MR imaging differentiation of benign and malignant peripheral nerve sheath tumors: use of the target sign

Pediatric Radiology - Tập 27 - Trang 124-129 - 1997
Ravi Bhargava1,2, David M. Parham3,4, Olga E. Lasater5, Radha S. Chari6, Gang Chen7, Barry D. Fletcher1,2,8
1Department of Diagnostic Imaging, St. Jude Children’s Research Hospital, Memphis, USA
2Department of Radiology, University of Tennessee, Memphis, USA
3Department of Pathology and Laboratory Medicine, St. Jude Children's Research Hospital, Memphis, USA
4Department of Pathology, University of Tennessee, Memphis, USA
5Department of Pathology, Le Bonheur Children’s Medical Center, Memphis, USA
6Department of Obstetrics and Gynecology, University of Tennessee, Memphis, USA
7Department of Biostatistics, St. Jude Children’s Research Hospital, Memphis, USA
8Department of Pediatrics, University of Tennessee, Memphis, USA

Tóm tắt

T2-weighted MR imaging of soft tissue tumors of neural origin may show round lesions with a central hypointensity and a hyperintense rim resembling a target. We define the “target sign” as a mass consisting of a solitary target, or a multicompartmental mass in which the largest component consists of multiple targets. The objective of this study was to determine whether the target sign can differentiate benign neurofibromas and their malignant counterparts, malignant peripheral nerve sheath tumors. Preoperative T2-weighted MR images of 23 neurofibromas or malignant peripheral nerve sheath tumors were retrospectively reviewed in 16 patients, aged 3 weeks to 20 years (median 15 years), without knowledge of the pathologic diagnosis. The presence or absence of a target sign was noted. The target sign was seen in all 12 neurofibromas and 1 of the 11 malignant peripheral nerve sheath tumors. Statistical analysis showed good differentiation of benign and malignant tumors using this sign (x = 0.91). The target sign on T2-weighted MR imaging is helpful in differentiating neurofibromas from malignant peripheral nerve sheath tumors.

Tài liệu tham khảo

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Pediatric Radiology

Tập 27

124-129

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