Low haemoglobin level predicts early hospital readmission in patients with cirrhosis and acute decompensation

Sepanlou, 2020, The global, regional, and national burden of cirrhosis by cause in 195 countries and territories, 1990–2017: a systematic analysis for the Global Burden of Disease Study 2017, Lancet Gastroenterol Hepatol, 5, 245, 10.1016/S2468-1253(19)30349-8 Berman, 2011, Incidence and predictors of 30-day readmission among patients hospitalized for advanced liver disease, Clin Gastroenterol Hepatol Off Clin Pract J Am Gastroenterol Assoc, 9, 254 Volk, 2012, Hospital readmissions among patients with decompensated cirrhosis, Am J Gastroenterol, 107, 247, 10.1038/ajg.2011.314 Bajaj, 2016, The 3-month readmission rate remains unacceptably high in a large North American cohort of patients with cirrhosis, Hepatology, 64, 200, 10.1002/hep.28414 Mumtaz, 2019, Validation of risk score in predicting early readmissions in decompensated cirrhotic patients: a model based on the administrative database, Hepatology, 70, 630, 10.1002/hep.30274 Chirapongsathorn, 2018, Incidence and cost analysis of hospital admission and 30-day readmission among patients with cirrhosis, Hepatol Commun, 2, 188, 10.1002/hep4.1137 Piano, 2017, Predictors of early readmission in patients with cirrhosis after the resolution of bacterial infections, Am J Gastroenterol, 112, 1575, 10.1038/ajg.2017.253 Jencks, 2009, Rehospitalizations among patients in the medicare fee-for-service program, N Engl J Med, 360, 1418, 10.1056/NEJMsa0803563 Neff, 2011, The current economic burden of cirrhosis, Gastroenterol Hepatol, 7, 661 Allen, 2016, Time trends in the health care burden and mortality of acute on chronic liver failure in the United States, Hepatology, 64, 2165, 10.1002/hep.28812 Boursier, 2020, Hospitalization costs and risk of mortality in adults with nonalcoholic steatohepatitis: analysis of a French national hospital database, EClinicalMedicine, 25, 10.1016/j.eclinm.2020.100445 Di Pascoli, 2017, Hospitalizations Due to cirrhosis: clinical aspects in a large cohort of Italian patients and cost analysis report, Dig Dis, 35, 433, 10.1159/000458722 Kanwal, 2016, Early outpatient follow-up and 30-day outcomes in patients hospitalized with cirrhosis, Hepatology, 64, 569, 10.1002/hep.28558 Morando, 2013, How to improve care in outpatients with cirrhosis and ascites: a new model of care coordination by consultant hepatologists, J Hepatol, 59, 257, 10.1016/j.jhep.2013.03.010 Morales, 2017, Early hospital readmission in decompensated cirrhosis: incidence, impact on mortality, and predictive factors, Dig Liver Dis Off J Ital Soc Gastroenterol Ital Assoc Study Liver, 49, 903 Sobotka, 2018, Paracentesis in cirrhotics is associated with increased risk of 30-day readmission, World J Hepatol, 10, 425, 10.4254/wjh.v10.i6.425 Ahn, 2020, Type 2 diabetes: a risk factor for hospital readmissions and mortality in Australian patients with cirrhosis, Hepatol Commun, 4, 1279, 10.1002/hep4.1536 Moreau, 2013, Acute-on-chronic liver failure is a distinct syndrome that develops in patients with acute decompensation of cirrhosis, Gastroenterology, 144, 1426, 10.1053/j.gastro.2013.02.042 Bartoletti, 2020, Prognostic role of bacterial and fungal infections in patients with liver cirrhosis with and without acute-on-chronic liver failure: a prospective 2-center study, Open Forum Infect Dis, 7, 10.1093/ofid/ofaa453 Mazzaferro, 1996, Liver transplantation for the treatment of small hepatocellular carcinomas in patients with cirrhosis, N Engl J Med, 334, 693, 10.1056/NEJM199603143341104 Charlson, 1987, A new method of classifying prognostic comorbidity in longitudinal studies: development and validation, J Chronic Dis, 40, 373, 10.1016/0021-9681(87)90171-8 Kamath, 2001, A model to predict survival in patients with end-stage liver disease, Hepatology, 33, 464, 10.1053/jhep.2001.22172 Kim, 2008, Hyponatremia and mortality among patients on the liver-transplant waiting list, N Engl J Med, 359, 1018, 10.1056/NEJMoa0801209 Pugh, 