Lower-Risk Cannabis Use Guidelines (LRCUG) for reducing health harms from non-medical cannabis use: A comprehensive evidence and recommendations update

International Journal of Drug Policy - Tập 99 - Trang 103381 - 2022
Benedikt Fischer1,2,3, Tessa Robinson2,4, Chris Bullen1,5, Valerie Curran6,7, Didier Jutras-Aswad8,9, Maria Elena Medina-Mora10,11, Rosalie Liccardo Pacula12, Jürgen Rehm13,14, Robin Room15,16, Wim van den Brink17,18, Wayne Hall19,20
1Schools of Population Health and Pharmacy, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand
2Centre for Applied Research in Mental Health and Addiction, Faculty of Health Sciences, Simon Fraser University, Vancouver, Canada
3Department of Psychiatry, Federal University of Sao Paulo, Sao Paulo, Brazil
4Department of Health Research Methods, Evidence & Impact, Faculty of Health Sciences, McMaster University, Hamilton, ON, Canada
5National Institute for Health Innovation (NIHI), The University of Auckland, Auckland, New Zealand
6Clinical Psychopharmacology Unit, Research Department of Clinical, Educational and Health Psychology, University College London, London, United Kingdom
7NIHR University College London Hospitals Biomedical Research Centre, London, United Kingdom
8Department of Psychiatry and Addictology, Université de Montréal, Montreal, Canada
9Research Centre of the Centre Hospitalier de l'Université de Montréal (CRCHUM), Montreal, Canada
10Center for Global Mental Health Research, National Institute of Psychiatry Ramón de la Fuente Muñiz, Mexico City, Mexico
11Department of Psychiatry and Mental Health, Faculty of Medicine, National Autonomous University of Mexico, Mexico City, Mexico
12Schaeffer Center for Health Policy and Economics, Sol Price School of Public Policy, University of Southern California, Los Angeles, United States
13Institute for Mental Health Policy Research, Centre for Addiction & Mental Health, Toronto, Canada
14Dalla Lana School of Public Health, University of Toronto, Toronto, Canada
15Centre for Alcohol Policy Research, La Trobe University, Melbourne, Australia
16Centre for Social Research on Alcohol and Drugs, Department of Public Health Sciences, Stockholm University, Stockholm, Sweden
17Department of Psychiatry, University of Amsterdam, Amsterdam, The Netherlands
18Amsterdam University Medical Centre, University of Amsterdam, Amsterdam, the Netherlands
19National Centre for Youth Substance Use Research, Faculty of Health and Behavioural Sciences, University of Queensland, St Lucia, QLD 4072, Australia
20National Addiction Centre, Institute of Psychiatry, Kings College London, United Kingdom

Tài liệu tham khảo

Agrawal, 2018, Genome-wide association study identifies a novel locus for cannabis dependence, Molecular Psychiatry, 23, 1293, 10.1038/mp.2017.200 Agrawal, 2017, Major depressive disorder, suicidal thoughts and behaviours, and cannabis involvement in discordant twins: a retrospective cohort study, Lancet Psychiatry, 4, 706, 10.1016/S2215-0366(17)30280-8 Alvarez, 2021, Young and under the influence: A systematic literature review of the impact of cannabis on the driving performance of youth, Accident Analysis & Prevention, 151, 10.1016/j.aap.2020.105961 Arkell, 2019, Cannabidiol (CBD) content in vaporized cannabis does not prevent tetrahydrocannabinol (THC)-induced impairment of driving and cognition, Psychopharmacology, 236, 2713, 10.1007/s00213-019-05246-8 Arkell, 2020, Effect of cannabidiol and Δ9-tetrahydrocannabinol on driving performance: A randomized clinical trial, Journal of the American Medical Association, 324 Armstrong, 2021, Legal cannabis market shares during Canada's first year of recreational legalisation, International Journal of Drug Policy, 88, 10.1016/j.drugpo.2020.103028 Arterberry, 2019, Higher average potency across the United States is associated with progression to first cannabis use disorder symptom, Drug and Alcohol Dependence, 195, 186, 10.1016/j.drugalcdep.2018.11.012 Asgarian, 2020, Prevalence of mortality in cannabis consumer motorcyclists: meta-analysis of international studies, International Journal of Injury Control and Safety Promotion, 27, 136, 10.1080/17457300.2019.1669667 Aston, 2019, Vaporization of marijuana among recreational users: A qualitative study, Journal of Studies on Alcohol and Drugs, 80, 56, 10.15288/jsad.2019.80.56 Azofeifa, 2019, Driving Under the Influence of Marijuana and Illicit Drugs Among Persons Aged >/=16 Years - United States, 2018, MMWR: Morbidity and Mortality Weekly Report, 68, 1153 Bahdila, 2020, Cocaine, polysubstance abuse, and oral health outcomes, NHANES 2009 to 2014, Journal of Periodontology, 10.1002/JPER.19-0509 Bahji, 2020, Prevalence of Cannabis Withdrawal Symptoms Among People With Regular or Dependent Use of Cannabinoids: A Systematic Review and Meta-analysis, Journal of the American Medical Association Network Open, 3 Bailey, 2020, Impact of pregnancy marijuana use on birth outcomes: results from two matched population-based cohorts, Journal of Perinatology, 40, 1477, 10.1038/s41372-020-0643-z Baker, 2018, Transfer of Inhaled Cannabis Into Human Breast Milk, Obstetrics and Gynecology, 131, 783, 10.1097/AOG.0000000000002575 Barrington-Trimis, 2020, Risk of persistence and progression of use of 5 cannabis products after experimentation among adolescents, Journal of the American Medical Association Network Open, 3 Barry, 2018, Marijuana Regulatory Frameworks in Four US States: An Analysis Against a Public Health Standard, American Journal of Public Health, 108, 914, 10.2105/AJPH.2018.304401 Batalla, 2019, The Potential of Cannabidiol as a Treatment for Psychosis and Addiction: Who Benefits Most? A Systematic Review, Journal of Clinical Medicine, 8, 1058, 10.3390/jcm8071058 Bertrand, 2018, Marijuana Use by Breastfeeding Mothers and Cannabinoid Concentrations in Breast Milk, Pediatrics, 142, 10.1542/peds.2018-1076 Biasutti, 2020, Systematic Review of Cannabis Use and Risk of Occupational Injury, Substance Use and Misuse, 55, 1733, 10.1080/10826084.2020.1759643 Bidwell, 2020, Association of Naturalistic Administration of Cannabis Flower and Concentrates With Intoxication and Impairment, Journal of the American Medical Association Psychiatry, 77, 787 Bidwell, 2021, Advancing the science on cannabis concentrates and behavioural health, Drug and Alcohol Review, 10.1111/dar.13281 Bisconti, 2019, Cannabinoids Identification in Lung Tissues of Young Cannabis Smokers Operated for Primary Spontaneous Pneumothorax and Correlation with Pathologic Findings, Respiration, 98, 503, 10.1159/000503456 Blest-Hopley, 2018, Residual effects of cannabis use in adolescent and adult brains - A meta-analysis of fMRI studies, Neuroscience & Biobehavioral Reviews, 88, 26, 10.1016/j.neubiorev.2018.03.008 Blest-Hopley, 2019, Regular cannabis use is associated with altered activation of central executive and default mode networks even after prolonged abstinence in adolescent users: Results from a complementary meta-analysis, Neuroscience & Biobehavioral Reviews, 96, 45, 10.1016/j.neubiorev.2018.10.026 Blevins, 2018, The Implications of Cannabis Policy Changes in Washington on Adolescent Perception of Risk, Norms, Attitudes, and Substance Use, Substance Abuse, 12 Blithikioti, 2019, Cerebellar alterations in cannabis users: A systematic review, Addiction Biology, 24, 1121, 10.1111/adb.12714 Bloomfield, 2019, The neuropsychopharmacology of cannabis: A review of human