MDCK (Madin-Darby Canine Kidney) Cells: A Tool for Membrane Permeability Screening

Journal of Pharmaceutical Sciences - Tập 88 Số 1 - Trang 28-33 - 1999
Jennifer D. Irvine1, Lori H. Takahashi1, Kenneth R. Lockhart1, Jonathan Cheong1, John W. Tolan1, H E Selick1, Jeffrey Grove1
1Affymax Research Institute (a Glaxo Wellcome Company), Santa Clara, California 95051.

Tóm tắt

Từ khóa


Tài liệu tham khảo

Pinto, 1983, Enterocyte‐like differentiation and polarization of the human colon carcinoma cell line Caco‐2 in culture, Biol. Cell, 47, 323

Hidalgo, 1989, Characterization of the human colon carcinoma cell line (Caco‐2) as a model system for intestinal epithelial permeability, Gastroenterol‐ogy, 96, 736, 10.1016/S0016-5085(89)80072-1

Wilson, 1990, Transport and permeability properties of human Caco‐2 cells: An in vitro model of the intestinal epithelial cell barrier, J. Controlled Release, 11, 25, 10.1016/0168-3659(90)90118-D

Artursson, 1990, Epithelial transport of drugs in cell culture. I: A model for studying the passive diffusion of drugs over intestinal absorbtive (Caco‐2) cells, J. Pharm. Sci., 79, 476, 10.1002/jps.2600790604

Hilgers, 1990, Caco‐2 cell monolayers as a model for drug transport across the intestinal mucosa, Pharm. Res., 7, 902, 10.1023/A:1015937605100

Artursson, 1991, Correlation between oral drug absorption in humans and apparent drug permeability coefficients in human intestinal epithelial (Caco‐2) cells, Biochem. Biophys. Res. Comm., 175, 880, 10.1016/0006-291X(91)91647-U

Stewart, 1995, Comparison of intestinal permeabilities determined in multiple in vitro and in situ models: relationship to absorption in humans, Pharm. Res., 12, 693, 10.1023/A:1016207525186

Artursson, 1996, Caco‐2 monolayers in experimental and theoretical predictions of drug transport, Adv. Drug Delivery Rev., 22, 67, 10.1016/S0169-409X(96)00415-2

Hidalgo, 1996, Cultured intestinal epithelial cell models, 35

Delie, 1997, A human colonic cell line sharing similarities with enterocytes as a model to examine oral absorption: Advantages and limitations of the Caco‐2 model, Crit. Rev. Ther. Drug Carrier Syst., 14, 221, 10.1615/CritRevTherDrugCarrierSyst.v14.i3.20

Chong, 1996, Evaluation of Biocoat intestinal epithelium differentiation environment as an absorption screening model with improved productivity, Pharm. Res., 13, S240, 10.1023/A:1016045820933

Horster, 1986, Transport and metabolic functions in cultured renal tubule cells, Kidney Int., 29, 46, 10.1038/ki.1986.7

Horio, 1989, Tran‐sepithelial transport of drugs by the multidrug transporter in cultured Madin‐Darby canine kidney cell epithelia, J. Biol. Chem., 264, 14880, 10.1016/S0021-9258(18)63784-6

Hunter, 1993, Transepithelial secretion, cellular accumulation and cytotoxicity of vinblas‐tine in defined MDCK cell strains, Biochim. Biophys. Acta, 1179, 1, 10.1016/0167-4889(93)90069-2

Hunter, 1993, Functional expression of p‐glycoprotein in apical membranes of human intestinal Caco‐2 cells, Kinetics of vinblastine secretion and interaction with modulators. J. Biol. Chem., 268, 14991

Brandsch, 1995, H+‐peptide contransport in Madin‐Darby canine kidney cells: expres‐sion and calmodulin‐dependent regulation, Am. J. Physiol., 268, F391

Ganapathy, 1995, Differential recognition of beta‐lactam antibiotics by intestinal and renal peptide transporters, PEPT1 and PEPT2, J. Biol. Chem., 270, 25672, 10.1074/jbc.270.43.25672

Misfeldt, 1976, Transepi‐theleal transport in cell culture, Proc. Natl. Acad. Sci. U.S.A., 73, 1212, 10.1073/pnas.73.4.1212

Cereijido, 1978, Polarized monolayers formed by epithelial cells on a permeable and translucent support, J. Cell Biol., 77, 853, 10.1083/jcb.77.3.853

Cho, 1989, The Madin‐Darby canine kidney (MDCK) epithelial cell monolayer as a model cellular transport barrier, Pharm. Res., 6, 71, 10.1023/A:1015807904558

Cho, 1990, Transepithelial transport of aliphatic carboxylic acids studied in Madin‐Darby canine kidney (MDCK) cell monolayers, Pharm. Res., 7, 325, 10.1023/A:1015802918845

Ranaldi, 1992, Epithelial cells in culture as a model for the intestinal transport of antimicrobial agents, Antimicrob. Agents Chemother., 36, 1374, 10.1128/AAC.36.7.1374

Ranaldi, 1996, Transport of the antibacterial agent oxazolidin‐2‐one and derivatives across intestinal (Caco‐2) and renal (MDCK) epithelial cell lines, Antimicrob. Agents Chemother., 40, 652, 10.1128/AAC.40.3.652

Rothen‐Rutishauser, 1998, MDCK cell cultures as an epithelial in vitro model: cytoskeleton and tight junctions as indicators for the definition of age‐related stages by confocal microscopy, Pharm. Res., 15, 964, 10.1023/A:1011953405272

Brown, 1977

Bryan, 1979, Bretylium tosylate: A review, Am. J. Pharm., 36, 1189

Dressman, 1985, Absorption potential: estimating the fraction absorbed for orally administered compounds, J. Pharm. Sci., 74, 588, 10.1002/jps.2600740523

Amidon, 1988, Estimating human oral fraction dose absorbed: a correlation using rat intestinal membrane permeability for passive and carrier‐mediated compounds, Pharm. Res., 5, 651, 10.1023/A:1015927004752

Gan, 1993, Mechanism of Intestinal Absorption of Ranitidine and On‐dansetron: Transport Across Caco‐2 Cell Monolayers, Pharm. Res., 10, 1722, 10.1023/A:1018965929419

Rubas, 1993, Comparison of the permeability characteristics of a human colonic epithelial (Caco‐2) cell line to colon of rabbit, monkey, and dog intestine and human drug absorption, Pharm. Res., 10, 113, 10.1023/A:1018937416447

Hu, 1994, Mechanism and kinetics of transcellular transport of a new beta‐lactam antibiotic loracarbef across an intestinal epithelial membrane model system (Caco‐2), Pharm. Res., 11, 1405, 10.1023/A:1018935704693

Chong, 1996, In Vitro permeability through Caco‐2 cells is not quantitatively predictive of in vivo absorption for peptide‐like drugs absorbed via the dipeptide transporter system, Pharm. Res., 13, 120, 10.1023/A:1016045820933

Wessel, 1998, Prediction of human intestinal absorption of drug compounds from molecular structure, J. Chem. Info. Comput. Sci., 38, 726, 10.1021/ci980029a

Thwaites, 1993, Passive transepithelial absorption of thyrotropin‐releasing hormone (TRH) via a paracellular route in cultured intestinal and renal epithelial cell lines, Pharm. Res., 10, 674, 10.1023/A:1018947430018