MYST family histone acetyltransferases take center stage in stem cells and development

BioEssays - Tập 31 Số 10 - Trang 1050-1061 - 2009
Anne K. Voss1,2, Tim Thomas1,2
1Department of Medical Biology, University of Melbourne, Parkville, Australia
2Walter and Eliza Hall Institute of Medical Research, Parkville, Australia

Tóm tắt

AbstractAcetylation of histones is an essential element regulating chromatin structure and transcription. MYST (Moz, Ybf2/Sas3, Sas2, Tip60) proteins form the largest family of histone acetyltransferases and are present in all eukaryotes. Surprisingly, until recently this protein family was poorly studied. However, in the last few years there has been a substantial increase in interest in the MYST proteins and a number of key studies have shown that these chromatin modifiers are required for a diverse range of cellular processes, both in health and disease. Translocations affecting MYST histone acetyltransferases can lead to leukemia and solid tumors. Some members of the MYST family are required for the development and self‐renewal of stem cell populations; other members are essential for the prevention of inappropriate heterochromatin spreading and for the maintenance of adequate levels of gene expression. In this review we discuss the function of MYST proteins in vivo.

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BioEssays

Tập 31 Số 10

1050-1061

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