imaging studies, Pharmacology & Therapeutics, 195, 132, 10.1016/j.pharmthera.2018.10.006 Boden, 2020, Life-course trajectories of cannabis use: a latent class analysis of a New Zealand birth cohort, Addiction, 115, 279, 10.1111/add.14814 Boggs, 2018, Clinical and Preclinical Evidence for Functional Interactions of Cannabidiol and Delta(9)-Tetrahydrocannabinol, Neuropsychopharmacology, 43, 142, 10.1038/npp.2017.209 Boisvert, 2020, Subjective effects of combustible, vaporized, and edible cannabis: Results from a survey of adolescent cannabis users, Drug and Alcohol Dependence, 206 Bonaccorso, 2019, Cannabidiol (CBD) use in psychiatric disorders: A systematic review, Neurotoxicology, 74, 282, 10.1016/j.neuro.2019.08.002 Bondallaz, 2016, Cannabis and its effects on driving skills, Forensic Science International, 268, 92, 10.1016/j.forsciint.2016.09.007 Boyd, 2012, Guideline funding and conflicts of interest: article 4 in Integrating and coordinating efforts in COPD guideline development. An official ATS/ERS workshop report, Proceedings of the American Thoracic Society, 9, 234, 10.1513/pats.201208-057ST Brabete, 2020, Sex- and Gender-Based Analysis in Cannabis Treatment Outcomes: A Systematic Review, International Journal of Environmental Research and Public Health, 17, 872, 10.3390/ijerph17030872 Brands, 2019, Acute and residual effects of smoked cannabis: Impact on driving speed and lateral control, heart rate, and self-reported drug effects, Drug and Alcohol Dependence, 205, 10.1016/j.drugalcdep.2019.107641 Brents, 2016, Marijuana, the Endocannabinoid System and the Female Reproductive System, Yale Journal of Biology and Medicine, 89, 175 Brezing, 2018, Abstinence and reduced frequency of use are associated with improvements in quality of life among treatment-seekers with cannabis use disorder, American Journal on Addictions, 27, 101, 10.1111/ajad.12660 Brown, 2020, Potential Adverse Drug Events with Tetrahydrocannabinol (THC) Due to Drug-Drug Interactions, Journal of Clinical Medicine, 9, 919, 10.3390/jcm9040919 Brown, 2016, Use of cannabis during pregnancy and birth outcomes in an Aboriginal birth cohort: a cross-sectional, population-based study, BMJ Open, 6, 10.1136/bmjopen-2015-010286 Brubacher, 2019, Cannabis use as a risk factor for causing motor vehicle crashes: a prospective study, Addiction, 114, 1616, 10.1111/add.14663 Bruni, 2018, Cannabinoid Delivery Systems for Pain and Inflammation Treatment, Molecules, 23, 2478, 10.3390/molecules23102478 Budney, 2017, The potential impact of cannabis legalization on the development of cannabis use disorders, Preventive Medicine, 104, 31, 10.1016/j.ypmed.2017.06.034 Budney, 2019, An update on cannabis use disorder with comment on the impact of policy related to therapeutic and recreational cannabis use, European Archives of Psychiatry and Clinical Neuroscience, 269, 73, 10.1007/s00406-018-0976-1 Burggren, 2019, Cannabis effects on brain structure, function, and cognition: considerations for medical uses of cannabis and its derivatives, American Journal of Drug and Alcohol Abuse, 45, 563, 10.1080/00952990.2019.1634086 Calabria, 2010, Does cannabis use increase the risk of death? Systematic review of epidemiological evidence on adverse effects of cannabis use, Drug and Alcohol Review, 29, 318, 10.1111/j.1465-3362.2009.00149.x Calakos, 2017, Mechanisms Underlying Sex Differences in Cannabis Use, Current Addiction Reports, 4, 439, 10.1007/s40429-017-0174-7 Callaghan, 2019, Who consumes most of the cannabis in Canada? Profiles of cannabis consumption by quantity, Drug and Alcohol Dependence, 205 Callaghan, 2020, Quantity and frequency of cannabis use in relation to cannabis-use disorder and cannabis-related problems, Drug and Alcohol Dependence, 217, 10.1016/j.drugalcdep.2020.108271 Campeny, 2020, The blind men and the elephant: Systematic review of systematic reviews of cannabis use related health harms, European Neuropsychopharmacology, 33, 1, 10.1016/j.euroneuro.2020.02.003 Cancilliere, 2018, Effects of co-occuring marijuana use and anxiety on brain structure and functioning: A systematic review of adolescent studies, Journal of Adolescence, 65, 177, 10.1016/j.adolescence.2018.03.013 Carliner, 2017, Cannabis use, attitudes, and legal status in the U.S.: A review, Preventive Medicine, 104, 13, 10.1016/j.ypmed.2017.07.008 Carvalho, 2020, The effects of cannabidiol on male reproductive system: A literature review, Journal of Applied Toxicology, 40, 132, 10.1002/jat.3831 Castellanos-Ryan, 2021, Academic, socioeconomic and interpersonal consequences of cannabis use: A narrative review, Drugs: Education, Prevention and Policy Caulkins, 2019, Triangulating web & general population surveys: Do results match legal cannabis market sales?, International Journal of Drug Policy, 73, 293, 10.1016/j.drugpo.2019.06.010 Caulkins, 2020, Intensity of cannabis use: Findings from three online surveys, International Journal of Drug Policy, 79, 10.1016/j.drugpo.2020.102740 Cavazos-Rehg, 2018, Operating a motor vehicle after marijuana use: Perspectives from people who use high-potency marijuana, Substance Abuse, 39, 21, 10.1080/08897077.2017.1365802 Cerda, 2020, Association Between Recreational Marijuana Legalization in the United States and Changes in Marijuana Use and Cannabis Use Disorder From 2008 to 2016, Journal of the American Medical Association Psychiatry, 77, 165 Chadi, 2020, Cannabis vaping: Understanding the health risks of a rapidly emerging trend, Paediatrics & Child Health, 25, S16, 10.1093/pch/pxaa016 Chan, 2020, Estimation of the proportion of population cannabis consumption in Australia that is accounted for by daily users using Monte Carlo Simulation, Addiction, 115, 1182, 10.1111/add.14909 Chapman, 2017, Evidence for Sex Convergence in Prevalence of Cannabis Use: A Systematic Review and Meta-Regression, Journal of Studies on Alcohol and Drugs, 78, 344, 10.15288/jsad.2017.78.344 Cherian, 2020, E-Cigarette or Vaping Product-Associated Lung Injury: A Review, American Journal of Medicine, 133, 657, 10.1016/j.amjmed.2020.02.004 Cherpitel, 2018, Single episode of alcohol use resulting in injury: a cross-sectional study in 21 countries, Bulletin of the World Health Organization, 96, 335, 10.2471/BLT.17.202093 Chesney, 2020, Adverse effects of cannabidiol: a systematic review and meta-analysis of randomized clinical trials, Neuropsychopharmacology, 45, 1799, 10.1038/s41386-020-0667-2 Chihuri, 2017, Interaction of marijuana and alcohol on fatal motor vehicle crash risk: a case-control study, Injury Epidemiology, 4, 8, 10.1186/s40621-017-0105-z Choi, 2019, Potential harms of marijuana use among older adults, Public Policy & Aging Report, 29, 88, 10.1093/ppar/prz011 Chu, 2019, Prevalence of Involuntary Environmental Cannabis and Tobacco Smoke Exposure in Multi-Unit Housing, International Journal of Environmental Research and Public Health, 16, 3332, 10.3390/ijerph16183332 Chye, 2020, Cannabis Use in Adolescence: A Review of Neuroimaging Findings, Journal of Dual Diagnosis, 16, 83, 10.1080/15504263.2019.1636171 Cohen, 2019, Positive and Negative Effects of Cannabis and Cannabinoids on Health, Clinical Pharmacology and Therapeutics, 105, 1139, 10.1002/cpt.1381 Colizzi, 2018, Cannabis use and the development of tolerance: a systematic review of human evidence, Neuroscience & Biobehavioral Reviews, 93, 1, 10.1016/j.neubiorev.2018.07.014 Conner, 2016, Maternal Marijuana