1973, Transection of the oesophagus for bleeding oesophageal varices, Br J Surg, 60, 1971 Jalan, 2015, The CLIF Consortium Acute Decompensation score (CLIF-C ADs) for prognosis of hospitalised cirrhotic patients without acute-on-chronic liver failure, J Hepatol, 62, 831, 10.1016/j.jhep.2014.11.012 Horan, 2008, CDC/NHSN surveillance definition of health care–associated infection and criteria for specific types of infections in the acute care setting, Am J Infect Control, 36, 309, 10.1016/j.ajic.2008.03.002 Rimola, 2000, Diagnosis, treatment and prophylaxis of spontaneous bacterial peritonitis: a consensus document, J Hepatol, 32, 142, 10.1016/S0168-8278(00)80201-9 Jalan, 2014, Bacterial infections in cirrhosis: a position statement based on the EASL Special Conference 2013, J Hepatol, 60, 1310, 10.1016/j.jhep.2014.01.024 Kruger, 2019, A validated risk model for prediction of early readmission in patients with hepatic encephalopathy, Ann Hepatol, 18, 310, 10.1016/j.aohep.2018.08.001 Wei, 2018, Hospital cirrhosis volume and readmission in patients with cirrhosis in California, Dig Dis Sci, 63, 2267, 10.1007/s10620-018-4964-0 Patel, 2019, Predictors of 1-month and 3-months hospital readmissions in decompensated cirrhosis: a prospective study in a large Asian cohort, Ann Hepatol, 18, 30, 10.5604/01.3001.0012.7859 Ufere, 2021, Burdensome transitions of care for patients with end-stage liver disease and their caregivers, Dig Dis Sci, 66, 2942, 10.1007/s10620-020-06617-4 Garrido, 2017, An educational tool for the prophylaxis of hepatic encephalopathy, BMJ Open Gastroenterol, 4, 10.1136/bmjgast-2017-000161 Bloom, 2020, A smartphone app to manage cirrhotic ascites among outpatients: feasibility study, JMIR Med Inform, 8, 10.2196/17770 Ganapathy, 2017, The patient buddy app can potentially prevent hepatic encephalopathy-related readmissions, Liver Int, 37, 1843, 10.1111/liv.13494 Bajaj, 2015, Validation of EncephalApp, smartphone-based Stroop test, for the diagnosis of covert hepatic encephalopathy, Clin Gastroenterol Hepatol, 13, 1828, 10.1016/j.cgh.2014.05.011 Di Pascoli, 2019, Long-term administration of human albumin improves survival in patients with cirrhosis and refractory ascites, Liver Int, 39, 98, 10.1111/liv.13968 Caraceni, 2018, Long-term albumin administration in decompensated cirrhosis (ANSWER): an open-label randomised trial, Lancet, 391, 2417, 10.1016/S0140-6736(18)30840-7 Scaglione, 2017, Early hospital readmissions and mortality in patients with decompensated cirrhosis enrolled in a large national health insurance administrative database, J Clin Gastroenterol, 51, 839, 10.1097/MCG.0000000000000826 Hospital readmissions reduction program (HRRP), CMS n.d. https://www.cms.gov/medicare/medicare-fee-for-service-payment/acuteinpatientpps/readmissions-reduction-program (accessed April 20, 2022). Singh, 2020, Association of liver cirrhosis severity with anemia: does it matter?, Ann Gastroenterol, 33, 272 Piano, 2017, Incidence, predictors and outcomes of acute-on-chronic liver failure in outpatients with cirrhosis, J Hepatol, 67, 1177, 10.1016/j.jhep.2017.07.008 Zaccherini, 2019, Prediction of nosocomial acute-on-chronic liver failure in patients with cirrhosis admitted to hospital with acute decompensation, JHEP Rep, 1, 270, 10.1016/j.jhepr.2019.07.005 Scheiner, 2020, Prevalence of and risk factors for anaemia in patients with advanced chronic liver disease, Liver Int, 40, 194, 10.1111/liv.14229 Villanueva, 2013, Transfusion strategies for acute upper gastrointestinal bleeding, N Engl J Med, 368, 11, 10.1056/NEJMoa1211801 Nadim, 2016, Management of the critically ill patient with cirrhosis: a multidisciplinary perspective, J Hepatol, 64, 717, 10.1016/j.jhep.2015.10.019 Maras, 2015, Dysregulated iron homeostasis is strongly associated with multiorgan failure and early mortality in acute-on-chronic liver failure, Hepatology, 61, 1306, 10.1002/hep.27636 Kohgo, 2008, Body iron metabolism and pathophysiology of iron overload, Int J Hematol, 88, 7, 10.1007/s12185-008-0120-5