Low free triiodothyronine and immune-related hyperthyroidism are associated with overall and progression-free survival in head and neck squamous cell carcinoma treated with pembrolizumab

International Immunopharmacology - Tập 123 - Trang 110799 - 2023
Markus Haas1, Alexander Lein1, Thorsten Fuereder2, Julia Schnoell1, Faris F. Brkic1, Nicholas J. Campion1, David T. Liu1, Lorenz Kadletz-Wanke1, Gregor Heiduschka1, Bernhard J. Jank1
1Department of Otorhinolaryngology, Head and Neck Surgery, Medical University of Vienna, Vienna, Austria
2Division of Oncology, Department of Medicine I, Medical University of Vienna, Vienna, Austria

Tài liệu tham khảo

Ferris, 2016, Nivolumab for Recurrent Squamous-Cell Carcinoma of the Head and Neck, N. Engl. J. Med., 375, 1856, 10.1056/NEJMoa1602252 Burtness, 2019, Pembrolizumab alone or with chemotherapy versus cetuximab with chemotherapy for recurrent or metastatic squamous cell carcinoma of the head and neck (KEYNOTE-048): a randomised, open-label, phase 3 study, Lancet., 394, 1915, 10.1016/S0140-6736(19)32591-7 Wagner, 2023, Real-world Data of Palliative First-line Checkpoint Inhibitor Therapy for Head and Neck Cancer, Anticancer. Res., 43, 1273, 10.21873/anticanres.16274 Zhai, 2017, Radiation-induced hypothyroidism after IMRT for nasopharyngeal carcinoma: Clinical and dosimetric predictors in a prospective cohort study, Oral. Oncol., 68, 44, 10.1016/j.oraloncology.2017.03.005 O'Meara, 2003, Follow-up of head and neck cancer patients post-radiotherapy, Radiother. Oncol., 66, 323, 10.1016/S0167-8140(02)00405-X Baghel, 2020, Is thyroid excision mandatory with laryngectomy in carcinoma larynx?, BMC. Cancer., 20, 700, 10.1186/s12885-020-07205-5 Nelson, 2006, Association between development of hypothyroidism and improved survival in patients with head and neck cancer, Arch. Otolaryngol. Head. Neck. Surg., 132, 1041, 10.1001/archotol.132.10.1041 Smith, 2009, Hypothyroidism in older patients with head and neck cancer after treatment with radiation: a population-based study, Head. Neck., 31, 1031, 10.1002/hed.21066 Yasar, 2014, Can non-thyroid illness syndrome predict mortality in lung cancer patients? A prospective cohort study, Horm. Cancer., 5, 240, 10.1007/s12672-014-0183-0 Cengiz, 2008, Nutritional and prognostic significance of sick euthyroid syndrome in non-small cell lung cancer patients, Intern. Med., 47, 211, 10.2169/internalmedicine.47.0423 Gao, 2018, Low T3 syndrome as a predictor of poor prognosis in chronic lymphocytic leukemia, Int. J. Cancer., 143, 466, 10.1002/ijc.31327 Pan, 2022, The Association Between Low T3 Syndrome and Survival in Patients With Newly Diagnosed Multiple Myeloma: A Retrospective Study, Technol. Cancer. Res. Treat., 21, 10.1177/15330338221094422 Economopoulou, 2020, Association of autoimmunity with survival in patients with recurrent/metastatic head and neck squamous cell carcinoma treated with nivolumab, Oral. Oncol., 111, 10.1016/j.oraloncology.2020.105013 Osorio, 2017, Antibody-mediated thyroid dysfunction during T-cell checkpoint blockade in patients with non-small-cell lung cancer, Ann. Oncol., 28, 583, 10.1093/annonc/mdw640 Sakakida, 2019, Clinical features of immune-related thyroid dysfunction and its association with outcomes in patients with advanced malignancies treated by PD-1 blockade, Oncol. Lett., 18, 2140 Yamauchi, 2019, Incidence, features, and prognosis of immune-related adverse events involving the thyroid gland induced by nivolumab, PLoS. One., 14, e0216954, 10.1371/journal.pone.0216954 Zhou, 2021, Thyroid function abnormality induced by PD-1 inhibitors have a positive impact on survival in patients with non-small cell lung cancer, Int. Immunopharmacol., 91, 10.1016/j.intimp.2020.107296 Eisenhauer, 2009, New response evaluation criteria in solid tumours: revised RECIST guideline (version 1.1), Eur. J. Cancer., 45, 228, 10.1016/j.ejca.2008.10.026 Harrington, 2023, Pembrolizumab With or Without Chemotherapy in Recurrent or Metastatic Head and Neck Squamous Cell Carcinoma: Updated Results of the Phase III KEYNOTE-048 Study, J. Clin. Oncol., 41, 790, 10.1200/JCO.21.02508 Cohen, 2019, Pembrolizumab versus methotrexate, docetaxel, or cetuximab for recurrent or metastatic head-and-neck squamous cell carcinoma (KEYNOTE-040): a