Use and Adverse Neonatal Outcomes: A Systematic Review and Meta-analysis, Obstetrics and Gynecology, 128, 713, 10.1097/AOG.0000000000001649 Connor, 2018, Thresholds for safer alcohol use might need lowering, Lancet, 391, 1460, 10.1016/S0140-6736(18)30545-2 Cooper, 2018, Sex-Dependent Effects of Cannabis and Cannabinoids: A Translational Perspective, Neuropsychopharmacology, 43, 34, 10.1038/npp.2017.140 Copeland, 2016, Progress toward pharmacotherapies for cannabis-use disorder: an evidence-based review, Substance Abuse and Rehabilitation, 7, 41, 10.2147/SAR.S89857 Corroon, 2020, Labeling of Cannabidiol Products: A Public Health Perspective, Cannabis and Cannabinoid Research, 5, 274, 10.1089/can.2019.0101 Craft, 2020, Characterising heterogeneity in the use of different cannabis products: Latent class analysis with 55 000 people who use cannabis and associations with severity of cannabis dependence, Psychological Medicine, 50, 2364, 10.1017/S0033291719002460 Curran, 2016, Keep off the grass? Cannabis, cognition and addiction, Nature Reviews: Neuroscience, 17, 293, 10.1038/nrn.2016.28 Dahlgren, 2020, Recreational cannabis use impairs driving performance in the absence of acute intoxication, Drug and Alcohol Dependence, 208, 10.1016/j.drugalcdep.2019.107771 De Genna, 2018, Prenatal exposures to tobacco and cannabis: Associations with adult electronic cigarette use, Drug and Alcohol Dependence, 188, 209, 10.1016/j.drugalcdep.2018.03.045 Decorte, 2020 Degenhardt, 2018, The global burden of disease attributable to alcohol and drug use in 195 countries and territories, 1990–2016: a systematic analysis for the Global Burden of Disease Study 2016, Lancet Psychiatry, 5, 987, 10.1016/S2215-0366(18)30337-7 Degenhardt, 2013, The global epidemiology and contribution of cannabis use and dependence to the global burden of disease: results from the GBD 2010 study, PloS One, 8, e76635, 10.1371/journal.pone.0076635 Degenhardt, 2017, Chapter 10: The global epidemiology and disease burden of cannabis use and dependence, 89 Demontis, 2019, Genome-wide association study implicates CHRNA2 in cannabis use disorder, Nature Neuroscience, 22, 1066, 10.1038/s41593-019-0416-1 Di Forti, 2019, The contribution of cannabis use to variation in the incidence of psychotic disorder across Europe (EU-GEI): a multicentre case-control study, Lancet Psychiatry, 6, 427, 10.1016/S2215-0366(19)30048-3 Doran, 2019, Cannabis edibles: Behaviours, attitudes, and reasons for use, Environmental Health Review, 62, 44, 10.5864/d2019-011 Doroudgar, 2018, Effects of chronic marijuana use on driving performance, Traffic Injury Prevention, 19, 680, 10.1080/15389588.2018.1501800 Dos Santos, 2020, Serious adverse effects of cannabidiol (CBD): a review of randomized controlled trials, Expert Opinion on Drug Metabolism & Toxicology, 16, 517, 10.1080/17425255.2020.1754793 Drummer, 2020, Odds of culpability associated with use of impairing drugs in injured drivers in Victoria, Australia, Accident Analysis & Prevention, 135, 10.1016/j.aap.2019.105389 Drummer, 2019, Cannabis as a cause of death: A review, Forensic Science International, 298, 298, 10.1016/j.forsciint.2019.03.007 Dryburgh, 2018, Cannabis contaminants: sources, distribution, human toxicity and pharmacologic effects, British Journal of Clinical Pharmacology, 84, 2468, 10.1111/bcp.13695 Dubovis, 2020, Effects of marijuana on human reproduction, Reproductive Toxicology, 94, 22, 10.1016/j.reprotox.2020.04.071 Dunkley, 2014, Diabetes prevention in the real world: effectiveness of pragmatic lifestyle interventions for the prevention of type 2 diabetes and of the impact of adherence to guideline recommendations: a systematic review and meta-analysis, Diabetes Care, 37, 922, 10.2337/dc13-2195 Eadie, 2021, Duration of neurocognitive impairment with medical cannabis use: A scoping review, Frontiers in Psychiatry, 12, 10.3389/fpsyt.2021.638962 Englund, 2017, Can we make cannabis safer?, Lancet Psychiatry, 4, 643, 10.1016/S2215-0366(17)30075-5 Erin Goodman, 2019, Risk perceptions of cannabis- vs. alcohol-impaired driving among Canadian young people, Drugs: Education, Prevention and Policy, 27, 205 ESPAD Group. (2016). ESPAD Report 2015: Results from the European School Survey Project on Alcohol and Other Drugs. Retrieved from http://espad.org/sites/espad.org/files/TD0116475ENN.pdf. Fares, 2021, Combined effect of alcohol and cannabis on simulated driving, Psychopharmacology, 10.1007/s00213-021-05773-3 Feingold, 2020, Probability and correlates of transition from cannabis use to DSM-5 cannabis use disorder: Results from a large-scale nationally representative study, Drug and Alcohol Review, 39, 142, 10.1111/dar.13031 Ferland, 2020, Deconstructing the neurobiology of cannabis use disorder, Nature Neuroscience, 23, 600, 10.1038/s41593-020-0611-0 Ferrari, 2015, Writing narrative style literature reviews, Medical Writing, 24, 230, 10.1179/2047480615Z.000000000329 Firth, 2019, Did marijuana legalization in Washington State reduce racial disparities in adult marijuana arrests?, Substance Use and Misuse, 54, 1582, 10.1080/10826084.2019.1593007 Fischer, 2020, Considering the health and social welfare impacts of non-medical cannabis legalization, World Psychiatry, 19, 187, 10.1002/wps.20736 Fischer, 2020, Facing the option for the legalisation of cannabis use and supply in New Zealand: An overview of relevant evidence, concepts and considerations, Drug and Alcohol Review, 39, 555, 10.1111/dar.13087 Fischer, 2011, Lower Risk Cannabis use Guidelines for Canada (LRCUG): a narrative review of evidence and recommendations, Canadian Journal of Public Health, 102, 324, 10.1007/BF03404169 Fischer, 2020, Initial indicators of the public health impacts of non-medical cannabis legalization in Canada, EClinicalMedicine, 20, 10.1016/j.eclinm.2020.100294 Fischer, 2017, Lower-risk cannabis use guidelines: A comprehensive update of evidence and recommendations, American Journal of Public Health, 107, e1, 10.2105/AJPH.2017.303818 Freeman, 2021, Does variation in trait schizotypy and frequency of cannabis use influence the acute subjective, cognitive and psychotomimetic effects of delta-9-tetrahydrocannabinol? A mega-analysis, Journal of Psychopharmacology, 10.1177/0269881120959601 Freeman, 2019, How does cannabidiol (CBD) influence the acute effects of delta-9-tetrahydrocannabinol (THC) in humans? A systematic review, Neuroscience and Biobehavioural Reviews, 107, 696, 10.1016/j.neubiorev.2019.09.036 Freeman, 2020, Cannabidiol for the treatment of cannabis use disorder: a phase 2a, double-blind, placebo-controlled, randomised, adaptive Bayesian trial, Lancet Psychiatry, 7, 865, 10.1016/S2215-0366(20)30290-X Freeman, 2020, Standard THC units': a proposal to standardize dose across all cannabis products and methods of administration, Addiction, 115, 1207, 10.1111/add.14842 Freeman, 2018, Changes in cannabis potency and first-time admissions to drug treatment: a 16-year study in the Netherlands, Psychological Medicine, 48, 2346, 10.1017/S0033291717003877 Friese, 2017, Use of Marijuana Edibles by Adolescents in California, Journal of Primary Prevention, 38, 279, 10.1007/s10935-017-0474-7 Gabrhelik, 2020, Cannabis use during pregnancy and risk of adverse birth outcomes: A longitudinal cohort study, European Addiction Research, 1, 10.1159/000510821 Ganzer, 2016, Weighing the Evidence: A Systematic Review on Long-Term Neurocognitive Effects of