MUC4 expression is a novel prognostic factor in patients with invasive ductal carcinoma of the pancreas

Journal of Clinical Pathology - Tập 58 Số 8 - Trang 845-852 - 2005
Miyuki Saitou1, Masamichi Goto1, Michiko Horinouchi2, Shugo Tamada1, Kohji Nagata1, Taiji Hamada1, Masahiko Osako3, Sonshin Takao4, Surinder K. Batra5, Takashi Aikou6, K Imai7, Suguru Yonezawa8
1Department of Human Pathology, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima 890-8544, Japan
2Department of Pathology, Kagoshima Medical Association Hospital, 890-0064, Japan
3Department of Surgery, Kagoshima Medical Association Hospital
4Research Centre for Life Science Resources, Kagoshima University, Kagoshima 890-8544, Japan
5Departments of Biochemistry and Molecular Biology, Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, NE 68198-4525, USA
6Surgical Oncology and Digestive Surgery, Field of Oncology, Kagoshima University Graduate School of Medical and Dental Sciences
7Department of Internal Medicine, Sapporo Medical College, Sapporo 060-8556, Japan
8Field of Oncology, Kagoshima University Graduate School of Medical and Dental Sciences, 8-35-1 Sakuragaoka, Kagoshima 890-8544, Japan

Tóm tắt

Background:Many patients with invasive ductal carcinoma of the pancreas (IDC) have a poor outcome. MUC4 expression has been implicated as a marker for diagnosis and progression of IDC, but there are no studies of the relation between MUC4 expression and patient prognosis in IDC.Aims:To investigate the prognostic significance of MUC4 expression in IDC.Methods:The expression profiles of MUC4, ErbB2, p27, and MUC1 were investigated in IDC tissues from 135 patients by means of immunohistochemistry.Results:MUC4 was expressed in 43 of the 135 patients with IDC (31.9%). The survival of 21 patients with high MUC4 expression (>20% of neoplastic cells stained) was significantly worse than that of the 114 patients with low MUC4 expression (<20% of neoplastic cells stained) (p  =  0.0043). Univariate analysis showed that high MUC4 expression (p  =  0.0061), large primary tumour status (>T2) (p  =  0.0436), distant metastasis (p  =  0.0383), lymphatic invasion (p  =  0.0243), and surgical margins (p  =  0.0333) were significant risk factors affecting the outcome of patients with IDC. Backward stepwise multivariate analysis showed that MUC4 expression (p  =  0.0121), lymph node metastasis (p  =  0.0245), and lymphatic invasion (p  =  0.0239) were significant independent risk factors. ErbB2, p27, and MUC1 were not independent risk factors.Conclusions:This study shows that MUC4 expression in IDC is a new independent factor for poor prognosis and predicts the outcome of patients with IDC.

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Journal of Clinical Pathology

Tập 58 Số 8

845-852

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