Lymphopenia-induced proliferation of donor T cells reduces their capacity for causing acute graft-versus-host disease

Tumpey, 2000, Depletion of lymphocytes and diminished cytokine production in mice infected with a highly virulent influenza A (H5N1) virus isolated from humans, J Virol, 74, 6105, 10.1128/JVI.74.13.6105-6116.2000 Merrick, 1997, Lymphocyte apoptosis during early phase of Listeria infection in mice, Am J Pathol, 151, 785 Sprent, 2001, T cell death and memory, Science, 293, 245, 10.1126/science.1062416 Min, 2003, Neonates support lymphopenia-induced proliferation, Immunity, 18, 131, 10.1016/S1074-7613(02)00508-3 Jameson, 2005, T cell homeostasis: keeping useful T cells alive and live T cells useful, Semin Immunol, 17, 231, 10.1016/j.smim.2005.02.003 Goldrath, 2000, Naive T cells transiently acquire a memory-like phenotype during homeostasis-driven proliferation, J Exp Med, 192, 557, 10.1084/jem.192.4.557 Murali-Krishna, 2000, Cutting edge: naive T cells masquerading as memory cells, J Immunol, 165, 1733, 10.4049/jimmunol.165.4.1733 Kieper, 1999, Homeostatic expansion and phenotypic conversion of naive T cells in response to self peptide/MHC ligands, Proc Natl Acad Sci U S A, 96, 13306, 10.1073/pnas.96.23.13306 Cho, 2000, Homeostasis-stimulated proliferation drives naive T cells to differentiate directly into memory T cells, J Exp Med, 192, 549, 10.1084/jem.192.4.549 Kieper, 2005, Recent immune status determines the source of antigens that drive homeostatic T cell expansion, J Immunol, 174, 3158, 10.4049/jimmunol.174.6.3158 Surh, 2005, Regulation of mature T cell homeostasis, Semin Immunol, 17, 183, 10.1016/j.smim.2005.02.007 La Gruta, 2000, Peripheral T cell expansion in lymphopenic mice results in a restricted T cell repertoire, Eur J Immunol, 30, 3380, 10.1002/1521-4141(2000012)30:12<3380::AID-IMMU3380>3.0.CO;2-P Almeida, 2005, Homeostasis of T cell numbers: from thymus production to peripheral compartmentalization and the indexation of regulatory T cells, Semin Immunol, 17, 239, 10.1016/j.smim.2005.02.002 Neujahr, 2006, Accelerated memory cell homeostasis during T cell depletion and approaches to overcome it, J Immunol, 176, 4632, 10.4049/jimmunol.176.8.4632 Cheever, 1980, Specificity of adoptive chemoimmunotherapy of established syngeneic tumors, J Immunol, 125, 711, 10.4049/jimmunol.125.2.711 Dummer, 2002, T cell homeostatic proliferation elicits effective antitumor autoimmunity, J Clin Invest, 110, 185, 10.1172/JCI0215175 Gattinoni, 2005, Removal of homeostatic cytokine sinks by lymphodepletion enhances the efficacy of adoptively transferred tumor-specific CD8+ T cells, J Exp Med, 202, 907, 10.1084/jem.20050732 Gattinoni, 2005, Acquisition of full effector function in vitro paradoxically impairs the in vivo antitumor efficacy of adoptively transferred CD8+ T cells, J Clin Invest, 115, 1616, 10.1172/JCI24480 Gattinoni, 2006, Adoptive immunotherapy for cancer: building on success, Nat Rev Immunol, 6, 383, 10.1038/nri1842 King, 2004, Homeostatic expansion of T cells during immune insufficiency generates autoimmunity, Cell, 117, 265, 10.1016/S0092-8674(04)00335-6 Marleau, 2005, T cell homeostasis in tolerance and immunity, J Leukoc Biol, 78, 575, 10.1189/jlb.0105050 Wu, 2004, Homeostatic proliferation is