Cannabis Use in Abstinent Adolescents and Adults, Neuropsychology Review, 26, 186, 10.1007/s11065-016-9316-2 Gates, 2016, Psychosocial interventions for cannabis use disorder, Cochrane Database of Systematic Reviews, 5 Ghasemiesfe, 2019, Association Between Marijuana Use and Risk of Cancer: A Systematic Review and Meta-analysis, Journal of the American Medical Association Network Open, 2 Ghasemiesfe, 2020, Acute Cardiovascular Effects of Marijuana Use, Journal of General Internal Medicine, 35, 969, 10.1007/s11606-019-05235-9 Ghasemiesfe, 2018, Marijuana Use, Respiratory Symptoms, and Pulmonary Function: A Systematic Review and Meta-analysis, Annals of Internal Medicine, 169, 106, 10.7326/M18-0522 Gjerde, 2016, Risk for involvement in road traffic crash during acute cannabis intoxication, Addiction, 111, 1492, 10.1111/add.13435 Gobbi, 2019, Association of Cannabis Use in Adolescence and Risk of Depression, Anxiety, and Suicidality in Young Adulthood: A Systematic Review and Meta-analysis, Journal of the American Medical Association Psychiatry, 76, 426 Gonzalez, 2017, Does Cannabis Use Cause Declines in Neuropsychological Functioning? A Review of Longitudinal Studies, Journal of the International Neuropsychological Society, 23, 893, 10.1017/S1355617717000789 Goodman, 2020, Lower-Risk Cannabis Use Guidelines: Adherence in Canada and the United States, American Journal of Preventive Medicine, 59, e211, 10.1016/j.amepre.2020.06.015 Goodman, 2020, Prevalence and forms of cannabis use in legal vs. illegal recreational cannabis markets, International Journal of Drug Policy, 76, 10.1016/j.drugpo.2019.102658 Gorey, 2019, Age-related differences in the impact of cannabis use on the brain and cognition: a systematic review, European Archives of Psychiatry and Clinical Neuroscience, 269, 37, 10.1007/s00406-019-00981-7 Government of Canada. (2020). Canada's lower-risk cannabis use guidelines. Retrieved from https://www.canada.ca/en/health-canada/services/drugs-medication/cannabis/resources/lower-risk-cannabis-use-guidelines.html Grant, 2018, Cannabis use during pregnancy: Pharmacokinetics and effects on child development, Pharmacology & Therapeutics, 182, 133, 10.1016/j.pharmthera.2017.08.014 Greaves, 2020, Sex and Gender Interactions on the Use and Impact of Recreational Cannabis, International Journal of Environmental Research and Public Health, 17, 509, 10.3390/ijerph17020509 Grzeskowiak, 2020, The deleterious effects of cannabis during pregnancy on neonatal outcomes, Medical Journal of Australia, 212, 519, 10.5694/mja2.50624 Gukasyan, 2020, Relationship between cannabis use frequency and major depressive disorder in adolescents: Findings from the National Survey on Drug Use and Health 2012–2017, Drug and Alcohol Dependence, 208, 10.1016/j.drugalcdep.2020.107867 Gunn, 2016, Prenatal exposure to cannabis and maternal and child health outcomes: a systematic review and meta-analysis, BMJ Open, 6, 10.1136/bmjopen-2015-009986 Gunn, 2020, Complex cannabis use patterns: Associations with cannabis consequences and cannabis use disorder symptomatology, Addictive Behaviors, 105, 10.1016/j.addbeh.2020.106329 Gurriaran, 2019, Relationships between substance abuse/dependence and psychiatric disorders based on polygenic scores, Genes, Brain, and Behavior, 18, e12504, 10.1111/gbb.12504 Guttmannova, 2017, The association between regular marijuana use and adult mental health outcomes, Drug and Alcohol Dependence, 179, 109, 10.1016/j.drugalcdep.2017.06.016 Hall, 2015, What has research over the past two decades revealed about the adverse health effects of recreational cannabis use?, Addiction, 110, 19, 10.1111/add.12703 Hall, 2017, Alcohol and cannabis: Comparing their adverse health effects and regulatory regimes, International Journal of Drug Policy, 42, 57, 10.1016/j.drugpo.2016.10.021 Hall, 2008, Cannabis use and the risk of developing a psychotic disorder, World Psychiatry, 7, 68, 10.1002/j.2051-5545.2008.tb00158.x Hall, 2010, What are the policy implications of the evidence on cannabis use and psychosis?, Addiction, 105, 1332, 10.1111/j.1360-0443.2010.02919.x Hall, 2021, Lessons from the public health responses to the US outbreak of vaping-related lung injury, Addiction, 116, 985, 10.1111/add.15108 Hall, 2020, Assessing the public health impacts of legalizing recreational cannabis use: the US experience, World Psychiatry, 19, 179, 10.1002/wps.20735 Hall, 2019, Public health implications of legalising the production and sale of cannabis for medicinal and recreational use, Lancet, 394, 1580, 10.1016/S0140-6736(19)31789-1 Halladay, 2019, Brief interventions for cannabis use in emerging adults: A systematic review, meta-analysis, and evidence map, Drug and Alcohol Dependence, 204, 10.1016/j.drugalcdep.2019.107565 Hamilton, 2017, Cannabis, psychosis and schizophrenia: unravelling a complex interaction, Addiction, 112, 1653, 10.1111/add.13826 Hammond, 2020, Cannabis use among US adolescents in the era of marijuana legalization: a review of changing use patterns, comorbidity, and health correlates, International Review of Psychiatry, 32, 221, 10.1080/09540261.2020.1713056 Hammond, 2021, Communicating THC levels and 'dose' to consumers: Implications for product labelling and packaging of cannabis products in regulated markets, International Journal of Drug Policy, 91, 10.1016/j.drugpo.2019.07.004 Han, 2021, Cannabis and prescription drug use among older adults with functional impairment, American Journal of Preventive Medicine, 61, 246, 10.1016/j.amepre.2021.01.042 Hanna, 2017, Cannabis and development of dual diagnoses: A literature review, American Journal of Drug and Alcohol Abuse, 43, 442, 10.1080/00952990.2016.1213273 Hartley, 2019, Effect of Smoked Cannabis on Vigilance and Accident Risk Using Simulated Driving in Occasional and Chronic Users and the Pharmacokinetic-Pharmacodynamic Relationship, Clinical Chemistry, 65, 684, 10.1373/clinchem.2018.299727 Hasan, 2020, Cannabis use and psychosis: a review of reviews, European Archives of Psychiatry and Clinical Neuroscience, 270, 403, 10.1007/s00406-019-01068-z Hasin, 2018, US Epidemiology of Cannabis Use and Associated Problems, Neuropsychopharmacology, 43, 195, 10.1038/npp.2017.198 Hasin, 2019, Time trends in US cannabis use and cannabis use disorders overall and by sociodemographic subgroups: a narrative review and new findings, American Journal of Drug and Alcohol Abuse, 45, 623, 10.1080/00952990.2019.1569668 Hauser, 2018, European Pain Federation (EFIC) position paper on appropriate use of cannabis-based medicines and medical cannabis for chronic pain management, European Journal of Pain, 22, 1547, 10.1002/ejp.1297 Hindley, 2020, Psychiatric symptoms caused by cannabis constituents: a systematic review and meta-analysis, Lancet Psychiatry, 7, 344, 10.1016/S2215-0366(20)30074-2 Hindocha, 2018, Cannabidiol reverses attentional bias to cigarette cues in a human experimental model of tobacco withdrawal, Addiction, 113, 1696, 10.1111/add.14243 Hines, 2020, Association of High-Potency Cannabis Use With Mental Health and Substance Use in Adolescence, Journal of the American Medical Association Psychiatry, 77, 1044 Hoch, E., Friemel, C. M., & Schneider, M. (2019). Cannabis: Potenzial und Risiko - eine wissenschaftliche Bestandsaufnahme. Retrieved from https://www.bundesgesundheitsministerium.de/fileadmin/Dateien/5_Publikationen/Drogen_und_Sucht/Berichte/Hoch_et_al_Cannabis_Potential_u_Risiko_SS.pdf. Holmes, 