MEK1–ERKs signal cascade is required for the replication of Enterovirus 71 (EV71)

Antiviral Research - Tập 93 - Trang 110-117 - 2012
Bo Wang1, Hao Zhang1, Meng Zhu1, Zhijun Luo2, Yihong Peng1
1Department of Microbiology, Peking University Health Science Center, 38 Xueyuan Road, Beijing 100191, PR China
2Department of Biochemistry, Boston University School of Medicine, Boston, MA, USA

Tài liệu tham khảo

Arita, 2009, Cellular kinase inhibitors that suppress enterovirus replication have a conserved target in viral protein 3A similar to that of enviroxime, J. Gen. Virol., 90, 1869, 10.1099/vir.0.012096-0 Avruch, 2007, MAP kinase pathways: the first twenty years, Biochim. Biophys. Acta, 1773, 1150, 10.1016/j.bbamcr.2006.11.006 Beck, 1990, Secondary enterovirus infection in the murine model of myocarditis. Pathologic and immunologic aspects, Am. J. Pathol., 136, 669 Belanger, 2003, Mek2 is dispensable for mouse growth and development, Mol. Cell. Biol., 23, 4778, 10.1128/MCB.23.14.4778-4787.2003 Brandt, 2010, A novel MEK2/PI3Kdelta pathway controls the expression of IL-1 receptor antagonist in IFN-beta-activated human monocytes, J. Leukoc. Biol., 88, 1191, 10.1189/jlb.0510312 Brooks, 2004 Chambard, 2007, ERK implication in cell cycle regulation, Biochim. Biophys. Acta, 1773, 1299, 10.1016/j.bbamcr.2006.11.010 Chang, 2002, Risk factors of enterovirus 71 infection and associated hand, foot, and mouth disease/herpangina in children during an epidemic in Taiwan, Pediatrics, 109, e88, 10.1542/peds.109.6.e88 Giroux, 1999, Embryonic death of Mek1-deficient mice reveals a role for this kinase in angiogenesis in the labyrinthine region of the placenta, Curr. Biol., 9, 369, 10.1016/S0960-9822(99)80164-X Hunter, 1995, Intracellular internalization and signaling pathways triggered by the large subunit of HSV-2 ribonucleotide reductase (ICP10), Virology, 210, 345, 10.1006/viro.1995.1351 Huttunen, 1998, Echovirus 1 infection induces both stress- and growth-activated mitogen-activated protein kinase pathways and regulates the transcription of cellular immediate-early genes, Virology, 250, 85, 10.1006/viro.1998.9343 Jacque, 1998, Modulation of HIV-1 infectivity by MAPK, a virion-associated kinase, EMBO J., 17, 2607, 10.1093/emboj/17.9.2607 Jelinek, 1994, RAS and RAF-1 form a signalling complex with MEK-1 but not MEK-2, Mol. Cell. Biol., 14, 8212, 10.1128/MCB.14.12.8212 Kelemen, 2002, Selective in vivo inhibition of mitogen-activated protein kinase activation using cell-permeable peptides, J. Biol. Chem., 277, 8741, 10.1074/jbc.M108459200 King, 1986, Vaccinia virus growth factor stimulates tyrosine protein kinase activity of A431 cell epidermal growth factor receptors, Mol. Cell. Biol., 6, 332, 10.1128/MCB.6.1.332 Kohno, 2006, Targeting the ERK signaling pathway in cancer therapy, Ann. Med., 38, 200, 10.1080/07853890600551037 Kolch, 2005, Coordinating ERK/MAPK signalling through scaffolds and inhibitors, Nat. Rev. Mol. Cell Biol., 6, 827, 10.1038/nrm1743 Ludwig, 2011, Disruption of virus–host cell interactions and cell signaling pathways as an anti-viral approach against influenza virus infections, Biol. Chem., 392, 837, 10.1515/BC.2011.121 Luo, 2002, Coxsackievirus B3 replication is reduced by inhibition of the