Lymph node ratio as a prognostic factor for survival in patients with head and neck squamous cell carcinoma

Torre, 2015, Global cancer statistics, 2012, CA Cancer J Clin, 65, 87, 10.3322/caac.21262 Sano, 2007, Metastasis of squamous cell carcinoma of the oral tongue, Cancer Metastasis Rev, 26, 645, 10.1007/s10555-007-9082-y Layland, 2005, The influence of lymph node metastasis in the treatment of squamous cell carcinoma of the oral cavity, oropharynx, larynx, and hypopharynx: N0 versus N+, Laryngoscope, 115, 629, 10.1097/01.mlg.0000161338.54515.b1 Bernier, 2005, Defining risk levels in locally advanced head and neck cancers: a comparative analysis of concurrent postoperative radiation plus chemotherapy trials of the EORTC (#22931) and RTOG (#9501), Head Neck, 27, 843, 10.1002/hed.20279 Myers, 2001, Extracapsular spread. A significant predictor of treatment failure in patients with squamous cell carcinoma of the tongue, Cancer, 92, 3030, 10.1002/1097-0142(20011215)92:12<3030::AID-CNCR10148>3.0.CO;2-P Pfister, 2013, Head and neck cancers, version 2.2013. Featured updates to the NCCN guidelines, J Natl Compr Cancer Netw, 11, 917, 10.6004/jnccn.2013.0113 Vinh-Hung, 2009, Lymph node ratio as an alternative to pN staging in node-positive breast cancer, J Clin Oncol, 27, 1062, 10.1200/JCO.2008.18.6965 Ceelen, 2010, Prognostic value of the lymph node ratio in stage III colorectal cancer: a systematic review, Ann Surg Oncol, 17, 2847, 10.1245/s10434-010-1158-1 Deng, 2012, Ratio between negative and positive lymph nodes is suitable for evaluation the prognosis of gastric cancer patients with positive node metastasis, PLoS One, 7, e43925, 10.1371/journal.pone.0043925 Patel, 2013, Lymph node density in oral cavity cancer: results of the International Consortium for Outcomes Research, Br J Cancer, 109, 2087, 10.1038/bjc.2013.570 Wang, 2013, Impact of lymph node ratio on the survival of patients with hypopharyngeal squamous cell carcinoma: a population-based analysis, PLoS One, 8, e56613, 10.1371/journal.pone.0056613 Wang, 2013, Lymph node ratio as a survival risk factor for oropharyngeal squamous cell carcinoma patients with lymph node metastasis: a surveillance, epidemiology and end results-based analysis, Head Neck Oncol, 5, 30 Rudra, 2014, Lymph node density—prognostic value in head and neck cancer, Head Neck, 36, 266, 10.1002/hed.23299 Ong, 2016, Prognostic significance of lymph node density in squamous cell carcinoma of the tongue, Head Neck, 38, E859, 10.1002/hed.24113 Prabhu, 2015, Lymph node ratio influence on risk of head and neck cancer locoregional recurrence after initial surgical resection: implications for adjuvant therapy, Head Neck, 37, 777, 10.1002/hed.23662 Robbins, 2002, Neck dissection classification update: revisions proposed by the American Head and Neck Society and the American Academy of Otolaryngology-Head and Neck Surgery, Arch Otolaryngol Head Neck Surg, 128, 751, 10.1001/archotol.128.7.751 Kunieda, 2014, Randomized phase II/III trial of post-operative chemoradiotherapy comparing 3-weekly cisplatin with weekly cisplatin in high-risk patients with squamous cell carcinoma of head and neck: Japan Clinical Oncology Group Study (JCOG1008), Jpn J Clin Oncol, 44, 770, 10.1093/jjco/hyu067 Harari, 2014, Postoperative chemoradiotherapy and cetuximab for high-risk squamous cell carcinoma of the head and neck: Radiation Therapy Oncology Group RTOG-0234, J Clin Oncol, 32, 2486, 10.1200/JCO.2013.53.9163 Ren, 2012, Prognostic value of the lymph node ratio in stage III colorectal cancer, Chin J Cancer, 31, 241, 10.5732/cjc.011.10374 Divi, 2015, Establishing quality indicators for neck dissection: correlating the number of lymph nodes with oncologic outcomes, NRG Oncology/RTOG 9501-0234, J Clin Oncol, 33, 10.1200/jco.2015.33.15_suppl.6011 Holsinger, 2005, Transoral lateral oropharyngectomy for squamous cell carcinoma of the tonsillar region: I. Technique, complications, and functional results, Arch Otolaryngol Head Neck Surg, 131, 583, 10.1001/archotol.131.7.583 Moore, 2011, Concurrent neck dissection and transoral robotic surgery, Laryngoscope, 121, 541, 10.1002/lary.21435 Dahlstrom, 2013, An evolution in demographics, treatment, and outcomes of oropharyngeal cancer at a major cancer center: a staging system in need of repair, Cancer, 119, 81, 10.1002/cncr.27727