2019, How should we set consumption thresholds for low risk drinking guidelines? Achieving objectivity and transparency using evidence, expert judgement and pragmatism, Addiction, 114, 590, 10.1111/add.14381 Holmes, 2020, Effects on alcohol consumption of announcing and implementing revised UK low-risk drinking guidelines: findings from an interrupted time series analysis, Journal of Epidemiology and Community Health, 74, 942 Hosseini, 2019, The Effect of Age of Initiation of Cannabis Use on Psychosis, Depression, and Anxiety among Youth under 25 Years, Canadian Journal of Psychiatry. Revue Canadienne de Psychiatrie, 64, 304, 10.1177/0706743718809339 Hostiuc, 2018, The Association of Unfavorable Traffic Events and Cannabis Usage: A Meta-Analysis, Frontiers in Pharmacology, 9, 99, 10.3389/fphar.2018.00099 Hudson, 2021, Risk Factors for Cannabis-Related Mental Health Harms in Older Adults: A Review, Clinical Gerontologist, 44, 3, 10.1080/07317115.2020.1808134 Huestis, 2015, Deterring driving under the influence of cannabis, Addiction, 110, 1697, 10.1111/add.13041 Hurd, 2019, Cannabis and the Developing Brain: Insights into Its Long-Lasting Effects, Journal of Neuroscience, 39, 8250, 10.1523/JNEUROSCI.1165-19.2019 Hutchison, 2019, Cannabinoids, Pain, and Opioid Use Reduction: The Importance of Distilling and Disseminating Existing Data, Cannabis and Cannabinoid Research, 4, 158, 10.1089/can.2018.0052 Iffland, 2017, An Update on Safety and Side Effects of Cannabidiol: A Review of Clinical Data and Relevant Animal Studies, Cannabis and Cannabinoid Research, 2, 139, 10.1089/can.2016.0034 Imtiaz, 2016, The burden of disease attributable to cannabis use in Canada in 2012, Addiction, 111, 653, 10.1111/add.13237 Jacobus, 2019, Cannabis and the developing brain: What does the evidence say?, Birth Defects Research, 111, 1302, 10.1002/bdr2.1572 Jayakumar, 2021, Co-use and Mixing Tobacco With Cannabis Among Ontario Adults, Nicotine & Tobacco Research, 23, 171, 10.1093/ntr/ntz238 Jepson, 2010, The effectiveness of interventions to change six health behaviours: a review of reviews, BMC Public Health, 10, 538, 10.1186/1471-2458-10-538 Johnson, 2021, Cannabis and crash risk among older drivers, Accident Analysis & Prevention, 152, 10.1016/j.aap.2021.105987 Jouanjus, 2017, What is the Current Knowledge About the Cardiovascular Risk for Users of Cannabis-Based Products? A Systematic Review, Current Atherosclerosis Reports, 19, 26, 10.1007/s11883-017-0663-0 Jutras-Aswad, 2019, Thinking Beyond Legalization: The Case for Expanding Evidence-Based Options for Cannabis Use Disorder Treatment in Canada, Canadian Journal of Psychiatry, 64, 82, 10.1177/0706743718790955 Karoly, 2020, Effects of high-potency cannabis on psychomotor performance in frequent cannabis users, Cannabis and Cannabinoid Research, 10.1089/can.2020.0048 Karoly, 2020, Exploring Cannabis and Alcohol Co-Use in Adolescents: A Narrative Review of the Evidence, Journal of Dual Diagnosis, 16, 58, 10.1080/15504263.2019.1660020 Karriker-Jaffe, 2018, Alcohol's Harm to Others: Opportunities and Challenges in a Public Health Framework, Journal of Studies on Alcohol and Drugs, 79, 239, 10.15288/jsad.2018.79.239 Kiburi, 2021, Cannabis use in adolescence and risk of psychosis: Are there factors that moderate this relationship? A systematic review and meta-analysis, Substance Abuse, 1 Ko, 2018, Marijuana use during and after pregnancy and association of prenatal use on birth outcomes: A population-based study, Drug and Alcohol Dependence, 187, 72, 10.1016/j.drugalcdep.2018.02.017 Kraan, 2016, Cannabis use and transition to psychosis in individuals at ultra-high risk: Review and meta-analysis, Psychological Medicine, 46, 673, 10.1017/S0033291715002329 Krauss, 2017, A latent class analysis of poly-marijuana use among young adults, Addictive Behaviors, 75, 159, 10.1016/j.addbeh.2017.07.021 Krebs, 2010, A meta-analysis of computer-tailored interventions for health behavior change, Preventive Medicine, 51, 214, 10.1016/j.ypmed.2010.06.004 Kroon, 2020, Heavy cannabis use, dependence and the brain: a clinical perspective, Addiction, 115, 559, 10.1111/add.14776 Kushi, 2012, American Cancer Society Guidelines on nutrition and physical activity for cancer prevention: reducing the risk of cancer with healthy food choices and physical activity, CA: A Cancer Journal for Clinicians, 62, 30 Larsen, 2020, Dosage, Efficacy and Safety of Cannabidiol Administration in Adults: A Systematic Review of Human Trials, Journal of Clinical Medicine Research, 12, 129, 10.14740/jocmr4090 Leadbeater, 2019, Age-varying effects of cannabis use frequency and disorder on symptoms of psychosis, depression and anxiety in adolescents and adults, Addiction, 114, 278, 10.1111/add.14459 Lee, 2020, The Lower-Risk Cannabis Use Guidelines' (LRCUG) recommendations: How are Canadian cannabis users complying?, Preventive Medicine Reports, 20, 10.1016/j.pmedr.2020.101187 Lee, 2019, Systematic review of outcome domains and measures used in psychosocial and pharmacological treatment trials for cannabis use disorder, Drug and Alcohol Dependence, 194, 500, 10.1016/j.drugalcdep.2018.10.020 Lemyre, 2019, The Relationship Between Tobacco and Cannabis Use: A Review, Substance Use and Misuse, 54, 130, 10.1080/10826084.2018.1512623 Leos-Toro, 2020, Cannabis labelling and consumer understanding of THC levels and serving sizes, Drug and Alcohol Dependence, 208, 10.1016/j.drugalcdep.2020.107843 Leung, 2020, What is the prevalence and risk of cannabis use disorders among people who use cannabis? a systematic review and meta-analysis, Addictive Behaviors, 109, 10.1016/j.addbeh.2020.106479 Leung, 2020, Adolescent cannabis use disorders, 111 Levine, 2017, Evidence for the Risks and Consequences of Adolescent Cannabis Exposure, Journal of the American Academy of Child and Adolescent Psychiatry, 56, 214, 10.1016/j.jaac.2016.12.014 Liao, 2019, Relationships between marijuana use, severity of marijuana-related problems, and health-related quality of life, Psychiatry Research, 279, 237, 10.1016/j.psychres.2019.03.010 Lin, 2016, Comparing adults who use cannabis medically with those who use recreationally: Results from a national sample, Addictive Behaviors, 61, 99, 10.1016/j.addbeh.2016.05.015 Lloyd, 2020, Sex differences in driving under the influence of cannabis: The role of medical and recreational cannabis use, Addictive Behaviors, 110, 10.1016/j.addbeh.2020.106525 Lorenzetti, 2016, Adolescent cannabis use: What is the evidence for functional brain alteration?, Current Pharmaceutical Design, 22, 1 Lorenzetti, 2019, Does regular cannabis use affect neuroanatomy? An updated systematic review and meta-analysis of structural neuroimaging studies, European Archives of Psychiatry and Clinical Neuroscience, 269, 59, 10.1007/s00406-019-00979-1 Lorenzetti, 2020, Adolescent cannabis use, cognition, brain health and educational outcomes: A review of the evidence, European Neuropsychopharmacology, 36, 169, 10.1016/j.euroneuro.2020.03.012 Lovell, 2020, Cognitive outcomes associated with long-term, regular, recreational cannabis use in adults: A meta-analysis, Experimental and Clinical Psychopharmacology, 28, 471, 10.1037/pha0000326 Lowe, 2019, Cannabis and mental illness: a review, European Archives of Psychiatry and Clinical Neuroscience, 269, 107, 10.1007/s00406-018-0970-7 Lustria, 2013, A meta-analysis of web-delivered