound Management Association and European Tissue Repair Society. London: Churchill Communications
Cooper R.M., 2002, Personal communication to the authors
Thomas, S. 1997.
Exudate, Proceedings Joint Meeting, European Wound
Management of Wound Exudate. London: Churchill Communications, 1997.
Dale, J. 1995.The anatomy and physiology of the circulation of the leg.
In, 1995, M., Roe, B. Leg Ulcers Nursing Management.
Dale J., 1995, (Eds.) Callum, M., Roe, B. Leg Ulcers Nursing Management.
Qualitative, it is, however, enriched with white blood cells.14 These serve as a source of proteases, particularly matrix metalloproteinases (MMPs)
Water, skin and the permeability barrier It has already been stated that maceration is not always due to exudate
Gilchrist B., 1999, (Eds.) Miller, M., Glover, D.Wound Management Theory and Practice London: Emap Healthcare
1996, Wounds, 8, 145
1996, JWOCN, 23, 283
Involvement of proteolytic enzymes - plasminogen activators - in the pathophysiology of pressure ulcers.Wound Repair Regen 1995; 3: 3, 273-283.
Biochemical analysis of wound fluid from nonhealing and healing chronic leg ulcers.Wound Rep Regen 1996; 4: 234-239.
the role of proteases and their inhibitors.Wound Repair Regen 1999
Ravanti L., 2000, Int J Mol Med, 6, 391
Cullen B, et al.The mechanism of action of Promogran, a proteinase modulating matrix.Wound Repair Regen 2002
Nelson A., G.
Proceedings, Joint Meeting, European Wound
Management Association and European Tissue Repair Society., 1997, Management of Wound Exudate
Bolton L.L., 2000, Ost Wound Man, 46, 51S
1985, (Eds.) Bronaugh, R.L., Maibach, H.I. Percutaneous Absorption - Mechanisms - Methodology - Drug Delivery.
In, the advancing rim of new epithelium often appears pale and slightly opaque. The inexperienced practitioner may interpret this as the effects of maceration36