Christina L. Hutson1, Kemba N. Lee1, Jason Abel1, Darin S. Carroll1, Joel M. Montgomery1, Victoria A. Olson1, Yu Li1, Whitni Davidson1, Christine M. Hughes1, Michael J. Dillon1, PAUL SPURLOCK1, James J. Kazmierczak1, Connie Austin1, Lori L Miser1, Faye E. Sorhage1, James F. Howell1, Jeffrey P. Davis1, Mary G. Reynolds1, Zachary Braden1, Kevin L. Karem1, Inger K. Damon1, Russell L. Regnery1
1Coordinating Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia; Bureau of Communicable Diseases, Wisconsin Division of Public Health, Madison, Wisconsin; Division of Infectious Diseases, Illinois Department of Public Health, Springfield, Illinois; Bureau of Animal Health, Illinois Department of Agriculture, Springfield, Illinois; Infectious and Zoonotic Disease Program, New Jersey Department of Health and Senior Services, Trenton...
Tóm tắt
At the onset of the 2003 US monkeypox outbreak, virologic data were unavailable regarding which animal species were involved with virus importation and/or subsequent transmission to humans and whether there was a risk for establishment of zoonotic monkeypox in North America. Similarly, it was unclear which specimens would be best for virus testing. Monkeypox DNA was detected in at least 33 animals, and virus was cultured from 22. Virus-positive animals included three African species associated with the importation event (giant pouched rats, Cricetomys spp.; rope squirrels, Funisciuris sp.; and dormice, Graphiuris sp.). Virologic evidence from North American prairie dogs (Cynomys sp.) was concordant with their suspected roles as vectors for human monkeypox. Multiple tissues were found suitable for DNA detection and/or virus isolation. These data extend the potential host range for monkeypox virus infection and supports concern regarding the potential for establishment in novel reservoir species and ecosystems.
