Lower androgenicity is associated with higher plasma levels of prothrombotic factors irrespective of age, obesity, body fat distribution, and related metabolic parameters in men

Hubert, 1983, Obesity as an independent risk factor for cardiovascular disease: A 26-year follow-up of participants in the Framingham Heart Study, Circulation, 67, 968, 10.1161/01.CIR.67.5.968 Larsson, 1984, Abdominal adipose tissue distribution, obesity, and risk of cardiovascular disease and death: 13 year follow up of participants in the study of men born in 1913, Br Med J, 288, 1401, 10.1136/bmj.288.6428.1401 Lapidus, 1984, Distribution of adipose tissue and risk of cardiovascular disease and death: A 12 year follow up of participants in the population study of women in Gothenburg, Sweden, Br Med J, 289, 1257, 10.1136/bmj.289.6454.1257 Bjorntorp, 1990, “Portal” adipose tissue as a generator of risk factors for cardiovascular disease and diabetes, Arteriosclerosis, 10, 493, 10.1161/01.ATV.10.4.493 Kissebah, 1994, Regional adiposity and morbidity, Physiol Rev, 74, 781, 10.1152/physrev.1994.74.4.761 Despres, 1990, Regional distribution of body fat, plasma lipoproteins and cardiovascular disease, Arteriosclerosis, 10, 497, 10.1161/01.ATV.10.4.497 De Pergola, 1993, Relation between sex hormones and serum lipoprotein and lipoprotein(a) concentrations in premenopausal obese woment, Arterioscler Thromb, 13, 675, 10.1161/01.ATV.13.5.675 Meade, 1986, Haemostatic function and ischaemic heart disease: Principal results of the Northwick Park Heart Study, Lancet, 2, 533, 10.1016/S0140-6736(86)90111-X Krobot, 1992, Determinants of plasma fibrinogen: Relation to body weight, waist-to-hip ratio, smoking, alcohol, age and sex—Results from the second MONICA Augsburg Survery, 1989–1990, Arterioscler Thromb, 12, 780, 10.1161/01.ATV.12.7.780 Bara, 1994, Expression of a paternal history of premature myocardial infarction on fibrinogen, factor VIIc and PAI-1 in European offspring—The EARS Study, Thromb Haemost, 71, 434, 10.1055/s-0038-1642456 Heinrich, 1994, Fibrinogen and factor VII in the prediction of coronary risk, 14, 54 Folsom, 1993, Association of hemostatic, 13, 1829 Green, 1994, Hemostatic factors in the Coronary Artery Risk Development in Young Adults (CARDIA) Study, Arterioscler Thromb, 14, 686, 10.1161/01.ATV.14.5.686 Ernst, 1993, Fibrinogen is a cardiovascular risk factor: A meta-analysis and review of the literature, ann Intern Med, 118, 956, 10.7326/0003-4819-118-12-199306150-00008 Conlan, 1993, Associations of factor VIII and von Willebrand factor with age, race, sex and risk factors for atherosclerosis, 70, 380 Hamsten, 1987, Plasminogen activator inhibitor in plasma: Risk factor for recurrent myocardial infarction, Lancet, 2, 3, 10.1016/S0140-6736(87)93050-9 Vague, 1989, Fat distribution and plasminogen activator inhibitor activity in nondiabetic women, Metabolism, 38, 913, 10.1016/0026-0495(89)90241-2 Landin, 1990, Abdominal obesity is associated with an impaired fibrinolytic activity and elevated plasminogen activator inhibitor-1, Metabolism, 39, 1044, 10.1016/0026-0495(90)90164-8 De Pergola, 1992, Influence of free testosterone on antigen levels of plasminogen activator inhibitor-1 (PAI-1) in premenopausal women with central obesity, Metabolism, 41, 131, 10.1016/0026-0495(92)90139-2 Eliasson, 1994, Fibrinogen and fibrinolytic variables in relation to anthropometry, lipids and blood pressure, 47, 513 Cigolini, 1994, Relationship of plasminogen activator inhibitor-1 to anthropometry, serum insulin, triglycerides, and adipose tissue fatty acids in healthy men, Atherosclerosis, 106, 139, 10.1016/0021-9150(94)90119-8 Cigolini, 1994, Plasma fibrinogen in relations to serum insulin, smoking habits and adipose tissue fatty acids in healthy men, Eur J Clin Invest, 24, 126, 10.1111/j.1365-2362.1994.tb00977.x Vermeulen, 1993, Attenuated luteinizing hormone (LH) pulse amplitude but normal LH pulse frequency and its relation to plasma androgens in hypogonadism of obese men, J Clin Endocrinol Metab, 76, 1140, 10.1210/jc.76.5.1140 Phillips, 1994, The association of hypotestosteronemia with coronary artery disease in men, Arterioscler Thromb, 