tailored health behavior change interventions, Journal of Health Communication, 18, 1039, 10.1080/10810730.2013.768727 Lynn, 2020, Effects of Cannabinoids on Female Sexual Function, Sexual Medicine Reviews, 8, 18, 10.1016/j.sxmr.2019.07.004 MacCallum, 2018, Practical considerations in medical cannabis administration and dosing, European Journal of Internal Medicine, 49, 12, 10.1016/j.ejim.2018.01.004 Mader, 2019, Correlates of lifetime cannabis use and cannabis use severity in a Canadian university sample, Addictive Behaviors, 98, 10.1016/j.addbeh.2019.06.004 Mason, 2021, Reduced responsiveness of the reward system is associated with tolerance to cannabis impairment in chronic users, Addiction Biology, 26, e12870, 10.1111/adb.12870 McCartney, 2021, Determining the magnitude and duration of acute Δ 9-tetrahydrocannabinol (Δ 9-THC)-induced driving and cognitive impairment: A systematic and meta-analytic review, Neuroscience and Biobehavioral Reviews, 126, 175, 10.1016/j.neubiorev.2021.01.003 McCartney, 2020, The effect of cannabidiol on simulated car driving performance: A randomised, double-blind, placebo-controlled, crossover, dose-ranging clinical trial protocol, Human Psychopharmacology: Clinical and Experimental, 35, e2749, 10.1002/hup.2749 Meier, 2016, A review of the additive health risk of cannabis and tobacco co-use, Drug and Alcohol Dependence, 166, 6, 10.1016/j.drugalcdep.2016.07.013 Meier, 2017, Associations between butane hash oil use and cannabis-related problems, Drug and Alcohol Dependence, 179, 25, 10.1016/j.drugalcdep.2017.06.015 Meier, 2021, Cannabis use and psychosocial functioning: evidence from prospective longitudinal studies, Current Opinion in Psychology, 38, 19, 10.1016/j.copsyc.2020.07.001 Meier, 2019, Associations between adolescent cannabis use frequency and adult brain structure: A prospective study of boys followed to adulthood, Drug and Alcohol Dependence, 202, 191, 10.1016/j.drugalcdep.2019.05.012 Memedovich, 2018, The adverse health effects and harms related to marijuana use: an overview review, CMAJ Open, 6, E339, 10.9778/cmajo.20180023 Metz, 2017, Maternal marijuana use, adverse pregnancy outcomes, and neonatal morbidity, American Journal of Obstetrics and Gynecology, 217, e471, 10.1016/j.ajog.2017.05.050 Metz, 2018, Marijuana Use in Pregnancy and While Breastfeeding, Obstetrics and Gynecology, 132, 1198, 10.1097/AOG.0000000000002878 Micallef, 2018, Cannabis smoking impairs driving performance on the simulator and real driving: a randomized, double-blind, placebo-controlled, crossover trial, Fundamental and Clinical Pharmacology, 32, 558, 10.1111/fcp.12382 Miech, 2017, Prevalence and Attitudes Regarding Marijuana Use Among Adolescents Over the Past Decade, Pediatrics, 140, 10.1542/peds.2017-0982 Mishra, 2017, Cannabis-induced bullous lung disease leading to pneumothorax: Case report and literature review, Medicine, 96, e6917, 10.1097/MD.0000000000006917 Moitra, 2016, Reductions in cannabis use are associated with mood improvement in female emerging adults, Depression and Anxiety, 33, 332, 10.1002/da.22460 Mokrysz, 2016, Are adolescents more vulnerable to the harmful effects of cannabis than adults? A placebo-controlled study in human males, Translational Psychiatry, 6, e961, 10.1038/tp.2016.225 Murray, 2020, Will Legalization and Commercialization of Cannabis Use Increase the Incidence and Prevalence of Psychosis?, Journal of the American Medical Association Psychiatry, 77, 777 Murray, 2016, Traditional marijuana, high-potency cannabis and synthetic cannabinoids: increasing risk for psychosis, World Psychiatry, 15, 195, 10.1002/wps.20341 Nader, 2018, Effects of regular cannabis use on neurocognition, brain structure, and function: a systematic review of findings in adults, American Journal of Drug and Alcohol Abuse, 44, 4, 10.1080/00952990.2017.1306746 2017 Newmeyer, 2017, Subjective and physiological effects, and expired carbon monoxide concentrations in frequent and occasional cannabis smokers following smoked, vaporized, and oral cannabis administration, Drug and Alcohol Dependence, 175, 67, 10.1016/j.drugalcdep.2017.02.003 Newmeyer, 2016, Free and Glucuronide Whole Blood Cannabinoids' Pharmacokinetics after Controlled Smoked, Vaporized, and Oral Cannabis Administration in Frequent and Occasional Cannabis Users: Identification of Recent Cannabis Intake, Clinical Chemistry, 62, 1579, 10.1373/clinchem.2016.263475 Noar, 2007, Does tailoring matter? Meta-analytic review of tailored print health behavior change interventions, Psychological Bulletin, 133, 673, 10.1037/0033-2909.133.4.673 Norberg, 2013, Primary prevention of cannabis use: a systematic review of randomized controlled trials, PloS One, 8, e53187, 10.1371/journal.pone.0053187 Ogunbiyi, 2020, Acute and chronic effects of Delta(9)-tetrahydrocannabinol (THC) on cerebral blood flow: A systematic review, Progress in Neuro-Psychopharmacology and Biological Psychiatry, 101, 10.1016/j.pnpbp.2020.109900 Pacher, 2018, Cardiovascular effects of marijuana and synthetic cannabinoids: the good, the bad, and the ugly, Nature Reviews: Cardiology, 15, 151 Pasman, 2019, Author Correction: GWAS of lifetime cannabis use reveals new risk loci, genetic overlap with psychiatric traits, and a causal effect of schizophrenia liability, Nature Neuroscience, 22, 1196, 10.1038/s41593-019-0402-7 Patel, 2020, Marijuana use and acute myocardial infarction: A systematic review of published cases in the literature, Trends in Cardiovascular Medicine, 30, 298, 10.1016/j.tcm.2019.08.003 Patel, 2020, The association between cannabis use and schizophrenia: Causative or curative? A systematic review, Cureus, 12, e9309 Paul, 2021, Associations Between Prenatal Cannabis Exposure and Childhood Outcomes: Results From the ABCD Study, Journal of the American Medical Association Psychiatry, 78, 64 Payne, 2019, Cannabis and Male Fertility: A Systematic Review, Journal of Urology, 202, 674, 10.1097/JU.0000000000000248 Peng, 2020, Residual blood THC levels in frequent cannabis users after over four hours of abstinence: A systematic review, Drug and Alcohol Dependence, 216, 10.1016/j.drugalcdep.2020.108177 Peters, 2018, Contemporary Routes of Cannabis Consumption: A Primer for Clinicians, Journal of the American Osteopathic Association, 118, 67 Pizzol, 2019, Relationship Between Cannabis Use and Erectile Dysfunction: A Systematic Review and Meta-Analysis, American Journal of Men's Health, 13, 10.1177/1557988319892464 Plunk, 2019, Youth and Adult Arrests for Cannabis Possession After Decriminalization and Legalization of Cannabis, Journal of the American Medical Association Pediatrics, 173, 763 Pope, 2018, Starting Off on the Best Foot: A Review of Message Framing and Message Tailoring, and Recommendations for the Comprehensive Messaging Strategy for Sustained Behavior Change, Health Communication, 33, 1068, 10.1080/10410236.2017.1331305 Power, 2021, Intelligence quotient decline following frequent or dependent cannabis use in youth: A systematic review and meta-analysis of longitudinal studies, Psychological Medicine, 51, 194, 10.1017/S0033291720005036 Poyatos, 2020, Oral Administration of Cannabis and Delta-9-tetrahydrocannabinol (THC) Preparations: A Systematic Review, Medicina, 56, 309, 10.3390/medicina56060309 Pratt, 2019, Benefits and harms of medical cannabis: a scoping review of systematic reviews, Systematic Reviews, 8, 320, 10.1186/s13643-019-1243-x