MTHFR C677T polymorphisms are associated with aberrant methylation of the IGF-2 gene in transitional cell carcinoma of the bladder

Marsit, 2010, Identification of meth-ylated genes associated with aggressive bladder cancer, PLoS One, 5, e12334, 10.1371/journal.pone.0012334 Vikram, 2009, Imaging and staging of transitional cell carcinoma: part 1, lower urinary tract, AJR Am J Roentgenol, 192, 1481, 10.2214/AJR.08.1318 Hansen, 1988, Tumor suppressors: recessive mutations that lead to cancer, Cell, 53, 173, 10.1016/0092-8674(88)90376-5 Hunter, 1997, Oncoprotein networks, Cell, 88, 333, 10.1016/S0092-8674(00)81872-3 Jones, 2007, The epigenomics of cancer, Cell, 128, 683, 10.1016/j.cell.2007.01.029 Fang, 2006, Regulation of hMSH2 and hMLH1 expression in the human colon cancer cell line SW1116 by DNA methyltransferase 1, Cancer Lett, 233, 124, 10.1016/j.canlet.2005.03.005 Tada, 2011, Aberrant DNA methylation of T-cell leukemia, homeobox 3 modulates cisplatin sensitivity in bladder cancer, Int J Oncol, 39, 727 Brait, 2011, Cancer epigenetics: above and be-yond, Toxicol Mech Methods, 21, 275, 10.3109/15376516.2011.562671 Eze, 2011, The role of epigenetic alterations in papillary thyroid carcinogenesis, J Thyroid Res, 2011, 895470, 10.4061/2011/895470 Choi, 2007, Hypomethylation of LINE-1 and Alu in well-differentiated neuroendocrine tumors (pancreatic endocrine tumors and carcinoid tumors), Mod Pathol, 20, 802, 10.1038/modpathol.3800825 Gonzalo, 2008, Epigenetics of cancer, Gastroenterol Hepatol, 31, 37, 10.1157/13114573 Oyama, 2004, The association between methylenetetrahydro-folate reductase polymorphism and promoter methylation in proximal colon cancer, Anticancer Res, 24, 649 Batra, 2007, Modulation of DNA methyltrans-ferase profile by methyl donor starvation followed by gamma irradiation, Mol Cell Biochem, 294, 181, 10.1007/s11010-006-9258-8 Zhu, 2011, Overex-pression of MBD2 in Glioblastoma Maintains Epigenetic Silencing and Inhibits the Antiangiogenic Function of the Tumor Suppressor Gene BAI1, Cancer Res, 71, 5859, 10.1158/0008-5472.CAN-11-1157 Huang, 2006, DNA methylation, riboswitches, and transcription factor activity: fundamental mechanisms of gene-nutrient interactions involving vitamins, Mol Biol Rep, 33, 253, 10.1007/s11033-006-9005-y Milutinovic, 2007, Val-proate induces widespread epigenetic reprogramming which involves demethylation of specific genes, Carcinogenesis, 28, 560, 10.1093/carcin/bgl167 Nicholson, 2008, Spatial and temporal con-trol of gene expression in Drosophila using the inducible GeneSwitch GAL4 system. I. Screen for larval nervous system drivers, Genetics, 178, 215, 10.1534/genetics.107.081968 Chalitchagorn, 2004, Distinctive pattern of LINE-1 methylation level in normal tissues and the association with carcinogenesis, Oncogene, 23, 8841, 10.1038/sj.onc.1208137 Fraga, 2007, Cross-talk between aging and cancer: the epigenetic language, Ann N Y Acad Sci, 1100, 60, 10.1196/annals.1395.005 Lu, 2006, The relationship of insulin-like growth factor-II, insulin-like growth factor binding protein-3, and estrogen receptor-alpha expression to disease progression in epithelial ovarian cancer, Clin Cancer Res, 12, 1208, 10.1158/1078-0432.CCR-05-1801 Elzagheid, 2006, Lymph node status as a guide to selection of available prognos-tic markers in breast cancer: the clinical practice of the future?, Diagn Pathol, 1, 41, 10.1186/1746-1596-1-41 Murrell, 2008, Distinct methylation changes at the IGF2-H19 locus in congenital growth disorders and can-cer, PLoS One, 3, e1849, 10.1371/journal.pone.0001849 Cui, 2003, Loss of IGF2 im-printing: a potential marker of colorectal cancer risk, Science, 299, 1753, 10.1126/science.1080902 Feil, 1994, Methylation analysis on individual chromosomes: improved pro-tocol for bisulphite genomic sequencing, Nucleic Acids Res, 22, 695, 10.1093/nar/22.4.695 Byun, 2007, Examination of IGF2 and H19 loss of imprinting in bladder cancer, Cancer Res, 67, 10753, 10.1158/0008-5472.CAN-07-0329 Liu, 2008, Gene-environment interactions and epigenetic basis of human diseases, Curr Issues Mol Biol, 10, 25 Feinberg, 2004, The epigenetics of cancer etiology, Semin Cancer Biol, 14, 427, 10.1016/j.semcancer.2004.06.005 Zhang, 2011, Dietary patterns are associated with levels of global genomic DNA methylation in a cancer-free population, J Nutr, 141, 1165, 10.3945/jn.110.134536 Friso, 2005, The MTHFR 1298A>C polymorphism and genomic DNA methylation in human lymphocytes, Cancer Epidemiol Biomarkers Prev, 14, 938, 10.1158/1055-9965.EPI-04-0601 Cellarier, 2003, Methionine dependency and cancer treatment, Cancer Treat Rev, 29, 489, 10.1016/S0305-7372(03)00118-X Weisberg, 1998, A second genetic polymorphism in methylenetetrahy-drofolate reductase (MTHFR) associated with decreased enzyme activity, Mol Genet Metab, 64, 169, 10.1006/mgme.1998.2714 Axume, 2007, The MTHFR 677TT genotype and folate intake interact to lower global leukocyte DNA methylation in young Mexican American women, Nutr Res, 27, 1317, 10.1016/j.nutres.2006.12.006 Supic, 2011, In-teraction between the MTHFR C677T polymorphism and alcohol–impact on oral cancer risk and multiple DNA methylation of tumor-related genes, J Dent Res, 90, 65, 10.1177/0022034510385243 Ma, 1997, Methylenetetrahydrofolate reductase polymorphism, dietary interactions, and risk of colorec-tal cancer, Cancer Res, 57, 1098 Yang, 2005, Gene-environment interactions between alcohol drinking and the MTHFR C677T polymorphism impact on esophageal cancer risk: results of a case-con-trol study in Japan, Carcinogenesis, 26, 1285, 10.1093/carcin/bgi076 Wang, 2005, Association of methylenetetrahydrofolate reductase and thymidylate synthase promoter polymorphisms with genetic susceptibility to esophageal and cardia cancer in a Chinese high-risk population, Dis Esophagus, 18, 177, 10.1111/j.1442-2050.2005.00492.x