a barrier to transplantation tolerance, Nat Med, 10, 87, 10.1038/nm965 Adams, 2003, Heterologous immunity provides a potent barrier to transplantation tolerance, J Clin Invest, 111, 1887, 10.1172/JCI200317477 Taylor, 2004, Heterologous immunity and homeostatic proliferation as barriers to tolerance, Curr Opin Immunol, 16, 558, 10.1016/j.coi.2004.07.007 Appelbaum, 2001, Haematopoietic cell transplantation as immunotherapy, Nature, 411, 385, 10.1038/35077251 Ferrara, 2006, Pathophysiology of graft-versus-host disease, Semin Hematol, 43, 3, 10.1053/j.seminhematol.2005.09.001 Le Campion, 2002, Naive T cells proliferate strongly in neonatal mice in response to self-peptide/self-MHC complexes, Proc Natl Acad Sci U S A, 99, 4538, 10.1073/pnas.062621699 Scollay, 1980, Thymus cell migration. Quantitative aspects of cellular traffic from the thymus to the periphery in mice, Eur J Immunol, 10, 210, 10.1002/eji.1830100310 Westermann, 1990, Lymphocyte subsets in the blood: a diagnostic window on the lymphoid system?, Immunol Today, 11, 406, 10.1016/0167-5699(90)90160-B Fraker, 2000, The dynamic link between the integrity of the immune system and zinc status, J Nutr, 130, 1399S, 10.1093/jn/130.5.1399S Coukell, 1998, Pamidronate. A review of its use in the management of osteolytic bone metastases, tumour-induced hypercalcaemia and Paget's disease of bone, Drugs Aging, 12, 149, 10.2165/00002512-199812020-00007 Alexandersen, 2001, Ipriflavone in the treatment of postmenopausal osteoporosis: a randomized controlled trial, JAMA, 285, 1482, 10.1001/jama.285.11.1482 Finnerty, 1996, Effects of theophylline on inflammatory cells and cytokines in asthmatic subjects: a placebo-controlled parallel group study, Eur Respir J, 9, 1672, 10.1183/09031936.96.09081672 Keel, 2005, Thiopental-induced apoptosis in lymphocytes is independent of CD95 activation, Anesthesiology, 103, 576, 10.1097/00000542-200509000-00021 Gergely, 1999, Drug-induced lymphopenia: focus on CD4+ and CD8+ cells, Drug Saf, 21, 91, 10.2165/00002018-199921020-00003 Wrzesinski, 2005, Less is more: lymphodepletion followed by hematopoietic stem cell transplant augments adoptive T-cell-based anti-tumor immunotherapy, Curr Opin Immunol, 17, 195, 10.1016/j.coi.2005.02.002 Reddy, 2005, A crucial role for antigen-presenting cells and alloantigen expression in graft-versus-leukemia responses, Nat Med, 11, 1244, 10.1038/nm1309 Reddy, 2004, Histone deacetylase inhibitor suberoylanilide hydroxamic acid reduces acute graft-versus-host disease and preserves graft-versus-leukemia effect, Proc Natl Acad Sci U S A, 101, 3921, 10.1073/pnas.0400380101 Min, 2003, Differential effects of IL-18 on the severity of acute graft-versus-host disease mediated by CD4+ and CD8+ T cell subsets after experimental allogeneic bone marrow transplantation, Blood, 102, 409b Reddy, 2001, Interleukin-18 regulates acute graft-versus-host disease by enhancing Fas-mediated donor T cell apoptosis, J Exp Med, 194, 1433, 10.1084/jem.194.10.1433 Hill, 2000, The primacy of the gastrointestinal tract as a target organ of acute graft-versus-host disease: rationale for the use of cytokine shields in allogeneic bone marrow transplantation, Blood, 95, 2754, 10.1182/blood.V95.9.2754.009k25_2754_2759 Cooke, 1998, Tumor necrosis factor-α