14, 701, 10.1161/01.ATV.14.5.701 Mitchell, 1994, Evidence for an association between dehydroepiandrosterone sulfate and nonfatal premature myocardial infarction in males, Circulation, 89, 89, 10.1161/01.CIR.89.1.89 Yang, 1993, Relation of hemostatic risk factors to other risk factors for coronary heart disease and to sex hormones in men, Arterioscler Thromb, 13, 467, 10.1161/01.ATV.13.4.467 Marques-Vidal, 1995, Relationship of plasminogen activator inhibitor activity and lipoprotein(a) with insulin, testosterone, 17β-estradiol and testosterone binding globulin in myocardial infarction patients and healthy men controls, J Clin Endocrinol Metab, 80, 1794, 10.1210/jc.80.6.1794 Caron, 1989, Plasminogen activator inhibitor in plasma is related to testosterone in men, Metabolism, 38, 1010, 10.1016/0026-0495(89)90014-0 Bonithon-Kopp, 1988, Relationship between sex hormones and haemostatic factors in healthy middle-aged men, Atherosclerosis, 71, 71, 10.1016/0021-9150(88)90303-6 Anderson, 1995, Haemostatic effects of supraphysiological elvesl of testosterone in normal men, Thromb Haemost, 74, 693, 10.1055/s-0038-1649799 Fearnley, 1962, Increase of blood fibrinolytic activity by testosterone, Lancet, 2, 128, 10.1016/S0140-6736(62)90009-0 Taylor, 1992, Anticoagulant and fibrinolytic activities are promoted, not retarded, in vivo after thrombin generation iin the presence of a monoclonal antibody that inhibits activation of protein C, Blood, 79, 172, 10.1182/blood.V79.7.1720.1720 World Health Organization, 1980, Second report, WHO Tech Rep Ser 646 Clauss, 1957, Gerinnungsphysiologische schnellmethode zur bestimmung des fibrinogens, Acta Haematol, 17, 237, 10.1159/000205234 1977, Spectrum of von Willebrand's disease: A study of 100 cases, Br J Haematol, 35, 101, 10.1111/j.1365-2141.1977.tb00566.x Phillips, 1993, Relationship between serum sex hormones and the glucose-insulin-lipid defect in men with obesity, Metabolism, 42, 116, 10.1016/0026-0495(93)90181-M Wu, 1993, Therapeutic effects of an androgenic preparation on myocardial ischemia and cardiac function in 62 elderly male coronary heart disease patients, Clin Med J, 106, 415 Alexandersen, 1996, The relationship of natural androgens to coronary heart disease in males: A review, Atherosclerosis, 125, 1, 10.1016/0021-9150(96)05864-9 Cigolini, 1995, Relationships of blood pressure to fibrinolysis: Influence of anthropometry, metabolic profile, and behavioural variables, J Hypertens, 13, 659, 10.1097/00004872-199506000-00013 Phillips, 1993, Sex hormones and haemostatic risk factors for coronary heart disease in men with hypertension, J Hypertens, 11, 699, 10.1097/00004872-199307000-00003 Asplund-Carlson, 1993, Relationship between plasma plasminogen activator inhibitor-1 activity and VLDL triglyceride concentrations, insulin levels and insulin sensitivity: Studies in randomly selected normo- and hypertriglyceridemic men, Diabetologia, 36, 817, 10.1007/BF00400356 Mussoni, 1992, Hypertriglyceridemia and regulation of fibrinolytic activity, Arterioscler Thromb, 12, 219, 10.1161/01.ATV.12.1.19 Potter van Loon, 1993, The cardiovascular risk factor plasminogen activator inhibitor type 1 is related to insulin resistance, Metabolism, 42, 945, 10.1016/0026-0495(93)90005-9 Alessi, 1988, Insulin stimulates the synthesis of plasminogen activator inhibitor-1 by the human hepatocellular cell line HepG2, Thromb Haemost, 60, 491, 10.1055/s-0038-1646997 Seljeflot, 1995, Effects of insulin and some vasoconstrictors on the synthesis and relase of t-PA and PAI-1 from cultured human umbilical vein endothelial cells, Fibrinolysis, 9, 253, 10.1016/S0268-9499(08)80068-9 Mykkanen, 1994, Insulin sensitivity is not an independent determination of plasma plasminogen activator inhibitor-1 activity, Arterioscler Thromb, 14, 1264, 10.1161/01.ATV.14.8.1264 Landin, 1994, Effects of metformin and metoprolol CR on hormones and fibrinolytic variables during a hyperinsulinemic, euglycemic clamp in man, Thromb Haemost, 71, 783, 10.1055/s-0038-1642523 Jansson, 1993, Predictive value of tissue plasminogen activator mass concentration on long-term mortality in patients with coronary artery disease, 88, 2030