Preuss, 2021, Cannabis Use and Car Crashes: A Review, Frontiers in Psychiatry, 12, 10.3389/fpsyt.2021.643315 Prince, 2019, Examining links between cannabis potency and mental and physical health outcomes, Behaviour Research and Therapy, 115, 111, 10.1016/j.brat.2018.11.008 Prochaska, 2008, Multiple health behavior change research: an introduction and overview, Preventive Medicine, 46, 181, 10.1016/j.ypmed.2008.02.001 Prom-Wormley, 2017, The genetic epidemiology of substance use disorder: A review, Drug and Alcohol Dependence, 180, 241, 10.1016/j.drugalcdep.2017.06.040 Pusiak, 2021, Growing pains: An overview of cannabis quality control and quality assurance in Canada, International Journal of Drug Policy, 93, 10.1016/j.drugpo.2021.103111 Rajanahally, 2019, The relationship between cannabis and male infertility, sexual health, and neoplasm: a systematic review, Andrology, 7, 139, 10.1111/andr.12585 Ramaekers, 2018, Driving Under the Influence of Cannabis: An Increasing Public Health Concern, Journal of the American Medical Association, 319, 1433, 10.1001/jama.2018.1334 Ramaekers, 2021, The why behind the high: Determinants of neurocognition during acute cannabis exposure, Nature Reviews: Neuroscience, 10.1038/s41583-021-00466-4 Ramaekers, 2020, Blunted highs: Pharmacodynamic and behavioral models of cannabis tolerance, European Neuropsychopharmacology, 36, 191, 10.1016/j.euroneuro.2020.01.006 Ramaekers, 2016, Cannabis and tolerance: acute drug impairment as a function of cannabis use history, Scientific Reports, 6, 26843, 10.1038/srep26843 Ravi, 2018, Associations Between Marijuana Use and Cardiovascular Risk Factors and Outcomes: A Systematic Review, Annals of Internal Medicine, 168, 187, 10.7326/M17-1548 Reddon, 2020, Frequent Cannabis Use and Cessation of Injection of Opioids, Vancouver, Canada, 2005-2018, American Journal of Public Health, 110, 1553, 10.2105/AJPH.2020.305825 Reece, 2016, Chromothripsis and epigenomics complete causality criteria for cannabis- and addiction-connected carcinogenicity, congenital toxicity and heritable genotoxicity, Mutation Research, 789, 15, 10.1016/j.mrfmmm.2016.05.002 Rehm, 2015, Cannabis legalization with strict regulation, the overall superior policy option for public health, Clinical Pharmacology and Therapeutics, 97, 541, 10.1002/cpt.93 Richards, 2020, The association of cannabis use and cardiac dysrhythmias: a systematic review, Clinical Toxicology (Philadelphia, Pa.), 58, 861, 10.1080/15563650.2020.1743847 Robertson, 2017, Prevalence and trends of drugged driving in Canada, Accident Analysis and Prevention, 99, 236, 10.1016/j.aap.2016.12.008 Roditis, 2016, Perceptions of social norms and exposure to pro-marijuana messages are associated with adolescent marijuana use, Preventive Medicine, 93, 171, 10.1016/j.ypmed.2016.10.013 Roncero, 2020, Cannabis use during pregnancy and its relationship with fetal developmental outcomes and psychiatric disorders. A systematic review, Reproductive Health, 17, 25, 10.1186/s12978-020-0880-9 Room, 2010 Ruisch, 2018, Maternal substance use during pregnancy and offspring conduct problems: A meta-analysis, Neuroscience and Biobehavioral Reviews, 84, 325, 10.1016/j.neubiorev.2017.08.014 Russell, 2018, Routes of administration for cannabis use - basic prevalence and related health outcomes: A scoping review and synthesis, International Journal of Drug Policy, 52, 87, 10.1016/j.drugpo.2017.11.008 Ryan, 2018, Marijuana Use During Pregnancy and Breastfeeding: Implications for Neonatal and Childhood Outcomes, Pediatrics, 142, 10.1542/peds.2018-1889 Sagar, 2018, Marijuana matters: reviewing the impact of marijuana on cognition, brain structure and function, & exploring policy implications and barriers to research, International Review of Psychiatry, 30, 251, 10.1080/09540261.2018.1460334 Sagar, 2019, Interactions between recreational cannabis use and cognitive function: lessons from functional magnetic resonance imaging, Annals of the New York Academy of Sciences, 1451, 42, 10.1111/nyas.13990 Salas-Wright, 2021, Prevalence and Correlates of Driving Under the Influence of Cannabis in the U.S, American Journal of Preventive Medicine, 60, e251, 10.1016/j.amepre.2021.01.021 Satcher, 2015, Sexual Health in America: Improving Patient Care and Public Health, Journal of the American Medical Association, 314, 765, 10.1001/jama.2015.6831 Schlienz, 2017, Cannabis withdrawal: A review of neurobiological mechanisms and sex differences, Current Addiction Reports, 4, 75, 10.1007/s40429-017-0143-1 Schlienz, 2018, Co-use of cannabis, tobacco, and alcohol during adolescence: policy and regulatory implications, International Review of Psychiatry, 30, 226, 10.1080/09540261.2018.1465399 Schlienz, 2020, Pharmacodynamic dose effects of oral cannabis ingestion in healthy adults who infrequently use cannabis, Drug and Alcohol Dependence, 211, 10.1016/j.drugalcdep.2020.107969 Schmidt, 2020, A Systematic Review: Adolescent Cannabis Use and Suicide, Addictive Disorders & Their Treatment, 19, 146, 10.1097/ADT.0000000000000196 Schoeler, 2017, Poor medication adherence and risk of relapse associated with continued cannabis use in patients with first-episode psychosis: a prospective analysis, Lancet Psychiatry, 4, 627, 10.1016/S2215-0366(17)30233-X Schoeler, 2016, Association Between Continued Cannabis Use and Risk of Relapse in First-Episode Psychosis: A Quasi-Experimental Investigation Within an Observational Study, Journal of the American Medical Association Psychiatry, 73, 1173 Schoeler, 2018, Developmental sensitivity to cannabis use patterns and risk for major depressive disorder in mid-life: findings from 40 years of follow-up, Psychological Medicine, 48, 2169, 10.1017/S0033291717003658 Schunemann, 2019, Methods for Development of the European Commission Initiative on Breast Cancer Guidelines: Recommendations in the Era of Guideline Transparency, Annals of Internal Medicine, 171, 273, 10.7326/M18-3445 Schunemann, 2017, GRADE Evidence to Decision (EtD) frameworks for adoption, adaptation, and de novo development of trustworthy recommendations: GRADE-ADOLOPMENT, Journal of Clinical Epidemiology, 81, 101, 10.1016/j.jclinepi.2016.09.009 Scott, 2019, A Systematic Review of the Neurocognitive Effects of Cannabis Use in Older Adults, Current Addiction Reports, 6, 443, 10.1007/s40429-019-00285-9 Scott, 2019, Cannabis use in youth is associated with limited alterations in brain structure, Neuropsychopharmacology, 44, 1362, 10.1038/s41386-019-0347-2 Scott, 2018, Association of Cannabis With Cognitive Functioning in Adolescents and Young Adults: A Systematic Review and Meta-analysis, Journal of the American Medical Association Psychiatry, 75, 585 Sherva, 2016, Genome-wide Association Study of Cannabis Dependence Severity, Novel Risk Variants, and Shared Genetic Risks, Journal of the American Medical Association Psychiatry, 73, 472 Shi, 2021, The association between prenatal cannabis use disorder and neonatal outcomes, Addiction, 10.1111/add.15467 Shield, 2017, Life-time risk of mortality due to different levels of alcohol consumption in seven European countries: implications for low-risk drinking guidelines, Addiction, 112, 1535, 10.1111/add.13827 Sholler, 2020, Therapeutic Efficacy of Cannabidiol (CBD): A Review of the Evidence from Clinical Trials and Human Laboratory Studies, Current Addiction Reports, 7, 405, 10.1007/s40429-020-00326-8 Sholler, 2020, Sex