Low vitamin D levels and the long‐term functional outcome of stroke up to 5 years

Brain and Behavior - Tập 11 Số 10 - 2021
Ya‐Ying Zeng1,2,3, Chunping Yuan1,3, Meng‐Xuan Wu4,3, Lin Cheng1,2, Shengnan Zhou1, Pinglang Hu1, Kaili Fan4, Wenjie Tang1,2, Jincai He1
1Department of Neurology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China
2First School of Clinical Medicine, Wenzhou Medical University, Wenzhou, China
3These authors are co-first authors of this article.
4School of Mental Health, Wenzhou Medical University, Wenzhou, China

Tóm tắt

AbstractBackground and purposePrevious studies have established that vitamin D was associated with stroke. The purpose of this study was to investigate the relationship between vitamin D and 5‐year outcome of patients with stroke including acute ischemic stroke (AIS) and intracranial hemorrhage (ICH) stroke.MethodsSerum 25‐hydroxyvitamin D levels were prospectively analyzed in patients admitted to the First Affiliated Hospital of Wenzhou Medical University from 2013 to 2015. Modified Rankin scale (mRS) was used to evaluate their 5‐year functional outcome, and univariate and multivariate logistic regressions were applied to evaluate the effects of vitamin D on stroke outcome.ResultsIn total, 668 patients diagnosed with stroke were recruited, and 420 completed the 5‐year follow‐up. Ninety‐five patients experienced poor outcome in the 5 years since stroke onset. Vitamin D levels in patients with poor outcome showed significant differences compared to good outcome patients (p < .001). In multivariable logistic regression analysis, after adjusting the potential confounders, the 5‐year functional outcome was significantly associated with vitamin D levels. Stroke patients with vitamin D levels less than 38.4 nmol/L had a higher risk for poor outcome compared with those with vitamin D level over 71.4 nmol/L at 5‐year (odds ratio [OR] = 3.66, 95% confidence interval [CI] = 1.42–9.45, p = .007), which was consistent with AIS patients (OR = 6.36, 95% CI = 1.89–21.44, p = .003).ConclusionVitamin D level less than 38.4 nmol/L at admission is a potential risk biomarker for poor functional outcome at 5‐year prognosis in AIS patients, which might provide new ideas for the prognostic assessment of stroke.

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Tài liệu tham khảo

10.1210/en.2011‐1783

10.1016/j.amjopharm.2010.02.004

10.1124/pr.116.013227

Bogazzi F., 2011, Vitamin D status may contribute to serum insulin‐like growth factor I concentrations in healthy subjects, Journal of Endocrinological Investigation, 34, e200

10.1016/j.mam.2008.05.001

10.2147/CIA.S187142

10.1016/j.amjcard.2012.10.006

10.1111/j.1468‐1331.2012.03758.x

10.1016/j.cellimm.2012.10.009

10.1111/j.1532‐5415.2009.02359.x

10.1111/jgs.15012

10.1111/ene.12607

10.1210/jc.2011‐0385

10.1016/S0924‐9338(09)70550‐4

10.3390/ijms20194907

10.1161/STROKEAHA.118.022242

10.1016/j.jacc.2008.08.050

Lips P., 2011, The effect of vitamin D on bone and osteoporosis. Best practice & research, Clinical Endocrinology & Metabolism, 25, 585

10.1093/eurjhf/hfr032

10.1172/JCI112134

10.1152/physrev.00032.2010

10.2174/15701611113119990119

10.3390/nu11061295

10.1159/000434691

10.1053/j.ajkd.2011.03.020

10.2174/138945011793591563

10.1007/s12603-016-0821-z

10.1016/j.jstrokecerebrovasdis.2017.07.006

10.1136/bmjopen-2018-025301

10.1016/j.jstrokecerebrovasdis.2012.11.006

10.1212/WNL.0b013e3181c7197b

10.1016/j.ijnurstu.2005.07.004

10.5853/jos.2019.01522

10.1042/CS20130284

10.5551/jat.40691

10.1161/01.STR.0000057976.53301.69

10.1155/2019/3652894

10.1016/S0028‐3908(99)00255‐5

10.1161/STROKEAHA.113.003508

10.1042/BSR20171509

10.1056/NEJMoa043814

10.1016/j.ecl.2012.04.003

10.1016/j.jad.2017.06.045

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Brain and Behavior

Tập 11 Số 10

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