production to lipopolysaccharide stimulation by donor cells predicts the severity of experimental acute graft versus host disease, J Clin Invest, 102, 1882, 10.1172/JCI4285 Chen, 2004, Transfer of allogeneic CD62L- memory T cells without graft-versus-host disease, Blood, 103, 1534, 10.1182/blood-2003-08-2987 Anderson, 2003, Memory CD4+ T cells do not induce graft-versus-host disease, J Clin Invest, 112, 101, 10.1172/JCI17601 Zhang, 2004, Dendritic cell–activated CD44hiCD8+ T cells are defective in mediating acute graft-versus-host disease but retain graft-versus-leukemia activity, Blood, 103, 3970, 10.1182/blood-2003-09-3135 Edinger, 2003, CD4+CD25+ regulatory T cells preserve graft-versus-tumor activity while inhibiting graft-versus-host disease after bone marrow transplantation, Nat Med, 9, 1144, 10.1038/nm915 Blazar, 2005, Regulatory T cells, Biol Blood Marrow Transplant, 11, 46, 10.1016/j.bbmt.2004.11.005 Bell, 1990, Interconversion of CD45R subsets of CD4 T cells in vivo, Nature, 348, 163, 10.1038/348163a0 Tough, 1994, Turnover of naive- and memory-phenotype T cells, J Exp Med, 179, 1127, 10.1084/jem.179.4.1127 Ge, 2002, Different contributions of thymopoiesis and homeostasis-driven proliferation to the reconstitution of naive and memory T cell compartments, Proc Natl Acad Sci U S A, 99, 2989, 10.1073/pnas.052714099 Tanchot, 2002, Conversion of naive T cells to a memory-like phenotype in lymphopenic hosts is not related to a homeostatic mechanism that fills the peripheral naive T cell pool, J Immunol, 168, 5042, 10.4049/jimmunol.168.10.5042 Min, 2005, Endogenous proliferation: burst-like CD4 T cell proliferation in lymphopenic settings, Semin Immunol, 17, 201, 10.1016/j.smim.2005.02.005 Zhang, 2005, Host-reactive CD8+ memory stem cells in graft-versus-host disease, Nat Med, 11, 1299, 10.1038/nm1326 Lenz, 2004, IL-7 regulates basal homeostatic proliferation of antiviral CD4+ T cell memory, Proc Natl Acad Sci U S A, 101, 9357, 10.1073/pnas.0400640101 Jameson, 2002, Maintaining the norm: T-cell homeostasis, Nat Rev Immunol, 2, 547, 10.1038/nri853 Guillet, 2001, TCR usage in naive and committed alloreactive cells: implications for the understanding of TCR biases in transplantation, Curr Opin Immunol, 13, 566, 10.1016/S0952-7915(00)00260-0 Brehm, 2003, Direct visualization of cross-reactive effector and memory allo-specific CD8 T cells generated in response to viral infections, J Immunol, 170, 4077, 10.4049/jimmunol.170.8.4077 Laughlin, 2004, Outcomes after transplantation of cord blood or bone marrow from unrelated donors in adults with leukemia, N Engl J Med, 351, 2265, 10.1056/NEJMoa041276 Arnold, 2005, Control of peripheral T-lymphocyte tolerance in neonates and adults, Trends Immunol, 26, 406, 10.1016/j.it.2005.06.002 Hazenberg, 2002, T-cell receptor excision circle and T-cell dynamics after allogeneic stem cell transplantation are related to clinical events, Blood, 99, 3449, 10.1182/blood.V99.9.3449 Shlomchik, 1999, Prevention of graft versus host disease by inactivation of host antigen-presenting cells, Science, 285, 412, 10.1126/science.285.5426.412 Alpdogan, 2003, IL-7 enhances peripheral T cell reconstitution after allogeneic hematopoietic stem cell transplantation, J Clin Invest, 112, 1095, 10.1172/JCI200317865