differences in the acute effects of oral and vaporized cannabis among healthy adults, Addiction Biology, e12968 Sims, 2018, The effect of cannabis exposure on pubertal outcomes: a systematic review. Adolescent Health, Medicine and Therapeutics, 9, 137 Singh, 2018, Cardiovascular Complications of Marijuana and Related Substances: A Review, Cardiol Therapeutics, 7, 45, 10.1007/s40119-017-0102-x Smart, 2019, Early evidence of the impact of cannabis legalization on cannabis use, cannabis use disorder, and the use of other substances: Findings from state policy evaluations, American Journal of Drug and Alcohol Abuse, 45, 644, 10.1080/00952990.2019.1669626 Solowij, 2018, Peering through the haze of smoked vs vaporized cannabis-to vape or not to vape?, Journal of the American Medical Association Network Open, 1 Solowij, 2019, A randomised controlled trial of vaporised Delta(9)-tetrahydrocannabinol and cannabidiol alone and in combination in frequent and infrequent cannabis users: acute intoxication effects, European Archives of Psychiatry and Clinical Neuroscience, 269, 17, 10.1007/s00406-019-00978-2 Sommer, 2019, High-potency cannabis and incident psychosis: Correcting the causal assumption, Lancet Psychiatry, 6, 464, 10.1016/S2215-0366(19)30130-0 Sorensen, 2017, Cannabinoid hyperemesis syndrome: Diagnosis, pathophysiology, and treatment - A systematic review, Journal of Medical Toxicology, 13, 71, 10.1007/s13181-016-0595-z Sorkhou, 2021, The behavioural sequelae of cannabis use in healthy people: A systematic review, Frontiers in Psychiatry, 12, 10.3389/fpsyt.2021.630247 Spindle, 2019, Changing landscape of cannabis: novel products, formulations, and methods of administration, Current Opinion in Psychology, 30, 98, 10.1016/j.copsyc.2019.04.002 Spindle, 2020, Pharmacokinetics of Cannabis Brownies: A Controlled Examination of Δ9-Tetrahydrocannabinol and Metabolites in Blood and Oral Fluid of Healthy Adult Males and Females, Journal of Analytical Toxicology, 44, 661, 10.1093/jat/bkaa067 Spindle, 2018, Acute Effects of Smoked and Vaporized Cannabis in Healthy Adults Who Infrequently Use Cannabis: A Crossover Trial, Journal of the American Medical Association Network Open, 1 Steeger, 2021, Associations between self-reported cannabis use frequency, potency, and cannabis/health metrics, International Journal of Drug Policy, 97, 10.1016/j.drugpo.2021.103278 Stockings, 2018, Evidence for cannabis and cannabinoids for epilepsy: a systematic review of controlled and observational evidence, Journal of Neurology, Neurosurgery, and Psychiatry, 89, 741, 10.1136/jnnp-2017-317168 Streck, 2019, Modes of cannabis use: A secondary analysis of an intensive longitudinal natural history study, Addictive Behaviors, 98, 10.1016/j.addbeh.2019.106033 Subbaraman, 2021, Cannabis use frequency, route of administration, and co-use with alcohol among older adults in Washington state, Journal of Cannabis Research, 3 Swan, 2021, Does how you use matter? The link between mode of use and cannabis-related risk, Addictive Behaviors, 112, 10.1016/j.addbeh.2020.106620 Tank, 2019, On the impact of cannabis consumption on traffic safety: a driving simulator study with habitual cannabis consumers, International Journal of Legal Medicine, 133, 1411, 10.1007/s00414-019-02006-3 Tashkin, 2019, Pulmonary effects of inhaled cannabis smoke, American Journal of Drug and Alcohol Abuse, 45, 596, 10.1080/00952990.2019.1627366 Thayer, 2019, Preliminary results from a pilot study examining brain structure in older adult cannabis users and nonusers, Psychiatry Research: Neuroimaging, 285, 58, 10.1016/j.pscychresns.2019.02.001 Timko, 2018, Polysubstance Use by Stimulant Users: Health Outcomes Over Three Years, Journal of Studies on Alcohol and Drugs, 79, 799, 10.15288/jsad.2018.79.799 Torres, 2020, Totality of the evidence suggest prenatal cannabis exposure does not lead to cognitive impairments: A systematic and critical review, Frontiers in Psychology, 11, 816, 10.3389/fpsyg.2020.00816 Tucker, 2019, Types of cannabis and tobacco/nicotine co-use and associated outcomes in young adulthood, Psychology of Addictive Behaviors, 33, 401, 10.1037/adb0000464 2020 Vacaflor, 2020, Mental Health and Cognition in Older Cannabis Users: a Review, Canadian Geriatrics Journal, 23, 242, 10.5770/cgj.23.399 van der Steur, 2020, Factors Moderating the Association Between Cannabis Use and Psychosis Risk: A Systematic Review, Brain Sciences, 10, 97, 10.3390/brainsci10020097 Volkow, 2017, The Risks of Marijuana Use During Pregnancy, Journal of the American Medical Association, 317, 129, 10.1001/jama.2016.18612 Volkow, 2016, Effects of Cannabis Use on Human Behavior, Including Cognition, Motivation, and Psychosis: A Review, Journal of the American Medical Association Psychiatry, 73, 292 Wadsworth, 2019, International differences in patterns of cannabis use among youth: Prevalence, perceptions of harm, and driving under the influence in Canada, England & United States, Addictive Behaviors, 90, 171, 10.1016/j.addbeh.2018.10.050 Weinberger, 2020, Cannabis Use Is Associated With Increased Risk of Cigarette Smoking Initiation, Persistence, and Relapse Among Adults in the United States, Nicotine & Tobacco Research, 22, 1404, 10.1093/ntr/ntz085 Weinberger, 2019, Serious psychological distress and daily cannabis use, 2008 to 2016: Potential implications for mental health?, Drug and Alcohol Dependence, 197, 134, 10.1016/j.drugalcdep.2019.01.010 Weinstein, 2020, The implications of late-life cannabis use on brain health: A mapping review and implications for future research, Ageing Researcg Reviews, 59 Wen, 2019, The Effect of Medical Marijuana Laws on Marijuana-Related Attitude and Perception Among US Adolescents and Young Adults, Prevention Science, 20, 215, 10.1007/s11121-018-0903-8 Wilson, 2019, Effects of increasing cannabis potency on adolescent health, Lancet Child & Adolescent Health, 3, 121, 10.1016/S2352-4642(18)30342-0 Woo, 2019, Wreck on the Highway: Intersectionality of Driver Culpability, Tetrahydrocannabinols, Other Intoxicants and Fatalities in Washington State, Transportation Research Record: Journal of the Transportation Research Board, 2673, 127, 10.1177/0361198119847986 Wood, 2018, Risk thresholds for alcohol consumption: combined analysis of individual-participant data for 599 912 current drinkers in 83 prospective studies, Lancet, 391, 1513, 10.1016/S0140-6736(18)30134-X World Health Organization. (2016). The health and social effects of nonmedical cannabis use. Retrieved from https://apps.who.int/iris/handle/10665/251056 Yang, 2021, Nonmedical marijuana use and cardiovascular events: A systematic reivew, Public Health Reports Young-Wolff, 2019, Trends in marijuana use among pregnant women with and without nausea and vomiting in pregnancy, 2009-2016, Drug and Alcohol Dependence, 196 Yurasek, 2017, Co-use of Alcohol and Cannabis: A Review, Current Addiction Reports, 4, 184, 10.1007/s40429-017-0149-8 Zehra, 2018, Cannabis Addiction and the Brain: a Review, Journal of Neuroimmune Pharmacology, 13, 438, 10.1007/s11481-018-9782-9 Zhao, 2020, Characteristics of secondhand cannabis smoke from common smoking methods: Calibration factor, emission rate, and particle removal rate, Atmospheric Environment, 242, 10.1016/j.atmosenv.2020.117731 Zhu, 2020, Diagnosis and acute management of adolescent cannabinoid hyperemesis syndrome: A systematic review, Journal of Adolescent Health, 30455