extracellular signal-regulated kinase (ERK) signaling pathway, J. Virol., 76, 3365, 10.1128/JVI.76.7.3365-3373.2002 McCubrey, 2007, Roles of the Raf/MEK/ERK pathway in cell growth, malignant transformation and drug resistance, Biochim. Biophys. Acta, 1773, 1263, 10.1016/j.bbamcr.2006.10.001 Moser, 2008, Suppression of astrovirus replication by an ERK1/2 inhibitor, J. Virol., 82, 7475, 10.1128/JVI.02193-07 Nasri, 2007, Basic rationale, current methods and future directions for molecular typing of human enterovirus, Expert Rev. Mol. Diagn., 7, 419, 10.1586/14737159.7.4.419 Perkins, 2002, The herpes simplex virus type 2 R1 protein kinase (ICP10 PK) blocks apoptosis in hippocampal neurons, involving activation of the MEK/MAPK survival pathway, J. Virol., 76, 1435, 10.1128/JVI.76.3.1435-1449.2002 Pleschka, 2008, RNA viruses and the mitogenic Raf/MEK/ERK signal transduction cascade, Biol. Chem., 389, 1273, 10.1515/BC.2008.145 Seger, 1994, Overexpression of mitogen-activated protein kinase kinase (MAPKK) and its mutants in NIH 3T3 cells. Evidence that MAPKK involvement in cellular proliferation is regulated by phosphorylation of serine residues in its kinase subdomains VII and VIII, J. Biol. Chem., 269, 25699, 10.1016/S0021-9258(18)47305-X Shaul, 2007, The MEK/ERK cascade: from signaling specificity to diverse functions, Biochim. Biophys. Acta, 1773, 1213, 10.1016/j.bbamcr.2006.10.005 Skarpen, 2008, MEK1 and MEK2 regulate distinct functions by sorting ERK2 to different intracellular compartments, FASEB J., 22, 466, 10.1096/fj.07-8650com Smith, 2000, Ras-GAP binding and phosphorylation by herpes simplex virus type 2 RR1 PK (ICP10) and activation of the Ras/MEK/MAPK mitogenic pathway are required for timely onset of virus growth, J. Virol., 74, 10417, 10.1128/JVI.74.22.10417-10429.2000 Solomon, 2010, Virology, epidemiology, pathogenesis, and control of enterovirus 71, Lancet Infect. Dis., 10, 778, 10.1016/S1473-3099(10)70194-8 Tung, 2011, Enterovirus 71 modulates a COX-2/PGE2/cAMP-dependent viral replication in human neuroblastoma cells: role of the c-Src/EGFR/p42/p44 MAPK/CREB signaling pathway, J. Cell. Biochem., 112, 559, 10.1002/jcb.22946 Tung, 2010, EV71 induces COX-2 expression via c-Src/PDGFR/PI3K/Akt/p42/p44 MAPK/AP-1 and NF-kappaB in rat brain astrocytes, J. Cell. Physiol., 224, 376, 10.1002/jcp.22133 Ussar, 2004, MEK1 and MEK2, different regulators of the G1/S transition, J. Biol. Chem., 279, 43861, 10.1074/jbc.M406240200 Wang, 2010, Replication of EV71 was suppressed by MEK1/2 inhibitor U0126, Chin. J. Biochem. Mol. Biol., 26, 538 Yang, 2009, Enterovirus 71 outbreak in the People’s Republic of China in 2008, J. Clin. Microbiol., 47, 2351, 10.1128/JCM.00563-09 Yao, 2009, The ERK signaling cascade – views from different subcellular compartments, BioFactors, 35, 407, 10.1002/biof.52 Yi, 2011, The virology and developments toward control of human enterovirus 71, Crit. Rev. Microbiol., 10.3109/1040841X.2011.580723 Zhang, 2010, Distinct effects of knocking down MEK1 and MEK2 on replication of herpes simplex virus type 2, Virus Res., 150, 22, 10.1016/j.virusres.2010.02.007 Zhang, 2002, MAPK signal pathways in the regulation of cell proliferation in mammalian cells, Cell Res., 12, 9, 10.1038/sj.cr.7290105