randomised, open-label, phase 3 study, Lancet., 393, 156, 10.1016/S0140-6736(18)31999-8 von Itzstein, 2022, Divergent prognostic effects of pre-existing and treatment-emergent thyroid dysfunction in patients treated with immune checkpoint inhibitors, Cancer. Immunol. Immunother., 71, 2169, 10.1007/s00262-022-03151-2 Fliers, 2021, An update on non-thyroidal illness syndrome, J. Endocrinol. Invest., 44, 1597, 10.1007/s40618-020-01482-4 Hoermann, 2022, Principles of Endocrine Regulation: Reconciling Tensions Between Robustness in Performance and Adaptation to Change, Front. Endocrinol. (Lausanne)., 13, 10.3389/fendo.2022.825107 Tognini, 2010, Non-thyroidal illness syndrome and short-term survival in a hospitalised older population, Age. Ageing., 39, 46, 10.1093/ageing/afp197 Kim, 2022, The Tri-iodothyronine (T3) Level Is a Prognostic Factor for Patients With Advanced NSCLC: Receiving Immune Checkpoint Inhibitors and Is Associated With Liver Metastasis, Clin. Med. Insights. Oncol., 16, 10.1177/11795549221139522 Gao, 2017, Low T3 syndrome is a strong prognostic predictor in diffuse large B cell lymphoma, Br. J. Haematol., 177, 95, 10.1111/bjh.14528 Xue, 2023, Low T3 syndrome as a predictor of poor outcomes in patients with follicular lymphoma, Ann. Hematol., 102, 851, 10.1007/s00277-023-05117-5 Green, 2020, Emerging immune checkpoint inhibitors for the treatment of head and neck cancers, Expert. Opin. Emerg. Drugs., 25, 501, 10.1080/14728214.2020.1852215 Roussot, 2022, Tumor Immunogenic Cell Death as a Mediator of Intratumor CD8 T-Cell Recruitment, Cells., 11, 10.3390/cells11223672 Welters, 2018, Intratumoral HPV16-Specific T Cells Constitute a Type I-Oriented Tumor Microenvironment to Improve Survival in HPV16-Driven Oropharyngeal Cancer, Clin. Cancer. Res., 24, 634, 10.1158/1078-0432.CCR-17-2140 Wondergem, 2020, The Immune Microenvironment in Head and Neck Squamous Cell Carcinoma: on Subsets and Subsites, Curr. Oncol. Rep., 22, 81, 10.1007/s11912-020-00938-3 Alamino, 2019, Dendritic Cells Exposed to Triiodothyronine Deliver Pro-Inflammatory Signals and Amplify IL-17-Driven Immune Responses, Cell. Physiol. Biochem., 52, 354, 10.33594/000000025 Florencia Soler, 2022, Triiodothyronine-stimulated dendritic cell vaccination boosts antitumor immunity against murine colon cancer, Int. Immunopharmacol., 110, 10.1016/j.intimp.2022.109016 Rubingh, 2020, The Role of Thyroid Hormone in the Innate and Adaptive Immune Response during Infection, Compr. Physiol., 10, 1277, 10.1002/cphy.c200003 Matsuo, 2020, Relationship between immune-related adverse events and the long-term outcomes in recurrent/metastatic head and neck squamous cell carcinoma treated with nivolumab, Oral. Oncol., 101, 10.1016/j.oraloncology.2019.104525 Haas, 2023, The Geriatric Nutritional Risk Index (GNRI) as a Prognostic Biomarker for Immune Checkpoint Inhibitor Response in Recurrent and/or Metastatic Head and Neck Cancer, Nutrients., 15, 10.3390/nu15040880 Mazarico, 2019, Low frequency of positive antithyroid antibodies is observed in patients with thyroid dysfunction related to immune check point inhibitors, J. Endocrinol. Invest., 42, 1443, 10.1007/s40618-019-01058-x Delivanis, 2017, Pembrolizumab-Induced Thyroiditis: Comprehensive Clinical Review and Insights Into Underlying Involved Mechanisms, J. Clin. Endocrinol. Metab., 102, 2770, 10.1210/jc.2017-00448 Chilelli, 2022, Immune-related Thyroid Dysfunction (irTD) in Non-small Cell Lung Cancer (NSCLC) Correlates With Response and Survival, Cancer. Diagn. Progn., 2, 55, 10.21873/cdp.10076 Thuillier, 2021, Thyroid dysfunction induced by immune checkpoint inhibitors is associated with a better progression-free survival and overall survival in non-small cell lung cancer: an original cohort study, Cancer. Immunol. Immunother., 70, 2023, 10.1007/s00262-020-02802-6 de Filette, 2016, Incidence of Thyroid-Related Adverse Events in Melanoma Patients Treated With Pembrolizumab, J. Clin. Endocrinol. Metab., 101, 4431, 10.1210/jc.2016-2300 Fidilio, 2021, Thyroid disorders associated with immune control point inhibitors, Endocrinol. Diabetes Nutr. (Engl. Ed)., 68, 408 Kotwal, 2020, PD-L1 Inhibitor-Induced Thyroiditis Is Associated with Better Overall Survival in Cancer Patients, Thyroid., 30, 177, 10.1089/thy.2019.0250